Artiklar / Articles - K8 (CNS)
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Recent submissions
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Reduced variability of bursting activity during working memory
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-01-30)Working memories have long been thought to be maintained by persistent spiking. However, mounting evidence from multiple-electrode recording (and single-trial analyses) shows that the underlying spiking is better characterized ... -
Working memory control dynamics follow principles of spatial computing
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-01-30)Working memory (WM) allows us to remember and selectively control a limited set of items. Neural evidence suggests it is achieved by interactions between bursts of beta and gamma oscillations. However, it is not clear how ... -
An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-17)Background: The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be ... -
Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-12-14)Multiple sclerosis (MS) is a leading cause of incurable progressive disability in young adults caused by inflammation and neurodegeneration in the central nervous system (CNS). The capacity of microglia to clear tissue ... -
MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-09-16)T cell-driven diseases account for considerable morbidity and disability globally and there is an urgent need for new targeted therapies. Both cancer cells and activated T cells have an altered redox balance, and up-regulate ... -
Human ISL1+ ventricular progenitors self-assemble into an in vivo functional heart patch and preserve cardiac function post infarction
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-07-01)The generation of human pluripotent stem cell (hPSC)-derived ventricular progenitors and their assembly into a 3-dimensional in vivo functional ventricular heart patch has remained an elusive goal. Herein, we report the ... -
Detecting prolonged sitting bouts with the ActiGraph GT3X
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)The ActiGraph has a high ability to measure physical activity; however, it lacks an accurate posture classification to measure sedentary behavior. The aim of the present study was to develop an ActiGraph (waist-worn, 30 ... -
Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-02-24)Background and aims: Unstable carotid atherosclerosis causes stroke, but methods to identify patients and lesions at risk are lacking. We recently found enrichment of genes associated with calcification in carotid plaques ... -
Lipids, apolipoproteins, and prognosis of amyotrophic lateral sclerosis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-06-08)Objective: To determine whether lipids and apolipoproteins predict prognosis of patients with amyo- trophic lateral sclerosis in a cohort study of 99 patients with amyotrophic lateral sclerosis who were diagnosed during ... -
Efficacy and cost-effectiveness of therapist-guided internet cognitive behavioural therapy for paediatric anxiety disorders : a single-centre, single-blind, randomised controlled trial
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-03-27)Background: Paediatric anxiety disorders are prevalent and associated with substantial disability and long-term adverse consequences. Only a minority of affected children have access to evidence-based treatment; ... -
Bidirectional relationship between eating disorders and autoimmune diseases
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-11-26)Background: Immune system dysfunction may be associated with eating disorders, and associations could have implications for detection, risk assessment, and treatment of both autoimmune diseases and eating disorders. However, ... -
Company employees as experimental participants in traffic safety research : prevalence and implications
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and EthicsInst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-11-08)The use of company employees as experimental participants when testing products, technology or paradigms developed by the same company raises questions about bias in results and research ethics. We aimed to investigate the ... -
Associations between cognition and serotonin receptor 1B binding in patients with major depressive disorder : a pilot study
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-01-04)The neurotransmitter serotonin has been widely implicated in the pathophysiology of major depressive disorder (MDD). In animal studies and human neuroimaging studies, involvement of the serotonin receptor 1B (5-HT1BR) in ... -
A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette’s/chronic tic disorders
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-11-29)The association between obsessive-compulsive disorder (OCD) and Tourette's/chronic tic disorders (TD/CTD) with autoimmune diseases (ADs) is uncertain. In this nationwide study, we sought to clarify the patterns of comorbidity ... -
European bioimaging facility survey report
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-10-05)This report describes the results of a survey undertaking by NatMEG (the Swedish national facility for magnetoencephalography; www.natmeg.se), performed under the auspices of Swedish Bioimaging. The three Swedish national ... -
Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity : a population based familial co-aggregation study in Sweden
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-07-07)BACKGROUND: Despite meta-analytic evidence for the association between attention-deficit/hyperactivity disorder (ADHD) and overweight/obesity, the mechanisms underlying the association are yet to be fully understood. ... -
Predictors of adolescents’ consent to use health records for research and results from data collection in a Swedish twin cohort
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-07-07)INTRODUCTION: Non-random selection into a study population due to differences between consenters and non-consenters may introduce participation bias. Past investigations of factors predicting consent to collection of medical ... -
Neurodegenerative and psychiatric diseases among families with amyotrophic lateral sclerosis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-07-07)Objective: To estimate risks of neurodegenerative and psychiatric diseases among patients with amyotrophic lateral sclerosis (ALS) and their families. Methods: We conducted a register-based nested case-control study ... -
Internet-delivered cognitive behavior therapy for adolescents with irritable bowel syndrome : a randomized controlled trial
(Institutionen för klinisk neurovetenskap / Departement for clinical neuroscience, 2017-06-30)OBJECTIVES: Few treatments have been able to effectively manage pediatric irritable bowel syndrome (IBS). Internet-delivered cognitive behavior therapy (Internet-CBT) based on exposure for abdominal symptoms is effective ... -
Mode of obstetrical delivery and type 1 diabetes : a sibling design study
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-06-14)OBJECTIVES: We investigated the association between cesarean section (CS) and type 1 diabetes (T1D), and if the association remains after accounting for familial confounding by using a sibling-control design. METHODS: ...