Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience: Recent submissions
Now showing items 1-20 of 529
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HCMV-induced epigenetic alterations : a novel pathway to CNS tumor?
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-06-01)Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented ... -
Men with borderline personality disorder and antisocial behavior : clinical characteristics, developmental perspectives and interventions.
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-05-25)Background: Borderline personality disorder (BPD) is a mental disorder characterized by a pervasive pattern of emotional instability, impulsivity, relationship problems and identity disturbance. As the disorder has been ... -
Clinical assessment of high-risk suicide attempters : intent, violence and biomarkers
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-05-24)Background One of the most important but also difficult tasks that a physician is responsible for is to assess the suicide risk of a patient. Understanding the complex role of distal and proximal risk factors and their ... -
Regulation of microglia and monocyte function by the cytokine TGF-beta
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-05-09)It has been almost a century since Pío del Río-Hortega described the microglial cell, proposing it to be primarily occupied with phagocytosis of waste products. While this makes up one of its functions, we know today ... -
Child and adult homicide in Sweden : epidemiological and forensic features
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-05-09)Homicide occurs worldwide and is often regarded a major public-health concern. The studies comprising the present thesis were conducted with a view to advancing knowledge of both child and adult homicide from the viewpoints ... -
From DNA to CBT : an investigation psychological therapy response and genetics
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-05-09)Background: Social anxiety disorder, panic disorder, and major depressive disorder are common, disabling, and heritable disorders. The first line of treatment for all anxiety disorders and mild to moderate depression is ... -
Return to work : methods for promoting health and productivity in employees on sickness absence
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-04-27)Background: Sickness absence (SA) due to common mental disorders and musculoskeletal pain is highly prevalent worldwide and has increased markedly over the past decade. Mental and behavioral disorders account for more ... -
Nonsuicidal self-injury and emotion regulation : clinical correlates and novel treatments
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-03-27)Background: Nonsuicidal self-injury (NSSI) and NSSI disorder are common, particularly among adolescents and young adults, and have been associated with several adverse outcomes, including general psychopathology and ... -
Deliberate self-harm : characteristics, clinical correlates and interventions
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-03-20)Background: Deliberate self-harm (DSH) and nonsuicidal self-injury (NSSI) are serious global health problems prevalent among both community and clinical samples. Several studies have suggested that aggression towards ... -
Idiopathic polyneuropathy : a pathogenetic study
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-03-13)Polyneuropathy (PNP) stands for dysfunction in the peripheral nerves. The classical clinical manifestations of PNP are distal, symmetric sensory symptoms, such as numbness and pain, as well as distal weakness in a sock- ... -
Immunogenicity of biopharmaceuticals in chronic inflammatory diseases
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-02-23)Multiple sclerosis (MS) and rheumatoid arthritis (RA) are chronic inflammatory diseases where genetic and environmental factors influence the pathogenesis. MS is a disease of the central nervous system, while RA primarily ... -
Self-harm in youth : predicting mental illness, social marginalisation and suicide
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-02-23)Aims: The aims of this thesis were to study self-harm in young people and to evaluate the risks of adverse outcomes through short- and long-term follow-up. The primary focus was on the risk of suicide, and also on the ... -
Immunological mechanisms regulating neuroinflammation : a role for C-type lectin receptors and vitamin D
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-02-20)Autoimmunity of the central nervous system (CNS) such as in Multiple Sclerosis (MS) or its animal model Experimental Autoimmune Encephalomyelitis (EAE) requires the activation of self-reactive immune cells and the presentation ... -
PS - a school-wide prevention programme : effects, core components and implementation.
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-02-08)PS is multi-component intervention at the primary prevention level and aims at creating a positive learning environment and decreasing problem behaviours among students in the school years 4-9. During 2009-2012 the ... -
Eating disorders and personality
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-02-01)Eating disorders are serious psychiatric conditions often demanding specialized psychiatric care. Several effective treatments have been developed and disseminated, but more needs to be done, as not all patients respond ... -
CBT in primary care : effects on symptoms and sick leave, implementation of stepped care and predictors of outcome
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-02-01)Background Common mental disorders (CMDs) cause great individual suffering and high societal costs including long-term sick leave. Cognitive behavioural therapy (CBT) can effectively treat CMDs, but access to treatment ... -
Associations between cognition and serotonin receptor 1B binding in patients with major depressive disorder : a pilot study
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-01-04)The neurotransmitter serotonin has been widely implicated in the pathophysiology of major depressive disorder (MDD). In animal studies and human neuroimaging studies, involvement of the serotonin receptor 1B (5-HT1BR) in ... -
Sickness absence, disability pension, and permanent medical impairment after a car crash
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-12-15)Background: Road traffic injuries constitute a major public health problem worldwide. Permanent medical impairment (PMI) is used as a measure of seriousness of injuries in Sweden. There is little knowledge on consequences ... -
Attention deficit hyperactivity disorder in adults : neuropsychological deficits and functional Impairments
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-11-28)The overall aim of the present thesis was to investigate the role of neuropsychological deficits in adult ADHD. Study I examined the psychometric properties of a new rating instrument, the Adult Executive Functioning ... -
Cognitive control in reinforcement learning : brain structure and function
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-11-23)Adapting behaviour according to internal or external feedback is a fundamental property of cognitive control. For example, humans tend to slow down when they make mistakes, a process called post-error slowing (PES), which ...