Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience: Recent submissions
Now showing items 1-20 of 500
-
Structural and functional brain connectivity abnormalities associated with adolescent conduct disorder in females
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-09-22)Background: Antisocial behavior (ASB) in childhood and adolescence is indexed by the diagnosis of conduct disorder (CD) and is associated with high rates of comorbid mental disorders, such as anxiety, depression, alcohol ... -
Violence among offenders with mental disorders
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-09-20)Background Interpersonal violence is described as a global health problem by the World Health Organization. Even though individuals with severe mental disorders commit only a fraction of all violent acts, they appear ... -
Brain networks in time : deriving and quantifying dynamic functional connectivity
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-09-18)Studying the brain’s structure and function as a network has provided insight about the brain’s activity in health and disease. Networks in the brain are often averaged over trials, frequency and time and this is called ... -
Information processing and expectations in delusion-proneness
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-09-11)One of the most characteristic features of psychosis is delusional ideation. Delusions represent incorrect and inflexible beliefs that are not based on reality. It has been proposed that delusions may be secondary to ... -
Never let go! : the etiology, clinical presentation and treatment of hoarding disorder
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-09-01)Background: Hoarding disorder (HD) is characterized by difficulties discarding possessions which results in clutter that is impeding and causes distress. Retrospective reports suggest HD debuts in childhood or adolescence ... -
More than pain : assessment and treatment of pain-related dysfunction in pediatric chronic pain
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-08-30)Background: Pediatric chronic pain is prevalent, affecting between 11-38% of children and adolescents, with a subset of individuals suffering from substantial pain-related disability. Dysfunction in emotional, social and ... -
Learning from the behaviors and experiences of others
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-08-25)Learning to fear and avoid what is dangerous is crucial for survival. Perhaps equally important is the ability to learn that something which was previously dangerous is now safe. Although we can learn about dangers ... -
The monoamine stabilizer (-)-OSU6162 : a potential novel treatment for alcohol use disorders
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-08-24)Alcohol use disorder (AUD) represent a major health problem worldwide. Despite the severe consequences of AUD, only four medications are approved in Sweden for this disease. In addition, the prescription rates are low, ... -
New approach to the treatment of ADHD through internet and smartphones : from impairment to improvement
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-08-18)Background: Attention deficit hyperactive disorder (ADHD) is a common and disabling disorder, affecting 2-4% of the adult population worldwide. Pharmacological treatment is often the only available option, however ... -
Vessel occlusion and functional outcome after acute stroke : prediction and evaluation
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-05-22)In the acute setting of ischaemic stroke, two proven treatments are available: intravenous thrombolysis (iv-tPA) with alteplase and endovascular thrombectomy. The main aim of this thesis was to investigate the ... -
Intimate partner homicide rates and characteristics
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-05-18)Aims: The overarching objective of present dissertation project is to study trends and characteristics of intimate partner homicide (IPH), and to investigate whether the trends and characteristics differ depending ... -
Involvement of epigenetic mechanisms in disease inheritance and pathogenesis of Multiple Sclerosis (MS) with a focus on genomic imprinting and DNA methylation in CD4+ T cells
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-05-03)Multiple Sclerosis (MS) is a chronic inflammatory and neurodegenerative disease driven by autoreactive CD4+ T cells. Disease etiology is mediated by a strong interplay between genetic and environmental factors implying ... -
PET studies on the immune cell marker TSPO in first episode psychosis patients
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-04-28)Several lines of evidence are indicative of a role for immune activation in the pathophysiology of schizophrenia. Nevertheless, studies using positron emission tomography (PET) and radioligands for the translocator protein ... -
Development of income following sickness absence from the workplace or long-term unemployment, and among individuals with Multiple Sclerosis
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-04-27)The overall aim of this thesis was to gain knowledge of how reduced work capacity due to morbidity is associated with subsequent individual economic outcomes and how different components of the Swedish welfare system were ... -
In vivo imaging markers for the characterization of molecular changes in Parkinson and Huntington's disease
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-04-21)Parkinson’s disease (PD) and Huntington’s disease (HD) are neurodegenerative disorders characterized by a progressive multi-systemic accumulation of misfolded proteins associated with neuronal dysfunction and neuronal ... -
Aspects of migraine and patent foramen ovale in ischemic stroke
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-04-10)Stroke is one of the main causes of death and disability worldwide, and only in Sweden approximately 25 000 individuals suffer from stroke each year. This thesis focuses on two common conditions; migraine and patent foramen ... -
Etiology, prevalence, and development of a novel treatment for body dysmorphic disorder
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-04-06)Body dysmorphic disorder (BDD) is characterized by an intense preoccupation with perceived defects in physical appearance that are not noticeable, or only appear slight to others. While effective treatment for this ... -
On gender dysphoria
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-03-10)Gender identity refers to an innate and deeply felt psychological identification as a female, male, or some other non-binary gender. Gender identity may be congruent or incongruent with the sex assigned at birth. Gender ... -
Genotype-phenotype characterization of familial hyperkinetic movement disorders : emphasis on ataxia and brain calcifications
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-03-08)Differential diagnosis of familial chorea encompasses Huntington’s disease along with a group of conditions referred to as Huntington’s disease-like (HDL). One such HDL is an inherited prion disorder (IPD) caused by ... -
Internet-delivered cognitive behavior therapy for adolescents with obsessive-compulsive disorder
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-03-02)Background: About one in 100 adolescents suffers from obsessive-compulsive disorder (OCD). OCD usually causes severe impairment in social, academic, and family functioning. As OCD often has a chronic course and is ...