Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience: Recent submissions
Now showing items 1-20 of 568
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Too tired to talk? Sleep, fatigue, and social functioning
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-11-21)Sleep has been shown to have many health promoting functions, and is vital for the maintenance of physiological, cognitive, and emotional well-being. Much of what we know about sleep derives from studies showing what happens ... -
Getting close with discomfort : exposure therapy for fibromyalgia
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-11-13)Background: Fibromyalgia (FM) is a common and debilitating disorder for which there are currently no treatments available that are satisfyingly effective. Cognitive behavior therapy (CBT) might be a promising treatment ... -
Immune cells and stem cells in spinal cord injury : defining spinal cord injury associated microglia
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-11-13)Traumatic spinal cord injury (SCI) commonly results from falls, sport activities or traffic accidents and most often results in lost sensory, motor and/or autonomic functions below the level of injury. The cellular- and ... -
Methodological issues in psychological treatment research : applications to gambling research and therapist effects
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-11-12)Over the last couple of decades evidence-based psychotherapies have flourished, and there are now therapies that are well-established for a wide range of problems. At the same time the mental-health burden is still enormous, ... -
Interactions between the opioid and serotonin systems in chronic pain : quantitative live cell study by Fluorescence Cross-Correlation Spectroscopy (FCCS)
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-11-11)Chronic pain is a major health issue worldwide. It enacts considerable suffering on the affected individuals and significantly increases the societal burden, as it is the most common reason why individuals seek sick leave ... -
Cognitive deficits in alcohol use disorder : etiology and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-11-04)Alcohol use disorder (AUD) is a psychiatric disorder characterized by a loss of control over drinking, tolerance, withdrawal and negative psychological, physical and social consequences due to excessive alcohol consumption. ... -
Risk factors and health consequences of obsessive-compulsive and chronic tic disorders
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-10-25)Background: Obsessive-compulsive disorder (OCD) is a severe and heterogenous mental disorder characterized by intrusive thoughts, urges or images, followed by repetitive behaviors aimed to reduce the associated anxiety. ... -
Involving concerned significant others in the treatment of problem gambling
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-10-18)Background: Problem gambling (PG) is a worldwide phenomenon that affects both gamblers and their concerned significant others (CSOs). Apart from financial difficulties, problem gambling is associated with disrupted ... -
Internet-delivered cognitive behaviour therapy for paediatric anxiety disorders in clinical settings : increasing access to evidence-based treatments
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-10-17)Background: Paediatric anxiety disorders are common, impairing and associated with a societal and economic burden. Even though there are efficacious treatments to treat these disorders, access to them are limited. ... -
Modelling and quantifying brain connectivity and dynamics with applications in aging and ADHD
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-10-04)Human brain is a complex organ and made up of integrative networks encompassing a large number of regions. These regions communicate with each other to share information involved in complex cognitive processes. Functional ... -
Epigenetics in health and disease : on smoking, multiple sclerosis, and rheumatoid arthritis disease states
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-10-03)The main aim of this thesis was to investigate the genome-wide DNA methylation in tissues associated with the immunopathogenesis of two autoimmune diseases, Rheumatoid Arthritis (RA) and Multiple Sclerosis (MS), as well ... -
Multiple sclerosis : from genetic variants to biomarkers
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-09-06)Multiple sclerosis (MS) is a common chronic autoimmune and neurodegenerative disease of the central nervous system (CNS). MS is a debilitating disease that affects young adults, especially females. Why we develop MS? Is ... -
Pediatric acute neuropsychiatric syndrome : diagnosis, biomarkers and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-05-23)Background: Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) are proposed diagnoses combining a clinical picture ... -
Pathways to labour market marginalisation : aspects of common mental disorders, migration status and age
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-05-21)Background: Labour market marginalisation (LMM), measured as sickness absence (SA)/disability pension (DP) or unemployment, differs between young immigrants and natives in several countries. The aim of this project was ... -
Development of novel 5-HT1B PET radioligands
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-05-15)Positron emission tomography (PET) is a useful tool for studying the central nervous system (CNS) in living subjects. PET is a non-invasive imaging technique that can visualize biochemical process such as receptor-ligand ... -
Testing principles from cognitive behavior therapy for preventing stress-related ill health among newly registered nurses
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-05-15)Transitioning from education to working life is a challenging endeavor and newly registered nurses are one professional group that report high levels of symptoms of stress-related ill health. Transition-to-practice programs ... -
Predicting suicide attempt and suicide : the role of standardised instruments in a psychiatric cohort
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-04-25)Aim. The aim of this thesis was to assess the role of standardised instruments in prediction of suicide attempt and suicide in patients known to have an increased risk of these outcomes, namely patients with self-harm. ... -
Myeloid cells in experimental neuropathologies
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-04-05)The first innate immune cells, most importantly for this thesis macrophages, microglia and eosinophils, were described more than 100 years ago and only now do we begin to understand more about their development, functions ... -
Efficacy and cost-effectiveness of therapist-guided internet cognitive behavioural therapy for paediatric anxiety disorders : a single-centre, single-blind, randomised controlled trial
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-03-27)Background: Paediatric anxiety disorders are prevalent and associated with substantial disability and long-term adverse consequences. Only a minority of affected children have access to evidence-based treatment; ... -
MRI in multiple sclerosis : early detection, cortical lesions and gadolinium retention
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-03-21)Background: Multiple sclerosis (MS) is a common neuroinflammatory and -degenerative disease. Magnetic Resonance Imaging (MRI) facilitates the diagnosis of MS, providing means to initiate early treatment and improving the ...