Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience: Recent submissions
Now showing items 1-20 of 596
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Structural, interpersonal, and individual factors influencing sexual orientation-based disparities in mental health : a socio-ecological perspective on sexual minority stigma
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-08-28)Background: Compared to heterosexual individuals, sexual minorities (e.g., those identifying as gay, lesbian, or bisexual) are at higher risk of several mental health problems, including suicidality, substance abuse, ... -
Acquisition strategies for fat/water separated MRI
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-08-28)This thesis focuses on new ways to more efficiently acquire the signal for fat/water separated MRI, also known as Dixon methods. In paper I, the concept of dual bandwidths was introduced to improve SNR efficiency by ... -
Development of radiofrequency pulses for fast and motion-robust brain MRI
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-08-21)This thesis is based on three projects and the three scientific articles that were the result of each project. Each project deals with various kinds of technical software development in the field of magnetic resonance ... -
Dimethyl fumarate for treatment of multiple sclerosis : clinical effects and mechanisms
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-08-10)Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS). Dimethyl fumarate (DMF) is one of the more recent additions to a rapidly expanding treatment repertoire for MS. While DMF ... -
Late-stage 11C-carbonylation of drug-like molecules for PET
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-07-23)Positron emission tomography (PET) is a non-invasive in vivo imaging technique used for translational biomedical research and clinical diagnosis. A fundamental pre-condition for PET is the radiolabelled tracer molecule ... -
Cerebral oedema after reperfusion therapy in patients with ischaemic stroke : predictors, outcomes and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-26)Introduction: Reperfusion therapy by intravenous thrombolysis (IVT) and/or endovascular thrombectomy (EVT) are established treatments in ischaemic stroke. Cerebral oedema (COED), caused by dysfunction the blood brain ... -
Immunopathogenesis of multiple sclerosis : big roles for small RNAs
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-21)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) and the leading cause of neurological disability in young adults. The exact cause of MS remains elusive despite enormous progress ... -
Magnetic resonance imaging techniques for diagnostics in Parkinson’s disease and atypical parkinsonism
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-20)Background: Parkinson’s disease (PD) is a neurodegenerative disease characterized by rigidity, hypokinesia, tremor and postural instability. PD is a clinical diagnosis based on neurological examination, patient history ... -
Investigating and explaining sex differences in episodic memory
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-18)Sex differences can be seen in a lot of different areas, one of them being cognition where, among other things, men tend to perform better at more spatial tasks and women at more verbal. When it comes to episodic memory ... -
Translational studies of molecular interactions in Parkinson's disease
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-08)Interactions between molecules are the basis of cellular function. In disease, these tightly regulated systems are often disturbed. Parkinson’s disease (PD) is recognized by protein aggregates in the brain of erroneously ... -
Between the lines : gambling among athletes and coaches in four elite sports
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-23)Background and aim: Knowledge of how gambling and problem gambling are distributed in different societal groups is valuable for developing preventive initiatives. Considering the financial connections between sports and ... -
Electrophysiology-based investigations of G protein-coupled receptor pharmacology
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-23)G protein-coupled receptors (GPCRs) constitute targets for ~34% of approved drugs. The muscarinic acetylcholine M2 receptor (M2R) activates G protein-coupled receptor inward rectifying potassium (GIRK) channels in the ... -
Sickness absence and disability pension among individuals injured in a bicycle crash
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-21)Bicyclists are the road user group with the highest number of severe injuries, yet little is known about the impact of such injuries on sickness absence (SA) and disability pension (DP). Therefore, the aim was to increase ... -
Make friends with your pain monster : internet-delivered acceptance- and value-based exposure in chronic pain : model and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-17)Background: Chronic pain is a complex and common condition, often affecting functioning across a wide range of outcomes as pain interferes with daily activities. The understanding of mechanisms for development and maintenance ... -
Fear and missing out : internet-treatment for social anxiety disorder in youth
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-17)Background: Social anxiety disorder (SAD) is common, highly impairing and associated with severe effects on functioning and with increased monetary costs for the society. The disorder typically emerges during childhood ... -
Adaptive treatment strategies in internet-delivered Cognitive behavior therapy : predicting and avoiding treatment failures
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-17)Background: Internet-delivered Cognitive Behavior Therapy (ICBT) is efficacious for a number of psychiatric disorders and can be successfully implemented in routine psychiatric care. Still, only about half of patients ... -
Healthcare professionals’ work with sickness absence : with focus on oncology
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-14)Background: Physicians have an important role in patients’ sickness absence (SA) process, and many initiatives have been taken to influence their sickness certification practice. Many physicians experience sickness ... -
The role of epigenetics in Multiple Sclerosis development, progression and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-03)The overall aim of this thesis was to determine epigenetic changes in peripheral immune cells from Multiple Sclerosis (MS) patients. MS is a chronic inflammatory neurodegenerative disease, which initially presents itself ... -
Reduced working hours and stress in the Swedish social services
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-01)Background: Since a financial crisis in the 1990’s employees in the Swedish public sector have suffered from work stress and related consequences such as long-term sick leave. Reduced working hours has long been debated ... -
Molecular approaches for characterization, diagnosis and therapy of allergy to pets
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-03-06)Allergy to furred animals is a common affliction, where up to 20% of the population in affluent countries are sensitized to one or more pet allergens. Several causative allergens from an array of species have been identified, ...