Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience: Recent submissions
Now showing items 1-20 of 646
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Interplay between blood-brain barrier disruption and neuroinflammation following severe traumatic brain injury
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2022-01-13)A severe traumatic brain injury (TBI) holds deleterious consequences for the afflicted, its next-of-kin and society. Still today, prognosis is semi-desolate. One explanation for this might be pathophysiological processes ... -
Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation
(Inst för klinisk neurovetenskap / Dept of Clinical NeuroscienceKarolinska Institutet, 2021-12-14)Multiple sclerosis (MS) is a leading cause of incurable progressive disability in young adults caused by inflammation and neurodegeneration in the central nervous system (CNS). The capacity of microglia to clear tissue ... -
The impact of social information on emotional learning
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-11-24)Our survival is contingent on our ability to observe and interact with conspecifics. For example, by observing the facial expressions of others, we can vicariously learn to avoid potentially dangerous events without ... -
Immunogenicity of biological therapies : frequency, predictability and clinical relevance in chronic inflammatory diseases
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-11-12)Over the past three decades, biologic therapies have revolutionised the treatment of chronic inflammatory diseases such as multiple sclerosis (MS), systemic lupus erythematosus (SLE), and anti-neutrophil cytoplasmic ... -
Suicidal behaviour and healthcare use among refugees
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-11-10)Background: Despite higher rates of mental disorders among refugees, there is limited evidence on their risk of suicidal behaviour (suicide attempt and suicide) and how such risk is influenced by differences in country-level ... -
Multisensory control of gaze stabilization : from brainstem to bedside
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-10-29)Without the continuous updates provided by the vestibular and visual systems, our world would appear blurry and unstable. In order to allow the retina to reliably record incoming light in a meaningful way, the vestibulo-ocular ... -
Self-harm among adolescents : correlates, treatment, and healthcare consumption
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-10-29)Background: Self-harm is common in adolescence and young adulthood, and it is associated with adverse outcomes, such as general psychopathology and suicide. We need a better understanding of self-harm and its correlates ... -
Treatment and logistics of acute ischemic stroke : safety and outcomes
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-10-22)BACKGROUND: Stroke, both ischemic and hemorrhagic, accounts for over 20000 hospital admissions in Sweden yearly. The vast majority of patients (85%), suffer from ischemic stroke, an occlusion of a cerebral artery that ... -
Bridging the gap : patients and professionals perspective on risk and recovery in forensic psychiatry
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-10-08)Background: The aim of forensic psychiatry is to protect society and care for offenders with severe mental illness (SMI). People with severe mental illness show a certain increased risk of committing violent crimes, which ... -
Brief online interventions for concerned gamblers in a gambling helpline
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-09-23)Background: Problem gambling (PG) is common throughout the world and affects approximately 2% of the adult population in Sweden and most other western countries. Individuals who gamble in a problematic way experience ... -
Subtypes of ischemic stroke : analysis of revascularization therapy, stroke etiology, and the role of blood pressure
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-09-01)Background: Treatment with intravenous thrombolysis (IVT) and endovascular thrombectomy (EVT) improve outcomes for patients with acute ischemic stroke. The efficacy and safety of IVT and EVT may differ based on specific ... -
Tracking selective attention in a musical cocktail
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-08-18)The cocktail party effect refers to mankind’s ability to focus attention on a single sound within noisy or complex auditory environments, in order to extract the most behaviourally-relevant information present. To investigate ... -
Executive functions and successful behavior
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-07-28)Executive functions are the underlying mechanisms that drive top-down regulation of information processing. While suboptimal executive functions have been investigated in various groups of patients, their impact and ... -
Mechanisms of flavor perception : how odor and taste interact when we eat
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-06-02)Every time we eat, our brains are bombarded with sensory information from the olfactory and gustatory modalities. Through a binding process that is not fully understood, the odor and taste are then merged into flavor, a ... -
Post-migration stress and mental health among refugees : a population-based survey among refugees from Syria recently resettled in Sweden
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-31)Refugees are exposed to several risk factors for mental ill health before, during, and after the migration. While the impact of traumatic experiences on the mental health of refugees is well-known, the effect of adverse ... -
Exposure-based cognitive behavior therapy for atrial fibrillation : a novel treatment paradigm
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-28)Background: Atrial fibrillation (AF) is a prevalent arrhythmia associated with symptoms such as irregular heartbeat, palpitations, dyspnea, chest pain and fatigue. In many patients, AF symptoms are not alleviated by ... -
An object's smell in the multisensory brain : how our senses interact during olfactory object processing
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-28)Object perception is a remarkable and fundamental cognitive ability that allows us to interpret and interact with the world we are living in. In our everyday life, we constantly perceive objects–mostly without being aware ... -
Novel measure of olfactory bulb function in health and disease
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-26)Present neuroimaging techniques are capable of recording the neural activity from all over the brain but the olfactory bulb (OB). The OB is the first olfactory processing stage of the central nervous system and the site ... -
Anti-CD20 therapy in multiple sclerosis : clinical and paraclinical outcomes
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-25)Multiple sclerosis is a chronic inflammatory disease of the central nervous system and the most common non-traumatic cause of neurological disability in young adults. Rituximab is a B-cell depleting drug targeting the CD20 ... -
Effects of child CBT and parent management training for children with disruptive behavioral disorders
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-21)Background: An early identification and treatment of children with disruptive behavior disorders such as oppositional defiant disorder and conduct disorder is important to prevent further development of psychiatric ...