Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience: Recent submissions
Now showing items 1-20 of 544
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The toxicological pharmacoepidemiology of suicide : population-based studies on psychotropic-mediation use in Sweden
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-02-14)The act of completed suicide is a complex phenomenon associated with numerous identified individual and combined risk factors. Mental illness and related disorders confer among the highest risks of completed suicide and ... -
ACT treatment for youth : a contextual behavioral approach
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-01-25)Background: Mental and substance abuse disorders in children and youth are the leading cause of disability in the world. According to the World Health Organization (2018), approximately 20% of the world’s children and ... -
Clinical translation of a regeneration strategy for spinal cord injury
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-01-18)The complex and vulnerable tissue of the spinal cord does not heal after injury, leaving patients with lifelong disability after spinal cord injury (SCI). Many milestones have been reached during the last century through ... -
Individually tailored internet-based treatment for depression and comorbid conditions
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-12-21)Background: Depression is a large societal problem. People suffering from depression are heterogeneous and have a high degree of comorbid conditions. Pharmacological treatment is widespread, but not effective for all ... -
Severe health anxiety : novel approaches to diagnosis and psychological treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-11-09)Background: It has long been known that severe health anxiety is a common psychiatric condition associated with significant distress, functional impairment, and societal costs. Nevertheless, challenges remain with regard ... -
Reliability, replicability and reproducibility in PET imaging
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-11-08)Positron Emission Tomography (PET) is a non-invasive biomedical imaging method which can quantify biochemical markers as well as functional and metabolic activity in vivo. Following image analysis, quantification can be ... -
Company employees as experimental participants in traffic safety research : prevalence and implications
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and EthicsInst för klinisk neurovetenskap / Dept of Clinical NeuroscienceKarolinska Institutet, 2018-11-08)The use of company employees as experimental participants when testing products, technology or paradigms developed by the same company raises questions about bias in results and research ethics. We aimed to investigate the ... -
Functional MRI characterization of animal models of parkinsonism
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-11-02)Parkinson's disease (PD) is the second most common neurological disorder. It is characterized by the progressive development of motor symptoms - bradykinesia, resting tremor, muscular rigidity and difficulty with postural ... -
Stem cells in inflammation and regeneration : focusing on animal models of multiple sclerosis and spinal cord injury
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-11-01)The main objective of regenerative medicine is to replace or restore injured cells and tissues in the body. Stem cells are identified playing a key role in the regeneration but action of inflammatory mediators in disease ... -
Human embryonic stem cells for retinal repair : preclinical in vitro and in vivo studies for the treatment of age-related macular degeneration with human embryonic stem cell-derived retinal pigment epithelial cells
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-10-25)Age-related macular degeneration (AMD) is the major cause of vision loss in the industrialized countries in people above sixty years of age. The dry advanced form of the disease, also termed as geographic atrophy (GA), ... -
Positron emission tomography : development, evaluation and application of quantification methods
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-08-31)Positron Emission Tomography (PET) is an imaging technique that allows for in vivo quantification of biochemical and physiological processes in the brain. Examples of targets in the brain that can be imaged using PET are ... -
Dissemination of motivational interviewing : the role of workshop training and subsequent supervision in the development of competence in clinical practice
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-08-30)Aim: Training practitioners is often used as the primary implementation strategy to disseminate evidence based practices into clinical and community settings. The overall objective of this thesis was to evaluate various ... -
A study of the foveal structure in prematurely born children by the use of optical coherence tomography
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-08-29)During the last decades there has been a rapid development in techniques for retinal imaging. The optical coherence tomography (OCT) examination is non-invasive, fast and patient-friendly which are good qualities when ... -
Retinal thickness measured with optical coherence tomography in patients with multiple sclerosis
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-08-29)The retina offers a unique window to the brain with its unmyelinated axons that converge to the optic nerve. Optical coherence tomography (OCT) is a well-established and non-invasive imaging technique in the ophthalmology ... -
Genetic landscape of multiple sclerosis susceptibility by leveraging multi-omics data
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-08-24)The main objective of the research studies presented in this thesis is to study the genetic variants and the expression of genes that relate to Multiple Sclerosis (MS). MS is a polygenic disease with HLA-DRB1*15:01 allele ... -
HCMV-induced epigenetic alterations : a novel pathway to CNS tumors?
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-06-01)Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented ... -
Men with borderline personality disorder and antisocial behavior : clinical characteristics, developmental perspectives and interventions.
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-05-25)Background: Borderline personality disorder (BPD) is a mental disorder characterized by a pervasive pattern of emotional instability, impulsivity, relationship problems and identity disturbance. As the disorder has been ... -
Clinical assessment of high-risk suicide attempters : intent, violence and biomarkers
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-05-24)Background One of the most important but also difficult tasks that a physician is responsible for is to assess the suicide risk of a patient. Understanding the complex role of distal and proximal risk factors and their ... -
Regulation of microglia and monocyte function by the cytokine TGF-beta
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-05-09)It has been almost a century since Pío del Río-Hortega described the microglial cell, proposing it to be primarily occupied with phagocytosis of waste products. While this makes up one of its functions, we know today ... -
Child and adult homicide in Sweden : epidemiological and forensic features
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-05-09)Homicide occurs worldwide and is often regarded a major public-health concern. The studies comprising the present thesis were conducted with a view to advancing knowledge of both child and adult homicide from the viewpoints ...