Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience: Recent submissions
Now showing items 1-20 of 591
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Cerebral oedema after reperfusion therapy in patients with ischaemic stroke : predictors, outcomes and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-26)Introduction: Reperfusion therapy by intravenous thrombolysis (IVT) and/or endovascular thrombectomy (EVT) are established treatments in ischaemic stroke. Cerebral oedema (COED), caused by dysfunction the blood brain ... -
Immunopathogenesis of multiple sclerosis : big roles for small RNAs
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-21)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) and the leading cause of neurological disability in young adults. The exact cause of MS remains elusive despite enormous progress ... -
Magnetic resonance imaging techniques for diagnostics in Parkinson’s disease and atypical parkinsonism
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-20)Background: Parkinson’s disease (PD) is a neurodegenerative disease characterized by rigidity, hypokinesia, tremor and postural instability. PD is a clinical diagnosis based on neurological examination, patient history ... -
Investigating and explaining sex differences in episodic memory
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-18)Sex differences can be seen in a lot of different areas, one of them being cognition where, among other things, men tend to perform better at more spatial tasks and women at more verbal. When it comes to episodic memory ... -
Translational studies of molecular interactions in Parkinson's disease
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-08)Interactions between molecules are the basis of cellular function. In disease, these tightly regulated systems are often disturbed. Parkinson’s disease (PD) is recognized by protein aggregates in the brain of erroneously ... -
Between the lines : gambling among athletes and coaches in four elite sports
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-23)Background and aim: Knowledge of how gambling and problem gambling are distributed in different societal groups is valuable for developing preventive initiatives. Considering the financial connections between sports and ... -
Electrophysiology-based investigations of G protein-coupled receptor pharmacology
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-23)G protein-coupled receptors (GPCRs) constitute targets for ~34% of approved drugs. The muscarinic acetylcholine M2 receptor (M2R) activates G protein-coupled receptor inward rectifying potassium (GIRK) channels in the ... -
Sickness absence and disability pension among individuals injured in a bicycle crash
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-21)Bicyclists are the road user group with the highest number of severe injuries, yet little is known about the impact of such injuries on sickness absence (SA) and disability pension (DP). Therefore, the aim was to increase ... -
Make friends with your pain monster : internet-delivered acceptance- and value-based exposure in chronic pain-model and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-17)Background: Chronic pain is a complex and common condition, often affecting functioning across a wide range of outcomes as pain interferes with daily activities. The understanding of mechanisms for development and maintenance ... -
Fear and missing out : internet-treatment for social anxiety disorder in youth
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-17)Background: Social anxiety disorder (SAD) is common, highly impairing and associated with severe effects on functioning and with increased monetary costs for the society. The disorder typically emerges during childhood ... -
Adaptive treatment strategies in internet-delivered Cognitive behavior therapy : predicting and avoiding treatment failures
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-17)Background: Internet-delivered Cognitive Behavior Therapy (ICBT) is efficacious for a number of psychiatric disorders and can be successfully implemented in routine psychiatric care. Still, only about half of patients ... -
Healthcare professionals’ work with sickness absence : with focus on oncology
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-14)Background: Physicians have an important role in patients’ sickness absence (SA) process, and many initiatives have been taken to influence their sickness certification practice. Many physicians experience sickness ... -
The role of epigenetics in Multiple Sclerosis development, progression and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-03)The overall aim of this thesis was to determine epigenetic changes in peripheral immune cells from Multiple Sclerosis (MS) patients. MS is a chronic inflammatory neurodegenerative disease, which initially presents itself ... -
Reduced working hours and stress in the Swedish social services
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-01)Background: Since a financial crisis in the 1990’s employees in the Swedish public sector have suffered from work stress and related consequences such as long-term sick leave. Reduced working hours has long been debated ... -
Molecular approaches for characterization, diagnosis and therapy of allergy to pets
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-03-06)Allergy to furred animals is a common affliction, where up to 20% of the population in affluent countries are sensitized to one or more pet allergens. Several causative allergens from an array of species have been identified, ... -
Penumbra oxygen metabolism and acute neuroinflammation in ischemic stroke : MRI and PET imaging of a M2 occlusion model in rat
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-03-04)Acute ischemic stroke (AIS) is caused by the sudden occlusion of a major artery of the brain, and results in infarction and severe ischemia within affected brain regions. If ischemic regions are rapidly revascularized, ... -
Sudden unexpected death in epilepsy, incidence, circumstances and risk factors
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-02-12)Although Sudden Unexpected Death in Epilepsy (SUDEP) has attracted increasing attention from the scientific community during the last 20 years, important gaps in knowledge still exist that hamper the development of methods ... -
Excessive worry in adolescents and adults : development and evaluation of theory-driven treatments
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-02-12)Background: Worry is common among both adolescents and adults, and excessive worry is related to a number of mental health problems. Current pharmacological and psychological treatments for worry are moderately effective, ... -
Sickness absence, disability pension, and permanent medical impairment among car occupants injured in a crash
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-02-06)Background: Health loss in the road transport system is a major global public health problem, with approximately 1.35 million people killed annually, and it is also the fifth leading cause of overall burden of disease. ... -
A behavioral defense against disease
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-01-31)Animals, including humans, have evolved under the continuous selection pressure posed by pathogens. As a result, we have developed a set of physiological mechanisms to combat pathogens – the immune system. However, engaging ...