Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience: Recent submissions
Now showing items 1-20 of 619
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Recruitment to multicentre randomised controlled trials in stroke : lessons learnt from the effects trial
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-26)Randomised controlled trials are the gold standard for evaluation treatments. Nevertheless, recruitment into trials is still challenging and many trials fail to meet their recruitment goals within the predetermined time. ... -
Method Development for [11C]carbon monoxide radiochemistry
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-25)Positron emission tomography (PET) is a non-invasive molecular imaging technique that has found extensive utility in biomedical research and in drug development. A fundamental pre-requisite for PET is the tracer, which is ... -
Positron emission tomography studies of the D₁ dopamine receptor in schizophrenia
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-19)This thesis is based on investigations of central D1-dopamine receptor (D1R) binding in vivo using positron emission tomography (PET). The aims were i) to examine the antipsychotic effect of a D1R antagonist in schizophrenia ... -
Repopulation of a microglia-depleted central nervous system : molecular characterization during homeostasis and disease
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-19)Microglia are predominant tissue resident macrophages within the central nervous system (CNS), and contribute to both CNS development and homeostasis. During disease conditions microglia undergo transcriptional re-programming ... -
Microglia : health promoting pathways and therapeutic targets in ageing and neuroinflammation
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-05)Microglia are the innate immune cells of the CNS with an embryonic origin and self-renew with a slow turnover throughout life. The health-promoting capacities of this cell are being acknowledged through updated and ... -
Mind and body exercises : associations with mental health, antidepressant medication, autonomic functioning and inflammatory biomarkers
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-05)Stress, depression and stress-related mental ill-health are common in societies all over the world, and people tend to use both conventional care within the health care system and complementary treatment methods to handle ... -
MRI quantification of multiple sclerosis pathology
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-02)Background: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease and a common cause of neurologic disability. MS pathology is characterized by demyelination, neuroaxonal loss and atrophy. ... -
Self-admission as a treatment tool in severe anorexia nervosa
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-01)Self-admission to psychiatric inpatient treatment is an innovative collaborative approach to healthcare rationing that invites patients to play a more active role in deciding when they need a higher level of care. In ... -
In vivo and in vitro studies of the serotonin 1B receptor in relation to major depressive disorder and treatment with ketamine
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-01-22)Despite the large implications of Major Depressive Disorder (MDD) on disease burden worldwide, current treatment options are suboptimal and a third of patients suffering from this disease do not respond to ... -
Multimodal neuroimaging of pain and inflammation in the central nervous system in patients with fibromyalgia and rheumatoid arthritis
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-01-22)The prevalence of concomitant fibromyalgia (FM) is puzzlingly high among rheumatoid arthritis (RA) patients and a contemporary challenge is to resolve why some RA patients continue to report pain despite adequate treatment ... -
Augmented navigation
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-01-14)Spinal fixation procedures have the inherent risk of causing damage to vulnerable anatomical structures such as the spinal cord, nerve roots, and blood vessels. To prevent complications, several technological aids have ... -
The longitudinal biology of depression : PET studies of the dopamine and serotonin systems
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-12-21)The involvement of monoamine neurotransmission in the pathophysiology of depression was established already in the 1960s. However despite an abundance of research, the exact role of the serotonin (5-HT) and dopamine systems ... -
Aspects of dose, dose rate and radioisotopes in brachytherapy of uveal melanoma
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-12-08)Uveal melanomas constitute melanomas arising from the choroid, the ciliary body or the iris, and in adults stands for the most common primary malignant intraocular tumor. It has a high risk of metastatic spread followed ... -
PET studies of the serotonin system in relation to behavioral phenotypes in psychiatry
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-27)Behavioral phenotypes beyond core symptoms of diagnoses have become an area of high interest in psychiatric research. All major psychiatric diagnoses are associated with deficits in cognitive function, including impairments ... -
Links between stress, sleep, and inflammation : a translational perspective of resilience
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-27)Most individuals will experience one or more extremely traumatic events during their lifetime. For the most part, humans are resilient and have a tremendous capacity to bounce back from hardships; however, for a critical ... -
Adolescent sleep : comorbid problems and behavioral treatment of insomnia
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-20)Background Sleep problems, especially insomnia, are common in adolescents and are often associated with other problems, such as anxiety, depression and chronic pain. Even though there are effective psychological ... -
Deliberate self-harm among adolescents : course, outcome and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-20)Background: Self-harm among adolescents is prevalent, and is a risk factor for suicide, which is one of the leading causes of death among youth worldwide. There is a need to better understand the role and impact of self-harm ... -
Neural and behavioral plasticity in olfactory sensory deprivation
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-20)The human brain has a remarkable ability to reorganize as a consequence of altered demands. This ability is particularly noticeable when studying the neural effects of complete sensory deprivation. Both structural and ... -
Daytime sleepiness in Parkinson's disease in relation to other symptoms, disease progression and daily life
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-12)The aim of this doctoral thesis is to explore daytime sleepiness (DS) in Parkinson’s disease (PD). The Papers will evaluate how DS is connected to both motor and non-motor symptoms in PD, changes in DS over time, and the ... -
Novel treatment approaches for children and adolescents with obsessive-compulsive disorder
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-11)Background: Obsessive-compulsive disorder (OCD) is a prevalent and disabling condition with typical onset during childhood. The recommended treatment is cognitive behavioral therapy (CBT), but it is seldom available to ...