Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience: Recent submissions
Now showing items 1-20 of 606
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PET studies of the serotonin system in relation to behavioral phenotypes in psychiatry
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-27)Behavioral phenotypes beyond core symptoms of diagnoses have become an area of high interest in psychiatric research. All major psychiatric diagnoses are associated with deficits in cognitive function, including impairments ... -
Links between stress, sleep, and inflammation : a translational perspective of resilience
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-27)Most individuals will experience one or more extremely traumatic events during their lifetime. For the most part, humans are resilient and have a tremendous capacity to bounce back from hardships; however, for a critical ... -
Adolescent sleep : comorbid problems and behavioral treatment of insomnia
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-20)Background Sleep problems, especially insomnia, are common in adolescents and are often associated with other problems, such as anxiety, depression and chronic pain. Even though there are effective psychological ... -
Deliberate self-harm among adolescents : course, outcome and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-20)Background: Self-harm among adolescents is prevalent, and is a risk factor for suicide, which is one of the leading causes of death among youth worldwide. There is a need to better understand the role and impact of self-harm ... -
Neural and behavioral plasticity in olfactory sensory deprivation
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-20)The human brain has a remarkable ability to reorganize as a consequence of altered demands. This ability is particularly noticeable when studying the neural effects of complete sensory deprivation. Both structural and ... -
Daytime sleepiness in Parkinson's disease in relation to other symptoms, disease progression and daily life
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-12)The aim of this doctoral thesis is to explore daytime sleepiness (DS) in Parkinson’s disease (PD). The Papers will evaluate how DS is connected to both motor and non-motor symptoms in PD, changes in DS over time, and the ... -
Novel treatment approaches for children and adolescents with obsessive-compulsive disorder
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-11)Background: Obsessive-compulsive disorder (OCD) is a prevalent and disabling condition with typical onset during childhood. The recommended treatment is cognitive behavioral therapy (CBT), but it is seldom available to ... -
Investigation of potential prognostic and therapeutic genes in pathologic neovascularization of the retina
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-09)Pathologic angiogenesis of the retina is a hallmark of frequent blinding conditions among the elderly, such as proliferative diabetic retinopathy (PDR) and neovascular age-related macular degeneration (nAMD). The underlying ... -
Stress and sleep : prevalence, vulnerability and day-to-day variation
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-10-27)Stress and sleep problems are increasingly common in society with consequences not only for individual health, but also high societal costs. The focus of this thesis is how sleep is affected by day-to-day variation in ... -
Delineating the construct of psychopathy : psychometric evidence of alternative measures.
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-10-23)Psychopathy is a complex construct with various definitions featuring both personality traits, such as egocentricity, lack of empathy and guilt, dishonesty, callousness, and interpersonal dominance, as well as maladaptive ... -
Structural, interpersonal, and individual factors influencing sexual orientation-based disparities in mental health : a socio-ecological perspective on sexual minority stigma
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-08-28)Background: Compared to heterosexual individuals, sexual minorities (e.g., those identifying as gay, lesbian, or bisexual) are at higher risk of several mental health problems, including suicidality, substance abuse, ... -
Acquisition strategies for fat/water separated MRI
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-08-28)This thesis focuses on new ways to more efficiently acquire the signal for fat/water separated MRI, also known as Dixon methods. In paper I, the concept of dual bandwidths was introduced to improve SNR efficiency by ... -
Development of radiofrequency pulses for fast and motion-robust brain MRI
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-08-21)This thesis is based on three projects and the three scientific articles that were the result of each project. Each project deals with various kinds of technical software development in the field of magnetic resonance ... -
Dimethyl fumarate for treatment of multiple sclerosis : clinical effects and mechanisms
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-08-10)Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS). Dimethyl fumarate (DMF) is one of the more recent additions to a rapidly expanding treatment repertoire for MS. While DMF ... -
Late-stage 11C-carbonylation of drug-like molecules for PET
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-07-23)Positron emission tomography (PET) is a non-invasive in vivo imaging technique used for translational biomedical research and clinical diagnosis. A fundamental pre-condition for PET is the radiolabelled tracer molecule ... -
Cerebral oedema after reperfusion therapy in patients with ischaemic stroke : predictors, outcomes and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-26)Introduction: Reperfusion therapy by intravenous thrombolysis (IVT) and/or endovascular thrombectomy (EVT) are established treatments in ischaemic stroke. Cerebral oedema (COED), caused by dysfunction the blood brain ... -
Immunopathogenesis of multiple sclerosis : big roles for small RNAs
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-21)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) and the leading cause of neurological disability in young adults. The exact cause of MS remains elusive despite enormous progress ... -
Magnetic resonance imaging techniques for diagnostics in Parkinson’s disease and atypical parkinsonism
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-20)Background: Parkinson’s disease (PD) is a neurodegenerative disease characterized by rigidity, hypokinesia, tremor and postural instability. PD is a clinical diagnosis based on neurological examination, patient history ... -
Investigating and explaining sex differences in episodic memory
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-18)Sex differences can be seen in a lot of different areas, one of them being cognition where, among other things, men tend to perform better at more spatial tasks and women at more verbal. When it comes to episodic memory ... -
Translational studies of molecular interactions in Parkinson's disease
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-08)Interactions between molecules are the basis of cellular function. In disease, these tightly regulated systems are often disturbed. Parkinson’s disease (PD) is recognized by protein aggregates in the brain of erroneously ...