Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience: Recent submissions
Now showing items 1-20 of 551
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Myeloid cells in experimental neuropathologies
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-04-05)The first innate immune cells, most importantly for this thesis macrophages, microglia and eosinophils, were described more than 100 years ago and only now do we begin to understand more about their development, functions ... -
Efficacy and cost-effectiveness of therapist-guided internet cognitive behavioural therapy for paediatric anxiety disorders : a single-centre, single-blind, randomised controlled trial
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-03-27)Background: Paediatric anxiety disorders are prevalent and associated with substantial disability and long-term adverse consequences. Only a minority of affected children have access to evidence-based treatment; ... -
MRI in multiple sclerosis : early detection, cortical lesions and gadolinium retention
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-03-21)Background: Multiple sclerosis (MS) is a common neuroinflammatory and -degenerative disease. Magnetic Resonance Imaging (MRI) facilitates the diagnosis of MS, providing means to initiate early treatment and improving the ... -
A neuroimaging perspective on the emotional sleepy brain
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-03-15)Sleep has been shown to be important for a number of emotional functions. Brain correlates to the effect of sleep deprivation on emotion have been studied in the last decades and increased amygdala reactivity has been ... -
Adults with cystic fibrosis : mental health and patient experiences of the CF treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-03-14)Background: Cystic fibrosis (CF) is an autosomal recessive inherited, life shortening multi organ disease most typically affecting the respiratory system and the gastrointestinal tract. In recent decades progresses in ... -
What makes cognitive behavior therapy work? An investigation of psychological and inflammatory processes
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-03-06)Background: Common mental disorders (CMDs; anxiety disorders, depression, insomnia and stress-related disorders) cause significant suffering, reduced functioning and impaired quality of life. Cognitive behavior therapy ... -
Children and adolescents with chronic pain: parental factors, functioning, and neurodevelopmental comorbidity
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-02-19)Background: Pediatric chronic pain affects between 11 and 38% of all children. Although pain may result from injury or disease, the cause of chronic pain is commonly unclear. The interaction between biological, psychological, ... -
The toxicological pharmacoepidemiology of suicide : population-based studies on psychotropic-mediation use in Sweden
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-02-14)The act of completed suicide is a complex phenomenon associated with numerous identified individual and combined risk factors. Mental illness and related disorders confer among the highest risks of completed suicide and ... -
ACT treatment for youth : a contextual behavioral approach
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-01-25)Background: Mental and substance abuse disorders in children and youth are the leading cause of disability in the world. According to the World Health Organization (2018), approximately 20% of the world’s children and ... -
Clinical translation of a regeneration strategy for spinal cord injury
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-01-18)The complex and vulnerable tissue of the spinal cord does not heal after injury, leaving patients with lifelong disability after spinal cord injury (SCI). Many milestones have been reached during the last century through ... -
Individually tailored internet-based treatment for depression and comorbid conditions
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-12-21)Background: Depression is a large societal problem. People suffering from depression are heterogeneous and have a high degree of comorbid conditions. Pharmacological treatment is widespread, but not effective for all ... -
Severe health anxiety : novel approaches to diagnosis and psychological treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-11-09)Background: It has long been known that severe health anxiety is a common psychiatric condition associated with significant distress, functional impairment, and societal costs. Nevertheless, challenges remain with regard ... -
Reliability, replicability and reproducibility in PET imaging
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-11-08)Positron Emission Tomography (PET) is a non-invasive biomedical imaging method which can quantify biochemical markers as well as functional and metabolic activity in vivo. Following image analysis, quantification can be ... -
Company employees as experimental participants in traffic safety research : prevalence and implications
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and EthicsInst för klinisk neurovetenskap / Dept of Clinical NeuroscienceKarolinska Institutet, 2018-11-08)The use of company employees as experimental participants when testing products, technology or paradigms developed by the same company raises questions about bias in results and research ethics. We aimed to investigate the ... -
Functional MRI characterization of animal models of parkinsonism
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-11-02)Parkinson's disease (PD) is the second most common neurological disorder. It is characterized by the progressive development of motor symptoms - bradykinesia, resting tremor, muscular rigidity and difficulty with postural ... -
Stem cells in inflammation and regeneration : focusing on animal models of multiple sclerosis and spinal cord injury
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-11-01)The main objective of regenerative medicine is to replace or restore injured cells and tissues in the body. Stem cells are identified playing a key role in the regeneration but action of inflammatory mediators in disease ... -
Human embryonic stem cells for retinal repair : preclinical in vitro and in vivo studies for the treatment of age-related macular degeneration with human embryonic stem cell-derived retinal pigment epithelial cells
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-10-25)Age-related macular degeneration (AMD) is the major cause of vision loss in the industrialized countries in people above sixty years of age. The dry advanced form of the disease, also termed as geographic atrophy (GA), ... -
Positron emission tomography : development, evaluation and application of quantification methods
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-08-31)Positron Emission Tomography (PET) is an imaging technique that allows for in vivo quantification of biochemical and physiological processes in the brain. Examples of targets in the brain that can be imaged using PET are ... -
Dissemination of motivational interviewing : the role of workshop training and subsequent supervision in the development of competence in clinical practice
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-08-30)Aim: Training practitioners is often used as the primary implementation strategy to disseminate evidence based practices into clinical and community settings. The overall objective of this thesis was to evaluate various ... -
A study of the foveal structure in prematurely born children by the use of optical coherence tomography
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-08-29)During the last decades there has been a rapid development in techniques for retinal imaging. The optical coherence tomography (OCT) examination is non-invasive, fast and patient-friendly which are good qualities when ...