Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience: Recent submissions
Now showing items 1-20 of 623
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Characterization and long-term follow-up of Pediatric Acute-onset Psychiatric Syndrome (PANS)
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-07)Background Pediatric acute-onset neuropsychiatric syndrome (PANS) is a cluster of psychiatric and somatic symptoms of proposed autoimmune etiology. It remains a descriptive entity, still of unclear validity and uncertain ... -
A neuroimaging perspective on regulation of emotion, reward, and attention
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-04-22)Emotional symptoms and non-emotional symptoms such as inattention often co-occur. Each of these symptom domains covers symptoms that are distributed along a continuum across the population; from non-clinical levels to ... -
Long-term aspects of stroke : survival, health-related quality of life and costs
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-04-15)Stroke, a disease that affects millions of people globally every year, is an emergency situation requiring fast and immediate action in hospital. Acute stroke treatments have rapidly improved and been developed over the ... -
Epiphora : impact on vision, outcome of lacrimal surgery and investigations with ultra-high-frequency ultrasound
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-04-08)Epiphora is a common condition that often receives little attention. Excessive tear production creates an irregular and ever-changing ocular surface, affecting refraction and reducing vision. However, in a standard test ... -
Recruitment to multicentre randomised controlled trials in stroke : lessons learnt from the effects trial
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-26)Randomised controlled trials are the gold standard for evaluation treatments. Nevertheless, recruitment into trials is still challenging and many trials fail to meet their recruitment goals within the predetermined time. ... -
Method development for [11C]carbon monoxide radiochemistry
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-25)Positron emission tomography (PET) is a non-invasive molecular imaging technique that has found extensive utility in biomedical research and in drug development. A fundamental pre-requisite for PET is the tracer, which is ... -
Positron emission tomography studies of the D₁ dopamine receptor in schizophrenia
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-19)This thesis is based on investigations of central D1-dopamine receptor (D1R) binding in vivo using positron emission tomography (PET). The aims were i) to examine the antipsychotic effect of a D1R antagonist in schizophrenia ... -
Repopulation of a microglia-depleted central nervous system : molecular characterization during homeostasis and disease
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-19)Microglia are predominant tissue resident macrophages within the central nervous system (CNS), and contribute to both CNS development and homeostasis. During disease conditions microglia undergo transcriptional re-programming ... -
Microglia : health promoting pathways and therapeutic targets in ageing and neuroinflammation
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-05)Microglia are the innate immune cells of the CNS with an embryonic origin and self-renew with a slow turnover throughout life. The health-promoting capacities of this cell are being acknowledged through updated and ... -
Mind and body exercises : associations with mental health, antidepressant medication, autonomic functioning and inflammatory biomarkers
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-05)Stress, depression and stress-related mental ill-health are common in societies all over the world, and people tend to use both conventional care within the health care system and complementary treatment methods to handle ... -
MRI quantification of multiple sclerosis pathology
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-02)Background: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease and a common cause of neurologic disability. MS pathology is characterized by demyelination, neuroaxonal loss and atrophy. ... -
Self-admission as a treatment tool in severe anorexia nervosa
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-01)Self-admission to psychiatric inpatient treatment is an innovative collaborative approach to healthcare rationing that invites patients to play a more active role in deciding when they need a higher level of care. In ... -
In vivo and in vitro studies of the serotonin 1B receptor in relation to major depressive disorder and treatment with ketamine
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-01-22)Despite the large implications of Major Depressive Disorder (MDD) on disease burden worldwide, current treatment options are suboptimal and a third of patients suffering from this disease do not respond to ... -
Multimodal neuroimaging of pain and inflammation in the central nervous system in patients with fibromyalgia and rheumatoid arthritis
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-01-22)The prevalence of concomitant fibromyalgia (FM) is puzzlingly high among rheumatoid arthritis (RA) patients and a contemporary challenge is to resolve why some RA patients continue to report pain despite adequate treatment ... -
Augmented navigation
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-01-14)Spinal fixation procedures have the inherent risk of causing damage to vulnerable anatomical structures such as the spinal cord, nerve roots, and blood vessels. To prevent complications, several technological aids have ... -
The longitudinal biology of depression : PET studies of the dopamine and serotonin systems
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-12-21)The involvement of monoamine neurotransmission in the pathophysiology of depression was established already in the 1960s. However despite an abundance of research, the exact role of the serotonin (5-HT) and dopamine systems ... -
Aspects of dose, dose rate and radioisotopes in brachytherapy of uveal melanoma
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-12-08)Uveal melanomas constitute melanomas arising from the choroid, the ciliary body or the iris, and in adults stands for the most common primary malignant intraocular tumor. It has a high risk of metastatic spread followed ... -
PET studies of the serotonin system in relation to behavioral phenotypes in psychiatry
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-27)Behavioral phenotypes beyond core symptoms of diagnoses have become an area of high interest in psychiatric research. All major psychiatric diagnoses are associated with deficits in cognitive function, including impairments ... -
Links between stress, sleep, and inflammation : a translational perspective of resilience
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-27)Most individuals will experience one or more extremely traumatic events during their lifetime. For the most part, humans are resilient and have a tremendous capacity to bounce back from hardships; however, for a critical ... -
Adolescent sleep : comorbid problems and behavioral treatment of insomnia
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-20)Background Sleep problems, especially insomnia, are common in adolescents and are often associated with other problems, such as anxiety, depression and chronic pain. Even though there are effective psychological ...