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  • PGE2 and other lipids in rheumatic diseases 

    Raouf, Joan (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-02-21)
    Despite numerous options for treatment of rheumatic diseases, there is an unfulfilled clinical need for therapeutic strategies that can reduce inflammation and prevent tissue destruction. Lipid mediators (eicosanoids and ...
  • Samverkan och lärande kring sårbehandling : erfarenheter från olika professionsperspektiv i primärvård och utbildning 

    Friman, Anne (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2017-02-20)
    Aim: The overall aim of this thesis is to explore collaboration and knowledge development in wound management in practice and in education. One specific aim is to investigate district nurses’ (DNs’) wound management ...
  • Methodological aspects on carotid artery intervention 

    Jonsson, Magnus (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2017-02-17)
    In Sweden, approximately 25000 patients suffer a cerebral infarction (stroke) annually. Stroke ranks as the third-leading cause of death, and is the leading cause of functional impairment. Carotid artery stenosis accounts ...
  • Elderly patients undergoing colorectal cancer surgery : can care be further improved? 

    Schubert Samuelsson, Katja (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-02-17)
    Introduction: Colorectal cancer (CRC) is one of the most common malignancies affecting approximately 6 400 new patients/year in Sweden of which 44% are 75 years and older at diagnosis. In order to identify potential ...
  • Porphyrins and phototherapy of oral bacteria 

    Bjurshammar, Nadja (Inst för odontologi / Dept of Dental Medicine, 2017-02-16)
    In the mid-1990s researchers became interesting in blue light-based therapies using light- emitting diodes (LED) light. Blue light therapy has been successfully used in treatment of acne, as well as shown wound healing ...
  • Genetic and lifestyle influences on memory, brain structure, and dementia 

    Ferencz, Beata (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-02-16)
    This doctoral thesis investigated genetic, inflammatory, and lifestyle influences on cognition, brain structure, and dementia. The influence of TOMM40 polymorphisms (Study I), a PICALM, BIN1 and CLU genetic risk score ...
  • Experimental, mild blast-induced traumatic brain injury : focus on the monoamine and galanin systems 

    Kawa, Lizan (Inst för neurovetenskap / Dept of Neuroscience, 2017-02-14)
    Traumatic brain injury (TBI) is a common cause of mortality and morbidity among civilians and servicemen alike. The spectrum of TBIs encompasses mild to severe cases, with the predominate number of TBIs being mild (mTBI). ...
  • Identification of biobehavioral markers of neurodevelopmental disorders in twins 

    Willfors, Charlotte (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2017-02-10)
    Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are complex neurodevelopmental disorders (NDD), heterogeneous in phenotypes and etiology. The exact mechanisms driving the phenotypes are ...
  • Apolipoprotein E and cholinergic enzymes : the interface in dementia 

    Vijayaraghavan, Swetha (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-02-10)
    The main confirmed genetic risk factor for sporadic form of Alzheimer’s disease (AD) is apolipoprotein E (ApoE) ε4 allele (APOE4). ApoE protein aids in receptor ligand mediated transport, distribution and metabolism of ...
  • Molecular and epigenetic control of CNS tumour and progenitor cells 

    Gracias, Aileen (Inst för neurovetenskap / Dept of Neuroscience, 2017-02-09)
    Despite advances in diagnosis and treatment, CNS tumours continue to result in high mortality and morbidity. Glioblastoma mutliforme (GBM), the most common primary brain tumour, is a recurrent tumour that despite advances ...
  • Quality of life in men with inguinal hernia and outcome after three different mesh techniques 

    Magnusson, Jesper (Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-02-08)
    Inguinal hernia repair (IHR) is a very common surgical procedure with approximately 16 000 procedures performed every year in Sweden. Previously, recurrence after IHR was a major concern, but with the introduction of the ...
  • Atrial fibrillation and lifestyle factors with focus on physical activity and alcohol consumption 

    Drca, Nikola (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-02-06)
    The overall aim of this thesis was to investigate how modifiable lifestyle factors, with a focus on alcohol consumption and physical activity, influence the risk of atrial fibrillation (AF). The thesis is based on data ...
  • Liver regeneration and function following portal vein occlusion and hepatectomy 

    Sparrelid, Ernesto (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-02-06)
    Background: Portal vein occlusion (PVO) and associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) are two strategies employed to render patients with unresectable liver tumours resectable ...
  • Purification and biodistribution of extracellular vesicles 

    Nordin, Joel Zacharias (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2017-02-06)
    Extracellular vesicles (EVs) are nano-sized vesicles that contain bioactive lipids, RNAs and proteins, which can be transferred to recipient cells. EVs are important for physiological as well as pathological processes, ...
  • CMV-infection in gay men with AIDS 

    Grützmeier, Sven (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-02-03)
    Background: Before the era of combination therapy (c-ART) more than 90 % of the patients with HIV-infection died of one or more opportunistic infections (OI). We and others noted early on that CMV was an important pathogen ...
  • Medical screening in dental settings 

    Friman, Göran (Inst för odontologi / Dept of Dental Medicine, 2017-02-03)
    Background Findings have shown medical screening in dental settings to be cost-effective by achieving both financial savings and health benefits. The general purpose of this thesis was to study the possibility of early ...
  • Bipolar disorder and lithium treatment : etiologies and consequences 

    Song, Jie (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-02-02)
    Bipolar disorder is a chronic disabling psychiatric disorder marked by episodic disruptive mood swings, accompanied by disturbances in cognition and behavior. Without effective treatment, bipolar disorder can have devastating ...
  • Falls in wheelchair users with spinal cord injury : incidence, risks and concerns 

    Butler Forslund, Emelie (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-02-02)
    Background: Knowledge about falls and related injuries in persons with spinal cord injuries (SCI) is limited, especially concerning wheelchair users. Further research is required in order to develop future prevention ...
  • Suicide : a pharmacoepidemiological database study in the region Friuli Venezia Giulia, Italy 

    Castelpietra, Giulio (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-02-02)
    Aims: The objective of this thesis is to examine the relationship between suicide and health care in Italy’s Friuli Venezia Giulia (FVG) region. First, it explores the correlation between suicide rates and antidepressant ...
  • Transcriptional regulation of neuronal differentiation in the developing CNS 

    Rraklli, Vilma (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-02-02)
    The central nervous system (CNS) is responsible for our intellectual and cognitive functions and it comprises the brain and spinal cord. Generation of the CNS occurs during embryonic development from the neural tube that ...

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