Doktorsavhandlingar / Doctoral Theses - K1 (MMK): Recent submissions
Now showing items 41-60 of 539
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Novel markers for smooth muscle cell modulation in vascular injury and disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-08-02)Smooth muscle cells (SMCs) are major constituents of the vascular wall, indispensable for basic physiological functions of a healthy vessel, such as regulating vascular tone and blood pressure, but also critical during ... -
Rethinking the artificial urinary sphincter : from current knowledge to the development of a new smart device
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-05-13)Background: Urinary incontinence (UI) plagues millions of women and men worldwide, leading to social stigma, low self-esteem, poor quality of life, and affects their loved ones. In women, frequent causes include childbirth, ... -
Subacromial pain syndrome : an experimental clinical investigation in primary care
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-04-13)This thesis presents the desired management for patients with Subacromial Pain Syndrome (SAPS) in primary care and consists of four papers based on data from two randomized controlled trials. Background: SAPS is a ... -
Studies on acromioclavicular joint dislocations : clinical outcomes and radiological classification
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-04-08)Background: Acromioclavicular joint (AC joint) dislocation is a common injury among young sports-active people. The injuries are divided into types I–VI based on the Rockwood classification. The classification system has ... -
Studies of genetic mosaicism in rare diseases
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-04-01)Mosaicism in human genetics refers to an individual harboring two or more genetic compositions, all derived from the same fertilized egg. Common signs of genetic mosaicism are asymmetric growth, skin aberrations or vascular ... -
Preoperative localisation of parathyroid adenoma in primary hyperparathyroidism using 99mTc-sestamibi SPECT/CT : an evolving scanning protocol
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-03-31)Primary hyperparathyroidism (pHPT) is caused by one or more hyperfunctional parathyroid gland causing an inappropriately high release of parathyroid hormone (PTH) in relation to the calcium concentration in the blood. PTH ... -
Carcinoma of the uterine cervix: aspects on preoperative staging and assessment of treatment effect using magnetic resonance imaging
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-03-30)Background: Uterine CC mainly affects young women as it is caused by persistent HPV infection most often acquired during adolescence. Early-stage disease is treated with surgery, and locally advanced disease with ... -
Aspects of low anterior resection syndrome : prevalence, risk factors and treatment
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-03-29)After sphincter sparing rectal cancer surgery an impaired bowel function, i.e. Low Anterior Resection Syndrome (LARS), is common. The symptoms included in LARS are incontinence for flatus and/or feces, urgency, fragmentation ... -
The perspective of being a family caregiver of a patient treated for oesophageal cancer : problems and needs
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-03-10)There is a need to put family caregivers on the cancer survivorship research agenda. Research among family caregivers of patients treated for oesophageal cancer is sparse. However, it has been indicated that they are at ... -
SBRT of large tumors and tumors located near organs at risk in the thoracic cavity
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-02-02)Stereotactic Body Radiotherapy (SBRT) is a non-invasive ablative radiation therapy developed at Karolinska University Hospital in the early 90-s. Its basic principles are highly focused inhomogeneous dose load with rapid ... -
GLP-1 secretion and signaling in patients with aneurysmal enlargement of the thoracic aorta : a potential contributor to reduced prevalence of aneurysm in diabetes
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-01-27)An aortic aneurysm is a localized dilation of the artery, greater than 50% of the normal size. It is the result of a weakening of the aortic wall, and untreated or unrecognized aortic aneurysms may be fatal due to massive ... -
Anterior cruciate ligament injuries in football
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-01-21)Anterior cruciate ligament (ACL) injuries and football are clearly intertwined. ACL injuries are principally sustained when participating in pivoting activities and, as it is such a popular sport, football is consequently ... -
Optimism and survivorship after esophageal cancer surgery
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-12-17)Dispositional optimism is a personality trait that represents generally favorable expectations about the future. The main aim of this thesis was to examine whether higher dispositional optimism was related to better ... -
Comorbidity and mortality in Prader-Willi syndrome
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-30)Background: Prader-Willi syndrome (PWS) is a multisymptomatic, rare, genetic, disorder, due to lack of the expression of paternal genes in the q11-q13 region of chromosome 15. The main characteristics of PWS are muscular ... -
Breast reconstruction with biological graft : clinical outcomes in the setting of breast cancer treatment
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-25)The overall aim of this thesis was to investigate the use of acellular dermal matrix (ADM) in implant-based breast reconstructions (IBBR) in the setting of breast cancer treatment. ADM refers to a surgical mesh developed ... -
Hereditary predisposition and prognostic prediction in cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-23)Cancer is a genetic disease. The cancer cells evolve clonally through changes of their genome, gaining malignant characteristics. In hereditary cancer syndromes, a genetic aberration which puts the cells one step closer ... -
Extracellular factors for preservation and delivery of stromal cells
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-19)Modulating the immune response after a myocardial infarction seems like an appropriate strategy for reducing myocardial fibrosis. Mesenchymal Stromal Cells are immunomodulatory and have thus gained interest, but have so ... -
Anterior cruciate ligament reconstruction : subjective knee function, graft failure and revision surgery
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-19)An anterior cruciate ligament (ACL) tear is a severe knee injury, which leads to increased knee laxity and often functional instability. An ACL reconstruction (ACLR) is generally recommended to patients who desire to return ... -
The role of smooth muscle cells in calcification of atherosclerotic plaques
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-18)Calcification (CALC) is a predominant feature of late-stage cardiovascular disease (CVD) but responsible mechanisms and its contribution to the risk of clinical events remain unclear. Formation of highly mineralized ... -
Mechanistic studies on the repression of cellular reaction to hypoxia as cause for chronic complications in diabetes
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-11)Diabetes Mellitus is an ongoing epidemic, causing individual suffering as well as constituting an enormous burden to society and healthcare systems globally. Much of diabetes-associated morbidity and mortality are caused ...