Now showing items 1-20 of 454

    • New diagnostic approaches for venous thromboembolism and thrombophilia 

      Farm, Maria (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-15)
      Background: Venous thromboembolism is a serious disease comprising both pulmonary embolism and deep vein thrombosis. Venous thromboembolism causes considerable mortality and morbidity, with residual symptoms such as pulmonary ...
    • Applications of the golden angle in cardiovascular MRI 

      Fyrdahl, Alexander (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-15)
      The use of radial trajectories has been seen as a potential solution to highly efficient cardiovascular magnetic resonance imaging (MRI). By acquiring a broad range of spatial frequencies per repetition time, the acquisition ...
    • Genetic causes and underlying disease mechanisms in early-onset osteoporosis 

      Kämpe, Anders (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-14)
      Adult-onset osteoporosis is a disorder that affects a significant proportion of the elderly population worldwide and entails a substantial disease burden for the affected individuals. Childhood-onset osteoporosis is a ...
    • Epidemiological studies on comorbidity, heritability and co-aggregation in organ-specific autoimmune diseases 

      Skov, Jakob (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-13)
      Autoimmunity is caused by loss of tolerance, whereby the immune system fails to distinguish self from non-self. The autoimmune panorama entails more than 100 diseases that collectively affect close to 5% of the total ...
    • Advanced electrocardiography in myocardial electrical remodeling : insights from cardiovascular magnetic resonance imaging 

      Maanja, Maren (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-08)
      The electrocardiogram (ECG) is a common diagnostic tool in cardiology thanks to its high accessibility and low cost. However, in several cardiovascular diagnoses, including left ventricular hypertrophy (LVH), current ...
    • Myocardial hypertrophy and extracellular volume by cardiovascular magnetic resonance imaging 

      Lundin, Magnus (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-05)
      Cardiovascular disease contributes greatly to the disease burden in many developed countries. Cardiovascular magnetic resonance (CMR) is a powerful imaging modality that can diagnose a vast range of these diseases. When ...
    • Ewing Sarcoma : treatment, prognosis and late effects 

      Hesla, Asle (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-04-17)
      Ewing sarcoma (ES) is a rare and aggressive childhood/adolescent malignancy which relies on a multidisciplinary treatment approach for cure. The overall survival rate for this young patient group has hardly improved over ...
    • Pulmonary hypertension and heart failure : physiological markers assessed by cardiovascular magnetic resonance 

      Ramos, Joao G. (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-04-09)
      Pulmonary hypertension (PH) is clinically and physiologically associated with heart failure, both with reduced and preserved ejection fraction (HFrEF and HFpEF). In HFpEF, the most likely underlying pathophysiological ...
    • Immediate breast reconstruction : patient information, regional variations and effects of radiotherapy 

      Frisell, Carl Axel (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-03-26)
      The type of surgical treatment in breast cancer shows strong regional variation. The aim of studies I-III was to specifically investigate causes of the disparity in breast conservation and immediate breast reconstruction ...
    • Clinical aspects of Lynch syndrome 

      Salomé, Jenny von (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-03-05)
      Colorectal cancer is the second most common cancer in women and the third most common cancer in men worldwide, with 1.8 million new cases and almost 861000 deaths in 2018. Approximately 5–10% of the annual CRC burden can ...
    • Diet and postprandial risk markers for complications in type 2 diabetes 

      Olofsson, Camilla (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-02-21)
      The period after a meal is complex with fluctuation in blood glucose, lipids and other metabolic responses. This may induce and/or increase inflammation and contribute to future development of diabetic complications. ...
    • Measures to prevent microembolization in cardiac surgery and during angiography with special reference to carbon dioxide 

      Nyman, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-02-21)
      Background: Cardiovascular interventions including open heart surgery using cardiopulmonary bypass (CPB) and coronary angiography may introduce air and particulate arterial embolism that may lead to tissue lesions of the ...
    • Translational studies on bipolar disorder and anorexia nervosa 

      Millischer, Vincent (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-02-18)
      Translational medicine aims at closing the gap between basic and clinical sciences in an integrative way. Psychiatry is one of the few medical specialties in which diagnosis is primarily based on clinical observation and ...
    • Esophageal squamous cell carcinoma : opportunities for prevention 

      Wang, Qiaoli (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-02-12)
      Esophageal squamous cell carcinoma (ESCC) is the predominant histological subtype of esophageal cancer, a highly fatal malignant neoplasm. Most ESCC patients are diagnosed at a late stage when tumors are unresectable or ...
    • Translational investigations of novel and current antitumoral therapies in gastrointestinal stromal tumors 

      Fröbom, Robin (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-11-21)
      Gastrointestinal stromal tumor (GIST) is the most common human sarcoma. Its incidence is around 10-15 per million person-years, translating into 150 new cases each year in Sweden. The molecular background for the absolute ...
    • Evaluation of potential antidiabetic and antibacterial activities of Bolivian nutraceutical plants 

      Zambrana Santander, Silvia Tatiana (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-11-19)
      Type 2 diabetes mellitus is a health problem worldwide that requires the search for novel therapeutic strategies. Natural products are a source of potential therapies due to their acceptation and traditional use or ...
    • A multifactorial approach to targeting signalling pathways in diabetic foot ulcers 

      Narayanan, Sampath Kumar (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-10-18)
      Diabetic foot ulcers (DFU) are one of the most debilitating complication of diabetes that adversely impacts the health, economics and quality of life of the afflicted individual. The primary pathogenic factor of DFU is ...
    • Characterization of structural chromosomal variants by massively parallel sequencing 

      Eisfeldt, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-10-10)
      Chromosomal Structural Variation (SV) such as translocations, inversions, deletions, and duplications are rearrangements of one or several DNA molecules. SVs are widespread across the human genome, and each individual ...
    • Hormones, muscles and oncological outcome in men with rectal cancer 

      Tapper, John (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-10-04)
      Paper I. The aim was to elucidate if testosterone (T) dose-dependently increase muscle size in abdomen and pelvis, analogous to the known anabolic influence on appendicular muscles. Participants were young (age 18-50) ...
    • Cancer after bariatric surgery : risk and prognosis 

      Tao, Wenjing (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-09-13)
      Obesity is a major public health challenge with a rapidly growing prevalence worldwide. The condition increases the risk of multiple diseases, including cancer in different locations. Current evidence on the effect of ...