Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery: Recent submissions
Now showing items 81-100 of 639
-
Antireflux surgery in the prevention of supra-esophageal cancer and mortality
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-03-02)Gastroesophageal reflux disease (GERD), mainly characterized by heartburn or regurgitation, is a common condition in the Western world with an increasing prevalence. GERD is associated with an increased risk of adenocarcinoma ... -
Left ventricular remodeling and function in ischemic heart disease and aortic valve disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-03-01)Background: Cardiac remodeling is a broad term that refers to structural and functional alterations of the heart in response to chronic changes in loading conditions or left ventricular (LV) contractile performance. Different ... -
Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-02-24)Background and aims: Unstable carotid atherosclerosis causes stroke, but methods to identify patients and lesions at risk are lacking. We recently found enrichment of genes associated with calcification in carotid plaques ... -
Complications following anterior cruciate ligament reconstruction
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-02-16)Background: Venous thromboembolism (VTE) and septic arthritis (SA) are two rare complications following anterior cruciate ligament reconstruction (ACLR). Due to their rare incidence, risk factors and outcome are difficult ... -
Studies on meniscus surgery with focus on preservation and meniscus function
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-12-23)The aim of this thesis was to investigate the effect of surgical preservation and restoration of the meniscus on knee function and outcomes. In Study I, 4497 patients with primary hamstring ACLR were evaluated regarding ... -
Identification of disease genes in rare neurological conditions
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-12-18)This thesis is about improving diagnosis and treatment to persons affected by rare diseases. Diagnosis before treatment is a principle often told to medical students. But what if a diagnosis can’t be made with the resources ... -
Evaluation of an automatic urinometer including use of silicone oil to decrease biofilm formation due to proteinuria, hemoglobinuria and bacterial growth
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-12-18)Background: A new capacitance-based automatic urinometer (AU) facilitates continuous urine output (UO) measurement, which may help to predict and diagnose acute kidney injury (AKI). To prevent mismeasurement due to bacterial, ... -
Microparticles in hemophilia : friend or foe? To improve hemostasis or to induce atherothrombosis?
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-27)As one of the most well-known inherited bleeding disorders, hemophilia A (HA) is caused by the deficiency or dysfunction of coagulation factor VIII (FVIII). Patients with HA (PWHA) suffer from abnormal bleeding after ... -
Effects of early functional mobilization after acute Achilles tendon rupture repair
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-24)Background: Patient outcome after Achilles tendon rupture (ATR) varies greatly, and complications such as deep venous thrombosis (DVT) and tendon elongation are common. Although accelerated rehabilitation is considered ... -
Translational studies on mitochondrial function and hypoxia in complications of diabetes mellitus
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-24)Diabetes Mellitus (DM) is a major concern for societies and healthcare systems globally. DM-associated morbidity and mortality is mediated by diabetic complications. Hypoxia and oxidative stress have emerged as key players ... -
Family history and prognosis of prostate cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-20)Background: Prostate Cancer (PCa) is the second most common malignancy among men in the world. In Sweden about 10,000 new cases are diagnosed each year. Mortality rates have been rather stable but have declined the past ... -
Epidemiological and experimental studies on sarcoma with focus on gastrointestinal stromal tumors
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-18)Sarcoma is the common denominator for malignant tumors of mesenchymal origin. Sarcomas encompass almost 100 diagnoses with different histology, molecular features and natural history, and may present in any part of the ... -
Exploring the gut-brain axis in attention-deficit hyperactivity disorder
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-13)There is a bidirectional interaction between the gut and the brain, termed the gut-brain axis (GBA), involving e.g. the gut microbiota, and connecting the peripheral intestinal elements to the central nervous system (CNS). ... -
Clinical and radiological aspects of traumatic pelvic ring injury
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-10-21)Epidemiological data regarding High-Energy Traumatic Pelvic Ring Injury in Sweden was missing. Further, there was no data regarding current knowledge and level of experience of Swedish first line trauma officers about the ... -
Oncological safety and health-related quality of life after reconstructive breast cancer surgery
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-10-02)The main aim of this thesis was to gain knowledge about the oncological safety of nipple-sparing mastectomy (NSM) with immediate implant-based reconstruction and delayed Deep Inferior Epigastric Perforator (DIEP) flap ... -
Geometric, biomechanical and molecular analyses of abdominal aortic aneurysm
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-08-20)Background: Abdominal aortic aneurysm (AAA) is defined as a dilatation of the abdominal aorta of 30 mm in diameter or more. Main risk factors are smoking, age and male sex. Pathophysiological features include inflammation, ... -
Development, evaluation and patient experiences of eHealth in the care of abdominal aortic aneurysm
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-08-14)Abdominal aortic aneurysm (AAA) is a weakening and widening of the abdominal aorta to a diameter of 30 mm or more. It is a fairly common condition among older men, and rarely occurs in women. The condition is generally ... -
New diagnostic approaches for venous thromboembolism and thrombophilia
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-15)Background: Venous thromboembolism is a serious disease comprising both pulmonary embolism and deep vein thrombosis. Venous thromboembolism causes considerable mortality and morbidity, with residual symptoms such as pulmonary ... -
Applications of the golden angle in cardiovascular MRI
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-15)The use of radial trajectories has been seen as a potential solution to highly efficient cardiovascular magnetic resonance imaging (MRI). By acquiring a broad range of spatial frequencies per repetition time, the acquisition ... -
Genetic causes and underlying disease mechanisms in early-onset osteoporosis
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-14)Adult-onset osteoporosis is a disorder that affects a significant proportion of the elderly population worldwide and entails a substantial disease burden for the affected individuals. Childhood-onset osteoporosis is a rare ...