Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery: Recent submissions
Now showing items 61-80 of 635
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Breast reconstruction with biological graft : clinical outcomes in the setting of breast cancer treatment
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-25)The overall aim of this thesis was to investigate the use of acellular dermal matrix (ADM) in implant-based breast reconstructions (IBBR) in the setting of breast cancer treatment. ADM refers to a surgical mesh developed ... -
Hereditary predisposition and prognostic prediction in cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-23)Cancer is a genetic disease. The cancer cells evolve clonally through changes of their genome, gaining malignant characteristics. In hereditary cancer syndromes, a genetic aberration which puts the cells one step closer ... -
Extracellular factors for preservation and delivery of stromal cells
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-19)Modulating the immune response after a myocardial infarction seems like an appropriate strategy for reducing myocardial fibrosis. Mesenchymal Stromal Cells are immunomodulatory and have thus gained interest, but have so ... -
Anterior cruciate ligament reconstruction : subjective knee function, graft failure and revision surgery
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-19)An anterior cruciate ligament (ACL) tear is a severe knee injury, which leads to increased knee laxity and often functional instability. An ACL reconstruction (ACLR) is generally recommended to patients who desire to return ... -
The role of smooth muscle cells in calcification of atherosclerotic plaques
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-18)Calcification (CALC) is a predominant feature of late-stage cardiovascular disease (CVD) but responsible mechanisms and its contribution to the risk of clinical events remain unclear. Formation of highly mineralized ... -
Mechanistic studies on the repression of cellular reaction to hypoxia as cause for chronic complications in diabetes
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-11)Diabetes Mellitus is an ongoing epidemic, causing individual suffering as well as constituting an enormous burden to society and healthcare systems globally. Much of diabetes-associated morbidity and mortality are caused ... -
Perineal healing following abdominoperineal excision for rectal and anal cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-03)Abdominoperineal rectal excision (APE) may be indicated for distal rectal cancer and anal cancer patients. For many patients the extralevator APE (ELAPE) technique in which a larger part of the pelvic floor is removed is ... -
Primary hyperparathyroidism : nonclassical symptoms and benefits from parathyroidectomy
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-09-28)Primary hyperparathyroidism (PHPT) is characterized by an inadequate increase in calcium and parathyroid hormone levels in blood. The cause is usually a benign tumor, parathyroid adenoma, and the only curative treatment ... -
Prenatal metabolic risks for offspring neurodevelopmental and psychiatric disorders
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-09-24)Prenatal metabolic disturbances have been reported to increase the risk for offspring adverse outcomes. However, the joint (i.e. combined) effects of several prenatal metabolic exposures on offspring neurodevelopmental and ... -
Open tibial fractures in Sweden
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-09-23)Background: Open tibial fractures are serious injuries, challenging both for patients and doctors. For the patients, personal, psychological and physical costs are enormous. For healthcare and society, open tibial fractures ... -
Bioinformatic methods in rare disease genomics
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-09-22)The larger goal of medical genetics is to map genotype to phenotype and to understand how genomic variation affects human health. In the field of rare disease genomics, there is a mendelian assumption that states: one ... -
Improved surgical treatment of oesophageal cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-08-20)Oesophageal cancer is the 7thmost common cancer globally and the 5-year survival is poor (below 20%). Curative treatment usually involves surgical resection of the tumour (oesophagectomy), with or without neoadjuvant ... -
Improving stroke risk prediction and individualised treatment in carotid atherosclerosis
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-05-28)Background: Unstable carotid atherosclerosis causes stroke, but methods to identify patients and lesions at risk are lacking. Currently, this risk estimation is based on measurements of stenosis and neurological symptoms, ... -
Diabetes, metformin and gastric adenocarcinoma
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-05-18)Diabetes may increase the risk and mortality of certain cancers, but its association with gastric adenocarcinoma is not clear. On the other hand, metformin, a first-line treatment for diabetes, may reduce cancer risks and ... -
Nutrient-regulated skeletal muscle metabolism and circadian clock
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-04-30)The prevalence of obesity has tripled in the last four decades, becoming a major risk for the development of cardiometabolic diseases such as type 2 diabetes. Obesity is associated with pathological storage of lipids in ... -
Systems biology of mitochondrial dysfunction
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-04-12)The human body consumes vast amounts of metabolites that are transformed into one another, modified to useful building blocks and broken down to harvest their energy. Mitochondria are at the core of this metabolic turnover ... -
Antireflux surgery in the prevention of supra-esophageal cancer and mortality
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-03-02)Gastroesophageal reflux disease (GERD), mainly characterized by heartburn or regurgitation, is a common condition in the Western world with an increasing prevalence. GERD is associated with an increased risk of adenocarcinoma ... -
Left ventricular remodeling and function in ischemic heart disease and aortic valve disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-03-01)Background: Cardiac remodeling is a broad term that refers to structural and functional alterations of the heart in response to chronic changes in loading conditions or left ventricular (LV) contractile performance. Different ... -
Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-02-24)Background and aims: Unstable carotid atherosclerosis causes stroke, but methods to identify patients and lesions at risk are lacking. We recently found enrichment of genes associated with calcification in carotid plaques ... -
Complications following anterior cruciate ligament reconstruction
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-02-16)Background: Venous thromboembolism (VTE) and septic arthritis (SA) are two rare complications following anterior cruciate ligament reconstruction (ACLR). Due to their rare incidence, risk factors and outcome are difficult ...