Now showing items 21-40 of 626

    • Pelvic fractures : epidemiology and treatment 

      Lundin, Natalie (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-20)
      The epidemiology of pelvic and acetabular fractures has been sparsely described and up-to date information on incidence, demographic distributions and treatment are lacking. Surgical treatment of pelvic and acetabular ...
    • Long-term follow-up after surgery for chronic thromboembolic pulmonary hypertension 

      Kallonen, Janica (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-12)
      Background: Pulmonary endarterectomy (PEA) is the treatment recommended for all operable patients with chronic thromboembolic pulmonary hypertension (CTEPH). The aim of this thesis was to evaluate long-term survival, quality ...
    • Biomechanical and morphological aspects of abdominal aortic aneurysm growth and rupture 

      Siika, Antti (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-05)
      Abdominal aortic aneurysms (AAAs) are dilatations of the abdominal aorta that pose a risk of rupture. The only effective treatment is intervention prior to rupture, but this is also associated with mortality and morbidity. ...
    • Abdominal aortic aneurysms : sex and gender disparities in surveillance, treatment and outcome 

      Talvitie, Mareia (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-03-07)
      Background: In the field of abdominal aortic aneurysm (AAA), a lot of what is unknown converge in two specific topics: untreated patients and women. Best management strategies related to surveillance, treatment and outcome ...
    • The male predominance in oesophageal adenocarcinoma and the role of sex hormones 

      Rabbani, Sirus (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-02-28)
      Oesophageal adenocarcinoma is a subtype of oesophageal cancer with rapidly rising incidence over the last decades. This rise in incidence is strongest in western countries and more among men than in women, with a male ...
    • Paediatric surgery in Uganda : burden of disease and barriers to quality of care 

      Ajiko, Mary Margaret (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-02-15)
      Background: In recent years there has been an increased awareness of surgical conditions within global health. A special emphasis is needed for children which constitute a large proportion of the populations in many ...
    • Novel biomarkers in regulating human dense connective tissue repair 

      Chen, Junyu (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-11-18)
      Painful and degenerative disorders of the musculoskeletal system pose a tremendous burden on the healthcare system. One main reason is the limited knowledge of the underlying key factors and pathways responsible for the ...
    • A multidisciplinary long-term evaluation of patients born with unilateral cleft lip and palate treated with different surgical protocols 

      Peterson, Petra (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-11-11)
      Introduction and aims: The aim of this project was to evaluate the long-term outcome after the multidisciplinary treatment of young adults born with unilateral cleft lip and palate (UCLP) regarding speech and communicative ...
    • Bicycle trauma and it‘s consequences 

      Zibung Hofmann, Evelyne (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-11-09)
      The popularity to ride a bicycle is increasing worldwide and significant political efforts are made to promote cycling. To bike to work is generally seen as a health-conscious and environment friendly way of commuting. ...
    • Outcomes of surgery for oesophageal cancer with focus on fatigue 

      Cheng, Zhao (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-10-31)
      Oesophageal cancer is the 6th leading cause of cancer mortality globally. Extensive surgery (oesophagectomy) with neoadjuvant chemo(radio)therapy is the backbone of curative treatment for oesophageal cancer. The thesis ...
    • Adverse effects of treatment for rectal cancer : sexual function, hormones, and bone health 

      Svanström Röjvall, Annika (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-10-20)
      Thanks to improved outcomes from multimodal rectal cancer (RC) treatment, long-term survival is increasing; thus, focus on the long-term adverse effects of treatment is required. This thesis aimed to increase knowledge ...
    • The role of proprotein convertases in vascular disease 

      Suur, Bianca E (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-10-18)
      To date, the role of the proprotein convertase subtilisin/kexin (PCSK) family in vascular disease is largely unknown, with the exception of PCSK9 and its key function in lipid metabolism. The PCSK family constitutes of 9 ...
    • Towards an improved survival in gastric cancer 

      Asplund, Johannes (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-10-14)
      Gastric cancer is a globally important contributor to morbidity and mortality from cancer. The age-standardised incidence has declined during the last decades, but the total incidence has not due to an aging population. ...
    • Epidemiological studies of bioprosthetic aortic valves 

      Dismorr, Michael (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-09-27)
      Background: The use of bioprosthetic valves is common and offers a prosthetic option that does not require anti-coagulant therapy, but with shorter valve longevity compared to mechanical prostheses. Valve model selection ...
    • Aspects of locally advanced colon cancer 

      Rosander, Emma (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-09-15)
      In Sweden, nearly 5000 patients are diagnosed with colon cancer annually and about 20% of these patients have a locally advanced tumor at the time of diagnosis. These tumors are challenging for both surgeons and oncologists ...
    • Linking quantitative radiology to molecular mechanism for improved vascular disease therapy selection and follow-up 

      Buckler, Andrew J (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-09-08)
      Objective: Therapeutic advancements in atherosclerotic cardiovascular disease have improved the prevention of ischemic stroke and myocardial infarction. However, diagnostic methods for atherosclerotic plaque phenotyping ...
    • Avidity-guided radionuclide therapy for thyroid cancer 

      Nilsson, Joachim (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-09-01)
      The treatment of differentiated thyroid cancer has three main modalities: surgery, hormone suppression and radioiodine therapy. Effective radioiodine therapy requires cancer cells to be iodine avid, i.e. exhibit relatively ...
    • Novel markers for smooth muscle cell modulation in vascular injury and disease 

      Rykaczewska, Urszula (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-08-02)
      Smooth muscle cells (SMCs) are major constituents of the vascular wall, indispensable for basic physiological functions of a healthy vessel, such as regulating vascular tone and blood pressure, but also critical during ...
    • Rethinking the artificial urinary sphincter : from current knowledge to the development of a new smart device 

      Reus, Christine (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-05-13)
      Background: Urinary incontinence (UI) plagues millions of women and men worldwide, leading to social stigma, low self-esteem, poor quality of life, and affects their loved ones. In women, frequent causes include childbirth, ...
    • Subacromial pain syndrome : an experimental clinical investigation in primary care 

      Eliason, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-04-13)
      This thesis presents the desired management for patients with Subacromial Pain Syndrome (SAPS) in primary care and consists of four papers based on data from two randomized controlled trials. Background: SAPS is a ...