Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery: Recent submissions
Now showing items 21-40 of 626
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Pelvic fractures : epidemiology and treatment
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-20)The epidemiology of pelvic and acetabular fractures has been sparsely described and up-to date information on incidence, demographic distributions and treatment are lacking. Surgical treatment of pelvic and acetabular ... -
Long-term follow-up after surgery for chronic thromboembolic pulmonary hypertension
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-12)Background: Pulmonary endarterectomy (PEA) is the treatment recommended for all operable patients with chronic thromboembolic pulmonary hypertension (CTEPH). The aim of this thesis was to evaluate long-term survival, quality ... -
Biomechanical and morphological aspects of abdominal aortic aneurysm growth and rupture
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-05)Abdominal aortic aneurysms (AAAs) are dilatations of the abdominal aorta that pose a risk of rupture. The only effective treatment is intervention prior to rupture, but this is also associated with mortality and morbidity. ... -
Abdominal aortic aneurysms : sex and gender disparities in surveillance, treatment and outcome
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-03-07)Background: In the field of abdominal aortic aneurysm (AAA), a lot of what is unknown converge in two specific topics: untreated patients and women. Best management strategies related to surveillance, treatment and outcome ... -
The male predominance in oesophageal adenocarcinoma and the role of sex hormones
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-02-28)Oesophageal adenocarcinoma is a subtype of oesophageal cancer with rapidly rising incidence over the last decades. This rise in incidence is strongest in western countries and more among men than in women, with a male ... -
Paediatric surgery in Uganda : burden of disease and barriers to quality of care
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-02-15)Background: In recent years there has been an increased awareness of surgical conditions within global health. A special emphasis is needed for children which constitute a large proportion of the populations in many ... -
Novel biomarkers in regulating human dense connective tissue repair
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-11-18)Painful and degenerative disorders of the musculoskeletal system pose a tremendous burden on the healthcare system. One main reason is the limited knowledge of the underlying key factors and pathways responsible for the ... -
A multidisciplinary long-term evaluation of patients born with unilateral cleft lip and palate treated with different surgical protocols
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-11-11)Introduction and aims: The aim of this project was to evaluate the long-term outcome after the multidisciplinary treatment of young adults born with unilateral cleft lip and palate (UCLP) regarding speech and communicative ... -
Bicycle trauma and it‘s consequences
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-11-09)The popularity to ride a bicycle is increasing worldwide and significant political efforts are made to promote cycling. To bike to work is generally seen as a health-conscious and environment friendly way of commuting. ... -
Outcomes of surgery for oesophageal cancer with focus on fatigue
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-10-31)Oesophageal cancer is the 6th leading cause of cancer mortality globally. Extensive surgery (oesophagectomy) with neoadjuvant chemo(radio)therapy is the backbone of curative treatment for oesophageal cancer. The thesis ... -
Adverse effects of treatment for rectal cancer : sexual function, hormones, and bone health
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-10-20)Thanks to improved outcomes from multimodal rectal cancer (RC) treatment, long-term survival is increasing; thus, focus on the long-term adverse effects of treatment is required. This thesis aimed to increase knowledge ... -
The role of proprotein convertases in vascular disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-10-18)To date, the role of the proprotein convertase subtilisin/kexin (PCSK) family in vascular disease is largely unknown, with the exception of PCSK9 and its key function in lipid metabolism. The PCSK family constitutes of 9 ... -
Towards an improved survival in gastric cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-10-14)Gastric cancer is a globally important contributor to morbidity and mortality from cancer. The age-standardised incidence has declined during the last decades, but the total incidence has not due to an aging population. ... -
Epidemiological studies of bioprosthetic aortic valves
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-09-27)Background: The use of bioprosthetic valves is common and offers a prosthetic option that does not require anti-coagulant therapy, but with shorter valve longevity compared to mechanical prostheses. Valve model selection ... -
Aspects of locally advanced colon cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-09-15)In Sweden, nearly 5000 patients are diagnosed with colon cancer annually and about 20% of these patients have a locally advanced tumor at the time of diagnosis. These tumors are challenging for both surgeons and oncologists ... -
Linking quantitative radiology to molecular mechanism for improved vascular disease therapy selection and follow-up
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-09-08)Objective: Therapeutic advancements in atherosclerotic cardiovascular disease have improved the prevention of ischemic stroke and myocardial infarction. However, diagnostic methods for atherosclerotic plaque phenotyping ... -
Avidity-guided radionuclide therapy for thyroid cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-09-01)The treatment of differentiated thyroid cancer has three main modalities: surgery, hormone suppression and radioiodine therapy. Effective radioiodine therapy requires cancer cells to be iodine avid, i.e. exhibit relatively ... -
Novel markers for smooth muscle cell modulation in vascular injury and disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-08-02)Smooth muscle cells (SMCs) are major constituents of the vascular wall, indispensable for basic physiological functions of a healthy vessel, such as regulating vascular tone and blood pressure, but also critical during ... -
Rethinking the artificial urinary sphincter : from current knowledge to the development of a new smart device
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-05-13)Background: Urinary incontinence (UI) plagues millions of women and men worldwide, leading to social stigma, low self-esteem, poor quality of life, and affects their loved ones. In women, frequent causes include childbirth, ... -
Subacromial pain syndrome : an experimental clinical investigation in primary care
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-04-13)This thesis presents the desired management for patients with Subacromial Pain Syndrome (SAPS) in primary care and consists of four papers based on data from two randomized controlled trials. Background: SAPS is a ...