Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology: Recent submissions
Now showing items 441-460 of 531
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Factors affecting growth, differentiation and apoptosis of osteoblastic and osteosarcoma cells
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2008-10-17)Osteoblasts play a fundamental role in determining bone structure and function. These cells originate from mesenchymal stem cells (MSCs) and through proliferation and differentiation develop into preosteoblasts and then ... -
Icodextrin metabolism in peritoneal dialysis : clinical and experimental studies
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2007-10-19)Icodextrin is a glucose polymer which is used as osmotic agent to provide sustained ultrafiltration (UF) during the long (8-16 hours) dwell in end-stage renal disease patients undergoing peritoneal dialysis (PD). The aims ... -
Genetic and functional studies on the thyroid hormone axis
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2008-10-24)This thesis has two main parts. The first is based on the first three papers with a focus on understanding the etiology and pathogenesis of thyroid malfunction and its effects on different organs. The second is about gaining ... -
Molecular mechanisms involved in the growth of human uterine leiomyomas
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2002-11-14)Human uterine leiomyomas (fibroids) are benign neoplasms arising from uterine smooth muscle cells, and are suggested to be sex steroid dependent. The aim of this study was to investigate the molecular mechanisms by which ... -
Aspects of foreign-born women's health and childbirth-related outcomes : an epidemiological study of women of childbearing age in Sweden
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2003-11-07)This thesis aims to study the association between aspects of health and childbirth-related outcomes and country of birth. A theoretical model has been developed from a feministic perspective to reflect foreign-born women's ... -
Perinatal HIV-1 infection : aspects on clinical presentation, viral dynamics and epidemiology
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2004-09-15)During the last 20 years HIV-1 infection has changed from being an unknown disease to being a widespread pandemic, in some areas affecting a large proportion of the human population. Mother-to-child transmission (MTCT) ... -
Ultrastructural studies of the blood-urine barrier in proteinuric states
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2010-04-30)The kidneys filter enormous amounts of blood every day, removing excess fluid and waste products while retaining cells and large proteins in the circulation. The podocytes with their foot processes and slit diaphragms (SD) ... -
Human ovarian follicles and oocytes : collection, cryopreservation, culture and gene expression
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2005-03-18)Infertility affects approximately 15% of couples globally. The most effective treatment today is in vitro fertilization. However, not all couples can be helped with the current techniques. To achieve better success, ... -
Glutamine to ICU patients
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2007-11-16)Intravenous glutamine supplementation to intensive care patients using a glutamine containing dipeptide is now widely accepted in clinical practice. There are evidences that glutamine supplementation of ICU patients in ... -
Diabetic glomerulopathy-natural history, intervention and prediction of complications
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2008-05-15)Diabetes mellitus is one of the most common chronic diseases in childhood. Diabetic nephropathy (DN) is one of the threatening complications of diabetes that occurs in 30-40% of patients after 20 years duration of disease. ... -
Molecular and morphological studies of folliculogenesis, oocyte maturation and embryogenesis in humans
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2008-05-22)Infertility is a problem that affects about 15 percent of all couples. Many can be helped by assisted reproductive techniques, but still today many couples are treated without a successful outcome. The reason for infertility ... -
Evaluation of strategies to predict and improve early graft survival in clinical islet transplantation
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2010-05-21)Transplantation of the islets of Langerhans as a treatment for type 1 diabetes (T1DM) is a procedure still under development. For the last decade it has been possible to obtain insulin independence by repeated infusions ... -
Perioperative nutrition and insulin resistance
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2006-01-27)Surgical trauma induces a catabolic response with development of insulin resistance as a central and well-characterised feature. In insulin resistance, the stimulating effect of insulin on peripheral glucose uptake and the ... -
Experimental studies of human fetal liver cells : in regard to in utero hematopoietic stem cell transplantation
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2002-02-22)Successful in utero hematopoietic stem cell transplantation represents a potential step forward in the management of patients with severe inherited hematological, metabolic and immunological disorders. Animal data from a ... -
Endothelial cells : dysfunction and repair mechanisms
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2010-05-20)Endothelial cells (ECs) are crucial component of the normal vascular wall, providing an interface between the bloodstream and surrounding tissue of the blood vessel wall. Endothelial progenitors cells (EPCs) circulate ... -
General practitioners' decision-making on drug treatment of hypercholesterolaemia
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2003-10-17)Drug treatment of elevated cholesterol values may be indicated for individuals at high risk for cardiovascular disease and as a complement to lifestyle advice. Guidelines recommend a numerical risk calculation as the basis ... -
Impact of peritoneal solute transport rate on nutritional status and clinical outcome in peritoneal dialysis patients
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2003-04-16)The transport characteristics of the peritoneal membrane may be influenced by inflammation and various comorbid diseases (CMD) in peritoneal dialysis (PD) patients. On the other hand, the peritoneal solute transport rate ... -
Glucose and ketone body metabolism : with emphasis on ketotic hypoglycemia
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2008-01-25)Idiopathic ketotic hypoglycemia is characterized by hypoglycemia and elevated levels of ketone bodies (beta-hydroxybutyrate and acetoacetate) during fasting. The affected children are otherwise healthy and they usually ... -
Risk factors for the development of chronic renal failure : epidemiological studies on the role of analgesic use, occupational exposures and socioeconomic background
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2003-01-17)Chronic renal failure is a severe condition that reduces life expectancy and typically progresses to end-stage renal disease and a need for renal replacement therapy. In a large proportion of cases, chronic renal failure ... -
A new computed tomography method for evaluation of orthopedic implants : applied to the acetabular cup
(Institutionen för klinisk vetenskap / Department of Clinical Sciences, 2009-12-25)Background: Two major long term complications after total hip arthroplasty (THA) is aseptic loosening and wear of the implant. In the clinical situation a detection level of approximately 1 mm is desirable. However, ...