Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology: Recent submissions
Now showing items 141-160 of 531
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On bioenergetic failure in septic shock : lactate kinetics and mitochondrial respiration
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-12-20)Septic shock, a dysregulated immune response to an infection, is a major cause of mortality and morbidity in patients treated in intensive care units (ICUs). The cause of the organ dysfunction seen in sepsis is still not ... -
The role of thyroid stimulating hormone receptor and novel candidate genes FAM13a and POM121c in adipocyte dysfunction
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-11-19)This thesis aimed to investigate the role of thyroid stimulating hormone receptors (TSHRs) in adipose tissue (AT) and their role in AT dysfunction and obesity-related metabolic complications. Furthermore, we aimed to ... -
Radiomics in cancer prognosis : applications and limitations of quantitative texture analysis
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-11-16)Medical imaging has become an integral part of clinical diagnostics since the discovery of X-rays at the end of the 19th century. Recent advances in computing power have opened up the possibility to extract quantitative ... -
Exploring the role of mesenchymal stromal cells in endometriosis
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-11-16)Endometriosis is a chronic inflammatory disease where there is growth of endometrial tissue in ectopic sites, most commonly within the pelvic cavity. The major symptoms of this disease are chronic pelvic pain and infertility. ... -
Cellular consequences of preterm birth : telomere biology, immune development and oxidative stress
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-11-15)Preterm infants are at risk for oxidative stress just by being born. The extra-uterine environment is relatively oxygen-rich, their antioxidant defenses are immature, diseases and treatments in the neonatal period will ... -
Auditory organotypic cultures and progenitor cell implantation
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-11-15)According to the WHO, about 5 % of the world’s population suffers from disabling hearing loss. In people above the age of 65 the number is more than 30 %. Common effects of this condition are poor speech discrimination and ... -
Nutritional intakes over time and perioperative nutrition in extremely preterm infants
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-11-08)Background: Despite improvements in nutrition practice during the last decades, problems still exist in meeting estimated nutritional needs, especially for extremely preterm (EPT) infants. Today, it is still not known how ... -
Investigation of cytogenetic markers in neonatal blood spots and of aberrant protein expression in bone marrow from children with leukemia
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-10-31)The general aim of this thesis was to contribute to a better understanding of the development and progression of leukemia in children. Biological markers identified in children with leukemia can contribute to the understanding ... -
Inverted papilloma and sinonasal malignancies in Sweden
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-10-29)Background: Sinonasal malignancies (SNMs) are rare and in Sweden they account for approximately 0,1% of all malignancies and 5% of all head and neck malignancies. Apart from sinonasal malignant melanoma (SNMM), their ... -
Medical decision-making in Alzheimer’s disease : a linguistic approach
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-10-26)Objectives. To explore medical decision-making capacity (MDC) for research participation, in patients with Alzheimer's disease, using a linguistic approach and including comparable groups. Materials and Methods. The ... -
Complicated vacuum extraction : focus on traction force
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-10-23)Introduction: Vacuum extraction is a common operative vaginal delivery in the final stage of labor, and generally considered a safe alternative to emergency cesarean section. However, there is insufficient evidence regarding ... -
Immune response and tumour cell detection in lymph nodes of head and neck cancer
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-10-18)Many patients with head and neck squamous cell carcinoma present with regional spread to the cervical lymph nodes. Lymph nodes metastases are today the most important factor influencing both the treatment and outcome for ... -
Growth hormones in chronic kidney disease
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-10-05)Several hormonal systems are disrupted in chronic kidney disease (CKD) and disturbances of the growth hormone axis could contribute to increased morbidity and mortality through effects on cardiovascular health, energy ... -
Development of vestibular evoked myogenic potentials and audiometry for the clinical diagnosis of superior canal dehiscence syndrome
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-10-01)Often in Audiology and Neurotology the focus is on disorders characterized by loss of hearing and vestibular function. A complementary approach is to look at the manifestations of abnormally augmented auditory or vestibular ... -
Review and prediction of trauma mortality
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-09-28)Quality management principles stipulate that outcome after injury is dependent upon patient factors, injury severity, structures and processes of care in a trauma system. Structures refers to the context in which care is ... -
Achilles tendon loading and deformation during rehabilitation and use of ankle foot orthoses
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-05-30)Achilles tendon rupture is a common injury which most often affects otherwise healthy individuals and which causes long periods of rehabilitation with absence from work and sport activities and frequently sequele with ... -
Outcome after liver resection : epidemiological and clinical studies with special focus on the role of post-hepatectomy liver failure
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-05-24)Background: Liver surgery has undergone significant developments over the last three decades. However, population-based data are scarce, and there is limited knowledge of the impact on mortality and possible treatment ... -
Exposure to hepatitis C virus early in life : epidemiological and Immunological aspects
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-05-24)Hepatitis C virus (HCV) is a blood borne virus affecting the liver. Globally, it is estimated that approximately 6 million children live with HCV infection today. The main transmission route in children today is vertical ... -
Aspects of fracture risk in elderly women
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-05-18)The main purpose of this thesis was to identify and further specify factors relevant for the assessment of fracture risk. The studies were conducted on two different cohorts of elderly women. The Osteoporosis Prospective ... -
Antibiotic prophylaxis and infectious complications in surgery for acute cholecystitis
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-05-07)The prevalence of gallstone disease in the world is 10-20%. Almost 20% of those with gallstone disease develop a complication during their lifetime. Acute cholecystitis (AC) is a common complication of gallstones, that is ...