Now showing items 1-20 of 457

    • Optimizing treatment : tumor markers and sclerotherapy in head and neck lesions 

      Wendt, Malin (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-05-06)
      Treatment of malignant and benign lesions in the head and neck area is challenging, due to complex anatomy and function. It is thus urgent to find ways to individualize treatment, in order to reduce side-effects, but ...
    • Chronic kidney disease : a clinical model of premature vascular aging 

      Dai, Lu (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-04-27)
      Patients with chronic kidney disease (CKD) are prone to develop an accelerated vascular aging phenotype characterized by vascular calcification (VC), a major culprit of cardiovascular complications and premature death. ...
    • Mapping the immune landscape in solid tumors : implications for immunotherapy 

      Foord, Emelie (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-04-27)
      Our cells are programmed with various safety mechanisms to avoid transformation into tumor cells. In case these fail, we have a guarding immune system ready to recognize and eliminate these cells. Despite these safety ...
    • Complications due to acute rhinosinusitis in children 

      Hultman Dennison, Sofia (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-04-15)
      Background There is a lack of population-based studies of complications to acute rhinosinusitis in children. Previous studies have demonstrated a possible effect of the conjugate pneumococcal vaccine (PCV) on hospital ...
    • Insulin resistance in children and adolescents : mechanisms and clinical effects 

      Ek, Anna E. (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-04-15)
      Background: Insulin resistance is a condition in which insulin does not achieve appropriate response in different target tissues, it is associated with obesity and one of the main culprits in the development of type 2 ...
    • Prostate cancer : population-based screening and markers for long-term clinical outcome 

      Lundgren, Per-Olof (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-04-12)
      In 1988 and 1989 a large screening study for prostate cancer was launched in Stockholm, Sweden. At the time approximately 27 000 men between 55 and 70 years of age resided within a defined area of southern Stockholm. 2400 ...
    • To cut or not to cut : the association between weight loss and cardiometabolic health in adolescents and adults after Roux-en-Y Gastric Bypass 

      Brissman, Markus (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-03-31)
      Energy cannot be destroyed, and in humans excess energy is stored as fat in adipose tissue. Accumulation of fat is thus the result of a positive energy balance, and obesity is defined as an excess amount of adipose tissue. ...
    • Nutritional status and dysphagia in patients with oesophageal cancer : the impact of oncological and surgical treatment 

      Ericson, Jessica (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-03-18)
      The most common symptom of oesophageal cancer is difficulty swallowing, dysphagia, due to the tumour obstructing the oesophageal lumen often resulting in weight loss. In patients diagnosed with oesophageal cancer malnutrition ...
    • Copeptin is independently associated with vascular calcification in chronic kidney disease stage 5 

      Golembiewska , Edyta; Qureshi , Abdul Rashid; Dai , Lu; Lindholm, Bengt ; Heimbürger, Olof ; Söderberg, Magnus; Brismar, Torkel B ; Ripsweden, Jonaz; Barany, Peter; Johnson, Richard J; Stenvinkel , Peter (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-03-05)
      Background: Vascular calcification (VC) is an independent predictor of cardiovascular disease (CVD) present in 30– 70% of patients with chronic kidney disease (CKD). Copeptin is a sensitive surrogate marker of arginine ...
    • Early vascular ageing and cellular senescence in chronic kidney disease 

      Dai, Lu; Quershi, Abdul Rashid; Witasp, Anna; Lindholm, Bengt; Stenvinkel, Peter (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-03-05)
      Chronic kidney disease (CKD) is a clinical model of premature ageing characterized by progressive vascular dis- ease, systemic inflammation, muscle wasting and frailty. The predominant early vascular ageing (EVA) process ...
    • Circulating proteins as predictors of cardiovascular mortality in endstage renal disease 

      Feldreich, T; Nowak, C; Fall, T; Carlsson, AC; Carrero, JJ; Ripsweden, J; Qureshi, AR; Heimburger, O; Barany, P; Stenvinkel, P; Vuilleumier, N; Kalra, PA; Green, D; Ärnlöf, J (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-02-24)
      Introduction: Proteomic profiling of end-stage renal disease (ESRD) patients could lead to improved risk prediction and novel insights into cardiovascular disease mechanisms. Plasma levels of 92 cardiovascular disease-associated ...
    • Neurophysiological conditions for hearing in children using hearing aids or cochlear implants : an intervention and follow-up study 

      Engström, Elisabet (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-02-19)
      OBJECTIVES The four studies in this thesis examine the central auditory pathways in children with hearing loss (HL) through recording event-related potentials (ERP) and mismatch negativity (MMN). The design of the ...
    • Aspects on advanced procedures during endoscopic retrograde cholangiopancreatography (ERCP) for complex hepatobiliary disorders 

      Lübbe, Jeanne Adéle (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-02-08)
      Background: The rapid development in endoscopic technology and associated skills has led to an increase in more advanced procedures being performed during endoscopic retrograde cholangiopancreatography (ERCP). Knowledge ...
    • Consequences of kidney dysfunction in the community : health care-based epidemiological studies from the Stockholm creatinine measurements (scream) project 

      Runesson, Björn (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-01-26)
      Chronic kidney disease (CKD) is affecting an increasing share of the world’s population, and presents a global health problem. The prevalence of CKD in society and its implication for various health outcomes have been ...
    • Differentiation of renal oncocytoma from renal cell carcinoma by means of ⁹⁹Tc-Sestamibi SPECT/CT 

      Tzortzakakis, Antonios (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-01-15)
      Purpose: An increasing body of literature indicates the beneficial role of [99m]Tc-Sestamibi SPECT/CT in the non-invasive differentiation of renal oncocytoma (RO) from renal cell carcinoma (RCC). This thesis presents a ...
    • Experimental approaches and clinical opportunities in metabolic liver diseases 

      Karadagi, Ahmad (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-11-27)
      Metabolic liver diseases are uncommon individually, however, collectively they represent significant cause of morbidity and mortality globally. The liver has many diverse functions, such as; detoxification from hazardous ...
    • Swedish children with moderate hearing loss : on the importance of monitoring auditory and early speech development the first three years 

      Persson, Anna (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-11-24)
      The overall aim of this thesis was to investigate the auditory and early speech development in a group of children born with moderate hearing loss (HL) who were fitted with hearing aids (HAs) before the age of 6 months, ...
    • Coagulation in liver failure : the role of thromboelastometry and fibrinogen 

      Dumitrescu, Gabriel (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-11-06)
      Liver failure is undeniably accompanied by distortions of the coagulation system. The modern theory of coagulation in patients with compensated liver disease (acute or chronic) states that the coagulation system is in a ...
    • Obesity in childhood : psychosocial consequences and premature mortality 

      Lindberg, Louise (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-10-21)
      Background It is estimated that 91 million children worldwide will have obesity by 2025. Obesity in childhood is associated with increased risk of obesity in adulthood, psychosocial maladjustment, mental health problems, ...
    • Uvulopalatopharyngoplasty : patient selection, long- term outcomes, and side effects 

      Sundman, Joar (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-10-16)
      Uvulopalatopharyngoplasty (UPPP) is the most common surgical treatment for adult patients with obstructive sleep apnea (OSA). Its short-term efficacy, as measured through polysomnography, is well-established and has been ...