Now showing items 1-20 of 429

    • Hygiene at CT and MRI 

      Palmqvist, Charlotte (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-26)
      Background: Preventing the spread of infections is a constant battle against microorganisms. Hospital-acquired infections (HAIs) with multidrug-resistant (MDR) bacteria are a global problem today and causes suffering for ...
    • Outcome of gastric cancer surgery in Sweden 

      Kung, Chih-Han (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-20)
      Gastric cancer worldwide is the fifth most common cancer and has the third highest cancer related mortality. Curative treatment includes surgical resection but comes with risk of complications and the optimal surgery ...
    • Intralymphatic immunotherapy in allergic rhinitis : Evaluating safety, efficacy and mechanisms 

      Hellkvist, Laila (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-15)
      Allergic rhinitis (AR) deprives work capacity, social activities and quality of life, and costs the Swedish society about €1.3 billion annually. Allergen-specific immunotherapy (AIT) amends the symptoms and improves the ...
    • Glutamine kinetics in critically ill patients 

      Smedberg, Marie (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-15)
      Critical illness, defined as a life-threatening organ failure, entails an extreme stress that results in a pathophysiology of its own. The abnormal metabolism of these patients causes a severe muscle wasting that is poorly ...
    • Sleep and obesity in children at different obesity risks : patterns, associations and early intervention 

      Xiu, Lijuan (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-13)
      Background: Childhood obesity is a global health concern with a range of adverse outcomes. Short sleep has been consistently linked to childhood obesity. However, associations between other sleep characteristics and obesity ...
    • Is it all about the money? The effects of low and high cost simulator training scenarios in surgical training 

      Oussi, Ninos (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-12)
      Background: The learning process is complex and dependent on several factors such as for instance, the environment to learn, prior knowledge and distinct abilities, motivation, goal-orientation as well as the effects of ...
    • Long term effects of lumbar disc herniation surgery in adolescents 

      Lagerbäck, Tobias (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-08)
      Background: In Sweden, about 2,900 surgeries due to a lumbar disc herniation are performed yearly, and the surgical incidence is low compared to the incidence in Denmark and Norway. Surgery for lumbar disc herniation in ...
    • Developmental insights and biomedical potential of human embryonic stem cells : modelling trophoblast differentiation and establishing novel cell therapies for age-related macular degeneration 

      Plaza Reyes, Alvaro (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-04)
      Understanding the molecular pathways responsible for lineage segregation in the preimplantation human embryo is critical in order to fully elucidate the mechanisms involved in pluripotency and differentiation of embryonic ...
    • The role of fibroblast growth factor 19 in human liver 

      Johansson, Heléne (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-04)
      Bile acids are synthesized in the liver and are essential for intestinal absorption of lipids. Bile acid homeostasis is crucial and if not maintained, bile acids can accumulate to toxic levels and cause severe damage to ...
    • Exploring childhood apraxia of speech : speech and language profiles in 5-year-olds with suspected apraxia of speech or cleft palate 

      Malmenholt, Ann (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-04)
      Introduction and aims: Childhood apraxia of speech (CAS) is a speech sound disorder (SSD) lacking a quantifiable measure discriminating all cases of CAS from other SSDs. This project aimed at exploring CAS using different ...
    • Exploring mammalian preimplantation development and pluripotency 

      Schell, John Paul (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-04-27)
      Our current understanding of how stem cells arise and transition during embryonic development has been limited by analysis tools that have lacked single-cell, whole-genome resolution. This thesis emphasizes the use of ...
    • A personalized approach to chronic rhinosinusitis with nasal polyps, based on biomarkers, phenotypes and new surgical thinking 

      Jonstam, Karin (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-04-27)
      Chronic rhinosinusitis (CRS) is a prevalent disease causing a substantial burden for the patient and the society. CRS is divided into CRS with (CRSwNP) and without nasal polyps (CRSsNP). Based on current knowledge on ...
    • Hands-on osteoporosis screening with digital x-ray radiogrammetry 

      Wilczek, Michael (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-04-24)
      According to epidemiological studies about one third of women and one fifth of men over 50 years will experience a fragility fracture. These fractures account for substantial mortality, morbidity and health care cost. ...
    • Off-label drug use, medication errors and adverse drug events : among Swedish pediatric inpatients 

      Nydert, Per (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-04-22)
      Background: In pediatrics, treatment with drugs is an important and fully integrated part of everyday medical practice. However, authorized drugs specified to be used in children are often lacking which leads to off-label ...
    • The new old normal : reassessing perioperative oxygen consumption and haemodynamics in the elderly 

      Jakobsson, Julia (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-04-01)
      Perioperative haemodynamic instability and disturbances of global oxygen transport are associated with complications and organ injury after surgery. The continuously growing population of elderly in surgical care are at ...
    • Scalable, safe and GMP-compatible production of embryonic stem cell derived retinal pigment epithelial cells 

      Padrell Sánchez, Sara (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-03-06)
      Regenerative medicine is an exponentially growing field that aims to regenerate a lost function, cell type or tissue due to damage, ageing or disease. Currently, more than 30,000 gene- and cell-based therapies have been ...
    • Hepatic ischemia-reperfusion injury 

      D'Souza, Melroy Alistair (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-02-28)
      Hepatic ischemia-reperfusion (I/R) injury is a complex phenomenon occuring in response to interruption of the liver’s blood and oxygen supply and the subsequent restoration of blood flow and tissue oxygenation. Techniques ...
    • Hearing in Children with cleft palate 

      Tengroth, Birgitta (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-02-21)
      Objective: The overall aim of this thesis was to collect longitudinal information about hearing thresholds and complications due to otitis media with effusion (OME) in children with cleft palate. Since OME is highly prevalent ...
    • Voice disorders and treatment effects in Parkinson's disease studied with a portable voice accumulator 

      Körner Gustafsson, Joakim (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-02-11)
      Background: Information about voice use outside the clinical setting has traditionally consisted of subjective data collected via interviews or questionnaires. Quantitative, objective information about voice use in daily ...
    • Microdialysis : potentials and limitations 

      Platen, Anna von (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-02-03)
      Despite improvements in operating technique and post-operative management, many patients undergoing liver transplantation still suffer post-operative complications, which may lead to graft loss or patient death. Patients ...