Now showing items 21-40 of 443

    • Long term effects of lumbar disc herniation surgery in adolescents 

      Lagerbäck, Tobias (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-08)
      Background: In Sweden, about 2,900 surgeries due to a lumbar disc herniation are performed yearly, and the surgical incidence is low compared to the incidence in Denmark and Norway. Surgery for lumbar disc herniation in ...
    • Developmental insights and biomedical potential of human embryonic stem cells : modelling trophoblast differentiation and establishing novel cell therapies for age-related macular degeneration 

      Plaza Reyes, Álvaro (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-04)
      Understanding the molecular pathways responsible for lineage segregation in the preimplantation human embryo is critical in order to fully elucidate the mechanisms involved in pluripotency and differentiation of embryonic ...
    • The role of fibroblast growth factor 19 in human liver 

      Johansson, Heléne (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-04)
      Bile acids are synthesized in the liver and are essential for intestinal absorption of lipids. Bile acid homeostasis is crucial and if not maintained, bile acids can accumulate to toxic levels and cause severe damage to ...
    • Exploring childhood apraxia of speech : speech and language profiles in 5-year-olds with suspected apraxia of speech or cleft palate 

      Malmenholt, Ann (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-04)
      Introduction and aims: Childhood apraxia of speech (CAS) is a speech sound disorder (SSD) lacking a quantifiable measure discriminating all cases of CAS from other SSDs. This project aimed at exploring CAS using different ...
    • Exploring mammalian preimplantation development & pluripotency 

      Schell, John Paul (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-04-27)
      Our current understanding of how stem cells arise and transition during embryonic development has been limited by analysis tools that have lacked single-cell, whole-genome resolution. This thesis emphasizes the use of ...
    • A personalized approach to chronic rhinosinusitis with nasal polyps : based on biomarkers, phenotypes and new surgical thinking 

      Jonstam, Karin (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-04-27)
      Chronic rhinosinusitis (CRS) is a prevalent disease causing a substantial burden for the patient and the society. CRS is divided into CRS with (CRSwNP) and without nasal polyps (CRSsNP). Based on current knowledge on ...
    • Hands-on osteoporosis screening with digital x-ray radiogrammetry 

      Wilczek, Michael (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-04-24)
      According to epidemiological studies about one third of women and one fifth of men over 50 years will experience a fragility fracture. These fractures account for substantial mortality, morbidity and health care cost. ...
    • Off-label drug use, medication errors and adverse drug events : among Swedish pediatric inpatients 

      Nydert, Per (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-04-22)
      Background: In pediatrics, treatment with drugs is an important and fully integrated part of everyday medical practice. However, authorized drugs specified to be used in children are often lacking which leads to off-label ...
    • The new old normal : reassessing perioperative oxygen consumption and haemodynamics in the elderly 

      Jakobsson, Julia (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-04-01)
      Perioperative haemodynamic instability and disturbances of global oxygen transport are associated with complications and organ injury after surgery. The continuously growing population of elderly in surgical care are at ...
    • Scalable, safe and GMP-compatible production of embryonic stem cell derived retinal pigment epithelial cells 

      Padrell Sánchez, Sara (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-03-06)
      Regenerative medicine is an exponentially growing field that aims to regenerate a lost function, cell type or tissue due to damage, ageing or disease. Currently, more than 30,000 gene- and cell-based therapies have been ...
    • Hepatic ischemia-reperfusion injury 

      D'Souza, Melroy Alistair (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-02-28)
      Hepatic ischemia-reperfusion (I/R) injury is a complex phenomenon occuring in response to interruption of the liver’s blood and oxygen supply and the subsequent restoration of blood flow and tissue oxygenation. Techniques ...
    • Hearing in Children with cleft palate 

      Tengroth, Birgitta (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-02-21)
      Objective: The overall aim of this thesis was to collect longitudinal information about hearing thresholds and complications due to otitis media with effusion (OME) in children with cleft palate. Since OME is highly prevalent ...
    • Voice disorders and treatment effects in Parkinson's disease studied with a portable voice accumulator 

      Körner Gustafsson, Joakim (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-02-11)
      Background: Information about voice use outside the clinical setting has traditionally consisted of subjective data collected via interviews or questionnaires. Quantitative, objective information about voice use in daily ...
    • Microdialysis : potentials and limitations 

      Platen, Anna von (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-02-03)
      Despite improvements in operating technique and post-operative management, many patients undergoing liver transplantation still suffer post-operative complications, which may lead to graft loss or patient death. Patients ...
    • Different perspectives of living with osteoarthritis and outcomes after knee arthroplasty 

      Skogö Nyvang, Josefina (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-01-31)
      Osteoarthritis (OA) is the most common joint disease affecting the population increasingly with age. Living with OA and pain can cause severe distress in an individual’s life and expectations of outcome after joint ...
    • Optimizing computed tomography : quality assurance, radiation dose and contrast media 

      Nowik, Patrik (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-01-22)
      Computed tomography (CT) is an important modality in radiology; it enables imaging of the inside of patients without superimposed anatomy. The radiation dose and quality of a CT image are highly dependent on the CT scanner, ...
    • The papilla of Vater : issues relevant to transpapillary cannulation and clinical management. 

      Haraldsson, Erik (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-12-20)
      Background: Many endoscopists have since the beginning of endoscopic retrograde cholangiopancreatography (ERCP) commented on the variation in the macroscopic appearance of the papilla of Vater. How the macroscopic appearance ...
    • Anabolic response to amino acid supplementation in critical illness 

      Liebau, Felix (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-11-07)
      Background: Critically ill patients suffer from protein catabolism with losses of skeletal muscle and whole-body proteins associated with morbidity and mortality. Catabolism is difficult to overcome, but nutritional ...
    • Neutrophil subsets in airway inflammation and hyperreactivity 

      Ekstedt, Sandra (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-11-06)
      Neutrophils are part of the first lines of defence against invading microbes. They play an essential role in antimicrobial host defence by recognizing microorganisms through the various receptors that can be expressed on ...
    • Radiation dose-, contrast media- and image quality optimization in computed tomography 

      Thor, Daniel (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-10-31)
      Computed tomography (CT) was introduced to medicine in the early 1970s, which brought slice imaging into wide use for the first time. Today, CT is an essential part of radiological diagnostics, and is used for a wide ...