Doktorsavhandlingar / Doctoral Theses - H7 (MedH): Recent submissions
Now showing items 41-60 of 330
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Adaptive immune responses to tick-borne encephalitis virus and SARS-CoV-2
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-01-11)Tick-borne encephalitis virus (TBEV) and SARS-CoV-2 are two unrelated viruses that currently cause substantially different public health burdens and distinct pathologies in humans. TBEV infection leads to neurological ... -
Studies on the links between white adipose tissue phenotype and the circulatory system
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-12-22)Obesity is a strong risk factor for cardiovascular disease. It is defined by an unhealthy excess of white adipose tissue (WAT). Adipose derived weight gains and losses are linked to changes in two other independent ... -
Streptococcal and staphylococcal tissue infections : therapeutic challenges and opportunities
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-11-26)Streptococcus pyogenes and Staphylococcus aureus have been leading causes of human infections throughout history. S. pyogenes is of the top-ten pathogens responsible for most death globally, 0.5 million deaths per year. ... -
Familial hypercholesterolemia in Sweden : genetic and clinical studies
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-11-12)Prevention of premature disease and death from cardiovascular complications of atherosclerosis is an important goal for public health, and the early identification of individuals with increased risk is an important goal ... -
Genetic predisposition to immune cell malfunction and inflammation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-09-10)Our genome contains all the instructions to control the synthesis of proteins, the development of cells and the interaction between body systems. We are armed with an immune system, made up of cells, chemical compounds and ... -
The epidemiology of varicella zoster virus disease in Sweden : before and after vaccination
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-09-10)Primary infection with the varicella zoster virus (VZV) presents as chickenpox, a highly contagious infection. Thereafter the virus establishes latency in nerve ganglia of the host. The virus may reactivate later in life ... -
Studies of inflammatory responses in hantavirus infection
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-05-28)Throughout the world, orthohantaviruses cause severe, acute infections in humans. Orthohantaviruses, commonly referred to as hantaviruses, are zoonotic viruses with a single stranded RNA genome of negative sense. Hantavirus ... -
From fatty liver to end-stage liver disease through type 2 diabetes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-05-28)The past decades have seen a marked increase in the incidence of type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Epidemiological studies have clearly demonstrated that there is an association between type 2 ... -
Clinical consequences of pancreatic exocrine insufficiency
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-05-27)Background: Chronic pancreatitis (CP) is characterized by a chronic inflammation with fibrosis and irreversible morphological changes that can result in permanent structural changes with a loss of exocrine and endocrine ... -
The antimicrobial role of human MAIT cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-03-19)MAIT cells are unconventional T cells that have characteristics of both innate and adaptive immunity. Their fast mobilization and wide distribution in tissues make them part of the first line of defense against infection. ... -
Strategies to assess and improve prognostication of plasma cell disorders
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-03-01)Plasma cell dyscrasias (PCD) are a group of disorders, most of which have the overproduction of monoclonal immunoglobulins (M-protein) in common. Included in the group of PCDs are both benign and treatment demanding ... -
Immunopathogenesis in pulmonary tuberculosis : impact of immunomodulation and diabetes co-morbidity
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-26)Even in the 21st century, tuberculosis (TB) remains a major global health threat, primarily due to the emergence of antibiotic resistance. Presence of co-morbidities such as diabetes mellitus (DM) has worsened the current ... -
Innate lymphoid cell plasticity and heterogeneity in human tissues
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-05)The human immune system is a vital mechanism that protects the host from outside threats. The two main branches of this system, consisting of innate and adaptive immunity, aid the host when dangers of both imminent and ... -
Platelet transfusions in hematological disorders
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-01-12)Platelets are important for clot formation and vascular integrity. Thrombocytopenic patients with hematological disorders are at risk of bleeding and platelet transfusions are important in supportive care and treatment of ... -
Chronic bone marrow failure and transfusion patterns : epidemiological studies of blood transfusions and outcomes in patients with myelodysplastic syndromes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-12-22)Myelodysplastic syndromes (MDS) encompass a diverse group of clonal hematological malignancies characterized by dysplasia and ineffective hematopoiesis with an increased risk of leukemic evolution. It is a disease of the ... -
Mesenchymal niche contribution to normal and malignant hematopoiesis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-11-05)Normal hematopoiesis is tightly regulated by hematopoietic microenvironment/niche in bone marrow (BM) via direct hematopoietic cell-niche cell interaction and factors secreted by various types of cellular niches. The BM ... -
Human innate lymphocytes in host defense, tissue function and reproduction
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-10-23)The immune system is present in all tissues of the human body. In order to respond appropriately to infections, cells of the innate and adaptive immune system work in concert. In this thesis, we focused on natural killer ... -
Viral gastrointestinal infections in allogeneic hematopoietic stem cell transplant patients
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-10-16)Gastrointestinal symptoms, and elevated liver enzymes, are common after HSCT, often due to drug toxicity, graft-versus-host disease (GVHD) or infections. It is essential to distinguish between GVHD and infection, since ... -
Assessment and prognostic importance of nutritional status and body composition in liver transplantation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-09-08)Chronic liver disease and liver cirrhosis are progressive diseases closely linked to metabolism and nutritional status. Weight loss is a result of negative energy balance and is therefore a good measure of risk of malnutrition. ... -
Models of the lung tissue microenvironment for studies of human myeloid cell function
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-07-31)Studies of the immune system requires knowledge concerning not only the perturbating event itself, i.e. specific microorganisms, and how it interacts with immune cells but also how it functions in its natural environment ...