Now showing items 21-40 of 322

    • Advancing cancer immunotherapy by exploring NK cell education, antibody targeting and tissue homing : stay tuned for directions reaching beyond the natural biology 

      Leijonhufvud, Caroline (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-10-21)
      Cancer immunotherapy is a fast-growing field. The natural killer (NK) cells’ innate ability to detect malignant cells and capacity to perform antibody-dependent cellular cytotoxicity (ADCC) together with low risk of inducing ...
    • Liver cirrhosis : epidemiology, prognosis, and cancer 

      Bengtsson, Bonnie (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-09-29)
      Liver cirrhosis is a major risk factor for hepatocellular carcinoma (HCC). Patients with liver cirrhosis also have a high risk to develop infections leading to deterioration of liver function and increased mortality. In ...
    • Innate lymphoid cell differentiation and functions in intestinal homeostasis and disease 

      Kokkinou, Efthymia (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-09-15)
      The gastrointestinal (GI) tract, which includes the small and the large intestine, is considered the largest immunological organ that plays a pivotal role in food digestion, nutrient absorption and fuel generation. ...
    • Clinical aspects of hidradenitis suppurativa 

      Killasli, Hassan (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-08-12)
      Hidradenitis suppurativa (HS) is often a chronic skin disease of unknown etiology characterized by formation of non-infectious inflammatory nodules, abscesses, and suppurating skin tunnels mainly in axillae and groins. The ...
    • The role of innate immunity in obesity-induced tissue inflammation 

      Stiglund, Natalie (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-08-02)
      The prevalence of obesity is rapidly increasing globally, which causes an increase in associated diseases such as type 2 diabetes, cardiovascular disease and non-alcoholic fatty liver disease (NAFLD). In addition to the ...
    • Origin and ontogeny of human lung macrophages 

      Evren, Elza (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-20)
      The lung is a vital organ occupied by a large diversity of immune cells due to its close proximity with the external environment. This thesis focuses on a particular type of immune cell: the macrophage. The lungs are ...
    • Implications of chronic kidney disease on presentation, treatment and outcomes in patients with aortic stenosis 

      Vavilis, Georgios (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-19)
      Background: Aortic valve stenosis (AS) is the most common valvular heart disease in the western world. No pharmacological treatment has been proved to halt the progression to severe disease and after symptom debut, the ...
    • Aspects of diagnosis, prognosis and treatment of nonalcoholic fatty liver disease 

      Holmer, Magnus (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-16)
      Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease globally. NAFLD is caused by obesity, often in combination with type 2 diabetes mellitus (T2D). Lifestyle modifications that lead to weight ...
    • Characterization and targeting of leukemia propagating cells 

      Virding Culleton, Stina (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-09)
      Patients with hematopoietic malignancies have a large, unmet medical need. Allogeneic hematopoietic stem cell transplantation remains the only curative option, but many patients are not eligible for such treatment. Many ...
    • Plasma cell malignancies in Sweden : subgroup descriptions and regional outcomes for multiple myeloma 

      Wålinder, Göran (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-04-13)
      Plasma cell disorders appear in various forms such as aggressive plasma cell leukemia (PCL), typical symptomatic multiple myeloma (MM), non-symptomatic smouldering multiple myeloma (SMM) and solitary plasmacytoma (SP). The ...
    • Maternal obesity and offspring metabolic outcomes : focus on sex differences 

      Savva, Christina (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-04-01)
      Obesity is a worldwide health issue affecting all ages and both sexes, and its prevalence is progressively increasing among adults and children. The predisposition to metabolic complications caused by obesity is sex ...
    • B cell responses to human flavivirus vaccination and SARS-CoV-2 infection 

      Sandberg, Tyler (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-02-25)
      Viral infections pose a major threat to global heath. As specific antiviral treatments are lacking against many human viruses, vaccination is the most effective medical intervention to prevent severe disease and death. ...
    • Adaptive immune responses to tick-borne encephalitis virus and SARS-CoV-2 

      Varnaitė, Renata (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-01-11)
      Tick-borne encephalitis virus (TBEV) and SARS-CoV-2 are two unrelated viruses that currently cause substantially different public health burdens and distinct pathologies in humans. TBEV infection leads to neurological ...
    • Studies on the links between white adipose tissue phenotype and the circulatory system 

      Bäckdahl, Jesper (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-12-22)
      Obesity is a strong risk factor for cardiovascular disease. It is defined by an unhealthy excess of white adipose tissue (WAT). Adipose derived weight gains and losses are linked to changes in two other independent ...
    • Streptococcal and staphylococcal tissue infections : therapeutic challenges and opportunities 

      Bergsten, Helena (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-11-26)
      Streptococcus pyogenes and Staphylococcus aureus have been leading causes of human infections throughout history. S. pyogenes is of the top-ten pathogens responsible for most death globally, 0.5 million deaths per year. ...
    • Familial hypercholesterolemia in Sweden : genetic and clinical studies 

      Benedek, Peter (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-11-12)
      Prevention of premature disease and death from cardiovascular complications of atherosclerosis is an important goal for public health, and the early identification of individuals with increased risk is an important goal ...
    • Genetic predisposition to immune cell malfunction and inflammation 

      Torralba-Raga, Lamberto J (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-09-10)
      Our genome contains all the instructions to control the synthesis of proteins, the development of cells and the interaction between body systems. We are armed with an immune system, made up of cells, chemical compounds and ...
    • The epidemiology of varicella zoster virus disease in Sweden : before and after vaccination 

      Widgren, Katarina (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-09-10)
      Primary infection with the varicella zoster virus (VZV) presents as chickenpox, a highly contagious infection. Thereafter the virus establishes latency in nerve ganglia of the host. The virus may reactivate later in life ...
    • Studies of inflammatory responses in hantavirus infection 

      Maleki, Kimia (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-05-28)
      Throughout the world, orthohantaviruses cause severe, acute infections in humans. Orthohantaviruses, commonly referred to as hantaviruses, are zoonotic viruses with a single stranded RNA genome of negative sense. Hantavirus ...
    • From fatty liver to end-stage liver disease through type 2 diabetes 

      Björkström, Karl (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-05-28)
      The past decades have seen a marked increase in the incidence of type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Epidemiological studies have clearly demonstrated that there is an association between type 2 ...