Inst för medicin, Huddinge / Dept of Medicine, Huddinge: Recent submissions
Now showing items 181-200 of 351
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In vitro studies of retinoids and arsenic in non-M3 acute myeloid leukemia
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2002-11-08)Despite advances in the treatment of patients with acute myeloid leukemia (AML), the majority of the patients will die from their disease. The current intensive therapy for AML is also complicated my substantial morbidity ... -
Tuberculosis and HIV interaction in Ethiopian children : aspects on epidemiology, diagnosis and clinical management
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2002-08-30)This thesis investigates the influence of HIV on childhood tuberculosis (TB) in a high TB and HIV endemic setting. It is based on four studies involving the same study population of 522 tuberculous children and their 25 ... -
Undergoing stem-cell transplantation : patients perceptions of symptoms, functional status and health-related quality of life
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2002-05-24)Stem-cell transplantation (SCT) is one therapy alternative in cases of cancer diseases. The SCT process begins with a course of high-dose chemotherapy with or without irradiation, which results in side- effects that can ... -
Pulmonary tuberculosis and HIV interaction in a setting with a high prevalence of HIV : clinical, diagnostic and epidemiological aspects
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2002-05-17)The overall aim of this study was to elucidate the influence of HIV infection on the occurrence, clinical presentation, diagnostic yield and transmission of M tuberculosis among consecutive out-patients with symptoms ... -
Skin sensitivity testing : a biophysical approach
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2002-04-12)The skin is regarded as the largest organ of the body, although it is only a few millimetres thick; it is also the interface between the environment and the body's vital structures. Its large surface area is constantly ... -
Infections in allogeneic stem cell transplanted patients : clinical and immunological aspects
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2001-05-11)In allogeneic haematopoietic stem cell transplantation (HSCT), 30 to 40 % of transplant related mortality is associated with infection complications. This includes invasive bacterial and fungal infection, and interstitial ... -
Immunological properties of dendritic cells in HIV-1 infection
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2001-04-20)Dendritic cells (DCs) capture antigens for intracellular processing to form MHC-peptide complexes involved in the generation of antigen specific T cell responses. After encountering microbes, DCs migrate from the periphery ... -
Hidradenitis suppurativa : with special reference to carbon dioxide laser surgery
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2001-04-13)Hidradenitis suppurativa (HS) is a chronic inflammatory disease with recurrent abscesses. In most cases, it involves the axillar and anogenital regions. In industrialised countries, the prevalence is of 0.3% to 4%, and ... -
Drug resistance in acute myeloid leukemia : pharmacokinetic and in vitro studies
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2001-03-16)Chemotherapy has improved clinical outcome in adult acute myeloid leukemia (AML) but still the majority of the patients die of their disease. One important explanation is transport mediated drug resistance resulting in ... -
Metabolic and endocrine function of human adipose tissue with focus on regional differences
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2001-03-16)The major function of human adipose tissue is to store excess ingested energy and to release free fatty acids after hydrolysis of triglycerides (lipolysis), to meet the energy demands of other organs. Adipose tissue also ... -
Tick-borne encephalitis : prognosis, immunization and virus strain characterization
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2000-10-20)The aims were to investigate the morbidity associated with tick-borne encephalitis (TBE) both in the acute phase and at long-term follow-up, to develop a rapid neutralization test for confirmation of TBEV-specific antibody ... -
On-line vectorcardiography during coronary angioplasty and unstable coronary artery disease
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2000-09-22)This thesis evaluates the usefulness of continuous vectorcardiography (VCG) in patients undergoing elective coronary angioplasty and in patients with unstable coronary artery disease (CAD), for detection and quantitation ... -
Immunopathology and signalling molecules involved during experimental African trypanosomiasis
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2000-09-21)In humans, African trypanosomiasis occurs in two forms; the chronic West African form is caused by T.b. gambiense and the acute or subacute East African form is caused by T.b. rhodiense. Trypanosomes are transmitted by ... -
Weight loss programmes over the internet : opportunities and limitations
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2007-11-21)Background: Overweight and obesity is increasing in Sweden and over the world. The societal resources to treat obesity are scarce. Eighty percent of the population in Sweden have access to a computer and hence the Internet. ... -
Studies on the molecular regulation of bile acids and lipoproteins in human liver
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2007-11-23)Elevated lipid levels in the bloodstream, in particular high levels of LDL cholesterol, are a major risk factor for the development of atherosclerosis. The liver has a central role in cholesterol metabolism and is the only ... -
Staphylococcus aureus bacteraemia and endocarditis : epidemiology, short- and long-term mortality
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2014-11-17)Staphylococcus aureus is a major cause of bloodstream infections and endocarditis. S. aureus bacteraemia (SAB) is associated with substantial morbidity and mortality, and endocarditis is a severe complication. Population-based ... -
Significance of adipose tissue characteristics for development of metabolic complications in obesity
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2014-11-14)Background: Obesity is closely related to development of insulin resistance and dyslipidemia. Intrinsic properties of adipose tissue are also of great importance for obesity related comorbidity. The aim of this thesis was ... -
Importance of iron overload and steatosis in patients with chronic liver disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2014-11-05)This thesis deals with the importance of hepatic iron and fat deposition in the context of chronicliver disease, with special focus on the role of the S65C mutation in the hemochromatosis cryptogenic cirrhosis (CC) in ... -
Host molecular determinants of toxoplasma gondii dissemination
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2014-10-31)Humans and animals acquire the parasite Toxoplasma gondii through contaminated food or water, upon which the parasite rapidly disseminates in the host. In immunocompetent individuals, this acute phase is transient and leads ... -
Mast cell activation disorders : a liaison between anaphylaxis and mastocytosis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2014-10-14)The term mast cell activation disorders (MCAD) comprises a broad spectrum of heterogeneous conditions, such as mastocytosis, characterized by inappropriate mast cell activation/accumulation. The patients present with protean ...