Inst för medicin, Huddinge / Dept of Medicine, Huddinge: Recent submissions
Now showing items 161-180 of 351
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Pelvic pouch in ulcerative colitis : surgical refinement and long-term mucosal outcome
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 1999-11-05)The surgical technique in performing restorative proctocolectomy has been extensively developed since its introduction in 1978. Recurrent attacks of inflammation in the neorectal ileal pouch mucosa, pouchitis, well known ... -
Human polymorphonuclear granulocytes in inflammation : studies with an emphasis on nitric oxide
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 1999-04-16)The function of the polymorphonuclear neutrophil granulocyte (PMN) is of vital importance in inflammation. For the defense against infections PMNs are armored with different weapons such as chemotaxis, phagocytosis and ... -
Hormonal regulation of hepatic cholesterol and lipoprotein metabolism : effects of estrogen and growth hormone
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 1999-02-19)Coronary heart disease is the result of the progression of atherosclerotic lesions, and represents the major cause of death in western countries. Age, male sex, plasma cholesterol, hypertension and smoking are major risk ... -
Treatment of helicobacter pylori infection : experimental and clinical studies
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 1997-05-23)The general aims of the present study were to investigate the reason for failed H. pylori eradication, and to improve the recommendations for treating H. pylori infection. Our in vitro studies are based on microscopy, ... -
Cholesterolinduced changes in macro- and microvessels in rabbits : effects of antioxidants
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 1997-05-09)A hyperlipidemic state induced by cholesterol feeding results in changes in both the structure and function of macro- and microvessels in rabbits. It has been proposed that oxidative modification of lipoproteins might be ... -
Optimization of cyclophosphamide therapy based on pharmacogenetics
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2006-11-03)Cyclophosphamide (CPA) is one of the most broadly used anticancer agents. CPA is also a potent immunosuppressive agent that is used for the treatment of autoimmune diseases. CPA is a prodrug that is activated in liver by ... -
Impaired glucose tolerance in ischemic heart disease
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-11-18)Background: Diabetes mellitus (DM) and impaired glucose tolerance test (IGT) are well known risk factors for cardiovascular disease (CVD). Individuals with IGT, a prediabetic state, are asymptomatic during many years ... -
Studies on fat cell function in human obesity and insulin resistance
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-09-30)Enlarged fat cells, due to excess tri-glyceride (TG) stores with increased basal lipolysis (TG breakdown) and blunted action of the major regulatory hormones of fat cell metabolism (catecholamines and insulin) are hallmarks ... -
Prevention and treatment of hepatitis B virus infection
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-05-06)Despite 25 years of effective vaccines and availability of treatment options for 15 years, hepatitis B virus (HBV) infections continue to be a major global health problem. In Sweden, selective screening and vaccination ... -
Studies of high mobility group chromosomal protein 1 as a pro-inflammatory cytokine
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-05-27)High mobility group box chromosomal protein 1 (HMGB 1) is a nuclear protein recently recognised as a pro-inflammatory cytokine with implications both in acute and in chronic inflammation. HMGB1 has been reported to act as ... -
Motivating clinical treatment of obesity : methods, education, supervision and outcome
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2004-11-05)Obesity has become an important health problem worldwide. It increases the medical risks and affects daily living. Environmental factors such as diet and sedentary lifestyle are likely to be the cause. In Sweden, the number ... -
Apoptosis in myelodysplastic syndromes : effects of hemopoietic growth factors
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2004-09-03)Increased apoptosis of hernatopoietic progenitors is a hallmark of myelodysplastic syndromes (MDS) and results in ineffective hematopoiesis. Erythroid apoptosis is thought to be the main mechanism underlying the severe ... -
Modulation of bile acid and cholesterol metabolism in health and disease
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2004-05-07)An increased level of plasma cholesterol is associated with premature development of atherosclerosis. It is therefore important to understand the regulation of plasma cholesterol. Stimulation of hepatic bile acid synthesis ... -
Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2004-04-02)Treatment failure due to development of drug resistance is a serious complication in cancer treatment and the major cause of death in these patients. This thesis has focused on to gain knowledge about the mechanisms of ... -
Biophysical aspects of contact dermatitis and its prevention
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2004-03-05)The skin, one of the largest organs of the body, is composed of three layers: the epidermis, dermis and subcutis. The outer most part of the epidermis i.e., the stratum corneum - serves as a protective barrier between the ... -
Cytomegalovirus after allogeneic haematopoietic stem cell transplantation : complications in the era of CMV-specific antiviral treatment
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2003-12-26)Since the start of treatment with allogeneic haematopoietic stem cell transplantation (SCT), cytomegalovirus (CMV) has been one of the most feared complications. With the help of different CMV-protective strategies, the ... -
Health economic assessment of medical technology in chronic progressive diseases : multiple sclerosis and rheumatoid arthritis
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2003-09-26)This thesis developed a method for economic evaluation in non-fatal chronic progressive diseases, applied to multiple sclerosis (MS) and rheumatoid arthritis (RA). In economic evaluation different treatment strategies are ... -
Rheumatoid arthritis in male patients : sex hormones, bone mineral density and clinical characteristics
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2003-04-25)The aims of this study were to investigate sex hormones in men with RA and the relation of these hormones with disease characteristics including bone mineral density, as well as to study gender differences in rheumatoid ... -
Nasal and bronchial airway reactivity in allergic and non allergic airway inflammation
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2003-01-24)In allergic or asthmatic airways disease, upper and lower airways show a uniform eosinophilic inflammation of the mucosa, and bronchial hyperreactivity is a common finding. To study the co- variation of mucosal reactivity ... -
Use of primary human hepatocytes for the elucidation of bile acid synthesis
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2003-01-03)In the present investigation we cultured primary human hepatocytes on matrigel under serum-free conditions and studied bile acid formation. The following observations were made: · The major steroid products excreted ...