Inst för medicin, Huddinge / Dept of Medicine, Huddinge: Recent submissions
Now showing items 201-220 of 351
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A battle between host and pathogen : the innate immune response and enterovirus evasion strategies
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2014-09-18)Infections with Coxsackieviruses are common and in most cases the infection is asymptomatic and efficiently cleared. On rare occasions, however, an infection can lead to severe diseases including myocarditis, hepatitis and ... -
Immune repertoire diversity in allogeneic stem cell transplantation and its implications for infections and the graft versus leukemia effect
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2014-08-29)The beneficial graft versus leukemia effect (GVL) and its detrimental counterparts, graft versus host disease (GVHD) and susceptibility to infections, are all coupled to a multitude of events during the immune reconstitution ... -
Quantitative echocardiographic methods for patients with acute coronary syndrome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2014-07-09)Background: The aim of this thesis was to evaluate two diagnostic and two prognostic quantitative echocardiographic methods for patients with acute coronary syndrome (ACS). Methods: Velocity tracking (VeT) presents ... -
Clinical and pathophysiological aspects of sepsis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2014-03-14)Severe sepsis and septic shock represent challenging problems for the health care system. Despite adequate antibiotics and modern intensive care, severe sepsis is associated with a substantial mortality rate of around 30%, ... -
Interactions between enteroviruses and the host : implications for type 1 diabetes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2014-02-28)Type 1 diabetes (T1D) is a disease that results after a selective destruction of the insulin-producing β-cells in the pancreas. The lack of β-cells renders T1D patients completely unable to synthesize and secrete insulin, ... -
The ontogeny and regulation of human natural killer cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2014-02-14)Natural Killer (NK) cells are members of the innate lymphoid cell (ILC) family and take part in the detection and eradication of virus-infected and transformed cells. In this thesis, together with my colleagues I have ... -
Molecular basis for enhanced T-cell recognition and cross-reactivity
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-12-20)T cells of the adaptive immune system recognize and kill infected cells by interacting with pathogenic peptides displayed on major histocompatibility complexes (MHC) through its T-cell receptor (TCR). TCR interactions with ... -
Specific T- and B-cell responses against human cytomegalovirus after hematopoietic stem cell transplantation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-11-21)Human cytomegalovirus (CMV) remains an important complication in allogeneic hematopoietic stem cell transplantation (HSCT). CMV-reactivation may lead to CMV-disease associated with high morbidity and mortality in patients ... -
Studies of immune response in human tuberculosis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-11-21)TB (tuberculosis), caused by Mycobacterium tuberculosis (Mtb), continues to be a world-leading killer and a serious global health problem primarily affecting poor people in many developing countries. The difficult situation ... -
Asthma and allergy in teenagers and young adults, risk-factors and T-cell regulation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-11-15)Asthma is one of the most common chronic diseases among teenagers and young adults. The prevalence of asthma among young adults in Sweden is approximately 7-10%. Despite this, only a limited number of studies have focused ... -
HIV/HCV co-infection in Sweden : epidemiology, HCV treatment and the importance of IL28B gene polymorphism
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-11-14)Liver disease, mainly due to hepatitis C virus (HCV) infection, is a leading cause of death in HIV positive patients with access to antiretroviral therapy (ART). HCV treatment, which can prevent long-term complications of ... -
Diagnostic and prognostic markers in sepsis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-11-01)Sepsis is a life-threatening disease affecting millions of people globally. The more severe forms are considered to be a consequence of an unbalanced systemic inflammatory response to infection, causing organ dysfunction, ... -
Assessment of patients with symptoms suggestive of acute coronary syndrome : the use of high sensitive cardiac troponin T and a risk score
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-10-11)The aim of this thesis was to evaluate patients with symptoms suggestive of acute coronary syndrome with regard to early diagnosis and prognosis by the use of high sensitive cardiac troponin T and a risk score: a low-risk ... -
Toll-like receptor-induced cytokine secretion by human monocytes in healthy donors and septic patients assessed at the single cell level
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-08-23)Following the ligation of Toll-like receptors (TLRs) by bacterial-derived signature molecules, innate immune cells such as monocytes, macrophages and neutrophils initiate the inflammatory process by secreting chemokines ... -
Development of classical Hodgkin’s lymphoma in an adult with biallelic STXBP2 mutations
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-07-31)Experimental model systems have delineated an important role for cytotoxic lymphocytes in the immunosurveillance of cancer. In humans, perforin-deficiency has been associated with occurrence of hematologic malignancies. ... -
Tissue regulation of dendritic cells : with focus on chemokines, function and migration
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-05-16)Tissue-specific cells, such as fibroblasts and epithelial cells in local microenvironments have been recognized to influence the function and phenotype of hematopoietic cells, such as dendritic cells (DC). The interaction ... -
Translational genomics of HIV-1 subtype C in India : molecular phylogeny and drug resistance
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-05-16)This thesis describes the translational genomics of HIV-1subtype C in India from its origin to therapeutic response with the aim to improve our knowledge for better therapeutic and preventive strategies to combat HIV/AIDS. ... -
Clinical studies on the role of eicosanoids in the asthmatic airway inflammation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-05-10)The underlying mechanisms in the asthmatic airway inflammation involve the interaction between different cells and mediators that consequently result in different clinical phenotypes. The aim of this thesis was to investigate ... -
Characterization of adipose factors regulated by body weight
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-05-02)White adipose tissue (WAT) constitutes our most expandable tissue and largest endocrine organ secreting hundreds of polypeptides collectively termed adipokines. Changes in WAT mass induce alterations in adipocyte secretion ... -
Mechanistic studies of APR-246 in leukemia
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2013-04-30)PRIMA-1 and its analog APR-246 are novel drugs that restore the active conformation of mutated and unfolded p53 protein and induce apoptosis and cell death in various tumors in pre-clinical models. We first aimed to explore ...