Inst för medicin, Huddinge / Dept of Medicine, Huddinge: Recent submissions
Now showing items 141-160 of 351
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Mechanisms influencing natural killer cell recognition of tumour cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-04-12)Natural killer (NK) cells are part of our innate immune defence against virus-infected and transformed cells. Through a yet undefined mechanism, expression of inhibitory receptors for self-HLA class I molecules endow NK ... -
The importance of fat and alcohol for progression and prognosis in chronic liver disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-04-06)Chronic liver disease is an increasing cause of global morbidity and mortality. The popular belief is that liver disease is caused mainly by alcoholic liver disease or viral hepatitis. However, the most common cause of ... -
Assessment of patients with late diagnosis and missed opportunities in the Swedish HIV-1 epidemic
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-02-22)Discovered in 1983, with a possibility to diagnose since 1985, and with efficient treatment existing now for two decades, HIV-1 still ranks among the top ten causes of death globally. Approximately 40 million people are ... -
Innate immunity in the immunopathogenesis of chronic viral infection
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-01-27)Natural killer (NK) cells have a key role in control and clearance of viral infections. To carry out this function NK cells are capable of recognising infected cells and responding with induction of apoptosis in these ... -
Antiretroviral drug resistance and treatment outcomes of human immunodeficiency virus type-1 : implications for low and middle income countries
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-12-21)My thesis contains comprehensive studies of antiretroviral treatment (ART) naïve and experienced patients from the beginning of the Swedish HIV-1 epidemic. Paper I was the first study to describe the ART usage and occurrence ... -
Tick-borne encephalitis : clinical and pathogenetic aspects
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-11-25)The aims of this study were to investigate the morbidity associated with tick-borne encephalitis (TBE) in the acute stage and at long-term follow-up, to identify the possible host risk factors for development of clinical ... -
Optimization of TB/HIV co-treatment in Ethiopian patients
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-11-20)Tuberculosis (TB) and HIV infection act with deadly synergy. HIV is the most important risk factor for latent TB reactivation and active TB progression following exposure or reinfection while TB accelerates HIV progression. ... -
Functional assays for the diagnosis of primary defects in lymphocyte cytotoxicity
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-11-02)Cytotoxic lymphocytes encompass natural killer (NK) cells and cytotoxic T lymphocytes (CTL). These cells detect and kill virus-infected as well as malignant cells. Primary defects in lymphocyte cytotoxicity are associated ... -
Innate immune responses in vivo after antigen administration : implications for vaccine development
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-09-18)Inducing high magnitude of antibodies with epitope breadth over prolonged periods of time is likely a prerequisite to prevent several of the world’s most serious infectious diseases such as HIV-1, malaria and tuberculosis ... -
A virologist’s guide to hide and seek : evasion of innate immunity by primate lentiviruses
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-08-28)HIV is the cause of a chronic, incurable infection in 37 million people worldwide in 2014. This thesis investigates how the immune system detects HIV and how in turn HIV avoids detection by the immune system. The understanding ... -
Biological markers and treatment as prognostic factors in multiple myeloma
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-08-10)Multiple myeloma (MM) is an incurable disease with an increasing number of treatment options. The introduction of what are called novel drugs (bortezomib, lenalidomide and thalidomide) was an important step. These ... -
Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-08-05)Background: Idiopathic scoliosis is a spinal deformity affecting approximately 3% of otherwise healthy children or adolescents. The etiology is still largely unknown but has an important genetic component. Genome-wide ... -
Studies of exercise-induced bronchoconstriction to define protective mechanisms in asthma
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-05-21)Exercise-induced bronchoconstriction (EIB) occurs in the majority of asthmatics following vigorous exercise. EIB is caused by a loss of water from the airways creating a hyperosmolar environment in the tissue that in turn ... -
Studies on cholesterol and lipoprotein metabolism : emphasis on diabetes and sugar
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-05-08)Cholesterol has important functions in the body; as a precursor in the synthesis of steroid hormones and bile acids (BAs), and as a component of cellular membranes. However, an elevated level of plasma cholesterol, transported ... -
Novel aspects of metabolic regulation and inflammation in human adipocytes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-04-28)The significance of adipose tissue and obesity has been recognized in numerous pathologies. However, the mechanisms behind this connection are not yet completely understood. The aim of this thesis was to investigate the ... -
Influenza specific T- and B-cell responses in immunosuppressed patients
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-04-15)Influenza, known as the ‘flu’, is a recurrent acute viral infection that might cause severe inflammation, particularly in vulnerable individuals, i.e. young children, the elderly, and immune-suppressed patients, such as ... -
Clinical and molecular effects of azacitidine in the myelodysplastic syndromes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-02-12)The myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant bone marrow disorders characterized by peripheral cytopenia and increased risk of leukemic progression. In higher-risk MDS, Azacitidine has ... -
Biliary epithelial cells, the immune system and PSC pathogenesis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2015-01-30)Primary sclerosing cholangitis (PSC) is a chronic, inflammatory liver disease that leads to destruction of the bile duct system. PSC is strongly associated with inflammatory bowel disease, and PSC patients have an increased ... -
Diversity and dynamics of Plasmodium falciparum malaria
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2000-05-10)The epidemiology of genetic diversity of malaria parasites in relation to clinical parameters, acquisition of immunity and malaria transmission has implications for the development and evaluation of control measures such ... -
Thyroid hormone receptor expression in cardiovascular disease and pharmacology
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 1999-11-19)The heart is a major target organ for thyroid hormone actions. Thyroid hormone exerts effects on the myocardium, which are mediated by specific nuclear receptors. The thyroid hormone receptors (TR) are members of the steroid ...