Inst för laboratoriemedicin / Dept of Laboratory Medicine: Recent submissions
Now showing items 61-80 of 469
-
Establishment of new potential biomarkers for cardiometabolic diseases
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-04-23)Cardiometabolic diseases is a growing health issue worldwide. New knowledge about the pathophysiological processes have been gained and several research discoveries have contributed to better management of the diseases. ... -
Targeting polo-like kinase 1 in pediatric leukemia
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-03-24)Acute lymphoblastic leukemia (ALL) is one of the most common cancers among children in the world, with almost 90% complete remission rate after the primary treatment. However, some patients are resistant to treatment and ... -
Machine learning and data-parallel processing for viral metagenomics
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-03-13)More than 2 million cancer cases around the world each year are caused by viruses. In addition, there are epidemiological indications that other cancer-associated viruses may also exist. However, the identification of ... -
From bedside to bench and back : future options for antiretroviral drugs in non-B HIV-1 subtypes
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-02-05)HIV-1 drug resistance remains a burden in low- and middle-income countries (LMIC). Regardless of the advances in antiretroviral (ARV) therapy, there is an increase in the trend of acquired and pre-treatment drug resistance ... -
Selenocompounds in leukemia treatment : advantages and pitfalls
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-01-27)In 2018, cancer was reported to be the second top cause of morbidity and mortality globally with over 9 million deaths. Hematological malignancies including leukemia constitute about 7% of the total cancer cases. Substantial ... -
Bruton tyrosine kinase in immunodeficiency and in B-cell malignancy
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-01-23)BTK inhibitors have induced high response rates in the treatment of leukemias and lymphomas. Ibrutinib is the first-in-class US Food and Drug Administration (FDA)-approved BTK covalent inhibitor to treat chronic lymphocytic ... -
Mantle cell lymphoma : studies of predictive markers, the role of the microenvironment in disease development and identification of new potential targets for therapy
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-01-16)Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma and accounts for 5-10 % of all non-Hodgkin lymphomas (NHL). In Sweden, the incidence of NHL is 21.6 and 15.3 per 100 000 persons for men and women, respectively, ... -
Optimization of pediatrics antiretroviral treatment outcomes among HIV infected children in Ethiopia
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-12-11)Ending the HIV/AIDS epidemic by 2030 is a global agenda. To meet this global goal, having safe and effective antiretroviral therapy is a key requirement. In Ethiopia, the safety and efficacy of combination antiretroviral ... -
Role of tartrate-resistant acid phosphatase in bone remodeling
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-11-27)Tartrate-resistant acid phosphatase is a metalloenzyme that exists as two isoforms: the monomeric TRAP 5a and the proteolytically cleaved TRAP 5b, responsible for phosphatase activity, which is highly expressed in osteoclasts ... -
Mesenchymal stromal cell crosstalk with the immune system
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-11-07)Cell therapy is a promising treatment for several diseases. One of the most commonly used cell types are mesenchymal stromal cells (MSCs). MSCs are found in most connective tissues but for clinical use they are commonly ... -
Reconstruction of vocal fold scarring with mesenchymal stromal cell therapy
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-10-24)Tissue injury/scarring of the vocal folds (VFs) can be caused by various factors including external trauma, cancer treatment or inflammation, leading to damage within the vibrating layers and a decrease in viscoelastic ... -
Bloodstream infections with ESBL-producing Enterobacterales : prediction, rapid diagnosis and molecular epidemiology
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-10-23)Antimicrobial-resistant bacteria are a threat to public health worldwide. Particularly, the increase of extended-spectrum β-lactamase (ESBL)-producing Enterobacterales (EPE) is a significant clinical problem. ESBLs confer ... -
Mutations and migration : molecular and epidemiological aspects of HIV-1 in Sweden
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-10-23)The Swedish HIV-1 epidemic is characterized by a wide variation in subtypes due to migration and travel. The aims of this thesis were to investigate molecular methods for estimating time to diagnosis and epidemiological ... -
Human amnion epithelial stem cells as a therapy for liver disease
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-10-04)Placenta-derived stem cells have been proposed as potential new treatments for acute and congenital liver diseases. Of all the different perinatal tissues, amnion membrane and isolated amnion epithelial cells have been ... -
Intrinsic and extrinsic mechanisms for B-cell lymphoma development and progression studied by global gene expression profiling
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-09-10)Mantle cell lymphoma (MCL) is a rare hematopoietic malignancy characterized by frequent relapses and poor survival, partly due to minimal residual disease, whereby a subset of malignant cells, harbored in protective niches, ... -
Novel diagnostic methods for rapid characterization of extended-spectrum beta-lactamase- and carbapenemase-producing Enterobacteriaceae
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-09-06)Klebsiella pneumoniae and Escherichia coli are two of the most clinically important pathogens of the family Enterobacteriaceae. Both can cause severe infections includ-ing urinary tract infections (UTI), bloodstream ... -
Purification, profiling and bioengineering of extracellular vesicles
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-08-30)The nano-sized membrane enclosed extracellular vesicles (EVs) transfer macromolecular information in the form of proteins, nucleic acids and lipids across cells. They are important mediators of cell-to-cell communication, ... -
Role of new podocyte-associated proteins in the renal ultrafiltration barrier
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-08-09)Chronic kidney disease (CKD) is a major health problem and an economical burden affecting people worldwide. The main causes of CKD are diabetes and hypertension and patient numbers keep increasing. In many cases, CKD is ... -
Possibilities of dried blood spots as a matrix in therapeutic drug monitoring of antiepileptic drugs in children
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-05-21)For children with epilepsy, therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is essential for treatment. TDM monitoring requires two visits to a health care unit, first for collection of the blood sample ... -
NGS based studies on primary immunodeficiencies (PIDs) : causative gene identification, tool development and application
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-05-20)Primary immunodeficiency diseases (PIDs) are composed by a group of highly heterogeneous immune system diseases, of which approximately 350 forms of PID have been described so far. The causative gene of around 60% of ...