Inst för laboratoriemedicin / Dept of Laboratory Medicine: Recent submissions
Now showing items 41-60 of 468
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Modelling and genetic correction of liver genetic diseases
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-03-24)The urea cycle is a set of biochemical reactions that converts highly toxic ammonia into urea for excretion. Deficiencies in any of the genes of the cycle can be life-threatening, with liver transplantation currently being ... -
Side effects and experiences of doping with anabolic androgenic steroids in men and women
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-03-21)Anabolic androgenic steroids (AAS) are mainly used in non-medical conditions for aesthetic and performance- enhancing purposes. The use of AAS is a growing public health problem and a concern in society due to side effects. ... -
Selenium compounds as a novel class of experimental cancer chemotherapeutics
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-02-25)Selenium is an essential micronutrient for humans, it has a narrow margin between antioxidant and pro-oxidant effects. Redox-active selenium compounds have the potency to increase ROS levels in cancer cells, providing a ... -
Selenite induces apoptosis in sarcomatoid malignant mesothelioma cells through oxidative stress
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-02-08)Malignant mesothelioma cells differentiate into sarcomatoid or epithelioid phenotypes. The sarcomatoid cell type is more resistant to chemotherapy and yields a worse prognosis. We have investigated whether selenite alone ... -
Multidrug-resistant Enterobacterales in Oman : molecular epidemiology and therapeutic insights
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-01-19)The spread of antibiotic resistance is a concerning issue causing limited treatment options for bacterial infections, particularly with Gram-negative bacteria. Surveillance and epidemiological studies help to determine the ... -
The role of cannabinoid receptors, G alpha z, and B cell receptor in lymphoma pathobiology with focus on chemotaxis
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-12-22)Mantle cell lymphoma (MCL) and chronic lymphocytic leukaemia (CLL) are two incurable B cell malignancies, with an overall survival of 5 to 8 years and 6 to 10 years, respectively. Therapies are available but are often very ... -
Immune deterioration in HIV-1 and HIV-2 infection with a focus on CD8 T cell exhaustion
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-11-05)Thanks to the development of antiretroviral treatment (ART), human immunodeficiency virus (HIV) infection is now considered a chronic infection rather than the death sentence it used to be. Despite constant expansion and ... -
Role of coxsackie- and adenovirus receptor (CXADR/CAR) in the regulation of cell plasticity in cancer and inflammation
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-10-29)The coxsackie- and adenovirus receptor (CXADR) is a transmembrane protein, which localizes at tight junctions (TJ) in epithelial cells. As highlighted by its name, CXADR was initially identified as a receptor for type C ... -
Prevalence of drug-drug interactions and clinical relevance for treatment with oral anticoagulants
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-10-26)The aim of this thesis was to describe prevalences and frequencies of potential DDIs in the Swedish outpatient population, and the clinical effects in treatment with oral anticoagulants. Two cross-sectional studies were ... -
Role of syndecan-1 in tumor cell proliferation and epithelial-mesenchymal plasticity
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-10-15)Syndecan-1 (SDC1) is a heparan sulfate proteoglycan (HSPG) intercalated in the cell membrane but also translocated to the cell nucleus in a regulated manner. SDC1 is involved in several malignancy-associated processes such ... -
Interactions between innate immune effectors and multidrug resistant bacteria
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-10-14)Antibiotic resistance is an increasingly difficult problem in the clinic, where conventional antibiotics are failing, and new alternative solutions are in high demand. Infections caused by Gram-negative bacteria with multi ... -
Vaccine effectiveness against HPV infections
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-10-02)Infections with human papilloma viruses (HPV) are the most prevalent sexually transmitted diseases. The vast majority of the sexually active population acquires them during lifetime but almost all HPV infections become ... -
Antimicrobial peptides in innate immunity : interactions with antibiotics and effects of post-translational modifications
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-10-01)Cationic antimicrobial peptides (AMPs) are important innate immunity factors contributing to the clearance of invading pathogens and immunomodulating immune responses. In this thesis, the focus is on AMPs of the cathelicidin ... -
Studying the cell cycle using systems biology and high content characterization of the ubiquitin proteasome system
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-09-02)The cell cycle is the process through which our cells grow and divide in a carefully orchestrated and controlled manner. An uncontrolled cell cycle is a basic hallmark of cancer, in which excessive cell growth leads to ... -
Cellular mechanisms of human muscle fatigue and disease-related loss of muscle function
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-08-27)A loss of skeletal muscle function and mass is a hallmark of several diseases resulting in a dismal life quality and poor prognosis. Impaired intracellular Ca2+-handling has been proposed as an underlying cause of these ... -
Fibrinogen-binding proteins from Staphylococcus aureus
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-06-08)Staphylococcus aureus produces a large number of proteins that specifically bind to molecules from plasma or from the human extracellular matrix where they are involved in processes associated with the colonization of the ... -
Fighting cardiometabolic disease : validation of new experimental models and therapeutic targets
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-05-14)The prevalence of cardiometabolic diseases (CMD) such as atherosclerotic cardiovascular diseases, type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), has grown dramatically during the last decades. Hence, ... -
MAIT cells in placental tissues and their reconstitution following allogeneic hematopoietic stem cell transplantation
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-05-14)The placenta is a temporary organ of human reproduction. Both the fetus and placenta are covered in a membrane of maternal origin, the decidua. After the 1st trimester, the fetus is supplied with oxygen and nutrients by ... -
Rapid microbiological diagnosis of infections in sterile body fluids including blood
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-04-24)Infections of normally sterile body fluids (SBF) including blood, cerebrospinal-, pleural-, peritoneal-, pericardial and synovial fluid are critical and require early diagnosis and rapid initiation of appropriate antimicrobial ... -
Establishment of new potential biomarkers for cardiometabolic diseases
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-04-23)Cardiometabolic diseases is a growing health issue worldwide. New knowledge about the pathophysiological processes have been gained and several research discoveries have contributed to better management of the diseases. ...