Inst för laboratoriemedicin / Dept of Laboratory Medicine: Recent submissions
Now showing items 81-100 of 469
-
Dynamics of drug-resistant minor viral populations and phenotypic drug susceptibility in diverse HIV-1 subtypes
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-05-06)Antiretroviral therapy (ART) has significantly reduced mortality in human immunodeficiency virus type 1 (HIV-1) infection, both in high- and low/middle-income countries (LMIC). However, the development of drug resistance ... -
Is the clinical autopsy no longer relevant?
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-05-03)Background: The total number of autopsies has dropped during the last decades to less than a quarter of the number during the 1980-ies. We studied the consequences of a decrease in the autopsy frequency for the accuracy ... -
Epidemiology of extended-spectrum β-lactamase-producing Escherichia coli
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-04-26)Extended-Spectrum β-Lactamase and plasmid mediated AmpC (ESBL/pAmpC)-producing Escherichia coli (E. coli) has during the last decades emerged worldwide and is now an increasing problem in both human and animal health. In ... -
Role of cholesterol metabolism in hepatic steatosis and glucose tolerance
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-04-12)The liver is the central organ for lipid, lipoprotein and glucose homeostasis, thus hepatic metabolic disturbances can predispose individuals to develop cardiometabolic disorders (CMD) such as atherosclerotic cardiovascular ... -
Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-02-08)The existence of latent HIV-1 reservoir (LR) in all HIV-1 infected patients serves as a major obstacle to completely cure HIV-1 infection. However, up to now there is still no available assay that provides an accurate ... -
Mechanisms of multicellular drug resistance and novel approaches for targeted therapy in cancer
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-01-24)Dysregulated gene expression, due to genetic and epigenetic aberrations, as well as cancer cell-stroma interactions underlie both tumorigenesis and resistance to anti-cancer therapy. Although governed by common mechanisms, ... -
Metabolic and pharmacokinetic study to enhance busulphan therapeutic efficacy
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-01-09)Busulphan (Bu) is an alkylating agent used in high-doses as part of the conditioning regimen prior to hematopoietic stem cell transplantation (HSCT). HSCT is a curative treatment for hematological malignancies and other ... -
Elucidating regulatory elements : studies in chronic lymphocytic leukemia and multiple myeloma
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-12-21)With next generation sequencing taking center stage in genetic and epigenetic research, its applications and challenges are many. This work revolves around the application of bioinformatics in different contexts: basic ... -
The role of Klotho in mineral metabolism and inflammation
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-11-22)Accumulated data suggest that a disrupted FGF23-Klotho axis is a major contributor to the development of chronic kidney disease (CKD). This axis might have a broader role in the regulation of inflammation, yet the underlying ... -
Gut derived chronic inflammation in HIV-1 and chronic kidney disease : the role of the microbial metabolite TMAO and immunomodulatory effects of Vitamin D
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-11-01)Persistent immune activation with premature ageing and increased risk of cardiovascular disease (CVD) are features shared by HIV-1 infected individuals and patients with chronic kidney disease (CKD). Underlying dysbiosis, ... -
Multidisciplinary analysis of HIV-1 elite controllers
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-10-11)Chronic HIV-1 infection is characterized by progressive depletion of CD4+ T lymphocytes, persistent immune activation and ongoing viral replication, leading to a profound immunodeficiency state if left untreated with ... -
Outcome after allogeneic stem cell transplantation with special reference to non-malignant disorders, chimerism and graft cell composition
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-10-03)The outcome for patients undergoing allogeneic stem cell transplantation (HSCT), a treatment for several severe malignant and non-malignant disorders with hematopoietic origin, is a balancing act between beneficiary effects ... -
Diversity and focus of CMV specific T-cell responses in patients post-HSCT and with solid tumor
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-08-09)Human Cytomegalovirus (CMV) is a beta-herpesvirus that commonly infects humans. Most symptoms in healthy individuals are very mild. The virus is never eliminated and remains in the individual life-long. Thus, CMV and the ... -
Antiretroviral treatment outcome and molecular epidemiology of HIV-1 subtype C drug resistance in Ethiopia
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-08-06)Over the last decade, antiretroviral therapy (ART) has been rolled out in Ethiopia at a large scale. However, the outcome and aspects of drug resistance have been poorly studied at the national level. Also, the epidemic ... -
Molecular characteristics of HIV-1 subtype C and its impact on therapeutic outcome in Ethiopia
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-07-26)HIV-1 is characterized by a high genetic diversity which poses several challenges and implications with regard to disease progression, drug resistance and outcome of antiretroviral therapy (ART). HIV-1 subtype C (HIV-1C) ... -
Functional adaptation of c-Myc and its role in lymphoma-associated gene regulation
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-05-30)The Myc proto-oncogene, is a highly disordered (lack of structure formation) transcription factor (TF), which can bind to its partner proteins and regulate different biological functions of the cells including proliferation, ... -
Oxidative stress in cell and tissue damage and selenium-based therapeutics in cancer
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-05-25)Redox homeostasis is the balance between cellular prooxidants and antioxidants, maintained by the interplay of electrons. Reactive oxygen species (ROS) is a term for molecules with unpaired valence electrons or unstable ... -
Profiling and exploiting lipid-based nanoparticles in vitro and in vivo
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-05-22)One of the major hurdles for therapeutic applications is the efficient delivery of bioactive molecules to the site of action. The high flexibility and biosafety of lipid-based nanoparticles has greatly enhanced their ... -
Bioanalytical studies of designer benzodiazepines
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-05-03)The fast appearance of benzodiazepine analogues, referred to as new psychoactive substance (NPS) or designer benzodiazepines, requires the continuous update of detection methods in order to keep up with the latest drugs ... -
Genetics of immunoglobulin a deficiency
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-03-19)Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasian populations. It is defined as a serum IgA level below 0.07 g/L with normal IgM and IgG levels in an individual older than four ...