Doktorsavhandlingar / Doctoral Theses - H1 (NVS): Recent submissions
Now showing items 1-20 of 581
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Students’ workplace learning in primary health care : learning from patients
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-09-24)Background: Facilitation of patients’ participation in own care is considered key component to achieve a person-centered, high-quality care delivery. Person-centered care, including communication techniques and ... -
Unraveling the role of NOTCH3 dysfunction in disease and for therapy development : a focus on CADASIL
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-08-20)The Notch signaling pathway, including the Notch3 receptor, is involved in many pivotal contexts of cell signaling and cell fate determination processes during development and in adulthood. Different mutations in the ... -
Resolving inflammation : analysis of mechanisms in relation to Alzheimer pathology and aging
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-08-10)Alzheimer’s disease (AD) is the most common type of dementia, and its clinical symptoms are the reflections of pathological changes in the brain. The main pathological features of AD are intracellular aggregates of ... -
Voices in the wake of eHealth : older adults’ and occupational therapists’ perceptions of using information and communication technology
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-08-09)Background People increasingly have access to and use information and communication technologies (ICTs) such as mobile phones and computers, and many social services are moving online. The digitalization of society ... -
Sexual violence : epidemiology, treatment and health care access
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-06-01)Sexual violence is recognized by the World Health Organization as a “… global public health problem of epidemic proportions, requiring urgent action” [1]. In Sweden, the estimated incidence of penetrative sexual violence ... -
Neuroinflammation and its resolution in Alzheimer's disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)Alzheimer's disease (AD) is the most common dementia with high prevalence among an increasing aged population. Despite the existence of symptom-reliving drugs for AD, the clinical trials performed until now have failed ... -
Recombinant BRICHOS domains delivered over the blood-brain barrier : a possible way to treat Alzheimer´s disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-28)One of the current major challenges to treat neurological diseases is the ability of drug candidates to cross the blood-brain barrier (BBB). Alzheimer´s disease (AD) is the most common form of dementia worldwide, affecting ... -
Mobilization immediately after elective abdominal surgery : respiratory effects and patients´ and healthcare professionals´ experiences
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-27)To prevent postoperative complications after abdominal surgery, mobilization is highly recommended and suggested to start as soon as possible. However, few studies have investigated the respiratory effects of immediate ... -
Conditions of everyday technology use and its Interplay in the lives of older adults with and without dementia
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-18)Background: Increased reliance on technology in society incurs a risk that older adults with and without dementia could become excluded from participating in aspects of everyday life in and outside home. This thesis responds ... -
Mitochondria-endoplasmic reticulum contacts in neuronal cells : from physiology to therapeutics
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-17)Mitochondria and the endoplasmic reticulum (ER) are intracellular organelles that play vital physiological functions. Mitochondria are key players in energy production through adenosine triphosphate (ATP) production and ... -
Upholding family relationships in a context of increasing awareness of parental illness
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-11)Background Children are affected when parents are ill and health care professionals are bound by law to consider children’s need for information on their parent’s illness. Effective interventions are available in settings ... -
Unequal tracks? Studies on work, retirement and health
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-03)Background. In Sweden, the proportion of people aged 65 and older has doubled since 1950, and is projected to continue to increase. The increased longevity and proportion of older people in the population pose a challenge ... -
Participation in everyday occupations and situations outside home for older adults living with and without dementia : places, familiarity and risks.
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-04-29)Participation in occupations and places outside the home has been related to health and social benefits as well as offering challenging and risks for older adults living with and without dementia, yet little is known ... -
Alzheimer’s disease heterogeneity assessment with MRI biomarkers and unsupervised statistical learning
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-04-23)Alzheimer’s disease (AD) is the most common cause of dementia. It is characterized by loss of memory and other cognitive functions. Although it is a heterogeneous condition, it has been studied as one disease for many ... -
Preventive home visits among older people : risk assessment, self-rated health and experiences of healthy ageing
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-04-07)Background: The worldwide population is ageing and life expectancy is increasing. This increase in age is associated with physiological and psychosocial challenges and changes that lead to decreased intrinsic capacity and ... -
Registered nurses with a PhD : an asset in clinical care
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-03-30)Background Shortcomings in providing health care may cause otherwise preventable patient harm and suffering, while also increasing the cost of healthcare delivery. Approximately one-third of all patients do not receive ... -
Perspectives on participation in dementia prevention clinical trials
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-03-25)Dementia is an enormous global health challenge with a rapid increase in the number of people affected. There is an urgent need for research to find effective treatments and preventive strategies. Dementia prevention ... -
How can older adults combat diabetes to achieve a longer and healthier life?
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-03-10)Type 2 diabetes (hereafter, diabetes) and prediabetes are very common in older adults and constitute a great health concern for this population. The objective of this project is to investigate the impact of prediabetes and ... -
Advancing the measurement of sedentary behaviour : classifying posture and physical (in-)activity
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-02-18)Sedentary behaviour, defined by a sitting body posture with minimal-intensity physical activity, is an emergent public health topic. The time spent sedentary is associated with the incidence of non-communicable chronic ... -
To be a child and survive a natural disaster
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-02-09)Introduction: Despite the fact that children or adolescents often are exposed to disasters, we do not know what happens to these children or adolescents in the end. Much of the international research has been concerned ...