Doktorsavhandlingar / Doctoral Theses - H1 (NVS): Recent submissions
Now showing items 1-20 of 561
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Diabetes mellitus in patients with dementia : clinical care and pharmacological treatment
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-01-07)Diabetes mellitus (DM) and dementia are frequent chronic disorders in the older population, however their relationship is complex - while DM is an established risk factor for dementia, cognitive symptoms in dementia may ... -
Supportive care for patients with breast cancer by using an interactive app during neoadjuvant chemotherapy : a randomized controlled trial
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-12-22)Background: Patients with breast cancer undergoing neoadjuvant chemotherapy are often treated as outpatients and experience several distressing symptoms and concerns over a long period, which must be managed at home. ... -
Multimodal phenotyping of synaptic damage in Alzheimer’s disease : translational perspective with focus on quantitative EEG
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-12-22)Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia. Accumulation of AD-associated pathology in the brain may begin a decade or more before the appearance of the first ... -
The participation of older people with and without dementia in public space, through the lens of Everyday Technology use
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-12-10)Participation in activities and places within public space has been linked to numerous health benefits and yet, little is known about participation among older people with and without dementia. Insights about participation ... -
Understanding the links : the exploration of care transitions between hospital and continued rehabilitation in the home after stroke
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-12-02)Background: Uncoordinated care transitions are known to be a risk of a substantial burden for patients and significant others with a risk of adverse events, rehospitalisation and dissatisfaction with services. After acute ... -
Development of dementia in older adults : the body-mind connection
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-11-20)Over the past years, two major lines have emerged in the field of dementia research that are focused on: (1) The accurate and early prediction of dementia, and (2) The identification of modifiable factors for dementia ... -
Molecular basis for chaperone activities of the BRICHOS domain against different types of clumpy clients : a route to prevent amyloid toxicity
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-11-17)Protein aggregation is a hallmark of a wide range of human disorders, including Alzheimer’s disease and type II diabetes, and are often associated with imbalances in the cellular protein homeostasis. Molecular chaperones ... -
Unraveling pathogenic proteins and pathways in Alzheimer disease : a focus on proteomics
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-11-05)Alzheimer disease (AD) is a multifactorial and complex neurodegenerative disorder. To date, different mechanisms, such as impairment of synaptic, mitochondrial and autophagic function, neuroinflammation and many more, are ... -
Vitamin D in palliative care : aspects on pain, infections and quality of life
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-11-04)The World Health Organization’s (WHO’s) definition of palliative care stresses the importance of early identification and assessment of physical symptoms in the palliative patient, to prevent and relieve suffering. The ... -
Identification and treatment of back pain in elderly women with osteoporosis
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-11-04)Older women with osteoporosis and back pain are common patients in primary health care. Varied physical exercise with focus on back extensor strength and balance is an important non-pharmacological treatment method that ... -
The interaction between astrocytes and excitatory synapses in health and disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-11-02)Synaptic transmission forms the basis of neuronal activity and astrocytes play an integral part in this process. Glutamate is the major excitatory neurotransmitter in the brain and an important function of astrocyte ... -
Heart failure with preserved ejection fraction in primary care
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-10-29)Background Heart failure with preserved ejection fraction (HFpEF) is a condition associated with low quality of life, high morbidity and mortality. It constitutes a diagnostic challenge and there is little evidence of ... -
The relation among aging, dopamine-regulating genes, and neurocognition
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-10-07)When people are getting old, they often feel increasingly harder to concentrate, and become slower and more inflexible during tasks that involve focused attention, information maintenance in the face of distractions, and ... -
Balance and gait in Parkinson’s disease : from perceptions to performance
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-10-01)The overall aim of this thesis was to explore perceptions and performance of balance and gait in people with Parkinson’s disease (PwPD), and to evaluate both the current evidence for exercise-induced neuroplasticity and ... -
Mundane mattering : how materialities come to matter in everyday life in dementia care units and in end of life care
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-09-30)To care for someone who is at the end of their life or someone who lives with a dementia disease is not about curing. Instead, care becomes concerned with what can make a situation as good as possible. Contributing to such ... -
Understanding preclinical dementia : early detection of dementia through cognitive and biological markers
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-09-14)Dementia is becoming a growing healthcare crisis, therefore identifying individuals at risk or in the earliest stages of dementia is essential if prevention or disease modification is to be achieved. The objective of ... -
Everyday life activities of people with chronic obstructive pulmonary disease : performance, management and everyday technology use
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-08-20)Background When a person is living with chronic obstructive pulmonary disease (COPD), his/her participation in everyday life activities is challenged due to a complex multitude of symptoms. Moreover, everyday ... -
Using CSF biomarkers to understand mechanisms of behavioral changes and effects of drug treatment in dementia
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-05-06)Dementia is affecting millions of people around the world, and the global prevalence will continuously rise. Neuropsychiatric symptoms (NPS) in dementia are frequent and constitute a key driving force in the disease ... -
Quantifying neurodegeneration from medical images with machine learning and graph theory
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-04-21)Neurodegeneration (or brain atrophy) is part of the pathological cascade of Alzheimer’s disease (AD) and is strongly associated with cognitive decline. In clinics, atrophy is measured through visual assessments of specific ... -
Oral health & olfactory function : what can they tell us about cognitive ageing?
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-04-17)The objective of this thesis was to advance our understanding of whether oral health and olfactory function may predict accelerated cognitive ageing. Data from two Swedish study populations and one from the United States ...