Doktorsavhandlingar / Doctoral Theses - H1 (NVS): Recent submissions
Now showing items 21-40 of 637
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Mental stimulation and multimodal trials to prevent cognitive impairment and Alzheimer ́s disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2023-08-17)Theoretical models of dynamic biomarkers underlying the development of Alzheimer´s Disease (AD) acknowledge that there is inter-individual variability in the cognitive performance associated with any level of AD pathology. ... -
Cardiovascular health and brain aging : a population-based MRI study
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2023-08-14)Deterioration of brain structure and cognitive function occurs as individuals reach advanced age. The former can be observed through various markers of cerebral small vessel disease on magnetic resonance imaging (MRI) scans ... -
Injurious falls in older adults : early identification of individuals at risk of falls—from observational studies to implementation
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2023-05-24)Falls among older adults is a rapidly growing research field with still remaining knowledge gaps that need to be addressed. Most available screening tools for falls have been developed for older adults in specific care ... -
The impact of macronutritional composition and ketosis on cognitive health : from normal aging to Alzheimer’s disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2023-05-22)Ketogenic diets (KD) are increasingly investigated for the prevention of cognitive decline and Alzheimer’s disease (AD). Without explicitly investigating a KD, this thesis disentangles two of its hallmarks: a reduced dietary ... -
Ambient air pollution and transportation noise : how they affect mental health in older adults
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2023-05-17)Whether environmental factors are associated with mental health issues among older adults remains unclear. This doctoral thesis aimed to determine the extent to which air pollution and transportation noise affect mental ... -
Alzheimer disease : subcellular Aβ mechanisms and treatment strategies
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2023-02-01)The amyloid β-peptide (Aβ) is the key molecule in the pathogenesis of Alzheimer disease (AD), but the mechanisms of its toxicity are still largely unknown. This thesis includes studies aimed at studying Aβ induced mechanisms ... -
Aspects of common mental disorders in primary care
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2023-01-13)Depression and anxiety disorders are common in the general population. Primary care is the first line of care for people with common mental disorders. This doctoral project investigated aspects of common mental disorders, ... -
Balance control in people with multiple sclerosis : mechanisms, experiences, design and feasibility of an exercise trial
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2023-01-03)Background: Everyday living entails navigating complex environments and perform-ing activities often requiring simultaneous motor and cognitive actions/tasks (dual-tasking). Disease-related impairments in people with ... -
Adults with spina bifida : from health and living conditions to motor-cognitive performance
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-10-26)Spina bifida (SB) is a congenital spinal cord dysfunction often leading to physical, medical and cognitive challenges. The level and extent of the spinal involvement often affects both sensory and motor function and secondary ... -
Unraveling the relationship between body mass index and cardiometabolic disease, dementia, and survival in old age
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-10-20)Overweight and obesity, commonly defined as a body mass index (BMI) ≥25 kg/m2, affect more than half of older adults. However, the relationship between BMI and health outcomes in old age are unclear. This PhD project aims ... -
Why do older adults seek emergency care? The impact of contextual factors, care, health, and social relations
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-09-21)Background: Emergency department (ED) visits are becoming more prevalent globally. EDs provide care for acute health conditions, but some of these visits are driven by needs unmet by primary health care and social care for ... -
Let's work it out : aspects of the occupational situation of survivors of allogeneic haematopoietic stem cell transplantation
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-09-20)Background: Work is an important part of life and contributes to an individual’s physical and mental well-being. Being diagnosed with a life-threatening haematological disease that requires an allogeneic haematopoietic ... -
Enjoying life and living healthier : impact of behavioral and psychosocial factors on physical function in old age
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-08-26)Declines in physical function vary substantially across older individuals due to, among others, several extrinsic modifiable factors. In this thesis, we aimed to better delineate the impact and interplay among indicators ... -
A 'new public health' perspective on building competence for end-of-life care and communication : how death literacy can be developed and measured
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-08-19)Background: Due to aging populations and prolonged dying trajectories in many high-income countries including Sweden, more people will need extended periods of care and support at the end-of-life (EOL). In light of these ... -
Real-world outcomes in oncology : assessing the value of rewardable innovation
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-07-29)Recent years have seen a remarkable expansion of therapeutic options available for many forms of cancer. Evidence for the efficacy of these treatments have mainly come from randomized controlled trials, however questions ... -
Aspects of medical knowledge sources among junior doctors and general practitioners : needs, use, values and effects
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-07-29)INTRODUCTION: Physicians are facing increasing demands to keep up with the accelerated expansion of medical knowledge. There is a rapid development and adoption of information technology in today’s health care, often driven ... -
Neural stem cell therapy and inflammation status of post-traumatic syringomyelia
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-05-30)Post-traumatic syringomyelia (PTS) is a severe complication of chronic spinal cord injury (SCI) with intraspinal expanding cysts as the major pathology. PTS occurs in up to 30 % of SCI patients, and time of diagnosis is ... -
eHealth support for physical activity and exercise training in people with COPD
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-05-23)Aim: The overall aim of this thesis was to apply user involvement and co-creation to generate knowledge on how an eHealth tool, including physical activity and exercise training, for people with chronic obstructive pulmonary ... -
Taking physical rehabilitation after abdominal cancer surgery further : by enhanced recovery and physical activity
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-05-11)The overall aim with this thesis was to increase knowledge of standardised methods for individualised mobilisation and rehabilitation after abdominal cancer surgery. Concerning mobilisation, both effect, and patients’ ... -
Interplay between autophagy and amyloid beta metabolism in Alzheimer’s disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-05-06)Alzheimer’s disease (AD), the most common neurodegenerative disease, is characterized by two pathological hallmarks: extracellular amyloid-beta peptide (Aβ) plaque depositions and neurofibrillary tangles (NFTs) composed ...