Now showing items 1-20 of 356

    • The development of psychiatric disorders and adverse behaviors : from context to prediction 

      Tate, Ashley (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-01-28)
      Psychiatric disorders by definition cause significant impairment in an individual’s daily functioning. Certain disorders, such as borderline personality disorder (BPD) and eating disorders, have worse prognosis and high ...
    • Medical and surgical treatment of inflammatory bowel disease 

      Forss, Anders (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-01-19)
      Inflammatory bowel disease (IBD), with its two main entities Crohn's disease (CD) and ulcerative colitis (UC), is a chronic and relapsing inflammatory condition affecting the entire gastrointestinal tract. IBD is associated ...
    • Convergent etiology among schizophrenia, eating disorders, and other medical conditions 

      Zhang, Ruyue (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-12-13)
      Schizophrenia and eating disorders (EDs) are complex traits with considerable somatic and psychiatric morbidity. Despite distinct diagnostic criteria and few symptoms in common, significant genetic correlations between ...
    • Behavioural outcomes of treatment with selective serotonin reuptake inhibitors 

      Lagerberg, Tyra (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-12-13)
      Mood and anxiety disorders are some of the biggest contributors to morbidity worldwide, and may be lethal. Appropriate treatment is therefore paramount. Antidepressant medications constitute the primary pharmacological ...
    • Drug safety and effectiveness in relation to kidney function : a pharmacoepidemiological approach 

      Trevisan, Marco (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-11-11)
      Kidney function plays an important role in drug safety and effectiveness. As many medications are excreted by the kidneys, patients with reduced kidney function are at a higher risk of supra-therapeutic or toxic drug levels. ...
    • Etiology and early detection of pancreatic cancer 

      Yu, Jingru (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-11-08)
      Pancreatic cancer is one of the most dismal malignancies. Although its incidence and prevalence are relatively low, the disease burden is still an important health issue, especially in terms of mortality. Primary prevention ...
    • An epidemiological study on nasopharyngeal carcinoma 

      Chen, Yufeng (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-10-25)
      Nasopharyngeal carcinoma (NPC) is a malignancy known for its unique geographic and ethnic distribution characterized by particularly high incidence in southern China, Southeast Asia, and North and East Africa, but being ...
    • Biological ages: correlations, genetic determinants, and health outcomes 

      Li, Xia (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-10-08)
      Population aging is a global trend and requires better evidence-based guidance. This thesis studied population aging from a molecular epidemiological angle. The overall work is centered on the “biological age (BA)”, which, ...
    • Attention-Deficit/Hyperactivity Disorder and educational outcomes : etiology, treatment effects, and occupational outcomes 

      Jangmo, Andreas (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-08-12)
      Attention-Deficit/Hyperactivity Disorder is one of the most prevalent childhood-onset developmental disorders, and is associated with a wide range of problematic functional outcomes such as low educational attainment ...
    • Improved statistical methodology for high-throughput omics data analysis 

      Deng, Wenjiang (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-07-19)
      Over the last two decades, the advent of high-throughput omics technology has substantially revolutionized biological and biomedical research. A large volume of omics data has been produced with the rapid development of ...
    • Causes and consequences of stress and tobacco exposure in utero on birth size, asthma and academic achievement 

      Lundholm, Cecilia (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-03-01)
      The objective of this thesis was to further the understanding of the consequences of stress and smoking during pregnancy, the causes of intrauterine growth and asthma as well as the consequences of asthma on school ...
    • Chlamydia trachomatis infection in Sweden : time trends, risk factors, and prevalence 

      Veličko, Inga (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-02-18)
      Chlamydia trachomatis (chlamydia) infection is the most common bacterial sexually transmitted infection (STI), with an estimated 127 million new cases occurring every year worldwide. Due to the asymptomatic nature of the ...
    • Risk assessment and prevention of breast cancer 

      Eriksson, Mikael (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-12-21)
      One woman in eight develops breast cancer during her lifetime in the Western world. Measures are warranted to reduce mortality and to prevent breast cancer. Mammography screening reduces mortality by early detection. ...
    • Attention-deficit/hyperactivity disorder and adverse health outcomes : from association to prevention 

      Sun, Shihua (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-11-23)
      Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder, characterized by persistent inattention and/or hyperactivity-impulsivity that are inappropriate for one’s developmental ...
    • Dietary habits, commensal microbiome, and nasopharyngeal carcinoma 

      Huang, Tingting (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-11-19)
      Nasopharyngeal carcinoma (NPC) is a malignant disease characterized by unique geographic distribution endemic to southern China, Southeast Asia, and the Middle East/North Africa. It has been widely accepted that the ...
    • Determinants and influence of mammographic features on breast cancer risk 

      Azam, Shadi (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-11-16)
      Mammographic density and mammographic microcalcifications are the key imaging features in mammography examination. Mammographic density is known as a strong risk factor for breast cancer and is the radiographic appearance ...
    • Investigations of body mass, gastrointestinal, and dietary factors influencing the emergence and maintenance of eating disorders 

      Wiklund, Camilla (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-10-20)
      Eating disorders are severe psychiatric illnesses, characterized by dysregulated eating and distorted attitudes toward weight and body shape, causing enormous suffering for patients and their families. Although great ...
    • Molecular epidemiology studies on risk factors for breast cancer and disease aggressiveness 

      Ugalde Morales, Emilio (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-09-10)
      Breast cancer is a heterogeneous disease. Aggressive subtypes are characterized by faster growth rates, increased capability to invade and metastasize, leading to poorer clinical outcomes. In this thesis, we use a molecular ...
    • Novel statistical methods for genome-wide association summary statistics 

      Ning, Zheng (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-08-20)
      A general objective of genetic studies is to understand the genetic basis of complex traits such as height, body mass index (BMI), disease endpoints, etc. Such researches have been facilitated due to the completion of ...
    • Lipids, apolipoproteins, and prognosis of amyotrophic lateral sclerosis 

      Ingre, Caroline; Chen, Lin; Zhan, Yiqiang; Termorshuizen, Jet; Yin, Li; Fang, Fang (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-06-08)
      Objective: To determine whether lipids and apolipoproteins predict prognosis of patients with amyo- trophic lateral sclerosis in a cohort study of 99 patients with amyotrophic lateral sclerosis who were diagnosed during ...