Now showing items 21-40 of 405

    • Integrative omics data analysis to discover novel signatures in complex diseases 

      Pan, Lu (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-03-09)
      Apart from diseases caused by the defect of a single gene, most diseases are highly complex and are usually caused by a combination of biological and environmental factors. In the biological context, cellular processes are ...
    • Development and application of competing risks and multi-state models in cancer epidemiology 

      Skourlis, Nikolaos (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-02-20)
      Competing risks and multi-state models allow us to study complex disease settings and answer composite research questions and should be used more widely in epidemiology. This thesis aims to explore the competing risks and ...
    • Maternal asthma and early fetal growth : the MAESTRO study 

      Rejnö, Gustaf; Lundholm, Cecilia; Saltvedt, Sissel; Larsson, Kjell; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-02-08)
      Background: Several maternal conditions can affect fetal growth, and asthma during pregnancy is known to be associated with lower birth weight and shorter gestational age. Objective: In a new Swedish cohort study ...
    • Register-based studies of sex steroid hormones and psychiatric disorders 

      Gotby, Vide (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-01-27)
      The focus of this thesis is the interplay between sex steroid hormones, psychiatric- and neurodevelopmental disorders and adverse behavioral outcomes. Sex steroid hormones are mostly known for their role in sexual ...
    • Paediatric asthma and non-allergic comorbidities : a review of current risk and proposed mechanisms 

      Brew, Bronwyn K; Osvald, Emma Caffrey; Gong, Tong; Hedman, Anna M; Holmberg, Kirsten; Larsson, Henrik; Ludvigsson, Jonas F; Mubanga, Mwenya; Smew, Awad I; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-01-24)
      It is increasingly recognized that children with asthma are at a higher risk of other non-allergic concurrent diseases than the non-asthma population. A plethora of recent research has reported on these comorbidities and ...
    • Season of birth, childhood asthma and allergy in a nationwide cohort : mediation through lower respiratory infections 

      Almqvist, Catarina; Ekberg, Sara; Rhedin, Samuel; Fang, Fang; Fall, Tove; Lundholm, Cecilia (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-01-23)
      Background: Previous studies have suggested an association between season of birth and risk of childhood asthma and allergic disease. The association may be modified by birth year and region, or mediated by respiratory ...
    • Understanding the relationship between asthma and autism spectrum disorder : a population-based family and twin study 

      Gong, Tong; Lundholm, Cecilia; Lundström, Sebastian; Kuja-Halkola, Ralf; Taylor, Mark; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-01-17)
      Background: There is some evidence that autism spectrum disorder (ASD) frequently co-occurs with immune-mediated conditions including asthma. We aimed to explore the familial co-aggregation of ASD and asthma using different ...
    • Limited association between markers of stress during pregnancy and fetal growth in 'Born into Life' : a new prospective birth cohort 

      Smew, Awad I; Hedman, Anna M; Chiesa, Flaminia; Ullemar, Vilhelmina; Andolf, Ellika; Pershagen, Göran; Almqvist, Catarina (Institutet för miljömedicin / Institute of Environmental MedicineInst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and BiostatisticsInst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2023-01-17)
      Aims: We aimed to investigate the associations between perceived maternal stress or salivary cortisol levels during pregnancy and birthweight. Methods: In 2010-2012, we recruited 92 women living in Stockholm, Sweden, ...
    • Developmental trajectories of attention-deficit/hyperactivity disorder into adulthood and aging : multimorbidity and polypharmacy 

      Zhang, Le (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-01-16)
      Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by developmentally inappropriate levels of inattentiveness, hyperactivity, and impulsivity. Previous studies have shown ...
    • Epidemiological studies on frailty and its associations with mortality, dementia, and polypharmacy 

      Bai, Ge (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-01-12)
      Frailty describes the status of decreased physiological reserves and increased vulnerability to adverse outcomes. As the aging population increases, frailty has become an important public health concern. However, longitudinal ...
    • Personalized prostate cancer management : AI-assisted prostate pathology and improved active surveillance 

      Olsson, Henrik (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-01-11)
      Prostate cancer is a major global health concern and is the most common cancer-related cause of death in Sweden. Prostate cancer screening using PSA has been shown to reduce prostate cancer mortality but also leads to ...
    • Prostate cancer testing in Sweden : the interplay between cost and effectiveness 

      Hao, Shuang (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-11-16)
      As a major cause of male deaths in Sweden, prostate cancer constitutes an essential public health issue to the society. Early detection through an organised testing program with the prostate-specific antigen (PSA) test and ...
    • Artificial intelligence for breast cancer precision pathology 

      Wang, Yinxi (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-11-09)
      Breast cancer is the most common cancer type in women globally but is associated with a continuous decline in mortality rates. The improved prognosis can be partially attributed to effective treatments developed for subgroups ...
    • Epidemiology, prevention and control of hepatitis A virus infection in the European Union 

      Severi, Ettore (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-10-13)
      Hepatitis A is an acute liver disease caused by the hepatitis A virus (HAV) and transmitted via the faecal-oral route through person-to-person transmission, contaminated food or water. The frequency and severity of symptoms ...
    • Epidemiological studies on gastroesophageal reflux disease and esophageal cancer 

      Zhang, Ji (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-08-17)
      Esophageal cancer is the seventh most common cancer and a lethal malignancy causing a considerably high number of deaths around the world. Despite intensive studies on risk factors associated with esophageal cancer, there ...
    • Register-based studies of infertility and the use of assisted reproductive techniques : possibilities and challenges 

      Wang, Chen (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-08-04)
      The implementation of assisted reproductive techniques (ART) has enabled over 10 million births in the past 45 years. Concern for excess risks of adverse birth outcomes has largely, but not entirely, been mitigated by ...
    • Machine learning methods for precision medicine 

      Gonzalez Ginestet, Pablo (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-06-17)
      In precision medicine, predicting the risk of an event during a specific period may help, for example, to identify patients that need early preventive treatment. Modern machine learning (ML) techniques are therefore ideal ...
    • A clinical epidemiological study on end-stage liver disease in Ghana 

      Nartey, Yvonne Ayerki (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-06-01)
      End-stage liver disease (ESLD), including advanced liver cirrhosis and hepatocellular carcinoma (HCC), is the final stage of long-standing injury to the liver due to risk factors such as chronic viral hepatitis and alcoholic ...
    • Microscopic colitis : epidemiology, death and associated disorders 

      Bergman, David (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-05-16)
      Microscopic colitis (MC) is the most recently recognized inflammatory condition of the large intestine. MC is an umbrella term for two disease entities, namely lymphocytic colitis (LC) and collagenous colitis (CC). These ...
    • Breast cancer natural history models and risk prediction in mammography screening cohorts 

      Strandberg, Rickard (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-03-31)
      In this thesis, the foundations are laid for a new natural history model for breast cancer—specifically designed to take advantage of detailed screening cohorts. Three diverse applications of this model are then presented. ...