Doktorsavhandlingar / Doctoral Theses - C6 (IMM): Recent submissions
Now showing items 21-40 of 314
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Toxic metals, essential micronutrients, gestational thyroid hormones, and size at birth
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-05-09)The toxicity of the metals cadmium (Cd), lead (Pb), and methylmercury [MeHg; an organic and very toxic form of mercury (Hg)] in adults have long been recognized. It is also well-established that early-life exposure to Pb ... -
Premenstrual disorders : risk factors, comorbidities and health impact
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-05-09)Premenstrual disorders (PMDs) are characterized by affective and physical symptoms that cyclically occur 7-10 days before the menstruation and affect millions of women of reproductive age worldwide. Despite its commonness, ... -
DissolvIt : development and validation of a new in vitro dissolution apparatus for dry powder aerosols
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-05-09)Today there are no recommended dissolution methods for use in the development of new inhalable drugs. In the absence of such tailored methods, standard dissolution test methods from oral- or skin administration routes are ... -
Application of the benchmark dose-response modelling approach for risk characterization of chemicals
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-04-28)Toxicology is the discipline that investigates the possible adverse effects of chemical exposure on human, animal and environmental health. Chemical risk assessment is the process that aims to identify potentially hazardous ... -
Socioeconomic factors and childhood cancer : survival and long-term consequences
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-04-19)Childhood cancer is rare and survival rates have increased substantially over the past 60 years as a result of better diagnostics and treatments. Despite this, childhood cancer is the most common disease-related cause of ... -
Biomedical factors in the risk and prognosis of amyotrophic lateral sclerosis
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-03-28)Amyotrophic lateral sclerosis (ALS) is a relatively rare but incurable and relentlessly progressive neurodegenerative disease, characterized by motor neuron loss in the brain and spinal cord. Majority of patients die within ... -
Precarious employment and occupational injuries in Sweden
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-02-23)Nowadays, employment arrangements come under many different forms, often difficult to trace in the statistics due to a lack of standard definitions and measurements. Precarious Employment (PE) is a multidimensional construct ... -
Trends in population health in an era of increasing longevity
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-01-26)In Sweden, the number of older adults over the age of 85 increased by 75% since 1990 while the number of centenarians has almost quadrupled. Rapid population ageing is a global phenomenon and projected to continue in almost ... -
Profiling of microglia in inflammation, aging, and the tumor microenvironment
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-12-10)In this thesis I aim to present our ongoing efforts to elucidate activation states and how these are regulated in microglia cells. An extensive body of work is dedicated to understanding how these resident immune cells can ... -
Immunity and inflammation in amyotrophic lateral sclerosis : an epidemiological approach
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-11-08)Amyotrophic lateral sclerosis (ALS) is a rare but lethal neurodegenerative disease, characterized by degeneration of both upper and lower motor neurons in the brain and spinal cord. The pathogenesis of ALS is, however, not ... -
Precarious employment in Sweden : methodological development and health associations
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-10-22)Precarious employment (PE), representing a multidimensional construct of (poor) employment conditions, has been found associated with several health outcomes. However, there is a lack of a recognized definition of PE and ... -
Silica particle-induced NLRP3 inflammasome activation and DNA damage in respiratory epithelium
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-08-27)Respirable crystalline silica particles (CSi) can persist and induce inflammation and DNA damage in human lungs. Previous studies have used complex model systems to characterize CSi-induced DNA damage, involving co-cultures ... -
Environmental arsenic exposure in humans : toxicity and adaptation in the Bolivian Andes
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-05-07)Arsenic, a potent toxicant and carcinogen, is naturally present in soil and leaches into groundwater. More than 140 million people worldwide are exposed to arsenic through drinking water. How well humans metabolize arsenic ... -
Experimental studies of lipid mediator modulation of airway responsiveness
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-03-26)Lipid mediators play an important role in responsiveness of the airways. The roles of prostanoids and leukotrienes in inducing airway inflammation and contraction are reasonably well established. The functions of specialised ... -
Risks and benefits of drinking water treatment : focusing on child health and prenatal development
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-02-24)Drinking water is our most important food item and its access is indispensable for a wellfunctioning society. Recent Swedish water-borne outbreaks have demonstrated a system vulnerability and a clear need for improved ... -
Dietary carbohydrate quality and health : focus on low-grade systemic inflammation and cardiometabolic risk factors
(Institutet för miljömedicin / Institute of Environmental Medicine, 2020-11-18)Dietary carbohydrate quality, characterized by content of whole grain (WG), dietary fiber, and sugars, is important for human health. Whole grain consumption and cereal fiber can reduce the risk of chronic disorders such ... -
Urban greenness and related health effects
(Institutet för miljömedicin / Institute of Environmental Medicine, 2020-11-11)Exposure to urban greenness has been linked to a wide range of health outcomes, including many non-communicable health conditions which are presently among the largest contributors to the global burden of disease, such as ... -
Health effects of air pollution : innovative approaches for spatio-temporal evaluations
(Institutet för miljömedicin / Institute of Environmental Medicine, 2020-09-17)Air pollution is one of the major risk factors to human health, causing both short- and long-term effects and the global burden on mortality is estimated in more than 4 million deaths every year. Most of the evidence on ... -
Short and long-term regulation of autophagy
(Institutet för miljömedicin / Institute of Environmental Medicine, 2020-09-04)Autophagy is a conserved catabolic pathway triggered by stress conditions in which portions of the cytoplasm, damage organelles, misfolded proteins and intracellular bacteria are delivered and degraded in the lysosome/vacuoles. ... -
Genotoxic effects among Bolivian farmers exposed to mixtures of pesticides : population and in vitro based studies
(Institutet för miljömedicin / Institute of Environmental Medicine, 2020-07-31)Human exposure to pesticides has increased exponentially in recent decades, especially in low- and middle-income countries where regulations on the use of pesticides and personal protective equipment (PPE) are not fully ...