Institutet för miljömedicin / Institute of Environmental Medicine: Recent submissions
Now showing items 21-40 of 370
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Early-life metal exposure and child growth and development
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-05-24)Cadmium, lead and arsenic are toxic metals, the exposure to which occurs primarily through food and drinking water. While many studies are available about their health effects in adults, studies in children and adolescents ... -
Exploring toxicity and fate of metal-based particles in the lung : from mechanistic screening to lung deposition modelling
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-05-24)We are all exposed to small particles in the air that we breath and some of them will contain metals in a dose and form that may be harmful. In addition, the field of nanotechnology holds great promises, but an increased ... -
Physical workload in surgery : from risk assessments to interventions
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-05-20)Surgeons often suffer from work-related musculoskeletal disorders (WMSDs), with the neck, shoulders, and low back being the most affected body sites. Among other factors, the high physical workload has been recognized as ... -
Eliminating guesswork : an exploration of the role of predictive modelling in care management for patients with multimorbidities
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2022-05-20)Introduction: Patients with multiple chronic conditions of diabetes, cardiovascular and kidney diseases are one of the most complex group of patients and high consumers of care. Multidisciplinary integrated care delivery ... -
Defining the role of mast cells in guinea pig models of asthma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-05-13)Asthma is a common respiratory disease characterized by several pathophysiological features, such as allergen induced bronchoconstriction (in allergic asthma), airway hyperresponsiveness (AHR), airway inflammation, airway ... -
Immune mechanisms and potential immunological treatment in atherosclerosis
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-05-11)Our immune system is an important and central part of the defence mechanisms of our body. It carries out various important functions such as protecting us from invading microorganisms, removing dead cells, and producing ... -
Toxic metals, essential micronutrients, gestational thyroid hormones, and size at birth
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-05-09)The toxicity of the metals cadmium (Cd), lead (Pb), and methylmercury [MeHg; an organic and very toxic form of mercury (Hg)] in adults have long been recognized. It is also well-established that early-life exposure to Pb ... -
Premenstrual disorders : risk factors, comorbidities and health impact
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-05-09)Premenstrual disorders (PMDs) are characterized by affective and physical symptoms that cyclically occur 7-10 days before the menstruation and affect millions of women of reproductive age worldwide. Despite its commonness, ... -
DissolvIt : development and validation of a new in vitro dissolution apparatus for dry powder aerosols
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-05-09)Today there are no recommended dissolution methods for use in the development of new inhalable drugs. In the absence of such tailored methods, standard dissolution test methods from oral- or skin administration routes are ... -
Application of the benchmark dose-response modelling approach for risk characterization of chemicals
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-04-28)Toxicology is the discipline that investigates the possible adverse effects of chemical exposure on human, animal and environmental health. Chemical risk assessment is the process that aims to identify potentially hazardous ... -
Socioeconomic factors and childhood cancer : survival and long-term consequences
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-04-19)Childhood cancer is rare and survival rates have increased substantially over the past 60 years as a result of better diagnostics and treatments. Despite this, childhood cancer is the most common disease-related cause of ... -
Biomedical factors in the risk and prognosis of amyotrophic lateral sclerosis
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-03-28)Amyotrophic lateral sclerosis (ALS) is a relatively rare but incurable and relentlessly progressive neurodegenerative disease, characterized by motor neuron loss in the brain and spinal cord. Majority of patients die within ... -
Precarious employment and occupational injuries in Sweden
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-02-23)Nowadays, employment arrangements come under many different forms, often difficult to trace in the statistics due to a lack of standard definitions and measurements. Precarious Employment (PE) is a multidimensional construct ... -
Trends in population health in an era of increasing longevity
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-01-26)In Sweden, the number of older adults over the age of 85 increased by 75% since 1990 while the number of centenarians has almost quadrupled. Rapid population ageing is a global phenomenon and projected to continue in almost ... -
Profiling of microglia in inflammation, aging, and the tumor microenvironment
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-12-10)In this thesis I aim to present our ongoing efforts to elucidate activation states and how these are regulated in microglia cells. An extensive body of work is dedicated to understanding how these resident immune cells can ... -
Immunity and inflammation in amyotrophic lateral sclerosis : an epidemiological approach
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-11-08)Amyotrophic lateral sclerosis (ALS) is a rare but lethal neurodegenerative disease, characterized by degeneration of both upper and lower motor neurons in the brain and spinal cord. The pathogenesis of ALS is, however, not ... -
Precarious employment in Sweden : methodological development and health associations
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-10-22)Precarious employment (PE), representing a multidimensional construct of (poor) employment conditions, has been found associated with several health outcomes. However, there is a lack of a recognized definition of PE and ... -
Silica particle-induced NLRP3 inflammasome activation and DNA damage in respiratory epithelium
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-08-27)Respirable crystalline silica particles (CSi) can persist and induce inflammation and DNA damage in human lungs. Previous studies have used complex model systems to characterize CSi-induced DNA damage, involving co-cultures ... -
Number of siblings and survival from childhood leukaemia : a national register-based cohort study from Sweden
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-05-31)Background: Previous studies suggest worse leukaemia survival for children with siblings, but the evidence is sparse, inconsistent and does not consider clinical factors. We explored the associations between number of ... -
Environmental arsenic exposure in humans : toxicity and adaptation in the Bolivian Andes
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-05-07)Arsenic, a potent toxicant and carcinogen, is naturally present in soil and leaches into groundwater. More than 140 million people worldwide are exposed to arsenic through drinking water. How well humans metabolize arsenic ...