Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology: Recent submissions
Now showing items 41-60 of 290
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Population and single-cell analysis of human cardiogenesis reveals unique LGR5 ventricular progenitors in embryonic outflow tract
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-15)The morphogenetic process of mammalian cardiac development is complex and highly regulated spatiotemporally by multipotent cardiac stem/progenitor cells (CPCs). Mouse studies have been informative for understanding mammalian ... -
Genome‐wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-02-15)Cardiac progenitor formation is one of the earliest committed steps of human cardiogenesis and requires the cooperation of multiple gene sets governed by developmental signaling cascades. To determine the key regulators ... -
From oncogenic replication stress to drug resistance : F-box proteins as signalling hubs in cancer
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-01-28)Cancer arises from cells that acquire genetic and epigenetic changes during the course of a, sometimes decades-long, somatic evolutionary process. These changes result in deregulation of a multitude of cellular processes ... -
Investigating adipose tissue turnover in humans using radiocarbon dating
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-12-28)Obesity, defined as an excessive accumulation of body fat, is considered one of the major health challenges facing the world today. Adipocyte and lipid turnover determine the number and the size of fat cells, respectively. ... -
Neural stem cells in the spinal cord : identity, function and potential
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-12-23)A large body of work has been dedicated to understanding and remedying the pathological processes that take place after spinal cord injury. Despite these efforts, treatment options are limited and patients with spinal cord ... -
The neurogenic potential of astrocytes : a story of transformation and renewal
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-10-15)To not simply repair an organ, but to regenerate and fully recover its function, like there was no injury at all, that is the goal of regenerative medicine. Of all the organs in the human body, the most delicate and difficult ... -
Notch signaling requiem : orchestral role of notch signaling in cancer and developmental disease
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-08-14)Notch signaling is an evolutionary conserved contact-dependent cell-cell communication pathway. This “contact” spans from hydra to fruit flies to human; orchestrating development, homeostasis and cancer, thus the Requiem, ... -
Oxygen sensing in myeloid cells : implications for physiology and cancer
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-07-31)All mammals depend on oxygen in order to produce life-essential energy. They acquire oxygen (O₂) through inspiration. In the lungs, O₂ is gathered by erythrocytes that consequently deliver it to all cells by the cardiovascular ... -
From quality control to neurodegeneration : regulation of autophagy and the DNA damage response by ubiquitin-modifying enzymes
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-05-18)Protein homeostasis and genome integrity are safeguarded by a variety of cellular quality control pathways. While protein quality is controlled by a delicate balance between protein biosynthesis, folding and degradation, ... -
X-chromosome upregulation is driven by increased burst frequency
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and BiophysicsInst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-05-12)Ohno's hypothesis postulates that X-chromosome upregulation rectifies X-dose imbalance relative to autosomal genes, present in two active copies per cell. Here we dissected X-upregulation into kinetics of transcription, ... -
Differential microRNA and metabolic expressions in neuroendocrine and cervical carcinomas
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-03-26)MicroRNAs (miRNAs) are important regulators of many biological processes involved in cancer development and progression. However, the functional roles of miRNAs in some cancer types are still poorly understood. The aim of ... -
Novel properties of mature adipocytes in obesity and hyperinsulinemia
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-02-10)Adipose tissue expansion and dysfunction, which leads to obesity and related metabolic diseases (e.g., diabetes and hypertension) are currently the most costly challenges for public health, yet the mechanisms underlying ... -
To scar or not to scar : origin and function of fibrotic tissue in the central nervous system
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-11-20)After injury, the adult mammalian central nervous system lacks long-distance axon regeneration, and insufficient repair results in the formation of a multicellular and compartmentalized scar. A great body of work has been ... -
Tailoring bioinformatics strategies for the characterization of the human microbiome in health and disease
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-08-22)The human microbiome is a very active area of research due to its potential to explain health and disease. Advances in high throughput DNA sequencing in the last decade have catalyzed the growth of microbiome research; ... -
Exploration of large molecular datasets using global gene networks : computational methods and tools
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-08-02)Defining gene expression profiles and mapping complex interactions between molecular regulators and proteins is a key for understanding biological processes and the functional properties of cells, which is therefore, the ... -
Single-cell RNA sequencing for subtype discovery in Plasmodium falciparum and mammalian cells
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-04-25)Since the dawn of massively parallel sequencing technologies in mid-2000s their utility in profiling the expression of genes in a genome-wide fashion has matured and progressed from cell populations to individual cells. ... -
Novel aspects of neuroblastoma : to hypoxia and beyond
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-02-27)Neuroblastoma (NB) is a pediatric cancer arising from the neural crest cells forming the sympathetic nervous system. Just as other types of pediatric cancer the driving mutations of neuroblastoma are few and the tumors are ... -
From nucleus to mitochondria : a ubiquitination study
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-01-18)Ubiquitination is a post-translational modification achieved by an enzymatic cascade. This post-translational modification is involved in many crucial cellular processes across different cellular compartments such as protein ... -
The role of HIF-1alpha in epigenetic regulation of transcription
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-11-27)The oxygen level inside cells, determine the amount of HIF protein. By directly being involved in HIF protein turnover rates, through a mechanism, by which, oxygen is utilized as a co-factor, for the PHD enzymes, regulating ... -
A genome-wide screen for essential genes that controls the formation of human heart progenitors
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-11-14)The heart is a complex organ system composed of multiple types of tissues. These tissues are produced by a diverse set of muscle and non-muscle cells, originated from a few pools of progenitors. During the heart development, ...