Now showing items 21-40 of 237

    • Cell cycle regulation and DNA damage response : a record of polo-like kinase 1 activity 

      Hukasova, Elvira (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-11-02)
      Division and cell proliferation is an essence of life. A human cell has in its core a very simple yet a very complex machinery to coordinate cell cycle activities and events. A somatic human cell has as a base four ...
    • Transcriptional regulation of development in time and space 

      Hagey, Daniel W. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-10-13)
      Human development requires the generation of trillions of cells with myriad functions from a single cell. This requires that restriction of stem cell fate competence and proliferation are precisely temporally and spatially ...
    • Astrocytes : a reservoir for new neurons 

      Magnusson, Jens (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-09-08)
      The goal of regenerative medicine is to be able to help the body to replace worn-out cells and tissues. To achieve this goal, one approach being pursued today is to recruit and boost the body’s own mechanisms for cell ...
    • Global regulation of gene expression in stem cells and regeneration 

      Abdullayev, Ilgar (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-08-17)
      Rapid developments in genomics and transcriptomics fields have made it possible to ask new questions as well as solve various old problems in biology that were not achievable previously. Novel techniques such as RNA ...
    • Brain matter matters : renewal in the human brain 

      Yeung Wong, Maggie (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-05-26)
      Many cells have a shorter life span than the organism itself and are continuously being replaced. However, for many cell types in the human body it is still largely unknown whether they turn over at all once development ...
    • Cell renewal : terms and conditions may apply 

      Réu, Pedro (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-04-10)
      The longevity and turnover of the different constituent cells of an organism define its development, size, health, and biological age. The present thesis discusses the renewal rates and functions of cells in several ...
    • The function of Smc5/6 in Drosophila development and at the heterochromatin-like locus HMR in budding yeast 

      Tran, Martin (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-03-15)
      The structural maintenance of chromosome 5/6 (Smc5/6) complex is one out of many factors in the cell that maintain genome stability. Smc5/6 has been implicated in processes such as DNA double-strand break (DSB) repair, ...
    • Transcriptional regulation of neuronal differentiation in the developing CNS 

      Rraklli, Vilma (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-02-02)
      The central nervous system (CNS) is responsible for our intellectual and cognitive functions and it comprises the brain and spinal cord. Generation of the CNS occurs during embryonic development from the neural tube that ...
    • SOX transcription factors : multifaceted regulators of central nervous system development 

      Zaouter, Cécile (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-01-26)
      The central nervous system (CNS) is composed of three major cell types, namely neurons, astrocytes and oligodendrocytes that are mainly generated during embryonic stages by multipotent neural progenitor cells (NPCs). The ...
    • The role of KIF1Bß in neuroblastoma tumour suppression during sympathetic neuron development 

      Fell, Stuart (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-01-19)
      Neuroblastoma, the most common extra-cranial childhood tumour, is believed to arise from precursor cells of the sympathetic nervous system (neuroblasts). Hemizygous loss of chromosome 1p36 strongly correlates with poor ...
    • Resolving developing neuronal lineages in the ventral midbrain 

      Kee, Nigel (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-01-09)
      The numerous cells and cell types of our bodies originate from a fertilised egg. Through the study of the developing embryo, we have come to understand much about how different cells in different tissues arise from this ...
    • High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation 

      Agostinho, Ana; Manneberg, Otto; van Schendel, Robin; Hernández-Hernández, Abrahan; Kouznetsova, Anna; Blom, Hans; Brismar, Hjalmar; Höög, Christer (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyScience for Life Laboratory, 2016-12-07)
      During meiosis, cohesin complexes mediate sister chromatid cohesion (SCC), synaptonemal complex (SC) assembly and synapsis. Here, using super-resolution microscopy, we imaged sister chromatid axes in mouse ...
    • Investigating cell turnover in the healthy and diseased adult human brain 

      Huttner, Hagen B. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-11-18)
      For decades it was thought that cells that lost in the human central nervous system because of ageing or disease – different from other cell tissues – cannot be replaced and that in humans all neurons are generated during ...
    • The Smc5/6 complex : the mysterious guardian of genome stability 

      Berta, Davide G. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-11-02)
      An intricate network of proteins ensures the faithful transmission of genetic information through cell generations. The Structural Maintenance of Chromosomes (SMC) protein complex family plays a pivotal role in maintaining ...
    • The role of the cohesin loader in genome stability : a journey from yeast to human 

      Giordano, Fosco (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-10-11)
      Structural Maintenance of Chromosome (SMC) complexes, as their name suggests, have a central role in maintaining the higher structure of genomes, from bacteria to human, and in doing so protecting their integrity. ...
    • Molecular organization and in situ assembly of the human skin barrier 

      Hollander, Lianne den (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-10-07)
      A deficient skin barrier function is a characteristic feature of skin diseases such as eczema, psoriasis and the ichtyoses. A malformation of the lipid matrix might be a major factor in barrier deficient skin disease. To ...
    • Trypanosoma cruzi genome plasticity and evolution 

      Talavera-López, Carlos (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-08-24)
      Trypanosoma cruzi, a protozoan from the Kinetoplastidae family, is the etiologic agent of Chagas disease, a major public health problem affecting mostly the poorest areas of Latin America. Due to the complex nature of the ...
    • Notch in cancer and cancer metabolism : six degrees of intracellular turbulence 

      Landor, Sebastian K.-J. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-08-12)
      Notch signaling is an evolutionarily conserved cell-to-cell contact-dependent signaling mechanism in multicellular organisms directing cellular fates both in early development and adult tissues. In metazoans the Notch ...
    • Cyclins on the move : a time and a place for cyclin A2 and cyclin B1 in the human cell cycle 

      Silva Cascales, Helena (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-05-27)
      The ultimate aim of the cell cycle is to create an identical daughter cell. Therefore, correct progression through the different phases of the cell cycle is crucial to ensure faithful cell division. Successful execution ...
    • Actin and myosin in transcription and chromatin regulation 

      Almuzzaini, Bader (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-05-02)
      In mammalian cells, actin and myosin have emerged as regulators of nuclear structure and function, involved in chromatin remodeling and histone modifications, and in different phases of gene transcription. Actin and myosin ...