Inst för neurovetenskap / Dept of Neuroscience: Recent submissions
Now showing items 21-40 of 292
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The dynamics of intra- and inter-organ communication during an acute kidney infection
(Inst för neurovetenskap / Dept of Neuroscience, 2022-01-27)This thesis focuses on the roles of neuro-immune communication and infection-mediated coagulation during bacterial kidney infections. We demonstrate dynamic intra- and inter-organ host responses, where the outcome of an ... -
Network asynchrony underlying increased broadband gamma power
(Inst för neurovetenskap / Dept of Neuroscience, 2021-05-31)Synchronous activity of cortical inhibitory interneurons expressing parvalbumin (PV) underlies expression of cortical γ rhythms. Paradoxically, deficient PV inhibition is associated with increased broadband γ power in the ... -
Adult trkB signaling in parvalbumin interneurons is essential to prefrontal network dynamics
(Inst för neurovetenskap / Dept of Neuroscience, 2021-05-31)Inhibitory interneurons expressing parvalbumin (PV) are central to cortical network dynamics, generation of c oscillations, and cognition. Dysfunction of PV interneurons disrupts cortical information processing and cognitive ... -
Deciphering the role of genetics and circadian rhythm in cluster headache
(Inst för neurovetenskap / Dept of Neuroscience, 2021-05-28)Cluster headache (CH) is a complex neurovascular disorder with a distinct circadian attack pattern. Although many aspects of the disease’s pathophysiology remain to be elucidated, it is likely caused by a combination of ... -
On the role of parvalbumin interneurons in neuronal network activity in the prefrontal cortex
(Inst för neurovetenskap / Dept of Neuroscience, 2021-04-30)The prefrontal cortex (PFC) is an area important for executive functions, the initiation and temporal organization of goal-directed behavior, as well as social behaviors. Inhibitory interneurons expressing parvalbumin (PV) ... -
The molecular basis of the development and diversity of proprioceptive neurons : a story of surviving and thriving
(Inst för neurovetenskap / Dept of Neuroscience, 2021-04-21)Proprioception, also known as the sixth sense, describes the sensation of our body position and movement. Its proper function is essential for our daily activities from coarse movements, e.g. locomotion, to precise movements, ... -
Bacterial sensors and controllers based on organic bioelectronics
(Inst för neurovetenskap / Dept of Neuroscience, 2021-01-14)Bacterial infections and contaminations are worldwide problems, leading to morbidity and mortality, food waste and economic losses in a variety of industries. The situation is aggravated by the increased occurrence of ... -
Neurons and glia in the peripheral nervous system : interactions in health and disease
(Inst för neurovetenskap / Dept of Neuroscience, 2020-11-17)The peripheral nervous system (PNS) is composed of nerves and ganglia that connect the brain and the spinal cord (the central nervous system, CNS) to the outside world. The nerves contain the extensions (axons) of both ... -
The claustrum is a highway not a hub : organizing principles of claustrocortical synaptic transmission
(Inst för neurovetenskap / Dept of Neuroscience, 2020-10-20)The claustrum (CLA) is a brain nucleus wedged between the cortex and striatum. The behaviors it has been implicated in include consciousness, attention, memory and salience detection; dysfunction of CLA circuits is associated ... -
In the right place and at the right time : cellular and functional neuroanatomy of endocannabinoids and neuropeptides
(Inst för neurovetenskap / Dept of Neuroscience, 2020-09-10)A plethora of chemical signals, including endocannabinoids and neuropeptides, enable neuronal communication beyond the classical neurotransmitters. Many of these molecules are also expressed during (early) brain development, ... -
Limb ownership and voluntary action : human behavioral and neuroimaging studies
(Inst för neurovetenskap / Dept of Neuroscience, 2020-08-05)To be able to interact with our surroundings in a goal directed manner, we need to have sense what our body is made up of as well as a sense of being able to control our body. These two experiences, the sense of body ... -
Neuromodulation shapes interneuron communication in the mouse striatum
(Inst för neurovetenskap / Dept of Neuroscience, 2020-07-24)A proper understanding of cognition relies on detailed knowledge about the functional connectivity within and between brain areas. The striatum is generally regarded as the input structure to the basal ganglia, a group of ... -
Idiopathic intracranial hypertension in Sweden : epidemiological studies focused on incidence and risk factors
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-07)Idiopathic intracranial hypertension (IIH) is a disorder which is not that unusual for neurologists and ophthalmologists to meet in clinical practice even though it only affects around 1 per 100,000 individuals. It gives ... -
Inter- and intracellular resistance and vulnerability in motor neuron diseases
(Inst för neurovetenskap / Dept of Neuroscience, 2020-05-06)Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are fatal diseases presenting with degeneration and loss of lower motor neurons in the brainstem and spinal cord. However, oculomotor and trochlear motor ... -
The role of dopaminergic and cholinergic modulation on the striatal network : a computational investigation
(Inst för neurovetenskap / Dept of Neuroscience, 2020-04-16)The famous words from the French philosopher René Descartes (1596-1650), “I think therefore I am”, proclaims that since we are thinking we must also exist. At the time when this was stated, very little was known about the ... -
Membrane mechanisms during exo- and endocytosis in excitable cells
(Inst för neurovetenskap / Dept of Neuroscience, 2020-04-09)Excitable cells, like endocrine cells and neurons release hormones and transmitters through exocytosis to mediate many important functions, such as stress responses, immune responses, control of blood glucose, and synaptic ... -
The functional organisation of basal ganglia inputs
(Inst för neurovetenskap / Dept of Neuroscience, 2020-04-07)The basal ganglia allow organisms to adjust their behaviour according to changes in their internal state or their environment. One essential prerequisite for the selection and execution of appropriate movements is the ... -
Regulations of neuronal plasticity by the Nogo system
(Inst för neurovetenskap / Dept of Neuroscience, 2020-04-02)Our brain has a lifelong capacity to create new memories, to learn and to adapt. This is due to the ability of neurons to modify their signaling depending on the situation to which the nervous system is exposed. The neurons ... -
Molecular and functional neuroanatomy of mood disorder circuits
(Inst för neurovetenskap / Dept of Neuroscience, 2020-03-26)The ability to interpret and react to external stimuli is essential for survival. An organism has to be able to predict a favorable outcome, and, more importantly, a non-favorable one that could mean danger for life. The ... -
Brain development in a dish
(Inst för neurovetenskap / Dept of Neuroscience, 2020-03-06)This thesis shows the path I took in the quest for modeling the brain, as the title says, in a dish. The introduction of induced pluripotent stem cells (iPSCs) as means to research biological processes has opened up whole ...