Now showing items 1-20 of 316

    • Renal Doppler resistive index : applications in perioperative and critical care 

      Renberg, Mårten (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-03-25)
      Doppler-derived renal resistive index (RRI) has emerged as a promising bedside tool for assessing renal hemodynamics, and elevated values ≥0.70 have been associated with adverse outcomes in various clinical settings. This ...
    • Single-cell analysis on specification of mammalian germline and its role in health and diseases 

      Luo, Qing (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-03-25)
      Germ cell specification is the first step for developing reproductive cells. The specification requires formative pluripotent stem cells as precursors. Previous attempts to capture formative pluripotency used opposite ...
    • Engineering cell communication from nanoscale to tissue levels towards therapeutic applications 

      Kolonelou, Christina (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-02-22)
      Cell communication which is vital for the proper function, development, and survival of multicellular organisms is often disrupted in diseases. This thesis aims to enhance our understanding of cell communication by employing ...
    • Skeletal muscle responses to physical activity in health and metabolic disease 

      Smith, Jonathon Alexander (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-01-12)
      Sedentary lifestyles, characterised by a lack of physical activity and prolonged periods of sitting, have been linked to reductions in whole-body metabolic flexibility and the increased risk of metabolic diseases, including ...
    • Polycystic ovary syndrome and maternal obesity : does it programme transgenerational dysfunction? 

      Lu, Haojiang (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-01-08)
      As one of the most prevalent syndromes among reproductive-aged women, polycystic ovary syndrome (PCOS) manifests with endocrine, reproductive and metabolic disturbances. However, the etiology of PCOS is yet to be fully ...
    • Randomised clinical trials with hyperbaric oxygen in COVID-19 and Long COVID : transcriptomic insights into benefits and harms 

      Kjellberg, Anders (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-01-08)
      The flow from transcription of genes through translation and processing of proteins is a common basis for all life. Redox homeostasis is crucial for the defence against oxidative stress. We adapt through hormesis; non-lethal ...
    • Cellular and molecular mechanisms of inflammatory arthritis and fibromyalgia 

      Morado Urbina, Carlos Eduardo (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-01-03)
      In Study I, we examined the impact of the hR100E-NGF mutation on inflammatory pain and bone erosion in both female and male mice. Our findings indicate that the hR100E-NGF mutation did not affect the development of the ...
    • Exploring dual-lipopolysaccharide exposure on schizophrenia-like behavior and the kynurenine pathway in rodent models 

      Zheng, Yiran (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-11-20)
      Immune activation contributes to the pathophysiology of schizophrenia. The kynurenine pathway, serving as the primary route of tryptophan catabolism, has been posited as a potential link between immune activation and the ...
    • Clinical and physiological consequences of preoxygenation using high-flow nasal oxygen in emergency anaesthesia 

      Sjöblom, Albin (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-11-10)
      Emergency anaesthesia is usually performed using a rapid sequence induction technique. The incidence of desaturation during rapid sequence induction is high, and preoxygenation prolongs the safe apnoea time. Apnoeic ...
    • Mechanistic analyses of hepatocyte plasticity 

      Oliva-Vilarnau, Nuria (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-11-07)
      Adult hepatocytes are highly plastic cells which have a molecular toolbox for efficient regeneration. Yet, end stage liver diseases are becoming an increasing clinical burden. Currently, most knowledge on the underlying ...
    • Invasive fungal infections in immunocompromised hosts : epidemiology and diagnostics 

      Krifors, Anders (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-10-16)
      This doctoral project aimed to attain a more in-depth knowledge of the epidemiology and diagnosis of invasive fungal infections. In Study I, we evaluated the diagnostic performance of PCR/ESI-MS. This novel broad- ...
    • Fate selection in the neural crest lineage and its regulation 

      Akkuratova, Natalia (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-08-16)
      The neural crest is a transient embryonic progenitor cell population that generates a diverse array of cell and tissue types, including cartilage, bone, teeth, soft connective and adipose tissues, peripheral sensory and ...
    • Personnel selection in tactical intervention units 

      Tedeholm, Peter G (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-08-09)
      Amid the increasing complexities and unpredictability of terrorism, the competence of tactical Intervention units is important. This doctoral thesis examines tactical intervention units, emphasizing the work-related ...
    • On sperm nuclear zinc and chromatin decondensation : an in vitro study on the physiology of the ejaculated human spermatozoon 

      Björndahl, Lars (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 1986-05-07)
      Ejaculated human spermatozoa were studied in vitro with respect to their capacity to decondense the chromatin in sodium dodecyl sulfate (SDS). The content of zinc in sperm heads was studied in epididymal, vasal, and ...
    • Novel in vitro systems elucidating metabolic health and disease 

      Shen, Joanne X. (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-05-22)
      The convoluted nature of biology warrants improved models that further insights into health and disease. Bioengineered features and platforms allow the modulation and study of a range of biological phenomena. However, there ...
    • Pathophysiological characterization of traumatic brain injury using novel analytical methods 

      Åkerlund, Cecilia (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-05-02)
      Severity of traumatic brain injury is usually classified by Glasgow coma scale (GCS) as “mild”, "moderate" or "severe’, which does not capture the heterogeneity of the disease. According to current guidelines, intracranial ...
    • Exploration of novel hepatic In-vitro systems for drug metabolism and pharmacokinetic studies 

      Preiss, Lena Catharina (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-03-24)
      The development of a novel drug is a highly cost-intensive and risky process and many drug candidates fail on the way to final approval. An important task during this development is to investigate the absorption, distribution, ...
    • Objective diagnostics of tinnitus 

      Edvall, Niklas K. (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-03-02)
      Background: Tinnitus is the phantom perception of sound reported by around 14% of the population. For over 120 million people worldwide tinnitus is perceived as a major problem. Still, tinnitus is a heterogenous condition ...
    • Complement mediated synapse elimination in schizophrenia 

      Gracias Lekander, Jessica Florentina (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-02-23)
      Schizophrenia (SCZ) is a devastating psychiatric disorder with a typically age of onset in late adolescence. The heritability is estimated to be in between 60-80% and large-scale genome-wide studies have revealed a prominent ...
    • Studies of experimental brain trauma and ischemia : effects of Epo 

      Blixt, Jonas (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-12-22)
      Traumatic brain injury has attained a lot of scientific and clinical focus during a considerable amount of time but is still as of today regarded a highly lethal condition with a high degree of morbidity amongst the ...