Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics: Recent submissions
Now showing items 61-80 of 319
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3D imaging and quantitative analysis of intact tissues and organs
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-04-17)Embryonic development and tumor growth are highly complex and dynamic processes that exist in both time and space. To fully understand the molecular mechanisms that control these processes, it is crucial to study RNA ... -
VEGF-B in islet of langerhans : role in vascular signaling and lipid handling
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-02-13)The discovery of Vascular endothelial growth factor (VEGF)-B’s role in endothelial fatty acid uptake and tissue lipid accumulation opened a new arena for exploration of VEGF-B in lipid metabolism. Indeed, later studies ... -
Novel methods to study genomic fragility and structural variation
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-11-15)DNA double-strand breaks (DSBs) are major DNA lesions that when repaired unfaithfully can give rise to loss of genetic information, chromosomal rearrangements such as insertions/deletions (indels) and copy number alterations ... -
Electrophysiological and molecular diversity of forebrain interneurons
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-09-25)Despite their low abundance, telencephalic interneurons demonstrate a great amount of molecular and electrophysiological heterogeneity, suggesting that they exhibit different functions within the circuit. Interneurons are ... -
Single-stranded DNA : methods and application in nanotechnology
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-09-13)Basic molecular and cell research, production of recombinant proteins, diagnostic detection of genetic mutations, construction of nanostructures and high-throughput DNA sequencing are only a few examples of the diverse set ... -
Long non-coding RNAs in the epigenetic regulation of oligodendrocyte differentiation
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-08-08)Long non-coding RNAs (lncRNAs) constitute a heterogeneous class of RNAs with limited coding potential, united by an arbitrarily placed cut off of >200 ntd. The past decade has seen the emergence of lncRNAs as versatile ... -
On GABAergic interneuron diversity and maturation
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-23)GABAergic interneurons provide finely, distinct styles of inhibition granted by their unique targeting preferences, molecular profiles, and morphological silhouettes. A central quest of my thesis was to explore what ... -
Applications of DNA origami encoded nanoscale patterns
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-15)It was almost four decades ago when the recognition of DNA’s potential use as a programmable, self-assembling building material for nanostructures led to the birth and rapid expansion of the field of DNA nanotechnology, ... -
Shedding light on the STAT3 small molecule inhibitor field
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-13)STAT3 is one of the seven family members of the STAT transcription factor family. STAT3 has become a very attractive target for cancer therapy and other diseases. It has a prominent role in cancer development as well as ... -
Metabolic disorders : genes and mechanisms
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-07)Mitochondrial disorders constitute a subgroup of the large family of rare monogenic diseases called Inborn Errors of Metabolism (IEM), but defects in mitochondrial activity have also been reported in more common and complex ... -
Specification of enteric neuron subtypes in the developing gut
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-06)The enteric nervous system (ENS) is the biggest subdivision of the peripheral nervous system and harbors more neurons than the spinal cord. Its intricate network of ganglia is spanning the entire length of the gastrointestinal ... -
tPA mediated activation of PDGF-C/PDGFRα signaling in the CNS
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-03)The platelet derived growth factors (PDGFs) and their tyrosine kinase receptors play an essential role during development, in adult tissue homeostasis and in several pathological events. PDGF-CC, a ligand for PDGFRα, is ... -
Effects of design choices on the stiffness of wireframe DNA origami structures
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-04-24) -
Regeneration and neural circuits in the spinal cord : an imaging study on zebrafish
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-03-14)The reversal of spinal cord injury (SCI) and its devastating effect on voluntary control is one of the most provocative challenges in neuroscience research. Preclinical and clinical research has for a very long time tried ... -
Molecular mechanisms and targets of new anticancer treatments
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-02-06)The work presented in this thesis is an effort to decipher and understand the mechanism of action (MOA) of anticancer agents by building on and complementing chemical proteomics methods. The backbone of the thesis relies ... -
Decoding the contribution of transcription factors to cell fate determination
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-11-19)It is well accepted that transcription factors (TFs) play a crucial role in determining cell identity. Although RNA expression or protein abundance data show that a large fraction of the total TFs are expressed in a given ... -
Kidney diseases : insights from omics approaches
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-11-12)Chronic kidney diseases (CKDs) affects about 11-15% of adults worldwide. When it progresses to the end-stage renal disease (ESRD), there is no effective medication for cure, the only treatment being chronic dialysis or ... -
Lineages and molecular heterogeneity in the developing nervous system
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-09-28)Information in the genome unfolds through a dynamic process leading to the molecular and anatomical organization of a physiologically functional organism. The nervous system is the most diverse and intricate architecture ... -
From genes to function in autoimmunity : a salty story
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-05-24)Autoimmunity is a condition in which the ability to tolerate self breaks down, resulting in immune responses against the body’s own healthy cells and tissues. Autoimmune diseases are complex and multifactorial, and both ... -
Functional investigation of prognostic biomarkers and therapeutic targets in glioma brain tumors
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-04-06)Gliomas are known to be the most prevalent primary tumors of the central nervous system, of which glioblastoma is the most aggressive type with a median survival less than 2 years and no available cure. Studies in this ...