Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics: Recent submissions
Now showing items 81-100 of 320
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Functional investigation of prognostic biomarkers and therapeutic targets in glioma brain tumors
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-04-06)Gliomas are known to be the most prevalent primary tumors of the central nervous system, of which glioblastoma is the most aggressive type with a median survival less than 2 years and no available cure. Studies in this ... -
Design and analysis of wireframe DNA nanostructures
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-04-05)In the last decades, the powerful self-assembly properties of DNA have been harnessed to produce complex structures at the nanoscale with high precision and yield. DNA origami is one of the most robust examples of this, ... -
Roles of NUDT5 and NUDT15 beyond oxidized nucleotide sanitation and their potential as therapeutic targets
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-03-15)The nucleotide precursor pool is readily susceptible to numerous sources of modification and damage, including alkylation, deamination and oxidation/nitrosylation, among others; most of which have deleterious effects on ... -
Identification of novel Wnt/PCP signaling regulators and their role in midbrain dopaminergic neuron development and Parkinson's disease
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-03-08)Wnt signaling controls a wide spectrum of complex cell responses during prenatal development, in the adulthood and during disease. In this doctoral study, we have identified and explored novel regulatory components of ... -
Endothelial : mural cell interplay in regulation of blood- and lymph vessel development and function
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-12-21)Blood- and lymphatic vascular development and homeostasis depend on correct endothelial-mural cell interaction, and dysregulation thereof is apparent in multiple human diseases. However the mechanisms controlling the ... -
Novel aspects of atherosclerosis : focusing on new target genes and the effect of cholesterol-lowering
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-12-15)Atherosclerosis is most often the main underlying cause of cardiovascular diseases (CVDs), accounting for more than 31% of all deaths worldwide. It is driven by the uptake of low-density lipoproteins (LDL) by a dysfunctional ... -
Eicosanoids and exosomes : a link between macrophages and lung cancer
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-11-01)Chronic inflammation increases the risk of lung cancer. Macrophages (MO) are important players in inflammation, with regulatory and executive functions. Eicosanoids and exosomes can be both triggers and mediators of these ... -
Cell wall remodeling proteins in Mycobacterium tuberculosis : structure, function and inhibition
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-10-27)The complex and peculiar cell wall architecture is vital for the survival of M. tuberculosis in the host and therefore an established target for several currently used drugs. Understanding of the cell wall maintenance and ... -
Molecular and cellular characterization of midbrain dopaminergic neuron development
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-08-18)Midbrain dopaminergic (mDA) development is a complex yet highly controlled mechanistic process that is conserved across species. The understanding of these molecular details can open windows to new avenues of therapeutic ... -
The role of CTLA-4 in health and autoimmune disease
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-05-19)FOXP3+ regulatory T (Treg) cells are powerful regulators of the immune system, as shown by the development of multi-organ autoimmunity in mice and men upon loss or dysfunction of these cells. Whilst Treg cells are vital ... -
Calcium signaling and network activity : mathematical modeling and molecular mechanisms
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-05-17)The calcium (Ca2+) ion is a versatile second messenger present in all cells. It is involved in such diverse processes as cell division, differentiation, vesicle transport and muscle contraction. Its widespread applicability ... -
Computational exploration of the medium-chain dehydrogenase/reductase superfamily
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-05-11)The medium-chain dehydrogenase/reductase (MDR) superfamily is a protein family with more than 170,000 members across all phylogenetic branches. In humans there are 18 representatives. The entire MDR superfamily contains ... -
Discovering cell-type dynamics in the nervous system by single-cell transcriptomics
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-04-21)The mammalian nervous system is arguably the most intricate system known to science. At its basis lie highly specialized single cells, specifically interacting to ensure everything from normal functionality to complex ... -
Cysteine biosynthesis in Mycobacterium tuberculosis as potential drug target
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-04-20)The bacterium Mycobacterium tuberculosis is the underlying cause of tuberculosis, one of the most devastating infectious diseases, causing 1.4 million deaths in 2015. In addition one third of the global population is ... -
Advancing bioinformatics methods for in-depth proteome analysis based on high-resolution mass spectrometry
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-04-19)Mass spectrometry-based shotgun proteomics has become one of the essential techniques for comprehensive studies of living systems. Due to the inherent complexity of proteomes and the data, bioinformatics plays a critical ... -
Antimicrobial peptides and eicosanoids : roles and interactions in inflammation and host defense
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-04-05)Antimicrobial peptides (AMPs) have a broad spectrum of activities and exert their functions by both direct killing of microbes through the interaction with the microbial membrane, and modulation of innate and adaptive ... -
Thioredoxin and glutaredoxin systems under oxidative and nitrosative stress
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-03-16)Our knowledge about reactive oxygen species (ROS) and reactive nitrogen species (RNS) has been changed from simple damaging molecules to redox signaling mediators. ROS/RNS mediated signaling is mainly based on the reversible ... -
Identification of genetic variants and their implications in autoimmunity
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-03-03)Autoimmune disorders start to develop when the body’s immune system recognizes organs and tissues as foreign and initiates uncontrolled immune reactions against them. Most of these disorders are regarded as complex with ... -
Targeting DNA repair pathways for cancer therapy
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-01-20)Accumulation of genomic mutations is the consequence of failure in DNA repair as well as increased exposure to endogenous/environmental mutagens. DNA repair pathways safeguard the human genome from such mutagens, and thereby ... -
Deciphering Ephrin/Eph signaling pathways in cancer cells using rationally designed ligand nanoclusters
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-01-05)The dynamic link between the nanoscale spatial distribution of biomolecules and their functional impact on cellular and downstream biological behaviors has been hypothesized, but only supported by limited evidences. This ...