Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology: Recent submissions
Now showing items 21-40 of 548
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Novel molecular techniques for diagnostics and cancer biology
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-11-25)Molecular biology is reliant on a large set of increasingly complex methods. The development of high-throughput DNA sequencing almost 20 years ago kicked off a revolution in method development due to its incredible ... -
Impact of targeting MYC in metabolic reprogramming and differentiation of cancer
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-11-25)Alterations in several metabolic pathways due to increased energy and biomass demand, as consequence of the uncontrolled proliferation of cancer cells, is known as metabolic reprogramming. Mutations in tumor suppressor ... -
Understanding allergies : how infections affect the function of T helper cells
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-11-24)Allergic disorders are caused by a combination of hereditary and environmental factors. The hygiene hypothesis postulates that early-life microbial exposures impede the development of subsequent allergic diseases. However, ... -
Characterisation of nanobodies directed against emerging viruses
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-11-02)The emergence of new viral pathogens, such as SARS-CoV-2, or re-emergence of known pathogens, like CHIKV, point out the need for further understanding of the biology behind viruses, as well as the urgent need for the ... -
Exploring the interaction between the human microbiota and infections
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-10-26)The microbiota is a living ecosystem that is influenced by a variety of host and environmental factors. Distinct microbiota colonizes various body sites, such as the gastrointestinal system and vaginal tract, corresponding ... -
Mechanisms for pneumococcal meningitis and a new vaccine platform to raise a serotype-independent protection in the host
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-09-30)Streptococcus pneumoniae is a highly relevant pathogenic bacterium, responsible for a large fraction of deaths and disease morbidity in the world. The pneumococcus remains the leading cause of life-threatening pneumonia, ... -
Exploring inter- and intra-heterogeneity in childhood neuroblastoma and pheochromocytoma
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-08-01)Neuroblastoma is the most common extra-cranial solid tumor of the sympathoadrenal cell lineage, which is a unique pediatric malignancy with remarkable inter- and intra-tumoral heterogeneity. In infants, neuroblastoma can ... -
Defining the role of migratory dendritic cells in priming T cells to mycobacteria
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-05-16)Dendritic cells (DCs) are professional antigen-presenting cells that bridge innate and adaptive immunity by priming T cells. DCs residing at body surfaces such as skin sense invading microbes and respond by internalizing ... -
Responsive nanostructured materials for bioanalyte detection and triggered antimicrobial therapy
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-04-29)Inorganic nanomaterials are attractive candidates for biomedicine as they can offer increased stability including light, temperature and chemical stability while also offering the benefits of high-throughput synthetic ... -
Exploration of factors that influence Plasmodium falciparum fitness and virulence
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-02-25)Malaria is an ancient disease that still has profound impact on human population. The virulence of the most lethal malaria parasite, Plasmodium falciparum, can be attributed to several features of the parasite. P. falciparum ... -
Towards personalized immunotherapy : development of in vitro models for imaging natural killer cell behavior in the tumor microenvironment
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-01-27)Tremendous advances in the tumor immunology field have transformed immunotherapy from a promising approach to a standard clinical practice. However, a subset of cancer patients is non-responsive to immunotherapy. More ... -
Elucidation of the molecular mechanisms of action of anti-cancer compounds reveals possible combination strategies for anti-cancer therapy
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-11-24)Cancer develops due to accumulation of mutations or epigenetic changes within normal cells, usually over a considerable period of time. When cancer patients are diagnosed at late stage, the tumor cells are often more ... -
Altered cell metabolism and migration in nasopharyngeal carcinoma
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-10-29)Nasopharyngeal carcinoma (NPC) is a subtype of head and neck cancer, originating from the nasopharynx. The etiology of NPC is considered a complex interaction between Epstein–Barr virus (EBV) infection, genetic susceptibility, ... -
Learning from primary immunodeficiencies to treat cancer
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-09-09)The immune system is a fine-tuned network of cells, tissues, organs and biological processes working together in order to protect our body. Immunodeficiency disorders occur when the body’s immune system is reduced or absent ... -
Hfq- and sRNA-mediated regulation in Neisseria meningitidis
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-09-03)Neisseria meningitidis, also known as the meningococcus, is a human-specific pathogen that commonly colonises the nasopharynx without causing disease. For reasons unknown, N. meningitidis can traverse the nasopharyngeal ... -
Receptor tyrosine kinase signaling and extracellular matrix cues in ovarian cancer metastasis and drug resistance
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-08-09)Albeit many studies have contributed towards understanding the origin, development, treatment response and evolution of high-grade serous ovarian carcinoma (HGSC), the exact supporting mechanisms are still not fully ... -
Targeting MYC and CDK2 in cancer : impacts on senescence, apoptosis and immune modulation
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-05-27)Cancer is a disease in which cells acquire the ability to divide uncontrollably and invade other tissues. An important component of this process is the activation of oncogenes and inactivation of tumor suppressor genes. ... -
RNA-mediated gene regulation in Neisseria meningitidis and other nasopharyngeal pathogens
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-05-07)Neisseria meningitidis is a transient commensal bacterium of the upper respiratory tract and spreads through respiratory secretions produced by the carrier. While mostly harmless, the bacterium can cause invasive meningococcal ... -
Pattern recognition and iNKT cell regulation of B cell activation
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-05-05)The immune system protects individuals against infections but can cause disease if the response is unbalanced. Immune responses include both innate and adaptive response, and these systems are connected. As the first line ... -
The role of oestrogens and antibiotics on the development of cancer
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-04-29)Despite advances in cancer treatment and surgery, cancer-related mortality remains the leading cause of death globally, harvesting over ten million lives annually. While the risk factors are both hormonal and non-hormonal, ...