Publications from KI: Recent submissions
Now showing items 201-220 of 10116
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Pathophysiological role and therapeutic potential of extracellular vesicles in cancer
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-01-04)Extracellular vesicles (EVs) are nanosized lipid bilayer vesicles that are endogenously generated through various biogenesis pathways within most cellular entities. Subsequently, they are released into the extracellular ... -
Cellular and molecular mechanisms of inflammatory arthritis and fibromyalgia
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-01-03)In Study I, we examined the impact of the hR100E-NGF mutation on inflammatory pain and bone erosion in both female and male mice. Our findings indicate that the hR100E-NGF mutation did not affect the development of the ... -
Pathophysiology of myocardial infarction with non-obstructive coronary arteries and Takotsubo syndrome
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2024-01-03)Introduction: The working diagnosis myocardial infarction with non-obstructive coronary arteries (MINOCA), with the subgroup myocardial infarction with normal coronary arteries (MINCA), encompasses conditions of diverse ... -
Appeasing the wheezing : determinants and outcomes of respiratory disease in childhood
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2024-01-03)The aim of this thesis was to study the determinants and outcomes asthma and cystic fibrosis in childhood by using study populations of persons born in Sweden and data from a clinical cohort and national health and demographic ... -
Targeting immune and desmoplastic tumor microenvironment to sensitize gynecological cancer cells to therapy
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2024-01-02)Cancer is a pervasive global threat that manifests with diverse clinical attributes and notable mortality rates, particularly attributable to its metastatic potential in solid cancers. These tumours encompass various types ... -
Idiopathic inflammatory myopathies and cancer : familial risk, genetics and consequences
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-02)Idiopathic inflammatory myopathies (IIMs) are a group of rare rheumatic inflammatory diseases (RIDs), characterised by a diverse range of clinical, serological and histopathological characteristics, with muscle weakness ... -
Methodological challenges in pregnancy pharmacoepidemiology : the case of antiseizure medication and offspring neurodevelopment
(Inst för global folkhälsa / Dept of Global Public Health, 2024-01-02)This thesis is driven by the overarching aim of elucidating methodological challenges inherent in pharmacoepidemiology during pregnancy, with a particular focus on antiseizure medications. In Study I, a substantial surge ... -
Interventional closure of persistent foetal cardiac shunts including PDA and PFO : study of outcome, complications and novel methods
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-12-28)Background: Persistent foramen ovale (PFO) and persistent ductus arteriosus (PDA) are two of the most common congenital heart defects (CHD). The incidence of PFO is reported to be between 10% and 35% (1, 2). In term infants, ... -
Congenital heart disease, genetic syndromes, and childhood cancer
(Institutet för miljömedicin / Institute of Environmental Medicine, 2023-12-27)Childhood cancer is a diverse group of rare diseases and remains a significant global concern, despite substantial improvements in survival outcomes. Yet, little is known about its etiology. Certain congenital disorders, ... -
Tau pathology in Alzheimer's disease and other dementias : translational approach from in vitro autoradiography to in vivo PET imaging
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2023-12-27)Tauopathies, including Alzheimer's disease (AD), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), are complex neurodegenerative disorders characterized by the pathological accumulation of tau ... -
Moral stress among Swedish health care workers during the COVID-19 pandemic : a cross-sectional study
(Inst för global folkhälsa / Dept of Global Public Health, 2023-12-21)Aims: This study quantifies to what extent Health care workers (HCWs) experienced moral stress and to what extent their experiences of moral stress were related to gender and age as well as to working directly with COVID-19 ... -
Dealing with difficult choices : a qualitative study of experiences and consequences of moral challenges among disaster healthcare responders
(Inst för global folkhälsa / Dept of Global Public Health, 2023-12-21)Background: Disasters are chaotic events with healthcare needs that overwhelm available capacities. Disaster healthcare responders must make difficult and swift choices, e.g., regarding who and what to prioritize. Responders ... -
Therapeutic and prognostic strategies in neuroblastoma : exploring nuclear hormone receptors, MYC targets, and DIAPH3
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-12-21)Neuroblastoma (NB) is a pediatric cancer derived from the cells of neural crest origin that form the sympathoadrenal system. Typically, the tumor cells migrate along the spinal cord and spread to the chest, neck, and/or ... -
Vulvar cancer : patterns of recurrence, quality of life and extended indications for the sentinel node technique
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-12-18)Background: Vulvar cancer is a rare malignancy and few studies have addressed the course of disease and the impact of physical and psychological symptoms on healthrelated quality of life (HRQOL) over time. In addition, ... -
Identifying individuals at risk of fragility fractures in a dental setting
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2023-12-15)Introduction: The increasing life expectancy is only positive if the added years are healthy years. Fragility fractures are most common in older adults, and they can result in lowered quality of life and high costs for the ... -
Anterior cruciate ligament injuries : studies on the adverse events and long-term outcomes
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-12-15)The overall aims of this thesis were to identify the main adverse events after anterior cruciate ligament (ACL) injuries, to study the clinical presentation and the consequences of the adverse event (post-operative septic ... -
The single leg squat in clinical testing : aspects of reliability, validity, and associated factors
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2023-12-13)Background: The Single Leg Squat (SLS) test is a functional test widely used in clinical settings to examine and evaluate rehabilitation goals. Research indicates that the SLS is reliable when the knee relative to the foot ... -
Mental illness in chronic kidney disease : prognosis, drug utilization, and treatment outcomes
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-12-11)Chronic kidney disease (CKD) is a common yet heterogeneous condition, covering a wide spectrum of disease severity ranging from mildly decreased kidney function to kidney failure. Patients with CKD can often encounter ... -
From oral infection to autoimmunity : studies of antibodies and B cells on the path towards rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-12-08)Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammation of the synovial joints, which can lead to irreversible joint destruction and disability if not treated properly. The majority ... -
Charting genomic heterogeneity in tumours : from bulk to single cell
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-12-06)Tumours do not consist of a single homogeneous population but are complex heterogeneous systems that contain billions of ever-evolving cells with no two tumours being the same. Tumour heterogeneity is present at three ...