Publications from KI: Recent submissions

Now showing items 181-200 of 10116

    • Comorbidities in early rheumatoid arthritis 

      Tidblad, Liselotte (Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-23)
      All of the studies that form part of this thesis concern the subject of comorbid conditions in early rheumatoid arthritis (RA). We have used linkage of Swedish clinical and demographic registers as well as the Swedish ...

    • Prostate cancer : investigating diagnosis, treatment and outcomes 

      Möller, Axel (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-01-19)
      Background: Prostate cancer is difficult to study. The prostate is located so that it is hard to palpate and because of the dense pelvic bones it is hard to visualize using radiology such as computed tomography. The prostate ...

    • Exploring signaling pathways in endothelial mechanotransduction 

      Zhang, Yumeng (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-01-19)
      Mechanotransduction, the process by which cells sense and convert mechanical forces from their surroundings, plays a pivotal role in cellular function. For vascular endothelial cells, coping with the continuous and significant ...

    • Airway hyperresponsiveness and viral recognizing toll-like receptors 

      Starkhammar, Magnus (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-01-18)
      Common colds caused by viruses are, in healthy individuals, usually self-limited and with relatively mild symptoms. In asthmatic individuals, respiratory viruses can burst the defense immune system and trigger asthma ...

    • Immune cell-derived adipokines : role in white adipose tissue function and link to metabolic health 

      Hofwimmer, Kaisa (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-01-17)
      The white adipose tissue (WAT) is home to a vast array of immune cells that control local homeostasis and metabolism by engaging in intricate crosstalk with adipocytes and their precursors through secreted factors (adipokines). ...

    • Protein and MRI profiling of genetic frontotemporal dementia 

      Ullgren, Abbe (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-01-17)
      Frontotemporal dementia (FTD) is a group of neurodegenerative diseases with a wide range of symptoms such as loss of inhibition and social cognition, language impairment and motor dysfunction. Genetic FTD, characterized ...

    • Prenatal risk factors for severe cardiovascular diseases up to middle-age : a Nordic collaborative study 

      Yang, Fen (Inst för global folkhälsa / Dept of Global Public Health, 2024-01-16)
      Background and objectives: Cardiovascular diseases (CVDs) are major causes of death and disability. However, the established traditional risk factors cannot explain a substantial proportion of CVD cases, prompting ...

    • On cardiovascular complications in people with type 2 diabetes : Aspects of incretin-based therapy and glycemic control 

      Santos Pardo, Irene (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-01-15)
      Background: Hyperglycemia, insulin resistance, and the presence of advanced glycation end products are key features of type 2 diabetes (T2DM) and the leading mechanisms behind the increased cardiovascular risk observed in ...

    • The dimensions of human and murine CD8 T lymphocyte diversity 

      Zwijnenburg, Anthonie Johan (Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-12)
      The adaptive immune system generates and maintains a pool of CD8+ T cells with an almost limitless specificity with the purpose of maintaining homeostasis. Upon antigen encounter, CD8+ T cells undergo functional diversification ...

    • Skeletal muscle responses to physical activity in health and metabolic disease 

      Smith, Jonathon Alexander (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-01-12)
      Sedentary lifestyles, characterised by a lack of physical activity and prolonged periods of sitting, have been linked to reductions in whole-body metabolic flexibility and the increased risk of metabolic diseases, including ...

    • Enhanced mobilisation and physical rehabilitation after abdominal cancer surgery : feasibility, effects, and experiences 

      Karlsson, Patrik (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-01-11)
      Cancer incidence is growing worldwide and, as advances in diagnostics, treatment, and rehabilitation are made, the numbers of cancer survivors are also increasing. Therefore, there is a need to find and evaluate methods ...

    • Aspects on heart failure and drug treatment in geriatric patients 

      Reimers Wessberg, Marianne (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-01-10)
      Background: Patients with chronic heart failure (HF) are very common in geriatric care, but the prevalence of different types of HF and comorbidities, as well as the nature of investigations, treatment, planning and outcome ...

    • Modifiable risk factors, blood proteins, and venous thromboembolism 

      Yuan, Shuai (Institutet för miljömedicin / Institute of Environmental Medicine, 2024-01-09)
      Venous thromboembolism (VTE) refers to blood clots in the veins, which is an underappreciated vascular disease that can cause disability and mortality. Although some triggers for VTE (e.g., surgery, fracture, infection, ...

    • The role of endoglin in vascular patterning and malformation across diverse vascular beds 

      García Collado, María (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-01-09)
      During development, numerous processes must be finely orchestrated to construct a functional vasculature, essential to sustain life. Hereditary haemorrhagic telangiectasia is a disease characterised by the development of ...

    • Moral conflicts in health crises : Swedish health care workers’ experiences and management of moral stress 

      Gustavsson, Martina E. (Inst för global folkhälsa / Dept of Global Public Health, 2024-01-09)
      Background: In health crises, elevated patient needs, and scarce resources may pose moral challenges for healthcare workers (HCWs), as they must prioritize and make complex professional decisions regarding the provision ...

    • Polycystic ovary syndrome and maternal obesity : does it programme transgenerational dysfunction? 

      Lu, Haojiang (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-01-08)
      As one of the most prevalent syndromes among reproductive-aged women, polycystic ovary syndrome (PCOS) manifests with endocrine, reproductive and metabolic disturbances. However, the etiology of PCOS is yet to be fully ...

    • Randomised clinical trials with hyperbaric oxygen in COVID-19 and Long COVID : transcriptomic insights into benefits and harms 

      Kjellberg, Anders (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-01-08)
      The flow from transcription of genes through translation and processing of proteins is a common basis for all life. Redox homeostasis is crucial for the defence against oxidative stress. We adapt through hormesis; non-lethal ...

    • Diverticular disease of the colon - risk factors and validation of diagnosis 

      Mahmood, Wael Mahmood (Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2024-01-08)
      Diverticular Disease (DD) is a common gastrointestinal disease, particularly among the population in western countries. The aetiology of DD is complex and have not yet been established conclusively. Dietary habits and ...

    • From cytologic features to serum markers: advancing prognostication of uveal melanoma 

      Herrspiegel, Christina (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-01-08)
      Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. As surveys show, almost all patients diagnosed with UM want prognostic information. However, the tools available today for early prognostication ...

    • On suicide and self-harm in university students and outcomes in persons with bipolar disorder and their offspring 

      Takami Lageborn, Christine (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2024-01-05)
      Suicide is one of the leading causes of death in young persons in Sweden and globally. The last decades have seen an increasing proportion of the youth population engaging in university level education. The university ...