Now showing items 21-40 of 8535

    • Association between metformin use and risk of esophageal squamous cell carcinoma in a population-based cohort study 

      Wang, Qiao-Li; Santoni, Giola; Ness-Jensen, Eivind; Lagergren, Jesper; Xie, Shao-Hua (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and SurgeryHUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, NorwayMedical Department, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, NorwaySchool of Cancer and Pharmaceutical Sciences, King's College London, United Kingdom, 2020-03-11)
      Objectives: Esophageal cancer is a highly fatal malignant neoplasm, with two etiologically different histological types. A large prospective study is expected to elucidate the specific risk of the 90% subtype of esophageal ...
    • Brain development in a dish 

      Pronk, Robin Johan (Inst för neurovetenskap / Dept of Neuroscience, 2020-03-06)
      This thesis shows the path I took in the quest for modeling the brain, as the title says, in a dish. The introduction of induced pluripotent stem cells (iPSCs) as means to research biological processes has opened up whole ...
    • Molecular approaches for characterization, diagnosis and therapy of allergy to pets 

      Wintersand, Anna (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-03-06)
      Allergy to furred animals is a common affliction, where up to 20% of the population in affluent countries are sensitized to one or more pet allergens. Several causative allergens from an array of species have been identified, ...
    • Scalable, safe and GMP-compatible production of embryonic stem cell derived retinal pigment epithelial cells 

      Padrell Sánchez, Sara (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-03-06)
      Regenerative medicine is an exponentially growing field that aims to regenerate a lost function, cell type or tissue due to damage, ageing or disease. Currently, more than 30,000 gene- and cell-based therapies have been ...
    • Clinical aspects of Lynch syndrome 

      Salomé, Jenny von (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-03-05)
      Colorectal cancer is the second most common cancer in women and the third most common cancer in men worldwide, with 1.8 million new cases and almost 861000 deaths in 2018. Approximately 5–10% of the annual CRC burden can ...
    • p53-dependent and -independent mechanisms of p53-targeting small molecules 

      Zhu, Jiawei (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-03-05)
      Tumor suppressor p53 (Tp53) is mutated in around half of human cancers, while in wild type p53 cells its activity is continuously inhibited by MDM2 through proteasome degradation resulting in the loss of its function. ...
    • Genetic and epigenetic studies of acute myeloid leukemia and therapeutic possibilities 

      Mujahed, Huthayfa (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-03-05)
      Acute myeloid leukaemia (AML) is malignant tumour that forms in the bone marrow and arises from immature myeloid progenitors. Consequently, this leads to excessive accumulation of dysfunctional blast cells and lack of ...
    • Elucidating the role of DNA damage and human cytomegalovirus in medulloblastoma and glioblastoma 

      Bartek, Jiri (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-03-05)
      The most common primary malignant brain tumor in children is Medulloblastoma, while Glioblastoma is the most common in adults. Treatment for both include some combination of surgery, radiation therapy, and chemotherapy. ...
    • Penumbra oxygen metabolism and acute neuroinflammation in ischemic stroke : MRI and PET imaging of a M2 occlusion model in rat 

      Little, Philip (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-03-04)
      Acute ischemic stroke (AIS) is caused by the sudden occlusion of a major artery of the brain, and results in infarction and severe ischemia within affected brain regions. If ischemic regions are rapidly revascularized, ...
    • Awareness of fetal movements and pregnancy outcomes 

      Akselsson, Anna (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2020-03-03)
      Fetal movements are one, among others, of the measurable factors indicating wellbeing of the fetus. Decreased fetal movements are associated with intrauterine growth restriction and stillbirth. Women with experience of ...
    • Hepatic ischemia-reperfusion injury 

      D'Souza, Melroy Alistair (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-02-28)
      Hepatic ischemia-reperfusion (I/R) injury is a complex phenomenon occuring in response to interruption of the liver’s blood and oxygen supply and the subsequent restoration of blood flow and tissue oxygenation. Techniques ...
    • Focus on fibroblasts : development, plasticity, and therapeutic challenges in the cardiac fibroblast lineage. 

      Palano, Giorgia (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-02-28)
      Cardiac fibroblasts (CFs) are cells of mesenchymal origin and represent a heterogeneous population in the mammalian heart. They secrete extracellular matrix (ECM) molecules providing structural support during heart development ...
    • Exploring the impact of virtual patient design : medical students' small group learning around medical error 

      Woodham, Luke A. (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2020-02-27)
      Background: The demands on medical and healthcare practitioners are continuously changing, with new technologies, treatments and regulatory guidelines emerging each year. One such example is increased focus on the impact ...
    • Coronary angiography in out-of-hospital cardiac arrest : why, when and for whom? 

      Elfwén, Ludvig (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-02-27)
      Study I. A national observational retrospective study, evaluating the effect on survival of early coronary angiography vs. no early coronary angiography in witnessed, unconscious OHCA patients with shockable rhythm and ...
    • Development of novel synthetic lung surfactants for treatment of respiratory distress syndrome 

      Basabe Burgos, Oihana (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-02-26)
      Pulmonary surfactant is a complex mixture of lipids and specific proteins found in the alveoli and its main role is to reduce the surface tension of the alveolar air/water interface, thereby preventing lung collapse. ...
    • Prevention and prognosis of cervical cancer : the interplay of human papillomavirus, vaccination and screening 

      Lei, Jiayao (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-02-26)
      Human papillomavirus (HPV) is the major cause of cervical cancer. The well-established natural history from HPV infection to the occurrence of invasive cervical cancer serves as the basis for prevention of cervical cancer ...
    • Treating postpartum emotional distress by a short-term psychodynamic infant-parent intervention integrated with Child Health Center care 

      Kornaros, Katarina (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2020-02-24)
      Objective: The thesis had two aims. (1) To qualitatively explore the perspectives of CHC nurses’ (study I) parents’ (II) and psychotherapists’ (III) in receiving/offering SPIPIC (Short-term Psychodynamic Infant-Parent ...
    • Sarcoidosis : expression of cell regulatory markers and the influence of patient phenotype on bronchoalveolar lavage cell differential counts 

      Abo Al Hayja, Muntasir (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-02-21)
      Sarcoidosis is a systemic inflammatory disease that can affect almost any organ, but the respiratory system is affected in more than 90% of the cases. To elicit an immune response, an antigen(s) is processed by ...
    • Hearing in Children with cleft palate 

      Tengroth, Birgitta (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-02-21)
      Objective: The overall aim of this thesis was to collect longitudinal information about hearing thresholds and complications due to otitis media with effusion (OME) in children with cleft palate. Since OME is highly prevalent ...
    • Prognostic factors for whiplash associated disorders 

      Rydman, Eric (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-02-21)
      Disability and chronic pain secondary to low- speed vehicle collisions has been a known condition since the nineteenth century. Today, whiplash-associated disorders (WAD) are the most common personal injuries reported to ...