Now showing items 21-40 of 8887

    • Complications following anterior cruciate ligament reconstruction 

      Kraus Schmitz, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-02-16)
      Background: Venous thromboembolism (VTE) and septic arthritis (SA) are two rare complications following anterior cruciate ligament reconstruction (ACLR). Due to their rare incidence, risk factors and outcome are difficult ...
    • Population and single-cell analysis of human cardiogenesis reveals unique LGR5 ventricular progenitors in embryonic outflow tract. 

      Sahara, Makoto; Santoro, Federica; Sohlmér, Jesper; Zhou, Chikai; Witman, Nevin; Leung, Chuen Yan; Mononen, Mimmi; Bylund, Kristine; Gruber, Peter; Kenneth R., Chien (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-15)
      The morphogenetic process of mammalian cardiac development is complex and highly regulated spatiotemporally by multipotent cardiac stem/progenitor cells (CPCs). Mouse studies have been informative for understanding mammalian ...
    • Genome‐wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors 

      Xu, Jiejia; Zhou, Chikai; Foo, Kylie S.; Yang, Ran; Xiao, Yao; Bylund, Kristine; Sahara, Makoto; Chien, Kenneth R. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-15)
      Cardiac progenitor formation is one of the earliest committed steps of human cardiogenesis and requires the cooperation of multiple gene sets governed by developmental signaling cascades. To determine the key regulators ...
    • Mechanisms of cancer cell death by mutant p53-reactivating compound APR-246 

      Ceder, Sophia (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-02-11)
      Tumor suppressor TP53 is the most frequently mutated gene in cancer. A majority of TP53 mutations result in a mutant p53 that disrupts its DNA binding capabilities but may also acquire novel gain-of-function activities ...
    • To be a child and survive a natural disaster 

      Adebäck, Petra (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-02-09)
      Introduction: Despite the fact that children or adolescents often are exposed to disasters, we do not know what happens to these children or adolescents in the end. Much of the international research has been concerned ...
    • Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure 

      Merid, Simon Kebede; Bustamante, Mariona; Standl, Marie; Sunyer, Jordi; Heinrich, Joachim; Lemonnier, Nathanaël; Aguilar, Daniel; Antó, Josep Maria; Bousquet, Jean; Santa-Marina, Loreto; Lertxundi, Aitana; Bergström, Anna; Kull, Inger; Wheelock, Åsa M.; Koppelman, Gerard H.; Melén, Erik; Gruzieva, Olena (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, SödersjukhusetKarolinska Institutet, 2021-02-09)
      Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this ...
    • Assessment of chronic bronchitis and risk factors in young adults : results from BAMSE 

      Wang, Gang; Hallberg, Jenny; Bergström, Petra Um; Janson, Christer; Pershagen, Göran; Gruzieva, Olena; van Hage, Marianne; Georgelis, Antonios; Bergström, Anna; Kull, Inger; Lindén, Anders; Melén, Erik (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-02-09)
      BACKGROUND: Chronic bronchitis is associated with substantial morbidity among elderly adults, but little is known about its prevalence and risk factors in young adults. Our aim was to assess the prevalence ...
    • Selenite induces apoptosis in sarcomatoid malignant mesothelioma cells through oxidative stress 

      Nilsonne, Gustav; Sun, Xiaojuan; Nyström, Christina; Rundlöf, Anna-Klara; Potamitou Fernandes, Aristi; Björnstedt, Mikael; Dobra, Katalin (Inst för laboratoriemedicin / Dept of Laboratory MedicineKarolinska Institutet, 2021-02-08)
      Malignant mesothelioma cells differentiate into sarcomatoid or epithelioid phenotypes. The sarcomatoid cell type is more resistant to chemotherapy and yields a worse prognosis. We have investigated whether selenite alone ...
    • Aspects on advanced procedures during endoscopic retrograde cholangiopancreatography (ERCP) for complex hepatobiliary disorders 

      Lübbe, Jeanne Adéle (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-02-08)
      Background: The rapid development in endoscopic technology and associated skills has led to an increase in more advanced procedures being performed during endoscopic retrograde cholangiopancreatography (ERCP). Knowledge ...
    • Web-based support for young adults with reproductive concerns following cancer : development, process and outcome evaluation of a self-help psychoeducational intervention 

      Micaux, Claire (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2021-02-05)
      AIM: To describe the development process and explain the outcomes of Fex-Can Fertility, a self-help web-based psychoeducational intervention aiming to alleviate reproductive concerns in young adults with cancer. METHODS: ...
    • Microglia : health promoting pathways and therapeutic targets in ageing and neuroinflammation 

      Berglund, Rasmus (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-05)
      Microglia are the innate immune cells of the CNS with an embryonic origin and self-renew with a slow turnover throughout life. The health-promoting capacities of this cell are being acknowledged through updated and ...
    • Mind and body exercises : associations with mental health, antidepressant medication, autonomic functioning and inflammatory biomarkers 

      Rådmark, Lina (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-05)
      Stress, depression and stress-related mental ill-health are common in societies all over the world, and people tend to use both conventional care within the health care system and complementary treatment methods to handle ...
    • Innate lymphoid cell plasticity and heterogeneity in human tissues 

      Mazzurana, Luca (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-05)
      The human immune system is a vital mechanism that protects the host from outside threats. The two main branches of this system, consisting of innate and adaptive immunity, aid the host when dangers of both imminent and ...
    • Optimizing school meals today : a pathway to sustainable dietary habits tomorrow 

      Eustachio Colombo, Patricia (Inst för global folkhälsa / Dept of Global Public Health, 2021-02-03)
      Food production and consumption substantially contribute to climate change and disease. School meals can reach children of every socioeconomic background and hold a near-unique potential to foster sustainable dietary habits ...
    • MRI quantification of multiple sclerosis pathology 

      Ouellette, Russell (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-02)
      Background: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease and a common cause of neurologic disability. MS pathology is characterized by demyelination, neuroaxonal loss and atrophy. ...
    • Self-admission as a treatment tool in severe anorexia nervosa 

      Strand, Mattias (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-01)
      Self-admission to psychiatric inpatient treatment is an innovative collaborative approach to healthcare rationing that invites patients to play a more active role in deciding when they need a higher level of care. In ...
    • From oncogenic replication stress to drug resistance : F-box proteins as signalling hubs in cancer 

      Brunner, Andrä (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-01-28)
      Cancer arises from cells that acquire genetic and epigenetic changes during the course of a, sometimes decades-long, somatic evolutionary process. These changes result in deregulation of a multitude of cellular processes ...
    • The effect of a progesterone receptor modulator on the endometrium and breast in premenopausal women 

      Papaikonomou, Kiriaki (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2021-01-28)
      Background The levonorgestrel intrauterine system, LNG-IUS 52 mg, is a highly effective and costeffective contraceptive, entailing minimal patient effort. Irregular bleeding patterns are common during the first ...
    • Expression of biomarkers by peripheral nerve fibres in human masseter muscle 

      Alhilou, Abdelrahman (Inst för odontologi / Dept of Dental Medicine, 2021-01-27)
      Background: Temporomandibular disorders (TMDs) often manifest as masticatory muscle pain (myalgia). Nerve growth factor (NGF) and glutamate injection into healthy human masseter muscle induced signs and symptoms mimicking ...
    • Epidemiological aspects of sarcoidosis : risk factors and long-term consequences 

      Rossides, Marios (Inst för medicin, Solna / Dept of Medicine, Solna, 2021-01-27)
      Sarcoidosis is a systemic inflammatory disease of unknown etiology in which granulomatous lesions form mostly in the lungs and the lymphatic system of patients. Although more than a century has passed since sarcoidosis ...