Now showing items 21-40 of 9215

    • Pre-analytical errors in blood sampling procedures in paediatric hospital care 

      Hjelmgren, Henrik (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2022-01-14)
      Introduction Blood tests are important for diagnosing and treating children who are hospitalised with illnesses. The blood test process follows the specific phases of pre-analysis, analysis and post-analysis. Most ...
    • Interplay between blood-brain barrier disruption and neuroinflammation following severe traumatic brain injury 

      Lindblad, Caroline (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2022-01-13)
      A severe traumatic brain injury (TBI) holds deleterious consequences for the afflicted, its next-of-kin and society. Still today, prognosis is semi-desolate. One explanation for this might be pathophysiological processes ...
    • Adaptive immune responses to tick-borne encephalitis virus and SARS-CoV-2 

      Varnaitė, Renata (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-01-11)
      Tick-borne encephalitis virus (TBEV) and SARS-CoV-2 are two unrelated viruses that currently cause substantially different public health burdens and distinct pathologies in humans. TBEV infection leads to neurological ...
    • Modelling of steatosis and insulin resistance development in human hepatic 3d spheroids : mechanisms and genetic aspects 

      Kozyra, Mikael (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-01-10)
      Hepatic steatosis and insulin resistance are common disease manifestations seen in metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) patients. Aberrant hepatic lipid accumulation leads ...
    • Potential role of MAIT cells in cancer immunotherapy and viral infection 

      Healy, Katie (Inst för odontologi / Dept of Dental Medicine, 2022-01-04)
      Mucosa-associated invariant T (MAIT) cells are an unconventional T cell subset with specialized antimicrobial functions. In humans, MAIT cells are characterized by their effector memory phenotype, rapid cytolytic capacity, ...
    • CRISPR-based drug target discovery : implications for CRISPR-based therapies 

      Jiang, Long (Inst för medicin, Solna / Dept of Medicine, Solna, 2022-01-04)
      The CRISPR system was discovered in prokaryotic cells, and it is now one of the most efficient molecular tools to modify genes in eukaryotic cells. It is widely used to inactivate or modify genes in cell lines, animal ...
    • Engineered extracellular vesicles for biomedical applications 

      Gupta, Dhanu (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-12-28)
      Nature's very own nanoparticle, Extracellular vesicles (EVs), are lipid membrane-enclosed vesicles encapsulated with diverse biomolecules and are actively secreted by all cell types for intercellular communication. The ...
    • Mitochondrial RNA processing in health and disease 

      Laine, Isabelle (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-12-28)
      Mitochondria are often described as the powerhouses of the cell, providing the main cellular energy source in the form of adenosine triphosphate. Five enzyme complexes, collectively termed the oxidative phosphorylation ...
    • Non-coding RNA-based therapeutics and biomarkers for treatment and detection of vascular disease 

      Winski, Greg (Inst för medicin, Solna / Dept of Medicine, Solna, 2021-12-23)
      Cardiovascular disease (CVD), with atherosclerosis as its main underlying pathology, is the most prominent cause of death worldwide. Progression and rupture of atherosclerotic plaques lead to potential adverse pathological ...
    • Studies on the links between white adipose tissue phenotype and the circulatory system 

      Bäckdahl, Jesper (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-12-22)
      Obesity is a strong risk factor for cardiovascular disease. It is defined by an unhealthy excess of white adipose tissue (WAT). Adipose derived weight gains and losses are linked to changes in two other independent ...
    • Factors associated with behavioral and psychological symptoms of dementia 

      Schwertner, Emilia (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-12-22)
      Most people with dementia suffer behavioral and psychological symptoms (BPSD). These symptoms add to caregiver stress and accelerate cognitive decline. The etiology of BPSD is complex, with multiple factors influencing ...
    • Disaster response and preparedness : focus on hospital incident command groups and emergency department registered nurses 

      Murphy, Jason (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-12-21)
      Background: While disasters per definition are rare, incidents that cause mass casualties that threaten to overwhelm its limited resources are an ever-present risk. Disaster medicine is a specific discipline of medicine ...
    • Biomarkers in frontotemporal dementia : findings from the GENFI study 

      Öijerstedt, Linn (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-12-21)
      Frontotemporal dementia (FTD) is a group of neurodegenerative diseases including a wide range of clinical phenotypes, neuropathological hallmarks, and genetic causes. People with FTD typically present with deficits in ...
    • Sickness absence among patients with chronic pain in Swedish specialist healthcare 

      Lo Martire, Riccardo (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-12-20)
      Background: Chronic pain beyond three months is a global public health problem. Every third adult suffers from a chronic pain condition, resulting in a socioeconomic burden that corresponds to 3-10% of gross domestic product ...
    • Optimism and survivorship after esophageal cancer surgery 

      Liu, Yangjun (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-12-17)
      Dispositional optimism is a personality trait that represents generally favorable expectations about the future. The main aim of this thesis was to examine whether higher dispositional optimism was related to better ...
    • Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation 

      Berglund, Rasmus; Guerreiro-Cacais, Andre Ortlieb; Adzemovic, Milena Z; Zeitelhofer, Manuel; Lund, Harald; Ewing, Ewoud; Ruhrmann, Sabrina; Nutma, Erik; Parsa, Roham; Thessen-Hedreul, Melanie; Amor, Sandra; Harris, Robert A; Olsson, Tomas; Jagodic, Maja (Inst för klinisk neurovetenskap / Dept of Clinical NeuroscienceKarolinska Institutet, 2021-12-14)
      Multiple sclerosis (MS) is a leading cause of incurable progressive disability in young adults caused by inflammation and neurodegeneration in the central nervous system (CNS). The capacity of microglia to clear tissue ...
    • On astrocytes and neural stem cells : a study of reactive and canonical neurogenesis 

      Zamboni, Margherita (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-12-14)
      The mammalian central nervous system has limited regenerative capacity and the long-lasting functional impairment resulting from trauma and neurodegenerative disease derives from a failure to repopulate neuronal cell ...
    • Convergent etiology among schizophrenia, eating disorders, and other medical conditions 

      Zhang, Ruyue (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-12-13)
      Schizophrenia and eating disorders (EDs) are complex traits with considerable somatic and psychiatric morbidity. Despite distinct diagnostic criteria and few symptoms in common, significant genetic correlations between ...
    • Behavioural outcomes of treatment with selective serotonin reuptake inhibitors 

      Lagerberg, Tyra (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-12-13)
      Mood and anxiety disorders are some of the biggest contributors to morbidity worldwide, and may be lethal. Appropriate treatment is therefore paramount. Antidepressant medications constitute the primary pharmacological ...
    • Profiling of microglia in inflammation, aging, and the tumor microenvironment 

      Friess, Lara (Institutet för miljömedicin / Institute of Environmental Medicine, 2021-12-10)
      In this thesis I aim to present our ongoing efforts to elucidate activation states and how these are regulated in microglia cells. An extensive body of work is dedicated to understanding how these resident immune cells can ...