Now showing items 21-40 of 8642

    • From quality control to neurodegeneration : regulation of autophagy and the DNA damage response by ubiquitin-modifying enzymes 

      Herzog Croona, Laura Katharina (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-05-18)
      Protein homeostasis and genome integrity are safeguarded by a variety of cellular quality control pathways. While protein quality is controlled by a delicate balance between protein biosynthesis, folding and degradation, ...
    • Investigating and explaining sex differences in episodic memory 

      Asperholm, Martin (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-18)
      Sex differences can be seen in a lot of different areas, one of them being cognition where, among other things, men tend to perform better at more spatial tasks and women at more verbal. When it comes to episodic memory ...
    • Intralymphatic immunotherapy in allergic rhinitis : Evaluating safety, efficacy and mechanisms 

      Hellkvist, Laila (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-15)
      Allergic rhinitis (AR) deprives work capacity, social activities and quality of life, and costs the Swedish society about €1.3 billion annually. Allergen-specific immunotherapy (AIT) amends the symptoms and improves the ...
    • New diagnostic approaches for venous thromboembolism and thrombophilia 

      Farm, Maria (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-15)
      Background: Venous thromboembolism is a serious disease comprising both pulmonary embolism and deep vein thrombosis. Venous thromboembolism causes considerable mortality and morbidity, with residual symptoms such as pulmonary ...
    • Glutamine kinetics in critically ill patients 

      Smedberg, Marie (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-15)
      Critical illness, defined as a life-threatening organ failure, entails an extreme stress that results in a pathophysiology of its own. The abnormal metabolism of these patients causes a severe muscle wasting that is poorly ...
    • Surgeon-performed ultrasound and timing of surgery in acute cholecystitis 

      Gustafsson, Camilla (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-05-15)
      Introduction: The use of bedside ultrasound has increased, as equipment has become accessible, user friendly, and ultrasound education is expanding in many specialties. The aim of this project was to validate surgeon-performed ...
    • Methods for studying memory B-cell immunity against malaria 

      Jahnmatz, Peter (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-05-15)
      Plasmodium falciparum malaria remains one of the world’s deadliest infectious diseases and the search for an effective vaccine is highly warranted. Memory B cells (MBCs) and the antibodies they produce, once activated, ...
    • Applications of the golden angle in cardiovascular MRI 

      Fyrdahl, Alexander (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-15)
      The use of radial trajectories has been seen as a potential solution to highly efficient cardiovascular magnetic resonance imaging (MRI). By acquiring a broad range of spatial frequencies per repetition time, the acquisition ...
    • Prognosis based classification and tumor biology of uterine sarcomas 

      Hardell, Elin (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-05-15)
      Uterine stromal sarcomas are a heterogenous group of tumors ranging from low-grade stromal sarcomas with a relatively good survival but high risk of recurrence, to undifferentiated uterine sarcomas with a far worse ...
    • Psoriasis : from transcriptome to miRNA function and biomarkers 

      Pasquali, Lorenzo (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-05-15)
      Psoriasis is a chronic inflammatory, immune-mediated skin condition that affects in average 2 to 3% of the world population, phenotypically characterized by red and scaly plaques on the skin of affected patients. It is a ...
    • Genetic causes and underlying disease mechanisms in early-onset osteoporosis 

      Kämpe, Anders (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-14)
      Adult-onset osteoporosis is a disorder that affects a significant proportion of the elderly population worldwide and entails a substantial disease burden for the affected individuals. Childhood-onset osteoporosis is a ...
    • Fighting cardiometabolic disease : validation of new experimental models and therapeutic targets 

      Minniti, Mirko Enea (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-05-14)
      The prevalence of cardiometabolic diseases (CMD) such as atherosclerotic cardiovascular diseases, type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), has grown dramatically during the last decades. Hence, ...
    • MAIT cells in placental tissues and their reconstitution following allogeneic hematopoietic stem cell transplantation 

      Solders, Martin (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-05-14)
      The placenta is a temporary organ of human reproduction. Both the fetus and placenta are covered in a membrane of maternal origin, the decidua. After the 1st trimester, the fetus is supplied with oxygen and nutrients by ...
    • Sleep and obesity in children at different obesity risks : patterns, associations and early intervention 

      Xiu, Lijuan (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-13)
      Background: Childhood obesity is a global health concern with a range of adverse outcomes. Short sleep has been consistently linked to childhood obesity. However, associations between other sleep characteristics and obesity ...
    • Epidemiological studies on comorbidity, heritability and co-aggregation in organ-specific autoimmune diseases 

      Skov, Jakob (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-13)
      Autoimmunity is caused by loss of tolerance, whereby the immune system fails to distinguish self from non-self. The autoimmune panorama entails more than 100 diseases that collectively affect close to 5% of the total ...
    • Factors associated with HIV susceptibility in the female genital tract 

      Bradley, Frideborg (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-05-13)
      The majority of new HIV infections in women are transmitted through vaginal intercourse where the female genital tract (FGT) functions as the portal of viral entry. The aim of this thesis was to characterize mucosal ...
    • Is it all about the money? The effects of low and high cost simulator training scenarios in surgical training 

      Oussi, Ninos (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-12)
      Background: The learning process is complex and dependent on several factors such as for instance, the environment to learn, prior knowledge and distinct abilities, motivation, goal-orientation as well as the effects of ...
    • X-chromosome upregulation is driven by increased burst frequency 

      Larsson , Anton J. M.; Coucoravas, Christos; Sandberg, Rickard; Reinius, Björn (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and BiophysicsInst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-05-12)
      Ohno's hypothesis postulates that X-chromosome upregulation rectifies X-dose imbalance relative to autosomal genes, present in two active copies per cell. Here we dissected X-upregulation into kinetics of transcription, ...
    • The value of new sonographic modalities, demographic, biometric and proliferative variables for the risk prediction in endometrial cancer 

      Green, Rasmus (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-05-11)
      Background: Endometrial cancer is the sixth most common type of cancer among women worldwide and constitutes 4.8% of all cancer in women. The incidence is highest in highincome countries, given how age and obesity are ...
    • Implications of brief episodes of atrial fibrillation (Micro-AF) 

      Fredriksson, Tove (Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2020-05-08)
      INTRODUCTION Atrial fibrillation (AF) is the most common clinically relevant arrhythmia. It is diagnosed using an electrocardiogram (ECG) and defined as an irregular heart rhythm without p-waves lasting for at least 30 ...