Publications from KI: Recent submissions
Now showing items 21-40 of 10113
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Child health in the Democratic Republic of the Congo : exploring subnational disparities and inequities in illnesses and mortality
(Inst för global folkhälsa / Dept of Global Public Health, 2024-05-24)Background: Today, sub-Saharan Africa accounts for a disproportionally high burden of deaths in children, with the Democratic Republic of the Congo (DRC) being one of the countries with the highest mortality burden. Ample ... -
Implementing digital interventions for problematic alcohol use in the psychiatric context : visions and reality
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-05-24)The relationship between alcohol use disorder (AUD) and other mental health disorders is complex, with genetic, environmental, and causal factors at play. Comorbid AUD and psychiatric disorders lead to elevated risks of ... -
Iron deficiency in heart failure
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-05-23)Background: Iron plays a central role in several vital processes in the human body and is fundamental for organs with high energy demands, like the heart. Iron deficiency (ID) is common in patients with heart failure (HF) ... -
Tumour-draining lymph nodes in head and neck cancer : immunological signatures and clinical implications
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-05-23)The lymphatic system is responsible for orchestrating immune responses, particularly in cancer. Oral squamous cell carcinoma (OSCC) represents a significant clinical challenge, with lymphatic metastasis being a crucial ... -
Socioeconomic determinants of quality of care and outcomes in multiple sclerosis
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-05-22)Background: Multiple sclerosis (MS) is a chronic, inflammatory disease affecting the central nervous system (CNS), leading to varying degrees of neurological disability. While disease-modifying treatment (DMT) can ... -
Antibiotics in pregnancy : utilization, determinants and safety
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-05-22)Antibiotics are indispensable in maternal health. Crucial for treating and preventing bacterial infections ranging from common ailments to life-threatening conditions, antibiotics are inevitably prescribed to pregnant women ... -
Lentigo maligna melanoma, a clinicopathological and grenz rays management study
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-05-22)Lentigo maligna (LM), a neoplastic proliferation of skin melanocytes, is the in situ form of lentigo maligna melanoma (LMM) and it was first described in 1892 by a british surgeon Sir Jonathan Hutchinson. LM and LMM are ... -
Exploring synbiotic treatment in ADHD, and immune-mediated prenatal risks for neurodevelopmental disorders
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-22)The etiologies of neurodevelopmental disorders (NDDs) and psychiatric disorders are considered to be multifactorial, with both genetic and environmental factors. NDDs are associated with early atypical brain development ... -
Long-term cardiovascular assessment in women with preeclampsia
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-05-22)Background: Preeclampsia (PE) is one of the most common medical multi-organ, pregnancy-specific disorder. PE is associated with endothelial dysfunction, elevated blood pressure, and inflammation. In addition to vascular ... -
Testosterone is performance enhancing in women but challenging to detect in doping analyses
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-05-22)BACKGROUND: There is an ongoing debate whether women with testosterone (T) within the male range shall be allowed to compete in the female class in sports. In men, T has an ergogenic effect, but the effect of T in young ... -
Local anaesthetics, fluid balance and perioperative outcomes in surgery for advanced ovarian cancer
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-05-21)The majority of women with ovarian cancer are diagnosed at an advanced stage with extensive dissemination of tumour to the mesothelial lining of the abdomen, the peritoneum. Moreover, large amounts of ascites are often ... -
Circulating factors affecting skeletal muscle metabolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-05-21)The overall aim of this doctoral thesis was to study the role of circulating factors in modulating skeletal muscle metabolism. To this end, we investigated two different scenarios: Type 2 diabetes, which is characterised ... -
Hantaviruses and SARS-CoV-2 : cell stress and novel antivirals
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-05-21)Hantaviruses and coronaviruses are zoonotic viral pathogens that can cause severe disease in humans. The global spread of SARS-CoV-2 demonstrated the full pandemic potential of viral infections and highlighted our need for ... -
Fibrotic lung disease : early signs, treatment and outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-05-21)Idiopathic pulmonary fibrosis (IPF) has gained a lot of attention by the research community in recent decades. Thanks to enhanced understanding on pathophysiological mechanisms behind the fibrosing process together with ... -
Unraveling predictive indicators for therapeutic response in HER2-positive breast cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-05-21)Breast cancer is a highly heterogeneous disease, exhibiting significant diversity both in its biological subtypes and clinical manifestations. Biologically directed therapies have revolutionized the treatment landscape for ... -
A problem-solving intervention for employees on sickness absence due to common mental disorders : effects, ethics and process
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-20)Purpose: Employees with common mental disorders (CMDs) which include depression, anxiety-, and adjustment disorder, are more often on sickness absence and have longer sickness absence episodes than employees with ... -
Omics-based immune profile in first-episode psychosis : revealing biomarkers for understanding schizophrenia pathophysiology
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-05-20)Schizophrenia is a lifelong, severe mental health disorder characterized by significant disability, disrupted psychosocial functioning, and premature mortality. Typically emerging in early adolescence, schizophrenia ... -
Prognostic factors in colorectal cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-20)Prognosis in colorectal cancer (CRC) is largely stage dependent. Classification of disease stage is done according to the tumor, node, and metastasis-staging system (TNM). Disease stage often dictates treatment options ... -
“Should i stay, or should i go” : teachers’ motivation to stay at their workplace
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-20)The overarching aim of this thesis was to increase the knowledge on the relationship between teachers’ psychosocial work environment and teachers’ retention intention. This was done by exploring the psychosocial work factors ... -
Bone health impairment in childhood cancer : from preclinical studies to clinical insights
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-05-20)Survival outcomes in childhood cancer have significantly improved over recent decades. While this is a remarkable achievement, it has also led to a growing number of survivors who face a great risk of long-term morbidities. ...