Licentiatavhandlingar / Licentiate Theses - SwePub: Recent submissions
Now showing items 161-180 of 255
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Optimization of intravenous contrast media at computed tomography
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2012-05-09)The administration of intravenous contrast media (IV CM) is essential for detecting lesions at most computed tomography (CT) examinations. The overall aim of this thesis is to investigate different aspects of IV CM ... -
Spread and distribution of drug resistance and compensatory mutations in Plasmodium falciparum
(Inst för medicin, Solna / Dept of Medicine, Solna, 2012-05-08)In 2010 there were an estimated 216 million cases of malaria worldwide. In Honduras there were ~9000 cases of which 88% were due to Plasmodium vivax mono-infection. Chloroquine (CQ) resistant Plasmodium falciparum have ... -
A treatment-strategy-based classification system for decision-making in patients with low-back pain : a biomedical approach: development and inter-examiner reliability
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2012-04-12)Background: Low-back pain (LBP) is a common, disabling and costly disorder and its treatment includes a range of interventions. Increased demands are put on effective care and rehabilitation offered to this population. ... -
Plasticity of salamander skeletal muscle cells
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2012-03-06)Regeneration is unevenly spread throughout the animal kingdom. Some of the invertebrates have a very high regenerative capacity but the capacity to replace lost or damaged tissues in mammals is limited. Among the vertebrates, ... -
Assessment of DNA damage, oxidative stress and inflammation in chronic kidney disease patients : and a clinical study of a dietary supplement
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2012-01-09)Decreased kidney function is associated with higher levels of oxidative stress, inflammation and malnutrition. Chronic kidney disease (CKD) patients have a higher risk to develop cardiovascular disease, atherosclerosis and ... -
Role of calcium in developing cellular network : Ca2+ in human fetal neural stem cells and rat neonatal cardiomyocytes
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2011-12-30)This thesis aimed to study Ca2+ homeostasis and its regulation in developing heart and brain cells. Cardiomyocytes rapidly developed a fast calcium machinery, (1) to regulate cytoskeletal protein interactions to the ... -
Prevention of liver cancer in chronic liver disease : an experimental study of sodium selenite and rat hepatocarcinogenesis
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2011-11-21)Selenium treatment in supranutritional but subtoxic doses has previously been shown to inhibit cell proliferation in preneoplastic lesions in a rat liver carcinogenesis model. The mechanisms are not known, but thioredoxin ... -
Studies of changes in volume in right ventricle with electrical bio impedance
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2002-12-12)In intracardiac impedance, electrical bio-impedance is measured inside the heart. This signal is known to reflect the volume of blood passing in and out of the ventricles. In transthoracic impedance the measurement current ... -
Assessment of environmental contaminants' neurotoxicity : in vitro and in vivo experimental studies
(Inst för neurovetenskap / Dept of Neuroscience, 2011-09-06)Accumulating evidence over several decades shows that environmental contaminants may lead to neurodevelopmental alterations. An essential prerequisite to prevention is recognition of a chemical‟s ability to harm the ... -
Studies of atherosclerosis in systemic lupus erythematosus
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-08-29)The role of inflammation in the development of atherosclerosis is now accepted and a focus of many studies because of its complex mechanisms. The risk of cardiovascular disease (CVD) and atherosclerosis is reported to be ... -
Molecular characterization of Mycobacterium tuberculosis isolates in Mozambique
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-05-27)Tuberculosis (TB) is one of the major health problems in Mozambique. It is estimated that 27,000 deaths caused by TB occur each year with an estimated incidence and prevalence rate of 431 and 504 per 100,000 population ... -
Studies on the oxysterols 4alpha- and 4beta-hydroxycholesterol
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2011-05-18)Cytochrome P450 (CYP) enzymes catalyze the metabolism of both foreign and endogenous substances such as drugs and steroids. Enzymes in subfamily CYP3A sum up to 30% of the total CYP content in the liver and metabolize about ... -
Research utilization in nursing care : concepts, indicators and measurements
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2011-05-10)Background and aim: To use research findings in patient care is a cornerstone in evidence-based practice. How and to what extent research findings are used in practice is studied in the field of research utilization (RU). ... -
Parental reactions in childhood cancer : distress, risk and resilience
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2011-05-04)Parents of children with cancer encounter an exceptionally difficult life experience. Acute and long-lasting distress adds to the initial traumatic experience of being told that a family member suffers from a potentially ... -
Substrate oxidation and plasma elimination of a long-chain triglyceride emulsion
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2011-05-04)Lipid emulsions based on long-chain triglycerides (LCTs) are frequently used during total parenteral nutrition (TPN) and are usually administrated together with glucose. The metabolism of fat is determined by the underlying ... -
Cumulative assessment of persistent organic pollutant toxicity in vivo
(Institutet för miljömedicin / Institute of Environmental Medicine, 2011-05-02)Humans are continuously exposed to a multitude of compounds present in the environment and in food. A major challenge in risk assessment is to determine the degree of exposure to multiple chemicals and the hazards associated ... -
Identification and functional characterization of Epstein-Barr virus-encoded deconjugases
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2011-03-07)The post-translational conjugation or deconjugation of proteins by ubiquitin (Ub) or ubiquitin-like molecules (UbLs: e.g. SUMO, NEDD8, ISG15) has emerged as a major regulatory mechanism of various cellular activities. The ... -
Standing with and without vibration in children with severe cerebral palsy
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2011-01-20)Children with severe cerebral palsy (CP) risk fragile bones, fractures and hip dislocation due to disuse. A standing shell allows these children weight bearing in an upright position. Recommended standing time is one to ... -
Learning to live with diabetes : as experiencing an expanding life world
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2011-01-20)Introduction: Chronic illness, such as diabetes, results in a transition process involving a variety of changes in both bodily function and conditions for living, and requiring broad knowledge and understanding in order ... -
CYP2C19 and CYP2C9 geno- and phenotypes in healthy Swedish and Korean subjects
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2010-12-23)Cytochrome P450s (CYPs) are responsible for approximately 75% of the phase I-dependent drug metabolism. Several important polymorphisms in these enzymes are known to affect the individual drug response. CYP2C19 and CYP2C9 ...