Artiklar / Articles - K2 (MedS): Recent submissions
Now showing items 1-20 of 25
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Temporal trends in adverse pregnancy outcomes in axial spondyloarthritis in Sweden : a cohort study
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-06-30)Background: Evidence on the risks associated with pregnancy and childbirth in women with axial spondyloarthritis is scarce and conflicting, with more research needed to guide policy and clinical practice. We aimed to assess ... -
Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-02-24)Background and aims: Unstable carotid atherosclerosis causes stroke, but methods to identify patients and lesions at risk are lacking. We recently found enrichment of genes associated with calcification in carotid plaques ... -
Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-02-09)Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this ... -
Assessment of chronic bronchitis and risk factors in young adults : results from BAMSE
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-02-09)BACKGROUND: Chronic bronchitis is associated with substantial morbidity among elderly adults, but little is known about its prevalence and risk factors in young adults. Our aim was to assess the prevalence and early life ... -
Sibship and dispensing patterns of asthma medication in young children : a population based study
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-08-06)Purpose: Our aim was to study the association between sibship and dispensing patterns of asthma medication in young children, focusing on incidence and persistence, and taking sibship status, asthma diagnoses, and siblings’ ... -
Cesarean delivery, preterm birth and risk of food allergy : nationwide Swedish cohort study of over 1 million children
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-08-06)Background & Objectives: Little is known about early life risk factors for food allergy in children. We examined the association between perinatal characteristics and future risk of food allergy in offspring. Methods: ... -
Internet-delivered cognitive behavior therapy for adolescents with irritable bowel syndrome : a randomized controlled trial
(Institutionen för klinisk neurovetenskap / Departement for clinical neuroscience, 2017-06-30)OBJECTIVES: Few treatments have been able to effectively manage pediatric irritable bowel syndrome (IBS). Internet-delivered cognitive behavior therapy (Internet-CBT) based on exposure for abdominal symptoms is effective ... -
TGF-β affects the differentiation of human GM-CSF+ CD4+ T cells in an activation- and sodium-dependent manner
(Inst för medicin, Solna / Dept of Medicine, Solna, 2017-05-24)The cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) is involved in the pathogenesis of chronic inflammatory diseases such as multiple sclerosis. However, the environmental cues promoting differentiation ... -
Comparative analysis of protocols to induce human CD4+Foxp3+ regulatory T cells by combinations of IL‐2, TGF‐beta, retinoic acid, rapamycin and butyrate
(Inst för medicin, Solna / Dept of Medicine, Solna, 2017-05-24)Regulatory T cells (Tregs) suppress other immune cells and are critical mediators of peripheral tolerance. Therapeutic manipulation of Tregs is subject to numerous clinical investigations including trials for adoptive Treg ... -
Registers of the Swedish total population and their use in medical research
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-03-28)The primary aim of the Swedish national population registration system is to obtain data that (1) reflect the composition, relationship and identities of the Swedish population and (2) can be used as the basis for correct ... -
Similar familial risk in multiple sclerosis subgroups
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-03-20)Background: A subgroup of patients diagnosed with multiple sclerosis (MS) present with no oligoclonal bands (OCB) in the cerebrospinal fluid (CSF). Several studies report different clinical characteristics and genetic ... -
Duration of second stage of labour at term and pushing time : risk factors for postpartum haemorrhage
(Inst för medicin, Solna / Dept of Medicine, Solna, 2017-02-21)BACKGROUND: Prolonged labour is associated with increased risk of postpartum haemorrhage (PPH), but the role of active pushing time and the relation with management during labour remains poorly understood. METHODS: ... -
Early exposure to dogs and farm animals and the risk of childhood asthma
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)IMPORTANCE: The association between early exposure to animals and childhood asthma is not clear, and previous studies have yielded contradictory results. OBJECTIVE: To determine whether exposure to dogs and farm ... -
Antibiotics in fetal and early life and subsequent childhood asthma : nationwide population based study with sibling analysis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-02)Erratum to this article in BMJ. 2014;349:g7395. OBJECTIVE: To investigate the association between exposure to antibiotics in fetal and early life and asthma in childhood, with adjustment for confounding factors. ... -
Sexual offending runs in families : a 37-year nationwide study
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2016-11-29)BACKGROUND: Sexual crime is an important public health concern. The possible causes of sexual aggression, however, remain uncertain. METHODS: We examined familial aggregation and the contribution of genetic and ... -
Prolonged second stage of labor is associated with low Apgar score
(Inst för medicin, Solna / Dept of Medicine, Solna, 2015-11-09)There is no consensus on the effects of a prolonged second stage of labor on neonatal outcomes. In this large Swedish population-based cohort study, our objective was to investigate prolonged second stage and risk of low ... -
Variability in the CIITA gene interacts with HLA in multiple sclerosis
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2015-02-09)The human leukocyte antigen (HLA) is the main genetic determinant of multiple sclerosis (MS) risk. Within the HLA, the class II HLA-DRB1*15:01 allele exerts a disease-promoting effect, whereas the class I HLA-A*02 allele ... -
The association between schizophrenia and rheumatoid arthritis : a nationwide population-based Swedish study on intra-individual and familial risks
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2014-06-27)Numerous studies have reported a reduced risk of rheumatoid arthritis (RA) in schizophrenia. The mechanisms are unknown, but recent genome-wide association studies of schizophrenia have shown strong associations with markers ... -
The Swedish Twin Registry : establishment of a biobank and other recent developments
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2013-12-20)The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these, approximately ... -
Validation of asthma and eczema in population-based Swedish drug and patient registers
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2013-11-25)Purpose: Validated measures of asthma and eczema at the population level remain a challenge. Our aim was to ascertain if register-based information on asthma/eczema medication can function as a proxy for an asthma/eczema ...