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Recent submissions

  • Protein intake and healthy aging : sooner rather than later? 

    Carballo-Casla, Adrián; Ortolá, Rosario; Calderón-Larrañaga, Amaia (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-03-05)
  • Standardization of antigen-emulsion preparations for the induction of autoimmune disease models 

    Topping, Louise M; Romero-Castillo, Laura; Urbonaviciute, Vilma; Bolinsson, Hans; Clanchy, Felix I; Holmdahl, Rikard; Bäckström, B Thomas; Williams, Richard O (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-09)
    Autoimmune murine disease models are vital tools for identifying novel targets and finding better treatments for human diseases. Complete Freund's adjuvant is commonly used to induce disease in autoimmune models, and the ...
  • Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice 

    Aoun, Mike; Coelho, Ana; Krämer, Alexander; Saxena, Amit; Sabatier, Pierre; Beusch, Christian Michel; Lönnblom, Erik; Geng, Manman; Do, Nhu-Nguyen; Xu, Zhongwei; Zhang, Jingdian; He, Yibo; Romero Castillo, Laura; Abolhassani, Hassan; Xu, Bingze; Viljanen, Johan; Rorbach, Joanna; Fernandez Lahore, Gonzalo; Gjertsson, Inger; Kastbom, Alf; Sjöwall, Christopher; Kihlberg, Jan; Zubarev, Roman A; Burkhardt, Harald; Holmdahl, Rikard (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-08)
    B cells undergo several rounds of selection to eliminate potentially pathogenic autoreactive clones, but in contrast to T cells, evidence of positive selection of autoreactive B cells remains moot. Using unique tetramers, ...
  • Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis 

    Urbonaviciute, Vilma; Romero-Castillo, Laura; Xu, Bingze; Luo, Huqiao; Schneider, Nadine; Weisse, Sylvia; Do, Nhu-Nguyen; Oliveira-Coelho, Ana; Fernandez Lahore, Gonzalo; Li, Taotao; Sabatier, Pierre; Beusch, Christian M; Viljanen, Johan; Zubarev, Roman A; Kihlberg, Jan; Bäcklund, Johan; Burkhardt, Harald; Holmdahl, Rikard (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-08)
    A longstanding goal has been to find an antigen-specific preventive therapy, i.e., a vaccine, for autoimmune diseases. It has been difficult to find safe ways to steer the targeting of natural regulatory antigen. Here, we ...
  • Being prevented from providing good care : a conceptual analysis of moral stress among health care workers during the COVID-19 pandemic 

    Gustavsson, Martina E; von Schreeb, Johan; Arnberg, Filip K; Juth, Niklas (Inst för global folkhälsa / Dept of Global Public Health, 2024-01-31)
    Background Health care workers (HCWs) are susceptible to moral stress and distress when they are faced with morally challenging situations where it is difficult to act in line with their moral standards. In times of crisis, ...
  • Reduced variability of bursting activity during working memory 

    Lundqvist, Mikael; Rose, Jonas; Brincat, Scott L; Warden, Melissa R; Buschman, Timothy J; Herman, Pawel; Miller, Earl K; Lundqvist, Mikael (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-01-30)
    Working memories have long been thought to be maintained by persistent spiking. However, mounting evidence from multiple-electrode recording (and single-trial analyses) shows that the underlying spiking is better characterized ...
  • Working memory control dynamics follow principles of spatial computing 

    Lundqvist, Mikael; Brincat, Scott L; Rose, Jonas; Warden, Melissa R; Buschman, Timothy J; Miller, Earl K; Herman, Pawel; Lundqvist, Mikael (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-01-30)
    Working memory (WM) allows us to remember and selectively control a limited set of items. Neural evidence suggests it is achieved by interactions between bursts of beta and gamma oscillations. However, it is not clear how ...
  • Moral stress among Swedish health care workers during the COVID-19 pandemic : a cross-sectional study 

    Gustavsson, Martina E; Juth, Niklas; von Schreeb, Johan; Arnberg, Filip K (Inst för global folkhälsa / Dept of Global Public Health, 2023-12-21)
    Aims: This study quantifies to what extent Health care workers (HCWs) experienced moral stress and to what extent their experiences of moral stress were related to gender and age as well as to working directly with COVID-19 ...
  • Dealing with difficult choices : a qualitative study of experiences and consequences of moral challenges among disaster healthcare responders 

    Gustavsson, Martina E; Juth, Niklas; Arnberg, Filip K; von Schreeb, Johan (Inst för global folkhälsa / Dept of Global Public Health, 2023-12-21)
    Background: Disasters are chaotic events with healthcare needs that overwhelm available capacities. Disaster healthcare responders must make difficult and swift choices, e.g., regarding who and what to prioritize. Responders ...
  • Pregnancy outcomes in women with a prior cervical intraepithelial neoplasia grade 3 diagnosis : a nationwide population-based cohort study with sibling comparison design 

    He, Wei; Sparén, Pär; Fang, Fang; Sengpiel, Verena; Strander, Björn; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-11-27)
    Background: Treatment of cervical intraepithelial neoplasia grade 3 (CIN3) removes or destroys part of the cervix and might subsequently influence pregnancy outcomes. Objective: To investigate pregnancy outcomes in women ...
  • Heritability of mammographic breast density, density change, microcalcifications, and masses 

    Holowko, Natalie; Eriksson, Mikael; Kuja-Halkola, Ralf; Azam, Shadi; He, Wei; Hall, Per; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-11-27)
    Background: Mammographic features influence breast cancer risk and are used in risk prediction models. Understanding how genetics influence mammographic features is important since the mechanisms through which they are ...
  • Chemotherapy, genetic susceptibility, and risk of venous thromboembolism in breast cancer patients 

    Brand, Judith S; Hedayati, Elham; Humphreys, Keith; Ludvigsson, Jonas F; Johansson, Anna L V; Bergh, Jonas; Hall, Per; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-10-25)
    Purpose: Venous thromboembolism (VTE) is highly heritable and a serious complication of cancer and its treatment. We examined the individual and joint effects of chemotherapy and genetic susceptibility on VTE risk in ...
  • MicroRNA-210 regulates dendritic morphology and behavioural flexibility in mice 

    Watts, Michelle; Williams, Gabrielle; Lu, Jing; Nithianantharajah, Jess; Claudianos, Charles (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-08-16)
    MicroRNAs are known to be critical regulators of neuronal plasticity. The highly-conserved, hypoxia- regulated microRNA-210 (miR-210) has been shown to be associated with long term memory in invertebrates and dysregulated ...
  • Could dietary nitrate affect dementia development? 

    Carballo-Casla, Adrián; Dunk, Michelle M.; Donat-Vargas, Carolina; Xu, Weili (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2023-08-16)
  • Temporal trends in adverse pregnancy outcomes in axial spondyloarthritis in Sweden : a cohort study 

    Morin, Matilda; Frisell, Thomas; Stephansson, Olof; Hellgren, Karin (Inst för medicin, Solna / Dept of Medicine, Solna, 2023-06-30)
    Background: Evidence on the risks associated with pregnancy and childbirth in women with axial spondyloarthritis is scarce and conflicting, with more research needed to guide policy and clinical practice. We aimed to assess ...
  • Dementia and psychotropic medications are associated with significantly higher mortality in geriatric patients hospitalized with COVID-19 : data from the StockholmGeroCovid project 

    Secnik, Juraj; Eriksdotter, Maria; Xu, Hong; Annetorp, Martin; SweGeroCOVID Project; Rytarowski, Aleksander; Johnell, Kristina; Hägg, Sara; Religa, Dorota (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2023-02-27)
    Background: Dementia and psychotropic medications are discussed as risk factors for severe/lethal outcome of the coronavirus disease 2019 (COVID-19). We aimed to explore the associations between the presence of dementia ...
  • Allergies to food and airborne allergens in children and adolescents : role of epigenetics in a changing environment 

    Melén, Erik; Koppelman, Gerard H; Vicedo-Cabrera, Ana Maria; Andersen, Zorana Jovanovic; Supinda, Bunyavanich (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-02-17)
    Allergic diseases today affect millions of children and adolescents worldwide. In this review, we focus on allergies to food and airborne allergens, and provide examples of prevalence trends during a time when climate ...
  • "You have to know why you're doing this" : a mixed methods study of the benefits and burdens of self-tracking in Parkinson's disease 

    Riggare, Sara; Scott Duncan, Therese; Hvitfeldt, Helena; Hägglund, Maria (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2023-02-17)
    Background: This study explores opinions and experiences of people with Parkinson's disease (PwP) in Sweden of using self-tracking. Parkinson's disease (PD) is a neurodegenerative condition entailing varied and changing ...
  • Meeting the burden of self-management : qualitative study investigating the empowering behaviors of patients and informal caregivers 

    Scott Duncan, Therese; Engström, Jon; Riggare, Sara; Hägglund, Maria; Koch, Sabine (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2023-02-16)
    Background: Patient empowerment is an important concept and a movement toward person-centered care of patients with chronic conditions. Nevertheless, to date, most research on empowered patients or informal caregivers has ...
  • From information seekers to innovators : qualitative analysis describing experiences of the second generation of e-patients 

    Scott Duncan, Therese; Riggare, Sara; Koch, Sabine; Sharp, Lena; Hägglund, Maria (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2023-02-15)
    Background: Current health care systems are rarely designed to meet the needs of people living with chronic conditions. However, some patients and informal caregivers are not waiting for the health care system to redesign ...

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