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Recent Submissions

  • Agreement between asthma questionnaire and health care register data 

    Hedman, Anna M; Gong, Tong; Lundholm, Cecilia; Dahlén, Elin; Ullemar, Vilhelmina; Brew, Bronwyn B; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-11-26)
    Purpose: Risk factors and consequences of asthma can be studied using validated questionnaires. The overall objective of this study was to assess the agreement of parental-reported asthma related questions regarding their ...
  • Allergen-specific IgE over time in women before, during and after pregnancy 

    Hedman, Anna M; Lundholm, Cecilia; Scheynius, Annika; Alm, Johan; Andolf, Annika; Pershagen, Göran; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-11-26)
    The trajectory of IgE levels before, during and after pregnancy in sensitized individuals is characterized by significant increase in specific IgE to birch allergens but not to other allergens after multiple testing. This ...
  • Bidirectional relationship between eating disorders and autoimmune diseases 

    Hedman, Anna; Breithaupt, Lauren; Hubel, Christopher; Thornton, Laura M; Tillander, Annika; Norring, Claes; Birgegård, Andreas; Larsson, Henrik; Ludvigsson, Jonas; Sävendahl, Lars; Almqvist, Catarina; Bulik, Cynthia M (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-11-26)
    Background: Immune system dysfunction may be associated with eating disorders, and associations could have implications for detection, risk assessment, and treatment of both autoimmune diseases and eating disorders. However, ...
  • Company employees as experimental participants in traffic safety research : prevalence and implications 

    Radun, Igor; Nilsonne, Gustav; Radun, Jenni; Helgesson, Gert; Kecklund, Göran; Nilsonne, Gustav (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and EthicsInst för klinisk neurovetenskap / Dept of Clinical NeuroscienceKarolinska Institutet, 2018-11-08)
    The use of company employees as experimental participants when testing products, technology or paradigms developed by the same company raises questions about bias in results and research ethics. We aimed to investigate the ...
  • Prognosis following cancer surgery during holiday periods 

    Lagergren, Jesper; Lagergren, Pernilla; Mattsson, Fredrik (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-10-19)
  • Weekday of cancer surgery in relation to prognosis 

    Lagergren, Jesper; Mattson, Fredrik; Lagergren, Pernilla (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-10-11)
    BACKGROUND: Later weekday of surgery seems to affect the prognosis adversely in oesophageal cancer, whereas any such influence on other cancer sites is unknown. This study aimed to test whether weekday of surgery influenced ...
  • Does treating vascular risk factors prevent dementia and Alzheimer’s disease? A systematic review and meta-analysis 

    Larsson, Susanna; Markus, Hugh (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-07-05)
    Background: Epidemiological evidence has associated Alzheimer’s disease (AD) with vascular risk factors (VRFs), but whether treatment of VRFs reduces the incidence of dementia and AD is uncertain. Objective: To ...
  • Helicobacter pylori eradication treatment and the risk of gastric adenocarcinoma in a Western population 

    Doorakkers, Eva; Lagergren, Jesper; Engstrand, Lars; Brusselaers, Nele (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-22)
    OBJECTIVE: Gastric infection with Helicobacter pylori is a strong risk factor for non-cardia gastric adenocarcinoma. The aim of this study was to assess whether the risk of gastric adenocarcinoma and non-cardia ...
  • Outcome-dependent associations between short interpregnancy interval and offspring psychological and educational problems : a population-based quasi-experimental study 

    Class, Quetzal A; Rickert, Martin E.; Larsson, Henrik; Öberg, Anna S.; Sujan, Ayesha; Amlqvist, Catarina; Lichtenstein, Paul; D’Onofrio, Brian (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-03-21)
  • Recurrence of reflux after laparoscopic antireflux surgery : reply 

    Maret-Ouda, John; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)
  • Nordic registry-based cohort studies : possibilities and pitfalls when combining Nordic registry data 

    Maret-Ouda, John; Tao, Wenjing; Wahlin, Karl; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)
    Aims: All five Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) have nationwide registries with similar data structure and validity, as well as personal identity numbers enabling linkage between registries. ...
  • Association between laparoscopic antireflux surgery and recurrence of gastroesophageal reflux 

    Maret-Ouda, John; Wahlin, Karl; El-Serag, Hashem B.; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)
    IMPORTANCE: Cohort studies, mainly based on questionnaires and interviews, have reported high rates of reflux recurrence after antireflux surgery, which may have contributed to a decline in its use. Reflux recurrence ...
  • Cohort profile: The Nordic Antireflux Surgery Cohort (NordASCo) 

    Maret-Ouda, John; Wahlin, Karl; Artama, Miia; Brusselaers, Nele; Färkkilä, Martti; Lynge, Elsebeth; Mattsson, Fredrik; Pukkala, Eero; Romundstad, Pål; Tryggvadottir, Laufey; von Euler-Chelpin, My; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-06)
    PURPOSE: To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare ...
  • Gastrectomy compared to oesophagectomy for Siewert II and III gastro-oesophageal junctional cancer in relation to resection margins, lymphadenectomy and survival. 

    Kauppila, Joonas Henrikki; Wahlin, Karl; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-02-12)
    It is unclear whether gastrectomy or oesophagectomy offer better outcomes for gastro-oesophageal junction (GOJ) cancer. A total of 240 patients undergoing total gastrectomy (n = 85) or oesophagectomy (n = ...
  • Serum proteases potentiate BMP-induced cell cycle re-entry of dedifferentiating muscle cells during newt limb regeneration 

    Wagner, Ines; Wang, Heng; Weissert, Philipp; Straube, Werner; Shevchenko, Anna; Gentzel, Marc; Brito, Goncalo; Tazaki, Akira; Oliveira, Catarina; Sugiura, Takuji; Shevchenko, Andrej; Simon, András; Drechsel, David; Tanaka, Elly (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-02-12)
    Limb amputation in the newt induces myofibers to dedifferentiate and re-enter the cell cycle to generate proliferative myogenic precursors in the regeneration blastema. Here we show that bone morphogenetic ...
  • Limited association between markers of stress during pregnancy and fetal growth in “Born into Life”, a new prospective birth cohort 

    Smew, Awad Idris; Hedman, Anna M.; Chiesa, Flaminia; Ullemar, Vilhelmina; Andolf, Ellika; Pershagen, Göran; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-02-12)
    AIMS: We aimed to investigate the associations between perceived maternal stress or salivary cortisol levels during pregnancy and birth weight. METHODS: In 2010-2012 we recruited 92 women living in Stockholm, ...
  • Tenascin-C and fibronectin in normal esophageal mucosa, Barrett's esophagus, dysplasia and adenocarcinoma. 

    Kauppila, Joonas Henrikki; Bogdanoff, Sara; Leppänen, Joni; Lehenkari, Petri; Saarnio, Juha; Karttunen, Tuomo; Huhta, Heikki; Helminen, Olli (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-31)
    BACKGROUND: Tenascin-C and fibronectin are adhesive glycoproteins modulating the structure of the extracellular matrix and cellular functions. Their expression and function in esophageal adenocarcinoma is ...
  • Prenatal maternal psychosocial stress and offspring’s asthma and allergic disease : a systematic review and meta-analysis 

    Flanigan, Catherine; Sheikh, Aziz; DunnGalvin, Audrey; Brew, Bronwyn K; Almqvist, Catarina; Nwaru, Bright I (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-01-31)
    BACKGROUND: Prenatal maternal stress may influence offspring's atopic risk through sustained cortisol secretion resulting from activation of the hypothalamic-pituitary-axis (HPA), leading to Th2-biased cell differentiation ...
  • Meta-analysis of health-related quality of life after minimally invasive versus open oesophagectomy for oesophageal cancer. 

    Kauppila, Joonas Henrikki; Xie, Shaohua; Johar, Asif; Markar, Sheraz; Lagergren, Pernilla (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-31)
    BACKGROUND: The aim of this systematic review and meta-analysis was to compare health-related quality of life (HRQoL) outcomes between minimally invasive and open oesophagectomy for cancer at different postoperative time ...
  • Skeletal muscle dedifferentiation during salamander limb regeneration 

    Wang, Heng; Simon, Andras (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-01-24)
    Salamanders can regenerate entire limbs throughout their life. A critical step during limb regeneration is formation of a blastema, which gives rise to the new extremity. Salamander limb regeneration has historically been ...

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