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  • MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells 

    Karsten, Stella; Fiskesund, Roland; Zhang, Xing-Mei; Marttila, Petra; Sanjiv, Kumar; Pham, Therese; Rasti, Azita; Bräutigam, Lars; Almlöf, Ingrid; Marcusson-Ståhl, Maritha; Sandman, Carolina; Platzack, Björn; Harris, Robert A.; Kalderén, Christina; Cederbrant, Karin; Helleday, Thomas; Warpman Berglund, Ulrika (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-09-16)
    T cell-driven diseases account for considerable morbidity and disability globally and there is an urgent need for new targeted therapies. Both cancer cells and activated T cells have an altered redox balance, and up-regulate ...
  • Human ISL1+ ventricular progenitors self-assemble into an in vivo functional heart patch and preserve cardiac function post infarction 

    Foo, Kylie S.; Lehtinen, Miia L.; Lian, Xiaojun; Xu, Jiejia; Keung, Wendy; Geng, Lin; Kolstad, Terje R.S.; Thams, Sebastian; Wong, Andy On-tik; Wong, Nicodemus; Bylund, Kristine; Zhou, Chikai; He, Xiaobing; Jin, Shao-Bo; Clarke, Jonathan; Lendahl, Urban; Li, Ronald A.; Louch, William E.; Chien, Kenneth R. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, HuddingeStem Cell and Regenerative Medicine Consortium, LKS Faculty of Medicine, The University of HongKong, Hong Kong, ChinaDr. Li Dak-Sum Research Centre, University of Hong Kong-Karolinska Institutet Collaborations in Regenerative Medicine, The Universityof Hong Kong, Hong Kong, ChinaInstitute for Experimental MedicalResearch, Oslo University Hospital and University of Oslo, Oslo, Norway, 2021-07-01)
    The generation of human pluripotent stem cell (hPSC)-derived ventricular progenitors and their assembly into a 3-dimensional in vivo functional ventricular heart patch has remained an elusive goal. Herein, we report the ...
  • Number of siblings and survival from childhood leukaemia : a national register-based cohort study from Sweden 

    Mogensen, Hanna; Modig, Karin; Talbäck, Mats; Erdmann, Friederike; Heyman, Mats; Feychting, Maria; Tettamanti, Giorgio (Institutet för miljömedicin / Institute of Environmental MedicineInst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2021-05-31)
    Background: Previous studies suggest worse leukaemia survival for children with siblings, but the evidence is sparse, inconsistent and does not consider clinical factors. We explored the associations between number of ...
  • Detecting prolonged sitting bouts with the ActiGraph GT3X 

    Kuster, Roman P; Grooten, Wilhelmus J A; Baumgartner, Daniel; Blom, Victoria; Hagströmer, Maria; Ekblom, Örjan (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)
    The ActiGraph has a high ability to measure physical activity; however, it lacks an accurate posture classification to measure sedentary behavior. The aim of the present study was to develop an ActiGraph (waist-worn, 30 ...
  • Network asynchrony underlying increased broadband gamma power 

    Guyon, Nicolas; Zacharias, Leonardo Rakauskas; de Oliveira, Eliezyer Fermino; Kim, Hoseok; Leite, João Pereira; Lopes-Aguiar, Cleiton; Carlén, Marie (Inst för neurovetenskap / Dept of Neuroscience, 2021-05-31)
    Synchronous activity of cortical inhibitory interneurons expressing parvalbumin (PV) underlies expression of cortical γ rhythms. Paradoxically, deficient PV inhibition is associated with increased broadband γ power in the ...
  • Active sitting with backrest support: Is it feasible? 

    Kuster, Roman P; Bauer, Christoph M; Gossweiler, Lukas; Baumgartner, Daniel (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)
    Ergonomics science recommends office chairs that promote active sitting to reduce sitting related complaints. Since current office chairs do not fulfil this recommendation, a new chair was developed by inverting an existing ...
  • Where to place which sensor to measure sedentary behaviour? A method development and comparison among various sensor placements and signal types 

    Kuster, Roman P; Baumgartner, Daniel; Hagströmer, Maria; Grooten, Wilhelmus J A (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)
    Background: Sedentary Behaviour (SB) is associated with several chronic diseases and especially office workers are at increased risk. SB is defined by a sitting or reclined body posture with an energy expenditure ≤1.5 ...
  • Adult trkB signaling in parvalbumin interneurons is essential to prefrontal network dynamics 

    Guyon, Nicolas; Zacharias, Leonardo Rakauskas; van Lunteren, Josina Anna; Immenschuh, Jana; Fuzik, Janos; Märtin, Antje; Xuan, Yang; Zilberter, Misha; Kim, Hoseok; Meletis, Konstantinos; Lopes-Aguiar, Cleiton; Carlén, Marie (Inst för neurovetenskap / Dept of Neuroscience, 2021-05-31)
    Inhibitory interneurons expressing parvalbumin (PV) are central to cortical network dynamics, generation of c oscillations, and cognition. Dysfunction of PV interneurons disrupts cortical information processing and cognitive ...
  • Copeptin is independently associated with vascular calcification in chronic kidney disease stage 5 

    Golembiewska , Edyta; Qureshi , Abdul Rashid; Dai , Lu; Lindholm, Bengt ; Heimbürger, Olof ; Söderberg, Magnus; Brismar, Torkel B ; Ripsweden, Jonaz; Barany, Peter; Johnson, Richard J; Stenvinkel , Peter (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-03-05)
    Background: Vascular calcification (VC) is an independent predictor of cardiovascular disease (CVD) present in 30– 70% of patients with chronic kidney disease (CKD). Copeptin is a sensitive surrogate marker of arginine ...
  • Early vascular ageing and cellular senescence in chronic kidney disease 

    Dai, Lu; Quershi, Abdul Rashid; Witasp, Anna; Lindholm, Bengt; Stenvinkel, Peter (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-03-05)
    Chronic kidney disease (CKD) is a clinical model of premature ageing characterized by progressive vascular dis- ease, systemic inflammation, muscle wasting and frailty. The predominant early vascular ageing (EVA) process ...
  • A DNA-nanoassembly-based approach to map membrane protein nanoenvironments 

    Ambrosetti, Elena; Bernardinelli, Giulio; Hoffecker, Ian; Hartmanis, Leonard; Kiriako, Georges; de Marco, Ario; Sandberg, Rickard; Högberg, Björn; Teixeira, Ana I. (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-03-05)
    Most proteins at the plasma membrane are not uniformly distributed but localize to dynamic domains of nanoscale dimensions. To investigate their functional relevance, there is a need for methods that enable comprehensive ...
  • Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age 

    Merid, Simon Kebede; Novoloaca, Alexei; Sharp, Gemma C.; Kupers, Leanne K.; Kho, Alvin T.; Roy, Ritu; Gao, Lu; Annesi-Maesano, Isabella; Jain, Pooja; Plusquin, Michelle; Kogevinas, Manolis; Allard, Catherine; Vehmeijer, Florianne O.; Kazmi, Nabila; Salas, Lucas A.; Rezwan, Faisal I.; Zhang, Hongmei; Sebert, Sylvain; Czamara, Darina; Rifas-Shiman, Sheryl L.; Melton, Phillip E.; Lawlor, Debbie A.; Pershagen, Göran; Breton, Carrie V.; Huen, Karen; Baiz, Nour; Gagliardi, Luigi; Nawrot, Tim S.; Corpeleijn, Eva; Perron, Patrice; Duijts, Liesbeth; Nohr, Ellen Aagaard; Bustamante, Mariona; Ewart, Susan L.; Karmaus, Wilfried; Zhao, Shanshan; Page, Christian M.; Herceg, Zdenko; Jarvelin, Marjo-Riitta; Lahti, Jari; Baccarelli, Andrea A.; Anderson, Denise; Kachroo, Priyadarshini; Relton, Caroline L.; Bergström, Anna; Eskenazi, Brenda; Soomro, Munawar Hussain; Vineis, Paolo; Snieder, Harold; Bouchard, Luigi; Jaddoe, Vincent W.; Sorensen, Thorkild I. A.; Vrijheid, Martine; Arshad, S. Hasan; Holloway, John W.; Haberg, Siri E.; Magnus, Per; Dwyer, Terence; Binder, Elisabeth B.; DeMeo, Dawn L.; Vonk, Judith M.; Newnham, John; Tantisira, Kelan G.; Kull, Inger; Wiemels, Joseph L.; Heude, Barbara; Sunyer, Jordi; Nystad, Wenche; Munthe-Kaas, Monica C.; Raikkonen, Katri; Oken, Emily; Huang, Rae-Chi; Weiss, Scott T.; Anto, Josep Maria; Bousquet, Jean; Kumar, Ashish; Söderhäll, Cilla; Almqvist, Catarina; Cardenas, Andres; Gruzieva, Olena; Xu, Cheng-Jian; Reese, Sarah E.; Kere, Juha; Brodin, Petter; Solomon, Olivia; Wielscher, Matthias; Holland, Nina; Ghantous, Akram; Hivert, Marie-France; Felix, Janine F.; Koppelman, Gerard H.; London, Stephanie J.; Melen, Erik (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-03-05)
    Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated ...
  • Circulating proteins as predictors of cardiovascular mortality in endstage renal disease 

    Feldreich, T; Nowak, C; Fall, T; Carlsson, AC; Carrero, JJ; Ripsweden, J; Qureshi, AR; Heimburger, O; Barany, P; Stenvinkel, P; Vuilleumier, N; Kalra, PA; Green, D; Ärnlöf, J (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-02-24)
    Introduction: Proteomic profiling of end-stage renal disease (ESRD) patients could lead to improved risk prediction and novel insights into cardiovascular disease mechanisms. Plasma levels of 92 cardiovascular disease-associated ...
  • Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization 

    Karlöf, E; Seime, T; Dias, N; Lengqvist, M; Witasp, A; Almqvist, H; Kronqvist, M; Gådin, JR; Odeberg, J; Maegdefessel, L; Stenvinkel, P; Perisic Matic, L; Hedin, U (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-02-24)
    Background and aims: Unstable carotid atherosclerosis causes stroke, but methods to identify patients and lesions at risk are lacking. We recently found enrichment of genes associated with calcification in carotid plaques ...
  • Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage 

    Mononen, Mimmi; Leng, Chuen Yan; Xu, Jiejia; Chien, Kenneth R. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-17)
    A family of multipotent heart progenitors plays a central role in the generation of diverse myogenic and nonmyogenic lineages in the heart. Cardiac progenitors in particular play a significant role in lineages involved in ...
  • Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration 

    Witman, Nevin; Zhou, Chikai; Grote Beverborg, Niels; Sahara, Makoto; Chien, Kenneth R. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-17)
    The mammalian hearts have the least regenerative capabilities among tissues and organs. As such, heart regeneration has been and continues to be the ultimate goal in the treatment against acquired and congenital heart ...
  • Population and single-cell analysis of human cardiogenesis reveals unique LGR5 ventricular progenitors in embryonic outflow tract. 

    Sahara, Makoto; Santoro, Federica; Sohlmér, Jesper; Zhou, Chikai; Witman, Nevin; Leung, Chuen Yan; Mononen, Mimmi; Bylund, Kristine; Gruber, Peter; Chien, Kenneth R. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-15)
    The morphogenetic process of mammalian cardiac development is complex and highly regulated spatiotemporally by multipotent cardiac stem/progenitor cells (CPCs). Mouse studies have been informative for understanding mammalian ...
  • Genome‐wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors 

    Xu, Jiejia; Zhou, Chikai; Foo, Kylie S.; Yang, Ran; Xiao, Yao; Bylund, Kristine; Sahara, Makoto; Chien, Kenneth R. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-15)
    Cardiac progenitor formation is one of the earliest committed steps of human cardiogenesis and requires the cooperation of multiple gene sets governed by developmental signaling cascades. To determine the key regulators ...
  • Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure 

    Merid, Simon Kebede; Bustamante, Mariona; Standl, Marie; Sunyer, Jordi; Heinrich, Joachim; Lemonnier, Nathanaël; Aguilar, Daniel; Antó, Josep Maria; Bousquet, Jean; Santa-Marina, Loreto; Lertxundi, Aitana; Bergström, Anna; Kull, Inger; Wheelock, Åsa M.; Koppelman, Gerard H.; Melén, Erik; Gruzieva, Olena (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, SödersjukhusetKarolinska Institutet, 2021-02-09)
    Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this ...
  • Assessment of chronic bronchitis and risk factors in young adults : results from BAMSE 

    Wang, Gang; Hallberg, Jenny; Bergström, Petra Um; Janson, Christer; Pershagen, Göran; Gruzieva, Olena; van Hage, Marianne; Georgelis, Antonios; Bergström, Anna; Kull, Inger; Lindén, Anders; Melén, Erik (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-02-09)
    BACKGROUND: Chronic bronchitis is associated with substantial morbidity among elderly adults, but little is known about its prevalence and risk factors in young adults. Our aim was to assess the prevalence ...

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