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  • Effects of inhaled corticosteroids on DNA methylation in peripheral blood cells in children with asthma 

    Kere, Maura; Gruzieva, Olena; Ullemar, Vilhelmina; Söderhäll, Cilla; Greco, Dario; Kull, Inger; Bergström, Anna; Pershagen, Göran; Almqvist, Catarina; Melén, Erik (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2019-09-25)
  • Cardiac remodeling in aortic and mitral valve disease : a simulation study with clinical validation 

    Maksuti, Elira; Westerhof, Berend; Ugander, Martin; Donker, Dirk; Carlsson, Marcus; Broomé, Michael (Inst för fysiologi och farmakologi / Dept of Physiology and PharmacologyKarolinska Universitetssjukhuset Solna / Karolinska University Hospital Solna, 2019-09-03)
    Background. Remodeling is an important long-term determinant of cardiac function throughout the progression of heart disease. Numerous biomolecular pathways for mechanosensing and transduction are involved. However, we ...
  • Sibship and dispensing patterns of asthma medication in young children : a population based study 

    Dahlén, Elin; Lundholm, Cecilia; Wikström Jonsson, Eva; Kull, Inger; Wettermark, Björn; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-08-06)
    Purpose: Our aim was to study the association between sibship and dispensing patterns of asthma medication in young children, focusing on incidence and persistence, and taking sibship status, asthma diagnoses, and siblings’ ...
  • Cesarean delivery, preterm birth and risk of food allergy : nationwide Swedish cohort study of over 1 million children 

    Mitselou, Niki; Hallberg, Jenny; Stephansson, Olof; Almqvist, Catarina; Melén, Erik; Ludvigsson, Jonas F (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-08-06)
    Background & Objectives: Little is known about early life risk factors for food allergy in children. We examined the association between perinatal characteristics and future risk of food allergy in offspring. Methods: ...
  • Everyday technologies and public space participation among people with and without dementia 

    Gaber, Sophie Nadia; Nygard, L; Brorsson, A; Kottorp, A; Malinowsky, C (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and SocietyMalmö University, 2019-06-12)
    BACKGROUND: Occupational therapists support everyday technology use; however, it is necessary to consider the challenges that people with dementia encounter with everyday technologies when participating in various places ...
  • Effects of design choices on the stiffness of wireframe DNA origami structures 

    Benson, Erik; Mohammed, Abdulmelik; Rayneau-Kirkhope, Daniel; Gådin, Andreas; Orponen, Pekka; Högberg, Björn (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-04-24)
  • Has the attention deficit hyperactivity disorder phenotype become more common in children between 2004 and 2014? Trends over 10 years from a Swedish general population sample 

    Rydell, Mina; Lundström, Sebastian; Gillberg, Christopher; Lichtenstein, Paul; Larsson, Henrik (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-03-27)
    Background: Studies have reported increases in clinically diagnosed and treated Attention deficit hyperactivity disorder (ADHD) during the last decade, but it is unclear if this reflects an increase in the underlying ADHD ...
  • Efficacy and cost-effectiveness of therapist-guided internet cognitive behavioural therapy for paediatric anxiety disorders : a single-centre, single-blind, randomised controlled trial 

    Jolstedt, Maral; Wahlund, Tove; Lenhard, Fabian; Ljótsson, Brjánn; Mataix-Cols, David; Nord, Martina; Öst, Lars-Göran; Högström, Jens; Serlachius, Eva; Vigerland, Sarah (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-03-27)
    Background: Paediatric anxiety disorders are prevalent and associated with substantial disability and long-term adverse consequences. Only a minority of affected children have access to evidence-based treatment; ...
  • How chronic is polypharmacy in old age? A longitudinal nationwide cohort study 

    Wastesson, Jonas W; Morin, Lucas; Laroche, Marie-Laure; Johnell, Kristina (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-03-14)
    OBJECTIVE: To evaluate the chronicity of polypharmacy among older adults, and to identify factors associated with chronic polypharmacy. DESIGN: Longitudinal cohort study using register data. SETTING: Nationwide, ...
  • Ageing, deep vein thrombosis and male gender predict poor outcome after acute Achilles tendon rupture 

    Domeij-Arverud, Erica; Anundsson, Per; Hardell, Eva; Barreng, Gunilla; Edman, Gunnar; Latifi, Ali; Labruto, Fausto; Ackermann, Paul (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-03-14)
    Background: Patients with acute Achilles tendon rupture (ATR) exhibit prolonged healing, high incidence of deep venous thrombosis (DVT) and a wide variation of functional outcome. This extensive discrepancy in outcome may ...
  • Reduced time to surgery improves patient-reported outcome after achilles tendon rupture. 

    Ackermann, Paul; Edman, Gunnar; Juthberg, Robin; Svedman, Simon (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-03-14)
    Background: Patient outcome after an acute Achilles tendon rupture (ATR) continues to be suboptimal and heterogeneous. Thus, prognostic factors are called for to optimize evidence-based ATR treatment protocols, however, ...
  • Anticholinergic burden and risk of stroke and death in people with different types of dementia 

    Tan, Edwin CK; Eriksdotter, Maria; Garcia-Ptacek, Sara; Fastbom, Johan; Johnell, Kristina (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-02-20)
    Background. Anticholinergic burden is associated with poorer cognitive and functional outcomes in people with dementia. However, the impact of anticholinergics on significant adverse outcomes such as stroke has not been ...
  • Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis 

    Lock, John G; Jones, Mattew C.; Askari, Janet A.; Gong, Xiaowei; Oddone, Anna; Olofsson, Helene; Göransson, Sara; Lakadamyali, Melike; Humphries, Martin J.; Strömblad, Staffan (Inst för biovetenskaper och näringslära / Dept of Biosciences and NutritionStrömblad laboratory of Clinical molecular biology, 2019-02-11)
    Adhesion to the extracellular matrix persists during mitosis in most cell types. However, while classical adhesion complexes, such as focal adhesions, do and must disassemble to enable mitotic rounding, the mechanisms of ...
  • Agreement between asthma questionnaire and health care register data 

    Hedman, Anna M; Gong, Tong; Lundholm, Cecilia; Dahlén, Elin; Ullemar, Vilhelmina; Brew, Bronwyn B; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-11-26)
    Purpose: Risk factors and consequences of asthma can be studied using validated questionnaires. The overall objective of this study was to assess the agreement of parental-reported asthma related questions regarding their ...
  • Allergen-specific IgE over time in women before, during and after pregnancy 

    Hedman, Anna M; Lundholm, Cecilia; Scheynius, Annika; Alm, Johan; Andolf, Annika; Pershagen, Göran; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-11-26)
    The trajectory of IgE levels before, during and after pregnancy in sensitized individuals is characterized by significant increase in specific IgE to birch allergens but not to other allergens after multiple testing. This ...
  • Bidirectional relationship between eating disorders and autoimmune diseases 

    Hedman, Anna; Breithaupt, Lauren; Hubel, Christopher; Thornton, Laura M; Tillander, Annika; Norring, Claes; Birgegård, Andreas; Larsson, Henrik; Ludvigsson, Jonas; Sävendahl, Lars; Almqvist, Catarina; Bulik, Cynthia M (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-11-26)
    Background: Immune system dysfunction may be associated with eating disorders, and associations could have implications for detection, risk assessment, and treatment of both autoimmune diseases and eating disorders. However, ...
  • Company employees as experimental participants in traffic safety research : prevalence and implications 

    Radun, Igor; Nilsonne, Gustav; Radun, Jenni; Helgesson, Gert; Kecklund, Göran; Nilsonne, Gustav (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and EthicsInst för klinisk neurovetenskap / Dept of Clinical NeuroscienceKarolinska Institutet, 2018-11-08)
    The use of company employees as experimental participants when testing products, technology or paradigms developed by the same company raises questions about bias in results and research ethics. We aimed to investigate the ...
  • Prognosis following cancer surgery during holiday periods 

    Lagergren, Jesper; Lagergren, Pernilla; Mattsson, Fredrik (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-10-19)
  • Weekday of cancer surgery in relation to prognosis 

    Lagergren, Jesper; Mattson, Fredrik; Lagergren, Pernilla (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-10-11)
    BACKGROUND: Later weekday of surgery seems to affect the prognosis adversely in oesophageal cancer, whereas any such influence on other cancer sites is unknown. This study aimed to test whether weekday of surgery influenced ...
  • Does treating vascular risk factors prevent dementia and Alzheimer’s disease? A systematic review and meta-analysis 

    Larsson, Susanna; Markus, Hugh (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-07-05)
    Background: Epidemiological evidence has associated Alzheimer’s disease (AD) with vascular risk factors (VRFs), but whether treatment of VRFs reduces the incidence of dementia and AD is uncertain. Objective: To ...

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