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Recent submissions

  • The new old normal : reassessing perioperative oxygen consumption and haemodynamics in the elderly 

    Jakobsson, Julia (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-04-01)
    Perioperative haemodynamic instability and disturbances of global oxygen transport are associated with complications and organ injury after surgery. The continuously growing population of elderly in surgical care are at ...
  • Scalable, safe and GMP-compatible production of embryonic stem cell derived retinal pigment epithelial cells 

    Padrell Sánchez, Sara (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-03-06)
    Regenerative medicine is an exponentially growing field that aims to regenerate a lost function, cell type or tissue due to damage, ageing or disease. Currently, more than 30,000 gene- and cell-based therapies have been ...
  • Hepatic ischemia-reperfusion injury 

    D'Souza, Melroy Alistair (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-02-28)
    Hepatic ischemia-reperfusion (I/R) injury is a complex phenomenon occuring in response to interruption of the liver’s blood and oxygen supply and the subsequent restoration of blood flow and tissue oxygenation. Techniques ...
  • Voice disorders and treatment effects in Parkinson's disease studied with a portable voice accumulator 

    Körner Gustafsson, Joakim (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-02-11)
    Background: Information about voice use outside the clinical setting has traditionally consisted of subjective data collected via interviews or questionnaires. Quantitative, objective information about voice use in daily ...
  • Microdialysis : potentials and limitations 

    Platen, Anna von (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-02-03)
    Despite improvements in operating technique and post-operative management, many patients undergoing liver transplantation still suffer post-operative complications, which may lead to graft loss or patient death. Patients ...
  • Different perspectives of living with osteoarthritis and outcomes after knee arthroplasty 

    Skogö Nyvang, Josefina (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-01-31)
    Osteoarthritis (OA) is the most common joint disease affecting the population increasingly with age. Living with OA and pain can cause severe distress in an individual’s life and expectations of outcome after joint ...
  • Optimizing computed tomography : quality assurance, radiation dose and contrast media 

    Nowik, Patrik (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-01-22)
    Computed tomography (CT) is an important modality in radiology; it enables imaging of the inside of patients without superimposed anatomy. The radiation dose and quality of a CT image are highly dependent on the CT scanner, ...
  • The papilla of Vater : issues relevant to transpapillary cannulation and clinical management. 

    Haraldsson, Erik (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-12-20)
    Background: Many endoscopists have since the beginning of endoscopic retrograde cholangiopancreatography (ERCP) commented on the variation in the macroscopic appearance of the papilla of Vater. How the macroscopic appearance ...
  • Anabolic response to amino acid supplementation in critical illness 

    Liebau, Felix (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-11-07)
    Background: Critically ill patients suffer from protein catabolism with losses of skeletal muscle and whole-body proteins associated with morbidity and mortality. Catabolism is difficult to overcome, but nutritional ...
  • Neutrophil subsets in airway inflammation and hyperreactivity 

    Ekstedt, Sandra (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-11-06)
    Neutrophils are part of the first lines of defence against invading microbes. They play an essential role in antimicrobial host defence by recognizing microorganisms through the various receptors that can be expressed on ...
  • Radiation dose-, contrast media- and image quality optimization in computed tomography 

    Thor, Daniel (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-10-31)
    Computed tomography (CT) was introduced to medicine in the early 1970s, which brought slice imaging into wide use for the first time. Today, CT is an essential part of radiological diagnostics, and is used for a wide ...
  • The cholinergic anti-inflammatory pathway and heart rate variability with special reference to dialysis and renal denervation 

    Hilderman, Marie (Inst för klinisk vetenskap, intervention och teknik - CLINTEC/ Department of Clinical Science, Intervention and Technology Clintec, 2019-10-30)
    Background: The Cholinergic Anti-inflammatory Pathway (CAP) is a nerve-mediated circuit through which the vagus nerve regulates the activity of the inflammatory immune response. Injury, ischemia or infection activate the ...
  • Chronic pancreatitis fibrogenesis : the role of TGFB pathway inhibitor Smad7 in the fibrosis development 

    Li, Xuan (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-10-02)
    Chronic pancreatitis is characterized by progressive inflammation, acinar atrophy and fibrosis. Transforming growth factor-B signaling (TGFB) is the most potent fibrogenic cytokine known, and its increased expression is a ...
  • Massive transfusion in relation to obstetric hemorrhage : with special attention to placenta accreta 

    Thurn, Lars (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-08-22)
    The overall purpose of this thesis was to assess risk factors, incidences, and complications of massive blood transfusions in relation to obstetric hemorrhage postpartum. Obstetric hemorrhage requiring blood transfusion ...
  • Cardiovascular health in children and adolescents with obesity : prevalence, prediction and supervised exercise 

    Hedvall Kallerman, Pernilla (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-08-19)
    Background: Cardiovascular disease (CVD) is a major cause of death worldwide and is preceded by a long process in which several cardiovascular (CV) risk factors are present, sometimes already in childhood. Some of these ...
  • Borderline and locally advanced pancreatic cancer : redefining the biological and technical profile of the disease 

    Rangelova, Elena (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-08-09)
    Surgery is the only treatment modality that provides a chance for long-term survival in pancreatic cancer (PC). Thus, the current classification systems for PC are technically skewed to predicted the probability for surgical ...
  • Music therapy : an intervention effecting quality of life and health in children going through hematopoietic stem cell transplantation 

    Uggla, Lena (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-05-21)
    Hematopoietic stem cell transplantation (HSCT) is an established treatment for several types of leukemic, hematopoietic, and metabolic diseases. The child is isolated during 4-6 weeks, followed by extensive follow-up for ...
  • Health related quality of life and swallowing problems in oesophageal cancer 

    Sunde, Berit (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-04-25)
    Poor overall survival, swallowing problems and severe side-effects from multi-modality treatment characterize the situation of patients with oesophageal and gastro oesophageal junction carcinoma (GOJ). With the poor prognosis ...
  • Quality of life, physical activity and bone health in idiopathic scoliosis 

    Diarbakerli, Elias (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-04-16)
    Idiopathic scoliosis is a deformation of the spine affecting 1-3% of children and adolescents during growth. Severe deformities may lead to pulmonary dysfunction, pain and decreased quality of life. The etiology of the ...
  • The reactive stroma in pancreatic diseases 

    Norberg, Jessica (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-04-16)
    Stroma, or activated connective tissue, is a key component in both pancreatitis and pancreatic tumors. Acute pancreatitis (AP) is an inflammation of the pancreas which ranges from mild and local to systemic with severe ...

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