Inst för medicin, Huddinge / Dept of Medicine, Huddinge: Recent submissions
Now showing items 41-60 of 349
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Characterization and targeting of leukemia propagating cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-09)Patients with hematopoietic malignancies have a large, unmet medical need. Allogeneic hematopoietic stem cell transplantation remains the only curative option, but many patients are not eligible for such treatment. Many ... -
Plasma cell malignancies in Sweden : subgroup descriptions and regional outcomes for multiple myeloma
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-04-13)Plasma cell disorders appear in various forms such as aggressive plasma cell leukemia (PCL), typical symptomatic multiple myeloma (MM), non-symptomatic smouldering multiple myeloma (SMM) and solitary plasmacytoma (SP). The ... -
Maternal obesity and offspring metabolic outcomes : focus on sex differences
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-04-01)Obesity is a worldwide health issue affecting all ages and both sexes, and its prevalence is progressively increasing among adults and children. The predisposition to metabolic complications caused by obesity is sex ... -
B cell responses to human flavivirus vaccination and SARS-CoV-2 infection
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-02-25)Viral infections pose a major threat to global heath. As specific antiviral treatments are lacking against many human viruses, vaccination is the most effective medical intervention to prevent severe disease and death. ... -
Adaptive immune responses to tick-borne encephalitis virus and SARS-CoV-2
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-01-11)Tick-borne encephalitis virus (TBEV) and SARS-CoV-2 are two unrelated viruses that currently cause substantially different public health burdens and distinct pathologies in humans. TBEV infection leads to neurological ... -
Studies on the links between white adipose tissue phenotype and the circulatory system
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-12-22)Obesity is a strong risk factor for cardiovascular disease. It is defined by an unhealthy excess of white adipose tissue (WAT). Adipose derived weight gains and losses are linked to changes in two other independent ... -
Streptococcal and staphylococcal tissue infections : therapeutic challenges and opportunities
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-11-26)Streptococcus pyogenes and Staphylococcus aureus have been leading causes of human infections throughout history. S. pyogenes is of the top-ten pathogens responsible for most death globally, 0.5 million deaths per year. ... -
Familial hypercholesterolemia in Sweden : genetic and clinical studies
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-11-12)Prevention of premature disease and death from cardiovascular complications of atherosclerosis is an important goal for public health, and the early identification of individuals with increased risk is an important goal ... -
MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-09-16)T cell-driven diseases account for considerable morbidity and disability globally and there is an urgent need for new targeted therapies. Both cancer cells and activated T cells have an altered redox balance, and up-regulate ... -
Genetic predisposition to immune cell malfunction and inflammation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-09-10)Our genome contains all the instructions to control the synthesis of proteins, the development of cells and the interaction between body systems. We are armed with an immune system, made up of cells, chemical compounds and ... -
The epidemiology of varicella zoster virus disease in Sweden : before and after vaccination
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-09-10)Primary infection with the varicella zoster virus (VZV) presents as chickenpox, a highly contagious infection. Thereafter the virus establishes latency in nerve ganglia of the host. The virus may reactivate later in life ... -
Human ISL1+ ventricular progenitors self-assemble into an in vivo functional heart patch and preserve cardiac function post infarction
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-07-01)The generation of human pluripotent stem cell (hPSC)-derived ventricular progenitors and their assembly into a 3-dimensional in vivo functional ventricular heart patch has remained an elusive goal. Herein, we report the ... -
Studies of inflammatory responses in hantavirus infection
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-05-28)Throughout the world, orthohantaviruses cause severe, acute infections in humans. Orthohantaviruses, commonly referred to as hantaviruses, are zoonotic viruses with a single stranded RNA genome of negative sense. Hantavirus ... -
From fatty liver to end-stage liver disease through type 2 diabetes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-05-28)The past decades have seen a marked increase in the incidence of type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Epidemiological studies have clearly demonstrated that there is an association between type 2 ... -
Clinical consequences of pancreatic exocrine insufficiency
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-05-27)Background: Chronic pancreatitis (CP) is characterized by a chronic inflammation with fibrosis and irreversible morphological changes that can result in permanent structural changes with a loss of exocrine and endocrine ... -
The antimicrobial role of human MAIT cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-03-19)MAIT cells are unconventional T cells that have characteristics of both innate and adaptive immunity. Their fast mobilization and wide distribution in tissues make them part of the first line of defense against infection. ... -
Strategies to assess and improve prognostication of plasma cell disorders
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-03-01)Plasma cell dyscrasias (PCD) are a group of disorders, most of which have the overproduction of monoclonal immunoglobulins (M-protein) in common. Included in the group of PCDs are both benign and treatment demanding ... -
Immunopathogenesis in pulmonary tuberculosis : impact of immunomodulation and diabetes co-morbidity
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-26)Even in the 21st century, tuberculosis (TB) remains a major global health threat, primarily due to the emergence of antibiotic resistance. Presence of co-morbidities such as diabetes mellitus (DM) has worsened the current ... -
Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-17)A family of multipotent heart progenitors plays a central role in the generation of diverse myogenic and nonmyogenic lineages in the heart. Cardiac progenitors in particular play a significant role in lineages involved in ... -
Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-02-17)The mammalian hearts have the least regenerative capabilities among tissues and organs. As such, heart regeneration has been and continues to be the ultimate goal in the treatment against acquired and congenital heart ...