Now showing items 21-40 of 342

    • Innate lymphocyte responses in inflammatory diseases 

      Emgård, Johanna (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-10-31)
      The immune system is a highly sophisticated system that has evolved to protect the host from external and internal threats. However, under some circumstances the immune response can get dysregulated and cause inflammatory ...
    • Advancing cancer immunotherapy by exploring NK cell education, antibody targeting and tissue homing : stay tuned for directions reaching beyond the natural biology 

      Leijonhufvud, Caroline (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-10-21)
      Cancer immunotherapy is a fast-growing field. The natural killer (NK) cells’ innate ability to detect malignant cells and capacity to perform antibody-dependent cellular cytotoxicity (ADCC) together with low risk of inducing ...
    • Liver cirrhosis : epidemiology, prognosis, and cancer 

      Bengtsson, Bonnie (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-09-29)
      Liver cirrhosis is a major risk factor for hepatocellular carcinoma (HCC). Patients with liver cirrhosis also have a high risk to develop infections leading to deterioration of liver function and increased mortality. In ...
    • Innate lymphoid cell differentiation and functions in intestinal homeostasis and disease 

      Kokkinou, Efthymia (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-09-15)
      The gastrointestinal (GI) tract, which includes the small and the large intestine, is considered the largest immunological organ that plays a pivotal role in food digestion, nutrient absorption and fuel generation. ...
    • Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure 

      De Genst, Erwin; Foo, Kylie S; Xiao, Yao; Rohner, Eduarde; de Vries, Emma; Sohlmér, Jesper; Witman, Nevin; Hidalgo, Alejandro; Kolstad, Terje R S; Louch, William E; Pehrsson, Susanne; Park, Andrew; Ikeda, Yasuhiro; Li, Xidan; Mayr, Lorenz M; Wickson, Kate; Jennbacken, Karin; Hansson, Kenny; Fritsche-Danielson, Regina; Hunt, James; Chien, Kenneth R (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-19)
      The dysregulated physical interaction between two intracellular membrane proteins, the sarco/endoplasmic reticulum Ca2+ ATPase and its reversible inhibitor phospholamban, induces heart failure by inhibiting calcium cycling. ...
    • Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy 

      Beverborg, Niels Grote; Spater, Daniela; Knoll, Ralph; Hidalgo, Alejandro; Yeh, Steve T; Elbeck, Zaher; Sillje, Herman H W; Eijgenraam, Tim R; Siga, Humam; Zurek, Magdalena; Palmer, Malin; Pehrsson, Susanne; Albery, Tamsin; Bomer, Nils; Hoes, Martijn F; Boogerd, Cornelis J; Frisk, Michael; van Rooij, Eva; Damle, Sagar; Louch, William E; Wang, Qing-Dong; Fritsche-Danielson, Regina; Chien, Kenneth R; Hansson, Kenny M; Mullick, Adam E; de Boer, Rudolf A; van der Meer, Peter (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-18)
      Heart failure (HF) is a major cause of morbidity and mortality worldwide, highlighting an urgent need for novel treatment options, despite recent improvements. Aberrant Ca2+ handling is a key feature of HF pathophysiology. ...
    • An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation 

      Rohner, Eduarde; Witman, Nevin; Sohlmér, Jesper; De Genst, Erwin; Louch, William E; Sahara, Makoto; Chien, Kenneth R (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-17)
      Background: The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be ...
    • Clinical aspects of hidradenitis suppurativa 

      Killasli, Hassan (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-08-12)
      Hidradenitis suppurativa (HS) is often a chronic skin disease of unknown etiology characterized by formation of non-infectious inflammatory nodules, abscesses, and suppurating skin tunnels mainly in axillae and groins. The ...
    • The role of innate immunity in obesity-induced tissue inflammation 

      Stiglund, Natalie (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-08-02)
      The prevalence of obesity is rapidly increasing globally, which causes an increase in associated diseases such as type 2 diabetes, cardiovascular disease and non-alcoholic fatty liver disease (NAFLD). In addition to the ...
    • Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors 

      Poch, Christine M; Foo, Kylie S; De Angelis, Maria Teresa; Jennbacken, Karin; Santamaria, Gianluca; Bähr, Andrea; Wang, Qing-Dong; Reiter, Franziska; Hornaschewitz, Nadja; Zawada, Dorota; Bozoglu, Tarik; My, Ilaria; Meier, Anna; Dorn, Tatjana; Hege, Simon; Lehtinen, Miia L; Tsoi, Yat Long; Hovdal, Daniel; Hyllner, Johan; Schwarz, Sascha; Sudhop, Stefanie; Jurisch, Victoria; Sini, Marcella; Fellows, Mick D; Cummings, Matthew; Clarke, Jonathan; Baptista, Ricardo; Eroglu, Elif; Wolf, Eckhard; Klymiuk, Nikolai; Lu, Kun; Tomasi, Roland; Dendorfer, Andreas; Gaspari, Marco; Parrotta, Elvira; Cuda, Giovanni; Krane, Markus; Sinnecker, Daniel; Hoppmann, Petra; Kupatt, Christian; Fritsche-Danielson, Regina; Moretti, Alessandra; Chien, Kenneth R; Laugwitz, Karl-Ludwig (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-02)
      Heart regeneration is an unmet clinical need, hampered by limited renewal of adult cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging, but unravelling cellular dynamics of host–graft ...
    • Origin and ontogeny of human lung macrophages 

      Evren, Elza (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-20)
      The lung is a vital organ occupied by a large diversity of immune cells due to its close proximity with the external environment. This thesis focuses on a particular type of immune cell: the macrophage. The lungs are ...
    • Implications of chronic kidney disease on presentation, treatment and outcomes in patients with aortic stenosis 

      Vavilis, Georgios (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-19)
      Background: Aortic valve stenosis (AS) is the most common valvular heart disease in the western world. No pharmacological treatment has been proved to halt the progression to severe disease and after symptom debut, the ...
    • Aspects of diagnosis, prognosis and treatment of nonalcoholic fatty liver disease 

      Holmer, Magnus (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-16)
      Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease globally. NAFLD is caused by obesity, often in combination with type 2 diabetes mellitus (T2D). Lifestyle modifications that lead to weight ...
    • Characterization and targeting of leukemia propagating cells 

      Virding Culleton, Stina (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-05-09)
      Patients with hematopoietic malignancies have a large, unmet medical need. Allogeneic hematopoietic stem cell transplantation remains the only curative option, but many patients are not eligible for such treatment. Many ...
    • Plasma cell malignancies in Sweden : subgroup descriptions and regional outcomes for multiple myeloma 

      Wålinder, Göran (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-04-13)
      Plasma cell disorders appear in various forms such as aggressive plasma cell leukemia (PCL), typical symptomatic multiple myeloma (MM), non-symptomatic smouldering multiple myeloma (SMM) and solitary plasmacytoma (SP). The ...
    • Maternal obesity and offspring metabolic outcomes : focus on sex differences 

      Savva, Christina (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-04-01)
      Obesity is a worldwide health issue affecting all ages and both sexes, and its prevalence is progressively increasing among adults and children. The predisposition to metabolic complications caused by obesity is sex ...
    • B cell responses to human flavivirus vaccination and SARS-CoV-2 infection 

      Sandberg, Tyler (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-02-25)
      Viral infections pose a major threat to global heath. As specific antiviral treatments are lacking against many human viruses, vaccination is the most effective medical intervention to prevent severe disease and death. ...
    • Adaptive immune responses to tick-borne encephalitis virus and SARS-CoV-2 

      Varnaitė, Renata (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-01-11)
      Tick-borne encephalitis virus (TBEV) and SARS-CoV-2 are two unrelated viruses that currently cause substantially different public health burdens and distinct pathologies in humans. TBEV infection leads to neurological ...
    • Studies on the links between white adipose tissue phenotype and the circulatory system 

      Bäckdahl, Jesper (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-12-22)
      Obesity is a strong risk factor for cardiovascular disease. It is defined by an unhealthy excess of white adipose tissue (WAT). Adipose derived weight gains and losses are linked to changes in two other independent ...
    • Streptococcal and staphylococcal tissue infections : therapeutic challenges and opportunities 

      Bergsten, Helena (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-11-26)
      Streptococcus pyogenes and Staphylococcus aureus have been leading causes of human infections throughout history. S. pyogenes is of the top-ten pathogens responsible for most death globally, 0.5 million deaths per year. ...