Inst för medicin, Huddinge / Dept of Medicine, Huddinge: Recent submissions
Now showing items 1-20 of 245
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Exploring the role of epigenetic alterations in myeloid malignancies with focus on drug response
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-11-19)The production of blood cells (hematopoiesis), where the hematopoietic stem cell (HSC) is the cell of origin of all blood cells, is regulated by a complex network of intrinsic and extrinsic signals. Dysregulation of ... -
Unraveling novel genes that are essential for acute myeloid leukemia and normal hematopoiesis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-10-31)Acute myeloid leukemia (AML) is the most common hematological malignancy among adults. This disease results from an abnormal expansion of myeloid progenitors that are blocked in differentiation. Malignant transformation ... -
Cervical intraepithelial neoplasia in migrant women living with HIV
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-10-19)The aim of this thesis was to study high-grade cervical intraepithelial neoplasia (CIN) in women living with HIV (WLWH) in Sweden compared with HIV-negative women (HNW) of the same region of birth. In Paper I ... -
Sex and gender differences in patients undergoing ablation of atrial arrhythmias
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-10-08)Background: Women and men differ in the prevalence of arrhythmias. Furthermore, there are sex and gender differences in referral for ablation, symptom severity, health-related quality of life (HRQOL), functional impairment ... -
Bile acid metabolism in humans : regulation of synthesis and circadian rhythms
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-10-03)Interfering with bile acids (BAs) signaling within the enterohepatic circulation (EHC) has recently emerged as an important way of controlling human metabolic homeostasis. This is highly relevant to a number of frequent ... -
Identification of novel genes with important functions in glioblastoma multiforme and acute myeloid leukemia
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-09-21)Glioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. The cancer stem cells of GBM (GSCs) are notorious for being invasive as well as resistant to radiation and chemotherapy. The current ... -
Inflammation and impaired adipogenesis in human white adipose tissue
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-08-30)This thesis aimed to study inflammation and adipogenesis capacity in human subcutaneous white adipose tissue with respect to the development of obesity and associated comorbidities, including insulin resistance. Study ... -
Identification and characterization of novel genetic and epigenetic factors required for normal and malignant hematopoiesis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-08-23)Acute myeloid leukemia (AML) is a type of blood cancer, characterized by clonal expansion and loss of differentiation ability of myeloid progenitor cells leading to abnormal accumulation of immature myeloid cells ... -
Redox alterations in inflammatory diseases : diabetes, kidney failure and cancer
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-08-10)In order to combat oxidative stress and maintain the intracellular redox homeostasis, cells are equipped with antioxidant systems. The thioredoxin and glutaredoxin systems are the major thiol reducing systems and central ... -
Renal dysfunction in heart failure : insights on prevalence and prognosis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-08-10)Background Kidney disease is common in heart failure (HF) and has been found to be associated with worse outcomes. The impact of different degrees of chronic kidney disease (CKD) in HF, as well as the link to, and ... -
Severe obesity in young adults : characterization and treatment outcomes with emphasis on mental health aspects
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-05-23)Background: Obesity (body mass index [BMI] ≥30 kg/m2) is associated with a range of physical and psychiatric comorbidities and premature mortality. Young adulthood (here 16-25 years) constitutes a vulnerable period for ... -
Hormonal influences on cholesterol and bile acid metabolism : focusing on involvement of PCSK9
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-05-07)Elevated plasma LDL-C is today considered a causative factor for the development of atherosclerosis. Increased plasma LDL-C levels are mainly due to reduced numbers of functional LDL receptors (LDLRs) in the liver. PCSK9 ... -
Biliary strictures in primary sclerosing cholangitis : aspects on inflammation and malignancy
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-05-02)Primary sclerosing cholangitis (PSC) is a rare liver disease that is characterized by chronic inflammation of bile ducts with development of fibrosis and strictures. The pathogenic mechanisms involved in this disease are ... -
New innovations to support self-care in persons with heart failure
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-04-24)Introduction: Heart failure (HF) in combination with multiple chronic conditions is increasing rapidly, mainly in the elderly. Self-care is presumed to be one of the best practices for chronic illness including HF. ... -
The mutational landscape and microenvironment in myelodysplastic syndromes with deletion of chromosome 5q
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-02-08)Myelodysplastic Syndromes (MDS) with deletion of chromosome 5q (del(5q) are malignant bone marrow disorders characterized by macrocytic anemia, chronic transfusion dependency and an increased risk of progression to acute ... -
Phagocytic cells and Streptococcus pyogenes in invasive infections : an inflammatory relationship
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-12-21)Severe Streptococcus pyogenes infections, such as streptococcal toxic shock syndrome and necrotizing soft tissue infections, are rare but life threatening conditions. They are characterized by high bacterial load and a ... -
Innate lymphoid cell heterogeneity in human tissues at steady state and during inflammation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-11-23)The family of innate lymphoid cells (ILCs) is the most recently identified group of innate immune cells. The ILC classification groups the cells according to their transcription factor and cytokine profile into ILC1, ... -
The role of monocytes in chronic inflammatory diseases
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-11-15)Monocytes and monocyte-derived cells are important players in the orchestration of inflammatory reactions in blood and peripheral tissues. However, little is known about the monocyte fate upon entry into human tissues, ... -
Role of MAIT cells in human antimicrobial immunity
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-10-31)Mucosa-associated invariant T (MAIT) cells are a relatively recently discovered subset of unconventional T cells. In humans, MAIT cells are predominantly CD8+CD4- (CD8+) with a smaller CD8-CD4- (double-negative, DN) ... -
Human cytotoxic lymphocyte differentiation in health and disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-10-26)Cytotoxic lymphocytes, comprising natural killer (NK) cells and CD8+ cytotoxic T cells, eradicate infected or malignant cells by release of lytic granules and alarm the immune system through production of pro-inflammatory ...