Inst för medicin, Huddinge / Dept of Medicine, Huddinge: Recent submissions
Now showing items 1-20 of 255
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Clinical aspects of chronic graft-versus-host disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-18)Chronic graft-versus-host disease (cGVHD) remains one of the most severe complications after allogeneic hematopoietic stem cell transplantation (HSCT), affecting both the quality of life and mortality of long-term survivors. ... -
Predictors of arrhythmias, cardiac arrest, and mortality in Acute coronary syndrome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-17)Background. Patients with acute coronary syndrome (ACS) face a high risk of lethal complications, both during the hospital course and after discharge. The aim of this thesis was to assess patient characteristics and ... -
Invariant T cell subsets in immune defense of oral mucosa and skin
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-12)Innate-like T lymphocytes such as mucosa-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells recognize antigens presented by MR1 and CD1d molecules, respectively. As MR1 presents microbial ... -
Natural killer cells, multiple myeloma, and daratumumab : a love-hate relationship
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-11)Multiple myeloma is a treatable, but not yet curable, malignant plasma cell disease. Over the last decades, the overall survival time of multiple myeloma patients has constantly increased thanks to improvements in ... -
Studies of innate and adaptive lymphocytes in human liver diseases and viral infections
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-01)The immune system, including innate and adaptive lymphocytes, is involved in determining the outcome of many human diseases. Two lymphocyte subsets, natural killer (NK) cells and T cells, which are present in both ... -
Identification of novel factors regulating human adipocyte function and their link to metabolic health
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-03-13)The white adipose tissue (WAT) regulates energy homeostasis by storing and releasing energy in the form of fat as well as functioning as an endocrine organ secreting a myriad of different peptides. The heterogeneous WAT ... -
Adipose markers of metabolic outcome after weight loss
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-02-28)Adipose tissue is closely linked to metabolic disturbances in obesity. Bariatric surgery such as roux-en-Y gastric bypass (RYGB) remains the most effective treatment of obesity and obesity-related disease. More factors ... -
Studies of effector functions in mycobacterium tuberculosis infected macrophages with implications for host-directed therapies
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-02-15)Tuberculosis infection remains a global health problem and the emergence of multidrugresistant TB (MDR-TB) adds further challenges in the battle to stop the spread of infection. Macrophages are the primary host cells to ... -
Bronchoprovocation studies to define mechanisms in asthma and airway inflammation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-01-31)Bronchial provocations with a variety of stimuli have been widely used over the past 70 years in both asthma research as well as in daily clinical praxis in order to aid the physician to establish the asthma diagnosis. In ... -
Understanding the role of bone marrow niche in myeloid malignancies
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-01-31)Normal hematopoiesis is generated and maintained by rare hematopoietic stem cells (HSCs) through their capacity to self-renew and differentiate. This process is rigorously controlled, both by HSC-intrinsic molecular ... -
Exploring the role of epigenetic alterations in myeloid malignancies with focus on drug response
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-11-19)The production of blood cells (hematopoiesis), where the hematopoietic stem cell (HSC) is the cell of origin of all blood cells, is regulated by a complex network of intrinsic and extrinsic signals. Dysregulation of ... -
Unraveling novel genes that are essential for acute myeloid leukemia and normal hematopoiesis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-10-31)Acute myeloid leukemia (AML) is the most common hematological malignancy among adults. This disease results from an abnormal expansion of myeloid progenitors that are blocked in differentiation. Malignant transformation ... -
Cervical intraepithelial neoplasia in migrant women living with HIV
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-10-19)The aim of this thesis was to study high-grade cervical intraepithelial neoplasia (CIN) in women living with HIV (WLWH) in Sweden compared with HIV-negative women (HNW) of the same region of birth. In Paper I ... -
Sex and gender differences in patients undergoing ablation of atrial arrhythmias
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-10-08)Background: Women and men differ in the prevalence of arrhythmias. Furthermore, there are sex and gender differences in referral for ablation, symptom severity, health-related quality of life (HRQOL), functional impairment ... -
Bile acid metabolism in humans : regulation of synthesis and circadian rhythms
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-10-03)Interfering with bile acids (BAs) signaling within the enterohepatic circulation (EHC) has recently emerged as an important way of controlling human metabolic homeostasis. This is highly relevant to a number of frequent ... -
Identification of novel genes with important functions in glioblastoma multiforme and acute myeloid leukemia
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-09-21)Glioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. The cancer stem cells of GBM (GSCs) are notorious for being invasive as well as resistant to radiation and chemotherapy. The current ... -
Inflammation and impaired adipogenesis in human white adipose tissue
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-08-30)This thesis aimed to study inflammation and adipogenesis capacity in human subcutaneous white adipose tissue with respect to the development of obesity and associated comorbidities, including insulin resistance. Study ... -
Identification and characterization of novel genetic and epigenetic factors required for normal and malignant hematopoiesis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-08-23)Acute myeloid leukemia (AML) is a type of blood cancer, characterized by clonal expansion and loss of differentiation ability of myeloid progenitor cells leading to abnormal accumulation of immature myeloid cells ... -
Redox alterations in inflammatory diseases : diabetes, kidney failure and cancer
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-08-10)In order to combat oxidative stress and maintain the intracellular redox homeostasis, cells are equipped with antioxidant systems. The thioredoxin and glutaredoxin systems are the major thiol reducing systems and central ... -
Renal dysfunction in heart failure : insights on prevalence and prognosis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-08-10)Background Kidney disease is common in heart failure (HF) and has been found to be associated with worse outcomes. The impact of different degrees of chronic kidney disease (CKD) in HF, as well as the link to, and ...