Inst för medicin, Huddinge / Dept of Medicine, Huddinge: Recent submissions
Now showing items 1-20 of 235
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Severe obesity in young adults : characterization and treatment outcomes with emphasis on mental health aspects
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-05-23)Background: Obesity (body mass index [BMI] ≥30 kg/m2) is associated with a range of physical and psychiatric comorbidities and premature mortality. Young adulthood (here 16-25 years) constitutes a vulnerable period for ... -
Hormonal influences on cholesterol and bile acid metabolism : focusing on involvement of PCSK9
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-05-07)Elevated plasma LDL-C is today considered a causative factor for the development of atherosclerosis. Increased plasma LDL-C levels are mainly due to reduced numbers of functional LDL receptors (LDLRs) in the liver. PCSK9 ... -
Biliary strictures in primary sclerosing cholangitis : aspects on inflammation and malignancy
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-05-02)Primary sclerosing cholangitis (PSC) is a rare liver disease that is characterized by chronic inflammation of bile ducts with development of fibrosis and strictures. The pathogenic mechanisms involved in this disease are ... -
New innovations to support self-care in persons with heart failure
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-04-24)Introduction: Heart failure (HF) in combination with multiple chronic conditions is increasing rapidly, mainly in the elderly. Self-care is presumed to be one of the best practices for chronic illness including HF. ... -
The mutational landscape and microenvironment in myelodysplastic syndromes with deletion of chromosome 5q
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-02-08)Myelodysplastic Syndromes (MDS) with deletion of chromosome 5q (del(5q) are malignant bone marrow disorders characterized by macrocytic anemia, chronic transfusion dependency and an increased risk of progression to acute ... -
Phagocytic cells and Streptococcus pyogenes in invasive infections : an inflammatory relationship
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-12-21)Severe Streptococcus pyogenes infections, such as streptococcal toxic shock syndrome and necrotizing soft tissue infections, are rare but life threatening conditions. They are characterized by high bacterial load and a ... -
Innate lymphoid cell heterogeneity in human tissues at steady state and during inflammation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-11-23)The family of innate lymphoid cells (ILCs) is the most recently identified group of innate immune cells. The ILC classification groups the cells according to their transcription factor and cytokine profile into ILC1, ... -
The role of monocytes in chronic inflammatory diseases
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-11-15)Monocytes and monocyte-derived cells are important players in the orchestration of inflammatory reactions in blood and peripheral tissues. However, little is known about the monocyte fate upon entry into human tissues, ... -
Role of MAIT cells in human antimicrobial immunity
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-10-31)Mucosa-associated invariant T (MAIT) cells are a relatively recently discovered subset of unconventional T cells. In humans, MAIT cells are predominantly CD8+CD4- (CD8+) with a smaller CD8-CD4- (double-negative, DN) ... -
Human cytotoxic lymphocyte differentiation in health and disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-10-26)Cytotoxic lymphocytes, comprising natural killer (NK) cells and CD8+ cytotoxic T cells, eradicate infected or malignant cells by release of lytic granules and alarm the immune system through production of pro-inflammatory ... -
Understanding chronic immunodeficiency disorders through assessment of cytotoxic lymphocyte function
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-09-20)Representing an evolving and diverse group of syndromes, immunodeficiencies can currently be viewed as a spectrum of disorders where a dysfunction of the immune system plays a significant etiologic role. Cytotoxic ... -
The role of microbial translocation and gut microbiota in HIV-1 infection
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-09-01)HIV-1 infection is characterized by persistent systemic inflammation and immune activation, even in patients receiving effective antiretroviral therapy (ART). Translocation of microbial compounds from a leaky gut to systemic ... -
Aberrant DNA methylation in acute myeloid leukemia
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-05-18)DNA methylation is an important epigenetic mechanism that influences development and cancer by regulating gene transcription. Aberrant DNA methylation is a feature of cancer including acute myeloid leukemia (AML). It was ... -
Long-term clinical, histological and virological outcomes after sustained virologic response in patients with chronic hepatitis C
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-05-09)Successful antiviral treatment of chronic hepatitis C (HCV), resulting in Sustained Virologic Response (SVR) has been shown to reduce the risk for liver related complications, hepatocellular carcinoma (HCC) and death. ... -
Enterovirus infections in type 1 diabetes and cystic fibrosis : antiviral defence and viral immune evasion strategies
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-04-20)Enteroviruses are common viruses which cause infections in humans that usually result in mild flu-like symptoms before viral clearance. However, in some cases these infections can progress to more severe diseases such ... -
Neutrophil interactions with Streptococcus pyogenes and Staphylococcus aureus
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-04-03)Streptococcus pyogenes and Staphylococcus aureus are Gram-positive bacteria that share many features, including clinical presentations and pathogenic mechanisms, and yet, they still have unique properties. They both cause ... -
Atrial fibrillation and lifestyle factors with focus on physical activity and alcohol consumption
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-02-06)The overall aim of this thesis was to investigate how modifiable lifestyle factors, with a focus on alcohol consumption and physical activity, influence the risk of atrial fibrillation (AF). The thesis is based on data ... -
Aspects on endoscopic characterization and clinical management of Barrett's esophagus
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-12-30)Barrett's esophagus (BE) is considered to result from prolonged gastroesophageal reflux and is the only known precursor of esophageal adenocarcinoma. The clinical management of BE patients aims to control esophageal ... -
Role of innate cellular immunity in the immunopathogenesis of HIV-1 infection in Uganda
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-11-17)The global epidemic of HIV has resulted in more than 34 million deaths and currently 36.9 million HIV-infected people worldwide. Uganda has an HIV prevalence of 7.3%, equating to about 1.6 million people. This has placed ... -
Genotype-phenotype relations in SF3B1 mutated myelodysplastic syndromes with ring sideroblasts
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-10-28)Myelodysplastic syndrome with ring sideroblasts (MDS-RS) is a clonal hematopoietic stem cell disorder characterized by hyperplastic and ineffective erythropoiesis, ring sideroblasts in the bone marrow, and anemia. ...