Inst för medicin, Huddinge / Dept of Medicine, Huddinge: Recent submissions
Now showing items 1-20 of 271
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On osmolality and sperm function during processing for assisted reproduction
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-03-24)Deep basic knowledge about sperm physiology is relevant and important to optimize the outcome of procedures used during Assisted Reproductive Technologies (ART) to select spermatozoa for fertilization. More specifically, ... -
Genetic and epigenetic studies of acute myeloid leukemia and therapeutic possibilities
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-03-05)Acute myeloid leukaemia (AML) is malignant tumour that forms in the bone marrow and arises from immature myeloid progenitors. Consequently, this leads to excessive accumulation of dysfunctional blast cells and lack of ... -
Focus on fibroblasts : development, plasticity, and therapeutic challenges in the cardiac fibroblast lineage.
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-02-28)Cardiac fibroblasts (CFs) are cells of mesenchymal origin and represent a heterogeneous population in the mammalian heart. They secrete extracellular matrix (ECM) molecules providing structural support during heart development ... -
Characterization of secondary and therapy-related acute myeloid leukemia
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-02-13)Secondary acute myeloid leukemia (s-AML) refers to patients with either therapy-related AML (t-AML), that is, AML after treatment with chemo- and/or radiation for a prior disease, or AML progressing from an antecedent ... -
Educational leadership in physicians´ specialist training : programme directors´ experiences
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-02-07)Competent physicians working in teams with other health professionals are a prerequisite for excellent patient care. The context for this thesis is physicians’ specialist training, which consists of workplace learning in ... -
Follicular lymphoma : clinical and biological factors associated with response to therapy and overall prognosis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-01-29)Follicular lymphoma (FL) is a heterogeneous group of malignancies within the adaptive immune system. The clinical course is highly variable. Treatment includes different chemotherapy regimens as well as the anti-CD20 ... -
Influence of chronic kidney disease on presentation, treatment and outcome in patients with coronary artery disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-11-20)Background. About one third of patients with myocardial infarction (MI) have renal dysfunction (RD). Concomitant coronary artery disease (CAD) and RD is accompanied by a markedly higher risk of death and subsequent ... -
Hantaviruses, escapees from the death row : viral mechanisms towards apoptosis resistance
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-10-25)Over the past decades, humanity has witnessed a constant stream of emerging pathogenic RNA viruses. The recurrent outbreaks of Ebola virus in Africa, the emergence of West Nile virus in North America and the sporadic but ... -
Modelling ineffective erythropoiesis in myelodysplastic syndromes with ring sideroblasts
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-10-02)Myelodysplastic syndromes with ring sideroblast (MDS-RS) is a clonal hematological malignancy characterized by accumulation of iron filled erythroblasts called ring sideroblasts in the bone marrow, and recurrent somatic ... -
Hypersexual disorder : clinical presentation and treatment
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-09-27)Background: Persistent hypersexual behavior (HB) leading to negative consequences is a phenomenon that has lacked a recognized diagnosis in the psychiatric nomenclature, despite extensive study. Due to differences in the ... -
Regulation of calcium flux by activating and inhibitory receptor crosstalk in NK cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-05-27)The birth of a new born child kicks off the immune system to be on call and to respond promptly to threats from the environment. Natural Killer cells, classified as a member of the innate lymphoid cell family, express ... -
Educational leadership in health professions education
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-05-24)The aim of this thesis was to explore perceptions and experiences of educational leaders leading educational change and development in health professions and interprofessional education. The sensitising concepts of the ... -
Dynamics of natural killer cell homeostasis : implications for cell-based cancer Immunotherapy
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-05-08)Natural killer (NK) cells comprise a central role within the innate immune system, eliminating virally infected, foreign and transformed cells through their natural cytotoxic capacity. Release of their cytotoxic granules ... -
Clinical and prophylactic studies of human tuberculosis in a low-endemic setting
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-05-03)Sweden is a low burden country for tuberculosis (TB). New cases occur mainly among immigrants from countries with a higher TB prevalence. Most persons infected with TB (latent TB) will not develop disease (active TB). ... -
Hepatitis C in people who inject drugs in the Stockholm needle exchange program : incidence, spontaneous clearance and change in risk behaviour
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-05-03)The major transmission route for hepatitis C virus (HCV) is sharing of unsterile injection equipment (needle/syringes and paraphernalia). Needle exchange programs (NEP) reduce injection risk behaviour and HCV spread among ... -
Degradomics : a study of the cellular proteolytic landscape in enterovirus infections
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-05-02)The common human pathogen, enteroviruses (EVs) are a genus of single stranded RNA viruses that include Coxsackie B virus (CVBs). The viral RNA encodes a polyprotein containing two viral proteases 2Apro and 3Cpro, that ... -
Clinical aspects of chronic graft-versus-host disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-18)Chronic graft-versus-host disease (cGVHD) remains one of the most severe complications after allogeneic hematopoietic stem cell transplantation (HSCT), affecting both the quality of life and mortality of long-term survivors. ... -
Predictors of arrhythmias, cardiac arrest, and mortality in acute coronary syndrome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-17)Background. Patients with acute coronary syndrome (ACS) face a high risk of lethal complications, both during the hospital course and after discharge. The aim of this thesis was to assess patient characteristics and ... -
Invariant T cell subsets in immune defense of oral mucosa and skin
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-12)Innate-like T lymphocytes such as mucosa-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells recognize antigens presented by MR1 and CD1d molecules, respectively. As MR1 presents microbial ... -
Natural killer cells, multiple myeloma, and daratumumab : a love-hate relationship
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-11)Multiple myeloma is a treatable, but not yet curable, malignant plasma cell disease. Over the last decades, the overall survival time of multiple myeloma patients has constantly increased thanks to improvements in ...