Inst för medicin, Huddinge / Dept of Medicine, Huddinge: Recent submissions
Now showing items 1-20 of 264
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Hantaviruses, escapees from the death row : viral mechanisms towards apoptosis resistance
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-10-25)Over the past decades, humanity has witnessed a constant stream of emerging pathogenic RNA viruses. The recurrent outbreaks of Ebola virus in Africa, the emergence of West Nile virus in North America and the sporadic but ... -
Modelling ineffective erythropoiesis in myelodysplastic syndromes with ring sideroblasts
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-10-02)Myelodysplastic syndromes with ring sideroblast (MDS-RS) is a clonal hematological malignancy characterized by accumulation of iron filled erythroblasts called ring sideroblasts in the bone marrow, and recurrent somatic ... -
Hypersexual disorder : clinical presentation and treatment
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-09-27)Background: Persistent hypersexual behavior (HB) leading to negative consequences is a phenomenon that has lacked a recognized diagnosis in the psychiatric nomenclature, despite extensive study. Due to differences in the ... -
Regulation of calcium flux by activating and inhibitory receptor crosstalk in NK cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-05-27)The birth of a new born child kicks off the immune system to be on call and to respond promptly to threats from the environment. Natural Killer cells, classified as a member of the innate lymphoid cell family, express ... -
Educational leadership in health professions education
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-05-24)The aim of this thesis was to explore perceptions and experiences of educational leaders leading educational change and development in health professions and interprofessional education. The sensitising concepts of the ... -
Dynamics of natural killer cell homeostasis : implications for cell-based cancer Immunotherapy
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-05-08)Natural killer (NK) cells comprise a central role within the innate immune system, eliminating virally infected, foreign and transformed cells through their natural cytotoxic capacity. Release of their cytotoxic granules ... -
Clinical and prophylactic studies of human tuberculosis in a low-endemic setting
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-05-03)Sweden is a low burden country for tuberculosis (TB). New cases occur mainly among immigrants from countries with a higher TB prevalence. Most persons infected with TB (latent TB) will not develop disease (active TB). ... -
Hepatitis C in people who inject drugs in the Stockholm needle exchange program : incidence, spontaneous clearance and change in risk behaviour
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-05-03)The major transmission route for hepatitis C virus (HCV) is sharing of unsterile injection equipment (needle/syringes and paraphernalia). Needle exchange programs (NEP) reduce injection risk behaviour and HCV spread among ... -
Degradomics : a study of the cellular proteolytic landscape in enterovirus infections
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-05-02)The common human pathogen, enteroviruses (EVs) are a genus of single stranded RNA viruses that include Coxsackie B virus (CVBs). The viral RNA encodes a polyprotein containing two viral proteases 2Apro and 3Cpro, that ... -
Clinical aspects of chronic graft-versus-host disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-18)Chronic graft-versus-host disease (cGVHD) remains one of the most severe complications after allogeneic hematopoietic stem cell transplantation (HSCT), affecting both the quality of life and mortality of long-term survivors. ... -
Predictors of arrhythmias, cardiac arrest, and mortality in acute coronary syndrome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-17)Background. Patients with acute coronary syndrome (ACS) face a high risk of lethal complications, both during the hospital course and after discharge. The aim of this thesis was to assess patient characteristics and ... -
Invariant T cell subsets in immune defense of oral mucosa and skin
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-12)Innate-like T lymphocytes such as mucosa-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells recognize antigens presented by MR1 and CD1d molecules, respectively. As MR1 presents microbial ... -
Natural killer cells, multiple myeloma, and daratumumab : a love-hate relationship
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-11)Multiple myeloma is a treatable, but not yet curable, malignant plasma cell disease. Over the last decades, the overall survival time of multiple myeloma patients has constantly increased thanks to improvements in ... -
Studies of innate and adaptive lymphocytes in human liver diseases and viral infections
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-01)The immune system, including innate and adaptive lymphocytes, is involved in determining the outcome of many human diseases. Two lymphocyte subsets, natural killer (NK) cells and T cells, which are present in both ... -
Identification of novel factors regulating human adipocyte function and their link to metabolic health
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-03-13)The white adipose tissue (WAT) regulates energy homeostasis by storing and releasing energy in the form of fat as well as functioning as an endocrine organ secreting a myriad of different peptides. The heterogeneous WAT ... -
Adipose markers of metabolic outcome after weight loss
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-02-28)Adipose tissue is closely linked to metabolic disturbances in obesity. Bariatric surgery such as roux-en-Y gastric bypass (RYGB) remains the most effective treatment of obesity and obesity-related disease. More factors ... -
Studies of effector functions in mycobacterium tuberculosis-infected macrophages with implications for host-directed therapies
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-02-15)Tuberculosis infection remains a global health problem and the emergence of multidrugresistant TB (MDR-TB) adds further challenges in the battle to stop the spread of infection. Macrophages are the primary host cells to ... -
Bronchoprovocation studies to define mechanisms in asthma and airway inflammation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-01-31)Bronchial provocations with a variety of stimuli have been widely used over the past 70 years in both asthma research as well as in daily clinical praxis in order to aid the physician to establish the asthma diagnosis. In ... -
Understanding the role of bone marrow niche in myeloid malignancies
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-01-31)Normal hematopoiesis is generated and maintained by rare hematopoietic stem cells (HSCs) through their capacity to self-renew and differentiate. This process is rigorously controlled, both by HSC-intrinsic molecular ... -
Exploring the role of epigenetic alterations in myeloid malignancies with focus on drug response
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-11-19)The production of blood cells (hematopoiesis), where the hematopoietic stem cell (HSC) is the cell of origin of all blood cells, is regulated by a complex network of intrinsic and extrinsic signals. Dysregulation of ...