Now showing items 1-20 of 228

  • The role of monocytes in chronic inflammatory diseases 

    Björnfot Holmström, Sofia (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-11-15)
    Monocytes and monocyte-derived cells are important players in the orchestration of inflammatory reactions in blood and peripheral tissues. However, little is known about the monocyte fate upon entry into human tissues, ...
  • Role of MAIT cells in human antimicrobial immunity 

    Dias, Joana (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-10-31)
    Mucosa-associated invariant T (MAIT) cells are a relatively recently discovered subset of unconventional T cells. In humans, MAIT cells are predominantly CD8+CD4- (CD8+) with a smaller CD8-CD4- (double-negative, DN) ...
  • Human cytotoxic lymphocyte differentiation in health and disease 

    Schlums, Heinrich (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-10-26)
    Cytotoxic lymphocytes, comprising natural killer (NK) cells and CD8+ cytotoxic T cells, eradicate infected or malignant cells by release of lytic granules and alarm the immune system through production of pro-inflammatory ...
  • Understanding chronic immunodeficiency disorders through assessment of cytotoxic lymphocyte function 

    Theorell, Jakob (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-09-20)
    Representing an evolving and diverse group of syndromes, immunodeficiencies can currently be viewed as a spectrum of disorders where a dysfunction of the immune system plays a significant etiologic role. Cytotoxic ...
  • The role of microbial translocation and gut microbiota in HIV-1 infection 

    Vesterbacka, Jan (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-09-01)
    HIV-1 infection is characterized by persistent systemic inflammation and immune activation, even in patients receiving effective antiretroviral therapy (ART). Translocation of microbial compounds from a leaky gut to systemic ...
  • Aberrant DNA methylation in acute myeloid leukemia 

    Qu, Ying (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-05-18)
    DNA methylation is an important epigenetic mechanism that influences development and cancer by regulating gene transcription. Aberrant DNA methylation is a feature of cancer including acute myeloid leukemia (AML). It was ...
  • Long-term clinical, histological and virological outcomes after sustained virologic response in patients with chronic hepatitis C 

    Hedenstierna, Magnus (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-05-09)
    Successful antiviral treatment of chronic hepatitis C (HCV), resulting in Sustained Virologic Response (SVR) has been shown to reduce the risk for liver related complications, hepatocellular carcinoma (HCC) and death. ...
  • Enterovirus infections in type 1 diabetes and cystic fibrosis : antiviral defence and viral immune evasion strategies 

    Svedin, Emma (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-04-20)
    Enteroviruses are common viruses which cause infections in humans that usually result in mild flu-like symptoms before viral clearance. However, in some cases these infections can progress to more severe diseases such ...
  • Neutrophil interactions with Streptococcus pyogenes and Staphylococcus aureus 

    Uhlmann, Julia (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-04-03)
    Streptococcus pyogenes and Staphylococcus aureus are Gram-positive bacteria that share many features, including clinical presentations and pathogenic mechanisms, and yet, they still have unique properties. They both cause ...
  • Atrial fibrillation and lifestyle factors with focus on physical activity and alcohol consumption 

    Drca, Nikola (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-02-06)
    The overall aim of this thesis was to investigate how modifiable lifestyle factors, with a focus on alcohol consumption and physical activity, influence the risk of atrial fibrillation (AF). The thesis is based on data ...
  • Aspects on endoscopic characterization and clinical management of Barrett's esophagus 

    Silva, Francisco Baldaque (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-12-30)
    Barrett's esophagus (BE) is considered to result from prolonged gastroesophageal reflux and is the only known precursor of esophageal adenocarcinoma. The clinical management of BE patients aims to control esophageal ...
  • Role of innate cellular immunity in the immunopathogenesis of HIV-1 infection in Uganda 

    Sekiziyivu, Proscovia Naluyima (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-11-17)
    The global epidemic of HIV has resulted in more than 34 million deaths and currently 36.9 million HIV-infected people worldwide. Uganda has an HIV prevalence of 7.3%, equating to about 1.6 million people. This has placed ...
  • Genotype-phenotype relations in SF3B1 mutated myelodysplastic syndromes with ring sideroblasts 

    Conte, Simona (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-10-28)
    Myelodysplastic syndrome with ring sideroblasts (MDS-RS) is a clonal hematopoietic stem cell disorder characterized by hyperplastic and ineffective erythropoiesis, ring sideroblasts in the bone marrow, and anemia. ...
  • Dynamic shaping of human NK cell receptor repertoires : implications for NK cell-based immunotherapy 

    Liu, Lisa (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-10-20)
    Natural killer (NK) cells are innate lymphocytes with a potent intrinsic capacity to kill tumor cells, which makes them attractive candidates for cell-based cancer immunotherapy. Advances during the past decade have revealed ...
  • Clinical studies in multiple myeloma 

    Lund, Johan (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-09-23)
    Multiple Myeloma (MM) is an incurably disease of the bone marrow. It is characterized by the uncontrolled growth of clonal plasma cells (PCs) and leads to production of non-functional gammaglobulin. Clinical features include ...
  • Role of syntaxin-11 and munc18-2 in lymphocyte cytotoxic granule exocytosis 

    Müller, Martha-Lena (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-08-18)
    Mutations in genes required for the exocytosis of cytotoxic granules by NK cells and cytotoxic T lymphocytes are associated with early-onset familial hemophagocytic lymphohistiocytosis (FHL). In this project, we examined ...
  • Studies on cholesterol and bile acid metabolism in relation to plasma lipoproteins 

    Sjöberg, Beatrice (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-06-01)
    The metabolism of cholesterol and bile acids is tightly controlled but only partially characterized. The liver is responsible for most of the clearance and catabolism of plasma cholesterol, and the hepatocyte expression ...
  • The regulatory role of microRNA in human adipocytes and their link to insulin resistance 

    Belarbi, Yasmina (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-05-30)
    White adipose tissue (WAT) is a highly plastic organ which secretes a large number of peptide factors termed adipokines. Increased caloric intake increases WAT mass which results in marked alterations in the secretory ...
  • Host-pathogen interactions in invasive Staphylococcus aureus infections 

    Mairpady Shambat, Srikanth (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-05-19)
    Staphylococcus aureus is a versatile human pathogen causing a wide range of diseases from uncomplicated skin and soft tissue infections to life-threatening invasive diseases like endocarditis, bacteremia, necrotizing ...
  • Cell-mediated immunity to flavivirus infections 

    Blom, Kim (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2016-04-27)
    NK cells and T cells constitute a major part of the cell-mediated immune system and play important roles in the host defense against viral infections. Most current knowledge of cell-mediated immune responses to primary ...