Inst för medicin, Huddinge / Dept of Medicine, Huddinge: Recent submissions
Now showing items 1-20 of 281
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Mesenchymal niche contribution to normal and malignant hematopoiesis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-11-05)Normal hematopoiesis is tightly regulated by hematopoietic microenvironment/niche in bone marrow (BM) via direct hematopoietic cell-niche cell interaction and factors secreted by various types of cellular niches. The BM ... -
Human innate lymphocytes in host defense, tissue function and reproduction
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-10-23)The immune system is present in all tissues of the human body. In order to respond appropriately to infections, cells of the innate and adaptive immune system work in concert. In this thesis, we focused on natural killer ... -
Viral gastrointestinal infections in allogeneic hematopoietic stem cell transplant patients
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-10-16)Gastrointestinal symptoms, and elevated liver enzymes, are common after HSCT, often due to drug toxicity, graft-versus-host disease (GVHD) or infections. It is essential to distinguish between GVHD and infection, since ... -
Assessment and prognostic importance of nutritional status and body composition in liver transplantation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-09-08)Chronic liver disease and liver cirrhosis are progressive diseases closely linked to metabolism and nutritional status. Weight loss is a result of negative energy balance and is therefore a good measure of risk of malnutrition. ... -
Models of the lung tissue microenvironment for studies of human myeloid cell function
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-07-31)Studies of the immune system requires knowledge concerning not only the perturbating event itself, i.e. specific microorganisms, and how it interacts with immune cells but also how it functions in its natural environment ... -
Interleukin 15 throughout murine natural killer cell biology
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-07-31)Natural killer (NK) cells are innate immune cells that mount responses against virally infected, transformed and allogeneic transplanted cells. Equipped with cytolytic molecules and death receptors, NK cells mediate ... -
Common respiratory virus infections in cystic fibrosis : from immunity to vaccine
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-05-27)Cystic fibrosis is the most common lethal monogenetic disease in Caucasians. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator protein which is responsible for appropriate ion and water ... -
Innate-like T cells in the immunopathogenesis of HIV-1 infection
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-05-20)The immunodynamics of HIV infection have been studied for over three decades in the hopes of determining underlying mechanisms that contribute to the sustained immune dysfunction observed even in individuals on therapy. ... -
Shame and stigma in weight management during pregnancy and post bariatric surgery : perspectives of patients and healthcare providers
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-04-20)Background: Body mass index (BMI) increases across the world, yet there is an alarming lack of obesity prevention and treatments that are effective, harmless and available for everyone in need. Stigmatizing attitudes ... -
Hepatitis C : prevalence, risk factors and implications for screening
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-04-17)Hepatitis C is a blood-borne virus that mainly affects the liver. The infection is often contracted early in life and remains as an asymptomatic slowly progressive disease. The World Health Organization (WHO) has set a ... -
On osmolality and sperm function during processing for assisted reproduction
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-03-24)Deep basic knowledge about sperm physiology is relevant and important to optimize the outcome of procedures used during Assisted Reproductive Technologies (ART) to select spermatozoa for fertilization. More specifically, ... -
Genetic and epigenetic studies of acute myeloid leukemia and therapeutic possibilities
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-03-05)Acute myeloid leukaemia (AML) is malignant tumour that forms in the bone marrow and arises from immature myeloid progenitors. Consequently, this leads to excessive accumulation of dysfunctional blast cells and lack of ... -
Focus on fibroblasts : development, plasticity, and therapeutic challenges in the cardiac fibroblast lineage.
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-02-28)Cardiac fibroblasts (CFs) are cells of mesenchymal origin and represent a heterogeneous population in the mammalian heart. They secrete extracellular matrix (ECM) molecules providing structural support during heart development ... -
Characterization of secondary and therapy-related acute myeloid leukemia
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-02-13)Secondary acute myeloid leukemia (s-AML) refers to patients with either therapy-related AML (t-AML), that is, AML after treatment with chemo- and/or radiation for a prior disease, or AML progressing from an antecedent ... -
Educational leadership in physicians´ specialist training : programme directors´ experiences
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-02-07)Competent physicians working in teams with other health professionals are a prerequisite for excellent patient care. The context for this thesis is physicians’ specialist training, which consists of workplace learning in ... -
Follicular lymphoma : clinical and biological factors associated with response to therapy and overall prognosis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-01-29)Follicular lymphoma (FL) is a heterogeneous group of malignancies within the adaptive immune system. The clinical course is highly variable. Treatment includes different chemotherapy regimens as well as the anti-CD20 ... -
Influence of chronic kidney disease on presentation, treatment and outcome in patients with coronary artery disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-11-20)Background. About one third of patients with myocardial infarction (MI) have renal dysfunction (RD). Concomitant coronary artery disease (CAD) and RD is accompanied by a markedly higher risk of death and subsequent ... -
Hantaviruses, escapees from the death row : viral mechanisms towards apoptosis resistance
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-10-25)Over the past decades, humanity has witnessed a constant stream of emerging pathogenic RNA viruses. The recurrent outbreaks of Ebola virus in Africa, the emergence of West Nile virus in North America and the sporadic but ... -
Modelling ineffective erythropoiesis in myelodysplastic syndromes with ring sideroblasts
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-10-02)Myelodysplastic syndromes with ring sideroblast (MDS-RS) is a clonal hematological malignancy characterized by accumulation of iron filled erythroblasts called ring sideroblasts in the bone marrow, and recurrent somatic ... -
Hypersexual disorder : clinical presentation and treatment
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-09-27)Background: Persistent hypersexual behavior (HB) leading to negative consequences is a phenomenon that has lacked a recognized diagnosis in the psychiatric nomenclature, despite extensive study. Due to differences in the ...