Inst för medicin, Huddinge / Dept of Medicine, Huddinge: Recent submissions
Now showing items 1-20 of 287
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The antimicrobial role of human MAIT cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-03-19)MAIT cells are unconventional T cells that have characteristics of both innate and adaptive immunity. Their fast mobilization and wide distribution in tissues make them part of the first line of defense against infection. ... -
Strategies to assess and improve prognostication of plasma cell disorders
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-03-01)Plasma cell dyscrasias (PCD) are a group of disorders, most of which have the overproduction of monoclonal immunoglobulins (M-protein) in common. Included in the group of PCDs are both benign and treatment demanding ... -
Immunopathogenesis in pulmonary tuberculosis : impact of immunomodulation and diabetes co-morbidity
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-26)Even in the 21st century, tuberculosis (TB) remains a major global health threat, primarily due to the emergence of antibiotic resistance. Presence of co-morbidities such as diabetes mellitus (DM) has worsened the current ... -
Innate lymphoid cell plasticity and heterogeneity in human tissues
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-05)The human immune system is a vital mechanism that protects the host from outside threats. The two main branches of this system, consisting of innate and adaptive immunity, aid the host when dangers of both imminent and ... -
Platelet transfusions in hematological disorders
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-01-12)Platelets are important for clot formation and vascular integrity. Thrombocytopenic patients with hematological disorders are at risk of bleeding and platelet transfusions are important in supportive care and treatment of ... -
Chronic bone marrow failure and transfusion patterns : epidemiological studies of blood transfusions and outcomes in patients with myelodysplastic syndromes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-12-22)Myelodysplastic syndromes (MDS) encompass a diverse group of clonal hematological malignancies characterized by dysplasia and ineffective hematopoiesis with an increased risk of leukemic evolution. It is a disease of the ... -
Mesenchymal niche contribution to normal and malignant hematopoiesis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-11-05)Normal hematopoiesis is tightly regulated by hematopoietic microenvironment/niche in bone marrow (BM) via direct hematopoietic cell-niche cell interaction and factors secreted by various types of cellular niches. The BM ... -
Human innate lymphocytes in host defense, tissue function and reproduction
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-10-23)The immune system is present in all tissues of the human body. In order to respond appropriately to infections, cells of the innate and adaptive immune system work in concert. In this thesis, we focused on natural killer ... -
Viral gastrointestinal infections in allogeneic hematopoietic stem cell transplant patients
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-10-16)Gastrointestinal symptoms, and elevated liver enzymes, are common after HSCT, often due to drug toxicity, graft-versus-host disease (GVHD) or infections. It is essential to distinguish between GVHD and infection, since ... -
Assessment and prognostic importance of nutritional status and body composition in liver transplantation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-09-08)Chronic liver disease and liver cirrhosis are progressive diseases closely linked to metabolism and nutritional status. Weight loss is a result of negative energy balance and is therefore a good measure of risk of malnutrition. ... -
Models of the lung tissue microenvironment for studies of human myeloid cell function
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-07-31)Studies of the immune system requires knowledge concerning not only the perturbating event itself, i.e. specific microorganisms, and how it interacts with immune cells but also how it functions in its natural environment ... -
Interleukin 15 throughout murine natural killer cell biology
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-07-31)Natural killer (NK) cells are innate immune cells that mount responses against virally infected, transformed and allogeneic transplanted cells. Equipped with cytolytic molecules and death receptors, NK cells mediate ... -
Common respiratory virus infections in cystic fibrosis : from immunity to vaccine
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-05-27)Cystic fibrosis is the most common lethal monogenetic disease in Caucasians. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator protein which is responsible for appropriate ion and water ... -
Innate-like T cells in the immunopathogenesis of HIV-1 infection
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-05-20)The immunodynamics of HIV infection have been studied for over three decades in the hopes of determining underlying mechanisms that contribute to the sustained immune dysfunction observed even in individuals on therapy. ... -
Shame and stigma in weight management during pregnancy and post bariatric surgery : perspectives of patients and healthcare providers
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-04-20)Background: Body mass index (BMI) increases across the world, yet there is an alarming lack of obesity prevention and treatments that are effective, harmless and available for everyone in need. Stigmatizing attitudes ... -
Hepatitis C : prevalence, risk factors and implications for screening
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-04-17)Hepatitis C is a blood-borne virus that mainly affects the liver. The infection is often contracted early in life and remains as an asymptomatic slowly progressive disease. The World Health Organization (WHO) has set a ... -
On osmolality and sperm function during processing for assisted reproduction
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-03-24)Deep basic knowledge about sperm physiology is relevant and important to optimize the outcome of procedures used during Assisted Reproductive Technologies (ART) to select spermatozoa for fertilization. More specifically, ... -
Genetic and epigenetic studies of acute myeloid leukemia and therapeutic possibilities
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-03-05)Acute myeloid leukaemia (AML) is malignant tumour that forms in the bone marrow and arises from immature myeloid progenitors. Consequently, this leads to excessive accumulation of dysfunctional blast cells and lack of ... -
Focus on fibroblasts : development, plasticity, and therapeutic challenges in the cardiac fibroblast lineage.
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-02-28)Cardiac fibroblasts (CFs) are cells of mesenchymal origin and represent a heterogeneous population in the mammalian heart. They secrete extracellular matrix (ECM) molecules providing structural support during heart development ... -
Characterization of secondary and therapy-related acute myeloid leukemia
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-02-13)Secondary acute myeloid leukemia (s-AML) refers to patients with either therapy-related AML (t-AML), that is, AML after treatment with chemo- and/or radiation for a prior disease, or AML progressing from an antecedent ...