Doktorsavhandlingar / Doctoral Theses - D1 (KI DS): Recent submissions
Now showing items 41-60 of 177
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Oral anticoagulants as stroke prevention in the setting of atrial fibrillation and cancer
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2020-09-24)Background: Cancer patients have elevated risk of both stroke and bleeding in comparison to individuals without cancer. The general population is ageing and the group of patients with atrial fibrillation (AF) and cancer ... -
Total hip arthroplasty, osteolysis and cardiovascular disease in patients with osteoarthritis of the hip
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2020-05-20)The pathogenesis of OA and CVD is currently related to inflammatory processes. It is unknown how OA and its surgical treatment impact the cardiovascular system. Hypotheses: We hypothesized that (1) THA patients more ... -
Implications of brief episodes of atrial fibrillation (micro-AF)
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2020-05-08)INTRODUCTION: Atrial fibrillation (AF) is the most common clinically relevant arrhythmia. It is diagnosed using an electrocardiogram (ECG) and defined as an irregular heart rhythm without p-waves lasting for at least 30 ... -
Screening for atrial fibrillation and treatment with anticoagulant to prevent stroke
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2020-02-19)AIMS AND METHODS: The aim of this thesis was to evaluate the outcomes of two cross-sectional screening projects for atrial fibrillation (AF) in primary care using intermittent ECG three times per day over a 2-week period. ... -
Interleukin 6 trans-signalling : cardiovascular risk marker or therapeutical target?
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2020-02-14)Background: Interleukin (IL) 6 signals in two pathways. In classical signalling, essential in antimicrobial defence and tissue regeneration, IL6 binds the membrane-bound IL6 receptor (IL6R) which associates with the signal ... -
Feasibility and efficacy of incorporating an exoskeleton in gait training during subacute stroke rehabilitation
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2020-02-12)Introduction: Hemiparesis is the most common acute manifestation of stroke and often has a strong negative impact on walking ability leaving one third of patients dependent in walking activities outside one’s home. Improved ... -
Evaluation of prostheses in shoulder arthroplasty : methods for assessment of outcome
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2020-01-15)Today, the shoulder joint is the third most commonly replaced joint after the hip and knee joints and the incidence is increasing. In Sweden, 1863 primary Shoulder Arthroplasties and 195 revisions were performed in 2017. ... -
Non-invasive imaging for improved cardiovascular diagnostics : shear wave elastography, relative pressure estimation, and tomographic reconstruction
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2019-08-28)Throughout the last century, medical imaging has come to revolutionise the way we diagnose disease, and is today an indispensable part of virtually any clinical practice. In cardiovascular care imaging is extensively ... -
New diagnostic approaches to monitor irrigating fluid absorption
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2019-08-27)Rinsing the endoscopic operating field with an irrigating solution entails the risk of absorption of the fluid. The physiological consequences of such absorption are explored and two new methods for monitoring the amount ... -
Endocrine and paracrine factors related to pregnancy and infertility
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2019-05-24)Unexplained infertility, one of the common gynecological disorders, affecting 10 to 15 % of women worldwide. Recurrent pregnancy loss affects approximately 1 to 3 % of pregnant women with an unknown etiology in 50 % of ... -
Platelet microparticles and hemostatic disturbances in renal insufficiency and cardiovascular disease
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2019-04-26)Background: Chronic kidney disease (CKD) affect up to 10-15% of the population worldwide and is a growing global health problem. Diabetes, hypertension and renal diseases, such as glomerulonephritis, are the major cause ... -
Nursing perspectives on patients' sleep during hospital care
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2019-04-25)Sleep is crucial for all humans in terms of health, daily functioning and well-being. Previous research has shown that sleep is considered a stressor for patients during hospital care. The general aim of this thesis was ... -
Adverse events following surgery of the hip
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2019-04-25)Introduction: An adverse event (AE) is when a patient is harmed in healthcare. There are many different definitions of AEs and internationally, many different definitions are used. It may seem obvious that the healthcare ... -
Mild traumatic brain injury : antecedents and aftermath
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2019-03-08)Mild Traumatic Brain Injury (mTBI) is a frequent, trauma-induced injury, associated with loss of consciousness and/or memory loss for the injury event. Injured individuals experience a wide range of somatic symptoms (e.g. ... -
Effects of MediYoga among patients with paroxysmal atrial fibrillation
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-12-20)Introduction: Patients with paroxysmal atrial fibrillation often experience impaired health-related quality of life. Standard treatment is not always sufficient and changes in life-style habits are suggested as a complement. ... -
Treating vascular dysfunction in chronic kidney disease : intervention with vitamin D
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-10-26)Background: Chronic kidney disease (CKD) is common, affecting 10-15% of the population worldwide. It is currently recognised by both cardiologists and nephrologists as a strong risk factor for cardiovascular events and ... -
Innate immune factors in recurrent and persistent infections of the lower female genital tract
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-10-18)Background: Infections of the female genital tract are common and have severe impact on the quality of life and sexual health of affected women. The innate immune system is crucial and is involved in the defense of infections. ... -
Paediatric intensive care in Sweden : an epidemiological survey focusing on diagnostic panorama, outcome and factors influencing long-term mortality
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-10-04)Background: In the 1990´s, studies of paediatric intensive care around the world had shown better outcome for children treated in PICUs compared to adult ICUs (AICU). In Sweden no nationwide data on children needing ICU ... -
Pituitary dysfunction and relation to cognitive and global outcome after traumatic brain injury or aneurysmal subarachnoid haemorrhage
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-09-19)Traumatic brain injury (TBI) and aneurysmal subarachnoid haemorrhage (aSAH) are leading causes of deaths and may cause permanent physical, cognitive, behavioural, and psychosocial disabilities limiting daily activities in ... -
Novel insights into echocardiographic assessment of cardiac function following heart surgery
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-09-07)Assessment of cardiac function is a fundamental in everyday clinical decision making and is essential diagnostic tool for choosing therapy in patients with cardiac disease. Currently, echocardiography is the integral part ...