Doktorsavhandlingar / Doctoral Theses - D1 (KI DS)
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Disability and health-related quality of life in patients with amyotrophic lateral sclerosis, and caregiving experience from the perspective of next of kin
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-11-20)Background: Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease leading to progressive muscle weakness resulting in respiratory failure and death. The average survival time from diagnosis is two to ... -
Treating vascular dysfunction in chronic kidney disease : intervention with vitamin D
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-10-26)Background: Chronic kidney disease (CKD) is common, affecting 10-15% of the population worldwide. It is currently recognised by both cardiologists and nephrologists as a strong risk factor for cardiovascular events and ... -
Innate immune factors in recurrent and persistent infections of the lower female genital tract
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-10-18)Background: Infections of the female genital tract are common and have severe impact on the quality of life and sexual health of affected women. The innate immune system is crucial and is involved in the defense of infections. ... -
Paediatric intensive care in Sweden : an epidemiological survey focusing on diagnostic panorama, outcome and factors influencing long-term mortality
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-10-04)Background: In the 1990´s, studies of paediatric intensive care around the world had shown better outcome for children treated in PICUs compared to adult ICUs (AICU). In Sweden no nationwide data on children needing ICU ... -
Pituitary dysfunction and relation to cognitive and global outcome after traumatic brain injury or aneurysmal subarachnoid haemorrhage
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-09-19)Traumatic brain injury (TBI) and aneurysmal subarachnoid haemorrhage (aSAH) are leading causes of deaths and may cause permanent physical, cognitive, behavioural, and psychosocial disabilities limiting daily activities in ... -
Novel insights into echocardiographic assessment of cardiac function following heart surgery
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-09-07)Assessment of cardiac function is a fundamental in everyday clinical decision making and is essential diagnostic tool for choosing therapy in patients with cardiac disease. Currently, echocardiography is the integral part ... -
Effects of cigarettes, e-cigarettes and Swedish snus on vascular function
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-07-17)Cigarette smoking is considered one of the leading causes of preventable morbidity and premature death worldwide. A large portion of this is attributable to cardiovascular disease such as ischemic heart disease and stroke. ... -
Assessment and management of patients at risk for persisting disability after mild traumatic brain injury
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-05-25)There is a lack of evidence-based interventions for patients with persisting problems after mild traumatic brain injury (mTBI). The interventions needed should focus on patients at particular risk for persisting disability ... -
Improving the quality of care for hip fracture patients : studies on fast-track to surgery and adverse events
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-05-16)Hip fractures in the elderly are common and are associated with high comorbidity and mortality. Their care and treatment present challenges for nurses and other healthcare professionals and impose a substantial burden on ... -
Platelet function and thrombin generation in ischemic stroke : clinical correlates and prognostic importance
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-05-15)Platelet function is central to atherothombotic diseases and antiplatelet agents prevent non-cardioembolic ischemic stroke (IS). Individual differences in platelet reactivity may limit the response to antiplatelet treatment, ... -
Biomarkers in endotoxemia with a special interest in citrullinated histone H3
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-05-09)Background: Sepsis with multi-organ failure has an unacceptably high mortality rate of 25- 30% despite the use of antibiotics and modern intensive care. Attenuating the multi-organ failure and finding new biomarkers for ... -
Vascular and endothelial function in human hypertension, and the importance of the renin-angiotensin-aldosterone system
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-03-01)Background: Hypertension induces structural vascular and cardiac changes with increased arterial stiffness and left ventricular (LV) hypertrophy and is major risk factor for cardiovascular morbidity and mortality. The ... -
Pain relief during labour and following obstetric and gynaecological surgery with special reference to neuroaxial morphine
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-02-22)Background: Pain is a major clinical problem during childbirth and postoperatively after caesarean section (CS) and hysterectomy. There are several reasons why pain should be minimized; pain is indeed a negative sensation, ... -
Studies on platelet function and microvesicles in acute coronary syndrome
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-01-19)INTRODUCTION: The cornerstone of treatment of acute coronary syndrome (ACS) is percutaneous coronary intervention (PCI) and dual antiplatelet therapy (DAT) with aspirin and the ADP-receptor inhibitor clopidogrel. However, ... -
Hyperthyroidism and its impact on cardiovascular disease : with special emphasis on atrial fibrillation
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-12-21)Background Hyperthyroidism is a common disease throughout the world, affecting 0.5%-2% of women and one-tenth as many men at some time. Graves’ disease and toxic nodular goitre are the two most common etiologies. ... -
Gastric bypass : positive and negative health effects
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-12-15)Obesity is a major health problem worldwide. It is preventable in theory, but in practice no country has been able to stop the development of increasing obesity. The only available treatment with sufficient long-term ... -
Treatment of displaced femoral neck fractures in the elderly
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-11-23)Femoral neck fracture (FNF) in elderly patients is a common cause of suffering and premature death in individuals with osteoporotic bones. This fracture type is more common in women after menopause, and the associated ... -
Cardiovascular function in normal pregnancy and fetal growth
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-10-20)Background: Pregnancy is a challenge to a woman’s cardiovascular system, and extensive haemodynamic changes are required for optimal utero-placental circulation and fetal growth. The aim of this thesis was firstly to ... -
Haemostatic and inflammatory alterations in hypertension and hyperlipidaemia, and the impact of angiotensin II
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-08-29)The process of atherosclerosis is multifactorial, and endothelial dysfunction is considered to precede atherosclerosis. Angiotensin (Ang) II, the main effector of renin-angiotensinaldosterone system (RAAS), is implicated ... -
Heart failure after myocardial infarction : contemporary trends, determinants and prognostic implications - nationwide observational studies
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-05-18)Coronary artery disease (CAD) is one of the leading causes of heart failure (HF). The overall aim of this thesis is to describe contemporary epidemiology of post myocardial infarction HF including temporal trends, changes ...