Doktorsavhandlingar / Doctoral Theses - D1 (KI DS)
Items in "Publications from KI" are protected by copyright, with all rights reserved, unless otherwise indicated. They may not be used for commercial purposes.
Recent Submissions
-
Haemostatic and inflammatory alterations in hypertension and hyperlipidaemia, and the impact of angiotensin II
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-08-29)The process of atherosclerosis is multifactorial, and endothelial dysfunction is considered to precede atherosclerosis. Angiotensin (Ang) II, the main effector of renin-angiotensinaldosterone system (RAAS), is implicated ... -
Heart failure after myocardial infarction : contemporary trends, determinants and prognostic implications - nationwide observational studies
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-05-18)Coronary artery disease (CAD) is one of the leading causes of heart failure (HF). The overall aim of this thesis is to describe contemporary epidemiology of post myocardial infarction HF including temporal trends, changes ... -
Acquired brain injury and evaluation of intensive training of attention in early neurorehabilitation : statistical evaluation and qualitative perspectives
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-05-11)Attention dysfunction is a cardinal symptom after an acquired brain injury (ABI) sometimes leading to life-long consequences that affect learning skills, daily functioning and social and emotional life. Attention may be ... -
Liver metastases from colorectal cancer
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-04-10)Introduction: Colorectal cancer (CRC) is the third most common cancer worldwide. At diagnosis of CRC 20-25% of patients have metastatic disease. The liver is the most common metastatic site and liver metastases are detected ... -
Quality of life in men with inguinal hernia and outcome after three different mesh techniques
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-02-08)Inguinal hernia repair (IHR) is a very common surgical procedure with approximately 16 000 procedures performed every year in Sweden. Previously, recurrence after IHR was a major concern, but with the introduction of the ... -
Troponin elevation in acute stroke : clinical characteristics and the link to cancer-associated neutrophil extracellular traps
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-01-18)Elevated plasma levels of troponin, a marker of myocardial injury, are a frequent observation in stroke patients. Despite several reports on an adverse short-term prognosis, however, the significance of troponin elevation ... -
Screening for atrial fibrillation in high-risk individuals : a stroke preventive effort
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2016-10-31)INTRODUCTION A condition can be suitable for population screening if the disease is an important health problem, can be detected by an appropriate test and has a silent/latent stage during which treatment could be ... -
Medical and nurse students’ perspective on learning in acute care
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2016-08-25)Background: Medical and nurse students’ professional training takes place in a complex and rapidly changing health care setting. Workplace learning in this context have a considerable potential to contribute to the development ... -
Clinical and surgical aspects of treatment of degenerative and traumatic rotator cuff tears
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2016-05-23)Pain caused by rotator cuff pathology or tear is a major source of discomfort and dysfunction in the shoulder joint. The prevalence of rotator cuff tear increases with age and also as the workforce becomes older. The number ... -
Implantable defibrillator at end of life with emphasis on deactivation and guideline compliance
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2016-04-26)Introduction Implantable Cardioverter Defibrillators (ICD) have been demonstrated to improve survival in cardiac patients with high risk for sudden death. The incidence of ICD implantations is increasing worldwide. The ... -
Aspects of diverting stoma and ERAS in rectal cancer surgery
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2016-04-25)Annually, nearly 2000 patients are diagnosed with rectal cancer in Sweden. To date, the only known curative treatment is surgery and low anterior resection (LAR) is the operation of choice for tumours in the middle rectum. ... -
Coping and emotional well-being in patients with chronic heart failure
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2015-08-19)Background: Chronic heart failure (CHF) is a serious illness, with a profound impact on the patient. Poor health-related quality of life (HRQoL) as well as anxiety and depression are prevalent in CHF and predict mortality ... -
Afflicted by an acute myocardial infarction : patients' thoughts, feelings and actions prior to care-seeking
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2015-03-20)Introduction: Acute myocardial infarction (AMI) is the most prevalent cause of death in Europe. The primary aim of early medical contact when afflicted by an AMI is to be able to treat fatal arrhythmias and to save heart ... -
Inflammatory bowel disease and complementary and alternative medicine - The perspectives of patients and healthcare professionals
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2015-03-17)Background: Inflammatory bowel disease (IBD) is a term that covers ulcerative colitis (UC) and Crohn’s disease (CD). The causes of IBD are unknown and the incidence is increasing. IBD is a lifelong disease with severe ... -
Predicting prostate cancer : on the use of biomarkers in prostate cancer diagnostics
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2015-01-08)Aims The aims of this thesis work were to answer the following questions. Paper I: How prevalent is testing and retesting with prostate-specific antigen (PSA)?; Paper II: Is a genetic score based on single-nucleotide ... -
Prostate cancer diagnostics - complications and ways to reduce unnecessary biopsies
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2014-12-29)Introduction: Prostate cancer is the most common form of cancer among men in Sweden. There has been a rapid increase in the incidence rate of prostate cancer following the introduction of PSA testing and, today, more ... -
Post-polio syndrome : analysis of inflammation and immune modulation
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2014-12-19)Poliomyelitis is a viral infection, which affects the anterior horn cells of the spinal cord leaving patients with different levels and distribution of muscle weakness and loss of, or decreased, function. This situation ... -
The pelvic floor and genital prolapse : a clinical, physiological and radiological study
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 2000-05-05)Objective: To determine the frequency of concomitant colorectal disorders in patients with rectocele, and to assess any such association with rectocele; to investigate if paradoxical sphincter reaction (PSR) is influenced ... -
Displaced femoral neck fractures : studies on osteosynthesis and total hip arthroplasty
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 2000-04-28)The treatment of femoral neck fractures has for many years in Sweden been reduction and osteosynthesis with nails or screws. For displaced fractures the risk of complications such as avascular necrosis and non-union is up ... -
Combined sulphonylurea and insulin treatment for type 2 diabetes mellitus : metabolic and electrophysiological studies
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 2000-03-10)Type 2 diabetes is a prevalent disorder characterized by elevated blood glucose levels and associated with increased morbidity from micro- and macrovascular complications. Lowering of blood glucose has been shown to reduce ...