Doktorsavhandlingar / Doctoral Theses - D1 (KI DS)
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Assessment and management of patients at risk for persisting disability after mild traumatic brain injury
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-05-25)There is a lack of evidence-based interventions for patients with persisting problems after mild traumatic brain injury (mTBI). The interventions needed should focus on patients at particular risk for persisting disability ... -
Improving the quality of care for hip fracture patients : studies on fast-track to surgery and adverse events
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-05-16)Hip fractures in the elderly are common and are associated with high comorbidity and mortality. Their care and treatment present challenges for nurses and other healthcare professionals and impose a substantial burden on ... -
Platelet function and thrombin generation in ischemic stroke : clinical correlates and prognostic importance
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-05-15)Platelet function is central to atherothombotic diseases and antiplatelet agents prevent non-cardioembolic ischemic stroke (IS). Individual differences in platelet reactivity may limit the response to antiplatelet treatment, ... -
Biomarkers in endotoxemia with a special interest in citrullinated histone H3
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-05-09)Background: Sepsis with multi-organ failure has an unacceptably high mortality rate of 25- 30% despite the use of antibiotics and modern intensive care. Attenuating the multi-organ failure and finding new biomarkers for ... -
Vascular and endothelial function in human hypertension, and the importance of the renin-angiotensin-aldosterone system
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-03-01)Background: Hypertension induces structural vascular and cardiac changes with increased arterial stiffness and left ventricular (LV) hypertrophy and is major risk factor for cardiovascular morbidity and mortality. The ... -
Pain relief during labour and following obstetric and gynaecological surgery with special reference to neuroaxial morphine
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-02-22)Background: Pain is a major clinical problem during childbirth and postoperatively after caesarean section (CS) and hysterectomy. There are several reasons why pain should be minimized; pain is indeed a negative sensation, ... -
Studies on platelet function and microvesicles in acute coronary syndrome
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-01-19)INTRODUCTION: The cornerstone of treatment of acute coronary syndrome (ACS) is percutaneous coronary intervention (PCI) and dual antiplatelet therapy (DAT) with aspirin and the ADP-receptor inhibitor clopidogrel. However, ... -
Hyperthyroidism and its impact on cardiovascular disease : with special emphasis on atrial fibrillation
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-12-21)Background Hyperthyroidism is a common disease throughout the world, affecting 0.5%-2% of women and one-tenth as many men at some time. Graves’ disease and toxic nodular goitre are the two most common etiologies. ... -
Gastric bypass : positive and negative health effects
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-12-15)Obesity is a major health problem worldwide. It is preventable in theory, but in practice no country has been able to stop the development of increasing obesity. The only available treatment with sufficient long-term ... -
Treatment of displaced femoral neck fractures in the elderly
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-11-23)Femoral neck fracture (FNF) in elderly patients is a common cause of suffering and premature death in individuals with osteoporotic bones. This fracture type is more common in women after menopause, and the associated ... -
Cardiovascular function in normal pregnancy and fetal growth
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-10-20)Background: Pregnancy is a challenge to a woman’s cardiovascular system, and extensive haemodynamic changes are required for optimal utero-placental circulation and fetal growth. The aim of this thesis was firstly to ... -
Haemostatic and inflammatory alterations in hypertension and hyperlipidaemia, and the impact of angiotensin II
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-08-29)The process of atherosclerosis is multifactorial, and endothelial dysfunction is considered to precede atherosclerosis. Angiotensin (Ang) II, the main effector of renin-angiotensinaldosterone system (RAAS), is implicated ... -
Heart failure after myocardial infarction : contemporary trends, determinants and prognostic implications - nationwide observational studies
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-05-18)Coronary artery disease (CAD) is one of the leading causes of heart failure (HF). The overall aim of this thesis is to describe contemporary epidemiology of post myocardial infarction HF including temporal trends, changes ... -
Acquired brain injury and evaluation of intensive training of attention in early neurorehabilitation : statistical evaluation and qualitative perspectives
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-05-11)Attention dysfunction is a cardinal symptom after an acquired brain injury (ABI) sometimes leading to life-long consequences that affect learning skills, daily functioning and social and emotional life. Attention may be ... -
Liver metastases from colorectal cancer
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-04-10)Introduction: Colorectal cancer (CRC) is the third most common cancer worldwide. At diagnosis of CRC 20-25% of patients have metastatic disease. The liver is the most common metastatic site and liver metastases are detected ... -
Quality of life in men with inguinal hernia and outcome after three different mesh techniques
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-02-08)Inguinal hernia repair (IHR) is a very common surgical procedure with approximately 16 000 procedures performed every year in Sweden. Previously, recurrence after IHR was a major concern, but with the introduction of the ... -
Troponin elevation in acute stroke : clinical characteristics and the link to cancer-associated neutrophil extracellular traps
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-01-18)Elevated plasma levels of troponin, a marker of myocardial injury, are a frequent observation in stroke patients. Despite several reports on an adverse short-term prognosis, however, the significance of troponin elevation ... -
Screening for atrial fibrillation in high-risk individuals : a stroke preventive effort
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2016-10-31)INTRODUCTION A condition can be suitable for population screening if the disease is an important health problem, can be detected by an appropriate test and has a silent/latent stage during which treatment could be ... -
Medical and nurse students’ perspective on learning in acute care
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2016-08-25)Background: Medical and nurse students’ professional training takes place in a complex and rapidly changing health care setting. Workplace learning in this context have a considerable potential to contribute to the development ... -
Clinical and surgical aspects of treatment of degenerative and traumatic rotator cuff tears
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2016-05-23)Pain caused by rotator cuff pathology or tear is a major source of discomfort and dysfunction in the shoulder joint. The prevalence of rotator cuff tear increases with age and also as the workforce becomes older. The number ...