Doktorsavhandlingar / Doctoral Theses - D1 (KI DS): Recent submissions
Now showing items 121-140 of 177
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Clinical and epidemiological aspects of obesity during pregnancy and the puerperium
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2013-11-12)Objective: To study different aspects of obesity during pregnancy, birth and the puerperium. Paper I is an intervention study of obese pregnant women. Paper II compares fatty acid (FA) patterns in breast milk and neonates ... -
Long-term sickness absence for psychiatric disorder : the association with staff downsizing, treatment, workplace-oriented rehabilitation, and subsequent cause-specific inpatient care and mortality
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2013-06-20)Psychiatric disorders have increased as causes of long-term sickness absence in Sweden as well as in other countries. Still, there is limited research on psychiatric sickness absence. The overall objective of this thesis ... -
Fractures of the distal radius : epidemiology, treatment and outcome assessment
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2013-04-16)This thesis aims to increase scientific knowledge of the most common fracture, namely the distal radius. Our understanding of this fracture is still limited, but every year in Sweden over 20,000 patients suffer from this ... -
Effects of in vitro fertilization on thrombosis and haemostasis and the relationship between infertility and cardiovascular disease
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2013-04-10)Background: Infertility afflicts more than 10% of all couples worldwide. In vitro fertilization (IVF) is now performed at an ever increasing rate. There is scarce information concerning the associations between cardiovascular ... -
Cell derived microparticles : method development, and clinical and experimental studies
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2013-02-15)Background: Cell derived microparticles (MP) are released from the cell membrane upon activation or apoptosis. They resemble their parent cell by exposing similar proteins or surface receptors. This enables identification ... -
Post-polio syndrome : physiotherapeutic analysis and interventions
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2013-01-24)This thesis presents four studies focusing on outcomes of gait performance using gait analysis and/or the Six-minute-walk test (6MWT), in patients with post-polio syndrome (PPS). Further, resistance training in combination ... -
Effect of endogenous and exogenous ghrelin on gastrointestinal function in rat and human
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2013-01-18)Background: Several peptides derived from the gastrointestinal tract (GI) have been shown to have profound effects on GI motility, food intake and metabolism. Two such peptides, derived from the same prohormone, are the ... -
Fatigue and cognition : hormonal perspectives
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2012-12-21)Fatigue is a common complaint and considered a very challenging symptom to cope with in many different medical diseases. The assessment of fatigue is bound up with the problems of both conceptualization and definition. In ... -
Adiponectin in atherosclerosis
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2012-11-23)Adiponectin is a protein secreted from adipocytes, circulating at high levels in plasma (3 30μg/mL), and in overweight subjects it is down regulated. Adiponectin inhibits the development of atherosclerosis in experimental ... -
Clinical and pathophysiological aspects of intrahepatic cholestasis of pregnancy
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2012-11-20)Objective: The pathogenesis of intrahepatic cholestasis of pregnancy (ICP) involves impaired bile acid and estrogen/progesterone metabolism and excretion based on genetic and environmental factors. In this thesis we evaluated ... -
Behavior change intervention and fear of hypoglycemia in type 1 diabetes
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2012-11-07)Introduction: Individuals with type 1 diabetes require lifelong insulin supply as well as behavioral adjustments for good treatment result. Only a minority reach the goal for glycemic control set in order to reduce the ... -
Clinical aspects on glucose-lowering therapies in type 2 diabetes
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2012-09-03)Type 2 diabetes is a progressive disease with deterioration of glycaemic control over time in association with loss of endogenous insulin secretion. As a consequence of this, sulphonylureas (SU), which exert their mode of ... -
MRSA and other resistant bacteria : prevalence, patient and staff experiences, wounds and infection control
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2012-08-23)Antibiotic resistance has become a major and serious global problem in healthcare. Limited treatment options for infections caused by these organisms can lead to increased morbidity and mortality. Sweden has a low prevalence ... -
Pelvic floor dysfunction depending on mode of delivery : clinical and epidemiological aspects
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2012-04-27)Objective: To study pelvic floor disorders in relation to mode of delivery using clinical and epidemiological methods; to compare the prevalence and risk of lower urinary tract symptoms (LUTS) in healthy primiparous women ... -
Evaluation of retrospective patient record review as a method to identify patient safety and quality information in orthopaedic care
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2012-04-18)The great benefits of modern healthcare must be weighed against the risk of patient injury due to human intervention. Studies show that adverse events (AE) are identified in up to 16.6% of all hospitalisations. As a step ... -
Transvaginal mesh for pelvic organ prolapse : clinical and histological aspects
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2012-04-04)The objectives of this thesis were to assess the objective, clinical, and sexual outcomes after transvaginal surgery for pelvic organ prolapse using a trocar guided mesh kit, to ascertain the vaginal in vivo histological ... -
Cutaneous lupus erythematosus : epidemiology, association with SLE and comorbidity
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2012-01-04)Lupus erythematosus (LE) is a disease that includes a broad spectrum of symptoms, from localized cutaneous LE (CLE) to severe systemic LE (SLE). Based on histopathological changes, the skin manifestations of LE can be ... -
Living with inflammatory bowel disease : health-related quality of life, worries, and stress
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2012-01-04)Background: Patients with inflammatory bowel disease have a number of worries and concerns related to the disease, and in comparison with a general population their health-related quality of life is impaired. These patients ... -
Hemostatic disturbances in acute ischemic stroke
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2011-12-16)Background: Stroke is the 2nd most common cause of death after ischemic heart disease. About 85% of all strokes are caused by a thrombus or an embolus in the cerebral circulation. Stroke causes major handicap with impaired ... -
Studies of haemostasis in acute coronary syndromes and diabetes mellitus
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2011-11-18)The pathophysiology of acute coronary syndromes (ACS) includes atherosclerotic plaque rupture and coronary thrombus formation. Antithrombotic treatment is effective but recurrent atherothrombotic or bleeding complications ...