Inst för neurovetenskap / Dept of Neuroscience: Recent submissions
Now showing items 101-120 of 294
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Neurodegenerative diseases studied in human brain and rodent models
(Inst för neurovetenskap / Dept of Neuroscience, 2015-02-19)Parkinson’s and Alzheimer’s disease are the two most common neurodegenerative diseases world-wide, but are still little understood. Papers in this thesis examine some of the possible pathogenic mechanisms with the help of ... -
Stem cells and mineralized tissue : characterization and disease modeling
(Inst för neurovetenskap / Dept of Neuroscience, 2015-01-08)Deficits in mineralized tissue, as a result of abnormal development, trauma, disease or aging, are major medical problems. Consequently, new methods to regenerate stable and functional bone is a main focus in the field of ... -
Leptin targets in the brain regulating body weight : receptors and down-stream mediators of leptin in neurons of the hypothalamus and brainstem
(Institutionen för neurovetenskap / Department of Neuroscience, 2000-05-25)Obesity is a disease which has become a global epidemic that is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health in the world. In particular, obesity is associated ... -
Hippocampal galanin and acetylcholine in spatial learning
(Institutionen för neurovetenskap / Department of Neuroscience, 2000-05-19)The aim of the present thesis was to study how the neuropeptide galanin affects the neurochemistry and functional activity of the cholinergic septohippocampal projection, which plays a pivotal role in learning and memory. ... -
Tetrodotoxin-resistant sodium channels in neuropathic pain
(Institutionen för neurovetenskap / Department of Neuroscience, 2000-05-15)Injury to the peripheral nervous system can cause neuropathic pain. Abnormal sodium channel activity has been implicated as a source of ectopic firing and changes in nociceptive threshold following nerve injury. Primary ... -
On the actions of neurotrophic factors on the chromaffin cells of the adrenal medulla
(Institutionen för neurovetenskap / Department of Neuroscience, 2000-04-14)Chromaffin cells producing adrenaline or noradrenaline are the predominant cell type in the adrenal medulla, but ganglion cells and Schwann cells are also present. All cells of the adrenal medulla are derived from the ... -
Changes in sensory systems during aging : an experimental study in the rat
(Institutionen för neurovetenskap / Department of Neuroscience, 1999-11-26)Aging is associated with sensorimotor disturbances, including increased proprioceptive thresholds. The present study aimed to clarify the occurrence of structural and biochemical alterations in sensory systems of behaviorally ... -
Spinal motoneurons and molecules related to neurotrophic function after axon injury
(Institutionen för neurovetenskap / Department of Neuroscience, 1999-12-24)The capacity of motoneurons to survive and regenerate new axons after injuries such as axotomy depends on a great variety of parameters. After sciatic nerve transection (SNT) in adult rats and to some extent after a ventral ... -
Observations on morphology and function of cutaneous and subcutaneous sensory mechanoreceptors : an experimental study in mammals
(Institutionen för neurovetenskap / Department of Neuroscience, 1999-11-24)Tactile sensory discrimination is dependent upon an intact system of peripheral mechanoreceptors, their nerve fibre afferents with cell bodies in the dorsal root ganglion and the dorsal column-medial lemniscal system which ... -
Structure and function of trigeminal primary sensory neurons after peripheral nerve injury
(Institutionen för neurovetenskap / Department of Neuroscience, 1999-11-25)Iatrogenic injuries to branches of the trigeminal nerve are common during surgical procedures in the jaws and teeth, and as the repercussion of facial fractures or certain pathologies. A portion of these patients are left ... -
Transcriptional regulation of the neuropeptide galanin : special reference to axotomy
(Institutionen för neurovetenskap / Department of Neuroscience, 1999-11-19)Galanin is a neuropeptide which is located in both the central and peripheral nervous system. In peripheral neurones, this peptide is thought to be involved in influencing pain sensation after nerve injury (neuropathic ... -
Behavioural and biochemical pharmacology of adenosine/dopamine receptor/receptor interaction
(Institutionen för neurovetenskap / Department of Neuroscience, 1999-11-11)The neurotransmitter dopamine seems to be involved in neuropsychiatric diseases such as schizophrenia and Parkinson's disease. Direct blockade of dopamine receptors of the D2 subtype has been the hallmark of pharmacotherapy ... -
Immunocytochemical studies of cutaneous nerves in human normal and prurigo nodularis skin
(Institutionen för neurovetenskap / Department of Neuroscience, 1999-11-05)Cutaneous nerves may regulate the immune system and be involved in inflammatory events of the skin. Prurigo nodularis is a skin disease which histologically reveals a massive neural hyperplasia and a local inflammation in ... -
Dopaminergic and serotonergic modulation of cellular and locomotor network properties in the lamprey spinal cord
(Institutionen för neurovetenskap / Department of Neuroscience, 1999-09-03)Motor activity is the basis for all behavior. It is therefore important to study the processes generating movement such as the neuronal networks in the spinal cord that generates and controls locomotion. The lamprey is ... -
Neuropeptide circuitries regulating food and water intake
(Institutionen för neurovetenskap / Department of Neuroscience, 1999-05-14)An adequate supply of nutrients through food intake is critical for survival, as evidenced by disorders such as obesity and anorexia, which in the long run may be life-threatening. Feeding behaviour is ultimately controlled ... -
Experimental studies on the sources, pathways and targets for volume transmission in the rat brain
(Institutionen för neurovetenskap / Department of Neuroscience, 1999-03-05)Volume transmission has been defined as the three-dimensional diffusion or convection of transmitters in the extracellular space (ECS) and cerebrospinal fluid (CSF) over a larger distance than the synaptic cleft. The ... -
Physiopathological aspects of NMDA transmission in the basal ganglia : in vitro and in vivo release studies
(Institutionen för neurovetenskap / Department of Neuroscience, 1998-12-25)N-methyl-D-aspartic acid (NMDA) is an excitatory amino acid selectively acting on a subclass of glutamate receptors (the NMDA ionotropic receptor) which has been involved in many of the physiological and pathological effects ... -
The internationalization of work : psychophysiological predictors of adjustment to foreign assignment
(Institutionen för neurovetenskap / Department of Neuroscience, 1998-11-27)Developments during the last decade have resulted in an increased globalization of both personal and financial resources. This thesis is based on a longitudinal, prospective study, following a group of employees and their ... -
Neuromuscular aspects of eccentric knee extensor actions : effects of electrical stimulation, age, gender and training
(Institutionen för neurovetenskap / Department of Neuroscience, 1998-11-13)The overall aim of this thesis was to study the effects of electrical stimulation, age, gender and training on the torque- and EMG-velocity relationships during eccentric knee extensor muscle actions in man. An isokinetic ... -
Neuronal tracers for fine caliber spinal primary afferents and their response to peripheral nerve injury
(Institutionen för neurovetenskap / Department of Neuroscience, 1998-11-13)The isolectin B4 from Griffonia simplicifolia I (B4) and soybean agglutinin from the plant Glycine max (SBA), have been shown to bind to rat small-diameter dorsal root ganglion (DRG) neurons, and to fibers and presumed ...