Doktorsavhandlingar / Doctoral Theses - C2 (MBB): Recent submissions
Now showing items 61-80 of 303
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Long non-coding RNAs in the epigenetic regulation of oligodendrocyte differentiation
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-08-08)Long non-coding RNAs (lncRNAs) constitute a heterogeneous class of RNAs with limited coding potential, united by an arbitrarily placed cut off of >200 ntd. The past decade has seen the emergence of lncRNAs as versatile ... -
On GABAergic interneuron diversity and maturation
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-23)GABAergic interneurons provide finely, distinct styles of inhibition granted by their unique targeting preferences, molecular profiles, and morphological silhouettes. A central quest of my thesis was to explore what ... -
Applications of DNA origami encoded nanoscale patterns
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-15)It was almost four decades ago when the recognition of DNA’s potential use as a programmable, self-assembling building material for nanostructures led to the birth and rapid expansion of the field of DNA nanotechnology, ... -
Shedding light on the STAT3 small molecule inhibitor field
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-13)STAT3 is one of the seven family members of the STAT transcription factor family. STAT3 has become a very attractive target for cancer therapy and other diseases. It has a prominent role in cancer development as well as ... -
Metabolic disorders : genes and mechanisms
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-07)Mitochondrial disorders constitute a subgroup of the large family of rare monogenic diseases called Inborn Errors of Metabolism (IEM), but defects in mitochondrial activity have also been reported in more common and complex ... -
Specification of enteric neuron subtypes in the developing gut
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-06)The enteric nervous system (ENS) is the biggest subdivision of the peripheral nervous system and harbors more neurons than the spinal cord. Its intricate network of ganglia is spanning the entire length of the gastrointestinal ... -
tPA mediated activation of PDGF-C/PDGFRα signaling in the CNS
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-03)The platelet derived growth factors (PDGFs) and their tyrosine kinase receptors play an essential role during development, in adult tissue homeostasis and in several pathological events. PDGF-CC, a ligand for PDGFRα, is ... -
Regeneration and neural circuits in the spinal cord : an imaging study on zebrafish
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-03-14)The reversal of spinal cord injury (SCI) and its devastating effect on voluntary control is one of the most provocative challenges in neuroscience research. Preclinical and clinical research has for a very long time tried ... -
Molecular mechanisms and targets of new anticancer treatments
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-02-06)The work presented in this thesis is an effort to decipher and understand the mechanism of action (MOA) of anticancer agents by building on and complementing chemical proteomics methods. The backbone of the thesis relies ... -
Decoding the contribution of transcription factors to cell fate determination
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-11-19)It is well accepted that transcription factors (TFs) play a crucial role in determining cell identity. Although RNA expression or protein abundance data show that a large fraction of the total TFs are expressed in a given ... -
Kidney diseases : insights from omics approaches
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-11-12)Chronic kidney diseases (CKDs) affects about 11-15% of adults worldwide. When it progresses to the end-stage renal disease (ESRD), there is no effective medication for cure, the only treatment being chronic dialysis or ... -
Lineages and molecular heterogeneity in the developing nervous system
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-09-28)Information in the genome unfolds through a dynamic process leading to the molecular and anatomical organization of a physiologically functional organism. The nervous system is the most diverse and intricate architecture ... -
From genes to function in autoimmunity : a salty story
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-05-24)Autoimmunity is a condition in which the ability to tolerate self breaks down, resulting in immune responses against the body’s own healthy cells and tissues. Autoimmune diseases are complex and multifactorial, and both ... -
Functional investigation of prognostic biomarkers and therapeutic targets in glioma brain tumors
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-04-06)Gliomas are known to be the most prevalent primary tumors of the central nervous system, of which glioblastoma is the most aggressive type with a median survival less than 2 years and no available cure. Studies in this ... -
Design and analysis of wireframe DNA nanostructures
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-04-05)In the last decades, the powerful self-assembly properties of DNA have been harnessed to produce complex structures at the nanoscale with high precision and yield. DNA origami is one of the most robust examples of this, ... -
Roles of NUDT5 and NUDT15 beyond oxidized nucleotide sanitation and their potential as therapeutic targets
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-03-15)The nucleotide precursor pool is readily susceptible to numerous sources of modification and damage, including alkylation, deamination and oxidation/nitrosylation, among others; most of which have deleterious effects on ... -
Identification of novel Wnt/PCP signaling regulators and their role in midbrain dopaminergic neuron development and Parkinson's disease
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-03-08)Wnt signaling controls a wide spectrum of complex cell responses during prenatal development, in the adulthood and during disease. In this doctoral study, we have identified and explored novel regulatory components of ... -
Endothelial : mural cell interplay in regulation of blood- and lymph vessel development and function
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-12-21)Blood- and lymphatic vascular development and homeostasis depend on correct endothelial-mural cell interaction, and dysregulation thereof is apparent in multiple human diseases. However the mechanisms controlling the ... -
Novel aspects of atherosclerosis : focusing on new target genes and the effect of cholesterol-lowering
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-12-15)Atherosclerosis is most often the main underlying cause of cardiovascular diseases (CVDs), accounting for more than 31% of all deaths worldwide. It is driven by the uptake of low-density lipoproteins (LDL) by a dysfunctional ... -
Eicosanoids and exosomes : a link between macrophages and lung cancer
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-11-01)Chronic inflammation increases the risk of lung cancer. Macrophages (MO) are important players in inflammation, with regulatory and executive functions. Eicosanoids and exosomes can be both triggers and mediators of these ...