Doktorsavhandlingar / Doctoral Theses - C2 (MBB): Recent submissions
Now showing items 41-60 of 302
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Analysis of antibodies to cartilage oligomeric matrix protein in rheumatoid arthritis and in mouse models
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-10-13)Rheumatoid arthritis (RA), a common autoimmune disease, affects 0.5-1% of the world’s population. It is not only an important health problem but also a socioeconomic problem considering that it can lead to joint destruction ... -
Redox regulation of T cells in autoimmunity
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-09-03)Autoimmune disorders affect a significant part of the population and therefore present a serious health and economic burden. One of the most common autoimmune diseases is rheumatoid arthritis (RA), affecting 0.5-1% of the ... -
Positional cloning of polymorphic loci that control autoreactive T cells
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-08-13)Autoimmune diseases are expensive diseases, both financially and socially, because they are in most cases life long and require a long-lasting treatment. They can also be life threatening, as they are among top 10 causes ... -
Identifying genetic determinants of T cell-dependent autoimmunity using forward genetics
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-07-29)Rheumatoid arthritis (RA) affects 0.5-1% of the population and is an important health and socioeconomic problem. RA has a high degree of heritability. Thus, extensive efforts have been made to better understand the genetic ... -
Antibodies as pathogenic factors and biomarkers in rheumatoid arthritis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-05-21)Ever since the evolution of an adaptive immune system capable of creating immune receptors that may recognize self-antigens, we have been at risk of autoimmunity. There are over 100 different types of autoimmune diseases ... -
Plurifaceted proteomics in studying cellular dynamics and action mechanisms of anticancer drugs
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-05-05)Mass spectrometry (MS)-based proteomics has developed tremendously in recent years and was the leading technology for many novel methods to study protein chemistry. Contrary to classical approaches based on Western blot, ... -
Methods development for the investigation of the mammalian genome radial architecture : the quantitative side
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-04-16)The nucleus of mammalian cells cradles the genome, an ensemble of nucleic acid macromolecular polymers that store information in a physical form. For a cell to perform life-sustaining processes, reading and utilizing the ... -
Spatial regulation of membrane receptor signaling using DNA origami
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-04-07)Juxtracrine signaling between apposing membrane receptors and ligands is an important class of intercellular communication. Much focus has been directed towards studying the biochemical interactions between receptors and ... -
Ribosomal RNA dynamics studied by NMR-spectroscopy
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-03-11)The ribosome is a large macromolecular machine that consists of both ribosomal proteins and ribosomal RNA (rRNA). It is a complex consisting of two subunits held together by non-covalent interactions, intersubunit bridges ... -
Cell states along oligodendrocyte development and disease
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-12-23)The brain, one of the most complex organs in the body, where an immense diversity of cell states emerges from simple structure, where function arises from sets of regulatory principles and pattern persist where individual ... -
Novel methods for mapping genome organization and genome fragility in the 3D space of the nucleus
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-11-13)For over a century, scientists have been trying to understand how the DNA molecule that is so tightly packed in the micro space of the nucleus sustains critical cellular processes such as transcription, replication or the ... -
Conformational dynamics in microRNAs : the example of miR-34a targeting Sirt1 mRNA
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-06-17)In biology, regulatory mechanisms are essential to achieve complex tasks, as virtually every process can be positively or negatively modulated in its outcome, upon different cues. In humans, microRNAs (miRNAs) constitute ... -
Studies of the thioredoxin system in redox signaling and oxidative stress
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-05-08)Reactive oxygen species exert reversible posttranslational modifications in proteins containing redox sensitive thiols, thereby affecting several cellular processes and protein functions. Reductive enzyme systems, such as ... -
Applications of genomic tools to decode genome function
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-04-27)The revolution in sequencing technologies has greatly advanced our understanding of genomes. Many regulatory elements lacking protein-coding ability, such as long non-coding RNAs have been identified and characterized in ... -
3D imaging and quantitative analysis of intact tissues and organs
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-04-17)Embryonic development and tumor growth are highly complex and dynamic processes that exist in both time and space. To fully understand the molecular mechanisms that control these processes, it is crucial to study RNA ... -
VEGF-B in islet of langerhans : role in vascular signaling and lipid handling
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-02-13)The discovery of Vascular endothelial growth factor (VEGF)-B’s role in endothelial fatty acid uptake and tissue lipid accumulation opened a new arena for exploration of VEGF-B in lipid metabolism. Indeed, later studies ... -
Novel methods to study genomic fragility and structural variation
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-11-15)DNA double-strand breaks (DSBs) are major DNA lesions that when repaired unfaithfully can give rise to loss of genetic information, chromosomal rearrangements such as insertions/deletions (indels) and copy number alterations ... -
Electrophysiological and molecular diversity of forebrain interneurons
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-09-25)Despite their low abundance, telencephalic interneurons demonstrate a great amount of molecular and electrophysiological heterogeneity, suggesting that they exhibit different functions within the circuit. Interneurons are ... -
Single-stranded DNA : methods and application in nanotechnology
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-09-13)Basic molecular and cell research, production of recombinant proteins, diagnostic detection of genetic mutations, construction of nanostructures and high-throughput DNA sequencing are only a few examples of the diverse set ... -
Long non-coding RNAs in the epigenetic regulation of oligodendrocyte differentiation
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-08-08)Long non-coding RNAs (lncRNAs) constitute a heterogeneous class of RNAs with limited coding potential, united by an arbitrarily placed cut off of >200 ntd. The past decade has seen the emergence of lncRNAs as versatile ...